{"id":"https://openalex.org/W427384268","doi":null,"title":"Functional and therapeutical implications of ligand recognition by the scavenger-like lymphocyte receptors CD5 and CD6","display_name":"Functional and therapeutical implications of ligand recognition by the scavenger-like lymphocyte receptors CD5 and CD6","publication_year":2011,"publication_date":"2011-01-01","ids":{"openalex":"https://openalex.org/W427384268","mag":"427384268"},"language":"en","primary_location":{"id":"pmh:oai:run.unl.pt:10362/6582","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10362/6582","pdf_url":"https://run.unl.pt/bitstreams/569af7e5-368d-429f-9151-fc68d4cb40c8/download","source":{"id":"https://openalex.org/S4306402433","display_name":"Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"master thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://run.unl.pt/bitstreams/569af7e5-368d-429f-9151-fc68d4cb40c8/download","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5073794877","display_name":"In\u00eas Sim\u00f5es","orcid":"https://orcid.org/0000-0003-1730-7263","observed_orcids":["https://orcid.org/0000-0003-1730-7263"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"In\u00eas Sim\u00f5es","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-1730-7263","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5073794877"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cd5","display_name":"CD5","score":0.9890000224113464},{"id":"https://openalex.org/keywords/cd6","display_name":"CD6","score":1.0},{"id":"https://openalex.org/keywords/transgenic-mice","display_name":"transgenic mice","score":0.5580000281333923},{"id":"https://openalex.org/keywords/lymphocyte-homeostasis","display_name":"lymphocyte homeostasis","score":0.6980000138282776},{"id":"https://openalex.org/keywords/regulatory-t-cells","display_name":"regulatory T cells","score":0.9340000152587891},{"id":"https://openalex.org/keywords/nkt-cells","display_name":"NKT cells","score":0.8569999933242798},{"id":"https://openalex.org/keywords/marginal-zone-b-cells","display_name":"marginal zone B cells","score":0.9929999709129333},{"id":"https://openalex.org/keywords/immune-response-to-antigens","display_name":"immune response to antigens","score":0.6150000095367432},{"id":"https://openalex.org/keywords/antitumor-immunity","display_name":"antitumor immunity","score":0.8080000281333923},{"id":"https://openalex.org/keywords/combination-chemotherapy","display_name":"combination chemotherapy","score":0.4620000123977661}],"concepts":[{"id":"https://openalex.org/C41443022","wikidata":"https://www.wikidata.org/wiki/Q27796666","display_name":"Scavenger receptor","level":4,"score":0.6791017651557922},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.6045865416526794},{"id":"https://openalex.org/C116569031","wikidata":"https://www.wikidata.org/wiki/Q899107","display_name":"Ligand (biochemistry)","level":3,"score":0.45939087867736816},{"id":"https://openalex.org/C2777761686","wikidata":"https://www.wikidata.org/wiki/Q715347","display_name":"Lymphocyte","level":2,"score":0.45566385984420776},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.37967461347579956},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3760315477848053},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3533087968826294},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.3530120849609375},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3360462784767151},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.17620974779129028},{"id":"https://openalex.org/C2780072125","wikidata":"https://www.wikidata.org/wiki/Q28350","display_name":"Lipoprotein","level":3,"score":0.0},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:run.unl.pt:10362/6582","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10362/6582","pdf_url":"https://run.unl.pt/bitstreams/569af7e5-368d-429f-9151-fc68d4cb40c8/download","source":{"id":"https://openalex.org/S4306402433","display_name":"Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"master thesis"},{"id":"mag:427384268","doi":null,"is_oa":false,"landing_page_url":"https://run.unl.pt/bitstream/10362/6582/1/Simoes_2011.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:run.unl.pt:10362/6582","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10362/6582","pdf_url":"https://run.unl.pt/bitstreams/569af7e5-368d-429f-9151-fc68d4cb40c8/download","source":{"id":"https://openalex.org/S4306402433","display_name":"Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"master thesis"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W427384268.pdf","grobid_xml":"https://content.openalex.org/works/W427384268.grobid-xml"},"referenced_works_count":39,"referenced_works":["https://openalex.org/W1520738008","https://openalex.org/W1540672909","https://openalex.org/W1558813989","https://openalex.org/W1608547690","https://openalex.org/W1799127337","https://openalex.org/W1964917126","https://openalex.org/W1974778244","https://openalex.org/W1992676642","https://openalex.org/W1994357251","https://openalex.org/W2003652884","https://openalex.org/W2005862926","https://openalex.org/W2006095839","https://openalex.org/W2010102595","https://openalex.org/W2018407954","https://openalex.org/W2021547032","https://openalex.org/W2021627528","https://openalex.org/W2023502808","https://openalex.org/W2031026925","https://openalex.org/W2038976175","https://openalex.org/W2040112038","https://openalex.org/W2049131071","https://openalex.org/W2051116488","https://openalex.org/W2057371303","https://openalex.org/W2065841237","https://openalex.org/W2067703817","https://openalex.org/W2070827084","https://openalex.org/W2088294528","https://openalex.org/W2089919417","https://openalex.org/W2091259187","https://openalex.org/W2092036047","https://openalex.org/W2100412095","https://openalex.org/W2112696943","https://openalex.org/W2128677073","https://openalex.org/W2146349935","https://openalex.org/W2156941611","https://openalex.org/W2157725183","https://openalex.org/W2165903695","https://openalex.org/W2764306030","https://openalex.org/W2817598174"],"related_works":["https://openalex.org/W7000232374","https://openalex.org/W4210315039","https://openalex.org/W2928846592","https://openalex.org/W3010334723","https://openalex.org/W7139567687","https://openalex.org/W7101190189","https://openalex.org/W177125688","https://openalex.org/W2984061997","https://openalex.org/W2413900814","https://openalex.org/W7049173913"],"abstract_inverted_index":{"The":[0],"CD5":[1,42,94,114],"and":[2,25,43,56,95,124,155,165,193,212,251,267],"CD6":[3,44],"lymphocyte":[4,54,99,249],"surface":[5],"receptors":[6],"are":[7,36,45],"highly":[8],"homologous":[9],"members":[10],"of":[11,29,84,109,129,153,184,224,235,239,246],"the":[12,26,33,61,67,89,107,110,127,151,166,181,210,244,253],"Scavenger":[13],"Receptor":[14],"Cystein":[15],"Rich":[16],"(SRCR)":[17],"superfamily":[18],"mainly":[19],"expressed":[20],"by":[21,58,93],"all":[22],"T":[23,154],"lymphocytes":[24],"B1a":[27],"subpopulation":[28],"B":[30,156,173],"cells.":[31],"Although":[32],"ultimate":[34],"function/s":[35],"far":[37],"from":[38],"being":[39],"completely":[40],"understood,":[41],"known":[46],"to":[47,121,147,191],"play":[48],"a":[49,75,81,148,236],"relevant":[50,237,248],"role":[51,238],"in":[52,150,168,218,233,243,259],"both":[53,209],"development":[55],"differentiation":[57],"negatively":[59],"modulating":[60],"survival/death-inducing":[62],"intracellular":[63],"signals":[64],"generated":[65],"during":[66],"antigen":[68,122],"recognition.":[69],"Recently,":[70],"this":[71],"group":[72],"has":[73],"developed":[74],"transgenic":[76],"mouse":[77,116],"line":[78],"which":[79],"expresses":[80],"soluble":[82,112],"form":[83],"human":[85,113],"CD5,":[86],"likely":[87,145],"blocking":[88],"ligand-receptor":[90],"interactions":[91,242],"mediated":[92],"interfering":[96],"with":[97,158,177,202],"normal":[98],"response.":[100],"This":[101],"study":[102,108],"was":[103,131,135],"aimed":[104],"at":[105],"furthering":[106],"recombinant":[111],"Transgenic(rshCD5Tg)":[115],"phenotypical":[117,179,211],"analysis,":[118],"its":[119],"response":[120],"stimuli":[123],"tumor":[125],"implantation;":[126],"function":[128,160],"rshCD6":[130],"also":[132],"tested.":[133],"It":[134],"observed":[136],"that":[137],"rshCD5Tg":[138,185],"mice":[139,186,220],"display":[140],"an":[141],"exacerbated":[142],"immune":[143,189],"response,":[144],"due":[146],"reduction":[149],"number":[152],"cells":[157,170],"regulatory/suppressive":[159],"(Treg,":[161],"B1a,":[162],"B10":[163],"cells)":[164],"increase":[167],"effector":[169],"(NKT,":[171],"MZ":[172],"cells).":[174],"In":[175],"agreement":[176],"these":[178,230],"characteristics,":[180],"functional":[182,213],"analysis":[183],"showed":[187],"enhanced":[188,199],"responses":[190],"Tdependent":[192],"\u2013independent":[194],"antigens,":[195],"as":[196,198,264],"well":[197],"anti-tumoral":[200],"responses,":[201],"or":[203],"without":[204],"concomitant":[205],"chemotherapy":[206],"treatment.":[207],"Importantly,":[208],"findings":[214],"could":[215],"be":[216],"reproduced":[217],"wild-type":[219],"following":[221],"prolonged":[222],"infusion":[223],"purified":[225],"exogenous":[226],"rshCD5":[227],"protein.":[228],"Overall,":[229],"results":[231],"argue":[232],"favor":[234],"CD5-mediated":[240],"molecular":[241],"homeostasis":[245],"functionally":[247],"subpopulations":[250],"open":[252],"possibility":[254],"for":[255],"CD5-based":[256],"therapeutical":[257],"interventions":[258],"different":[260],"disease":[261],"settings":[262],"such":[263],"cancer,":[265],"infection":[266],"immunodeficiency.":[268]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2016-06-24T00:00:00"}
