{"id":"https://openalex.org/W42639007","doi":"https://doi.org/10.5923/j.diabetes.20130203.02","title":"Melatonin Supplementation Improves Glycemic Control While Lowering Oxidative Stress in Type 2 Diabetes","display_name":"Melatonin Supplementation Improves Glycemic Control While Lowering Oxidative Stress in Type 2 Diabetes","publication_year":2013,"publication_date":"2013-01-01","ids":{"openalex":"https://openalex.org/W42639007","doi":"https://doi.org/10.5923/j.diabetes.20130203.02","mag":"42639007"},"language":"en","primary_location":{"id":"pmh:oai:digitalcommons.odu.edu:hms_fac_pubs-1043","doi":"https://doi.org/10.5923/j.diabetes.20130203.02","is_oa":true,"landing_page_url":"https://digitalcommons.odu.edu/hms_fac_pubs/43","pdf_url":"https://digitalcommons.odu.edu/hms_fac_pubs/43","source":{"id":"https://openalex.org/S4377196314","display_name":"ODU Digital Commons (Old Dominion University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I81365321","host_organization_name":"Old Dominion University","host_organization_lineage":["https://openalex.org/I81365321"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Human Movement Studies & Special Education Faculty Publications","raw_type":"article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://digitalcommons.odu.edu/hms_fac_pubs/43","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103714309","display_name":"Carmine R. Grieco","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I95551543","display_name":"Glenville State College","ror":"https://ror.org/04q2w0g82","country_code":"US","type":"education","lineage":["https://openalex.org/I95551543"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Carmine R. Grieco","raw_affiliation_strings":["Glenville State  College"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Glenville State  College","institution_ids":["https://openalex.org/I95551543"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031778225","display_name":"Sheri R. Colberg","orcid":"https://orcid.org/0000-0001-7574-2533","observed_orcids":["https://orcid.org/0000-0001-7574-2533"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sheri R. Colberg","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-7574-2533","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113610758","display_name":"C. Thomas Somma","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C. Thomas Somma","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Andrew G.B. Thompson","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Andrew G.B. Thompson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5088412188","display_name":"Aaron I. Vinik","orcid":"https://orcid.org/0000-0002-5279-0628","observed_orcids":["https://orcid.org/0000-0002-5279-0628"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Aaron I. Vinik","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-5279-0628","affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.2684,"has_fulltext":true,"cited_by_count":4,"citation_normalized_percentile":{"value":0.5137951,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":93},"biblio":{"volume":"2","issue":"3","first_page":"45","last_page":"49"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10342","display_name":"Circadian rhythm and melatonin","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10342","display_name":"Circadian rhythm and melatonin","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10401","display_name":"Diabetes Treatment and Management","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11140","display_name":"Natural Antidiabetic Agents Studies","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/melatonin","display_name":"melatonin","score":0.8659999966621399},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.9810000061988831},{"id":"https://openalex.org/keywords/glycemic-control","display_name":"glycemic control","score":0.9990000128746033},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":1.0},{"id":"https://openalex.org/keywords/malondialdehyde","display_name":"malondialdehyde","score":0.9919999837875366},{"id":"https://openalex.org/keywords/hba1c","display_name":"HbA1c","score":0.9089999794960022},{"id":"https://openalex.org/keywords/dietary-supplementation","display_name":"dietary supplementation","score":0.6119999885559082}],"concepts":[{"id":"https://openalex.org/C2780473172","wikidata":"https://www.wikidata.org/wiki/Q5572518","display_name":"Glycemic","level":3,"score":0.8442129492759705},{"id":"https://openalex.org/C2778182776","wikidata":"https://www.wikidata.org/wiki/Q180912","display_name":"Melatonin","level":2,"score":0.7204345464706421},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7129476070404053},{"id":"https://openalex.org/C2777180221","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 diabetes","level":3,"score":0.7051035165786743},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6714762449264526},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6664876341819763},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.6415905952453613},{"id":"https://openalex.org/C2778401633","wikidata":"https://www.wikidata.org/wiki/Q418661","display_name":"Malondialdehyde","level":3,"score":0.6385055780410767},{"id":"https://openalex.org/C87813604","wikidata":"https://www.wikidata.org/wiki/Q1242899","display_name":"Crossover study","level":4,"score":0.6154727339744568},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.5816758275032043},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.540664792060852},{"id":"https://openalex.org/C2910068830","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 Diabetes Mellitus","level":3,"score":0.43341347575187683},{"id":"https://openalex.org/C2778917026","wikidata":"https://www.wikidata.org/wiki/Q43041","display_name":"Hemoglobin","level":2,"score":0.42898499965667725},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:digitalcommons.odu.edu:hms_fac_pubs-1043","doi":"https://doi.org/10.5923/j.diabetes.20130203.02","is_oa":true,"landing_page_url":"https://digitalcommons.odu.edu/hms_fac_pubs/43","pdf_url":"https://digitalcommons.odu.edu/hms_fac_pubs/43","source":{"id":"https://openalex.org/S4377196314","display_name":"ODU Digital Commons (Old Dominion University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I81365321","host_organization_name":"Old Dominion University","host_organization_lineage":["https://openalex.org/I81365321"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Human Movement Studies & Special Education Faculty Publications","raw_type":"article"},{"id":"mag:42639007","doi":"https://doi.org/10.5923/j.diabetes.20130203.02","is_oa":false,"landing_page_url":"http://article.sapub.org/pdf/10.5923.j.diabetes.20130203.02.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"International Journal of Diabetes Research","raw_type":null}],"best_oa_location":{"id":"pmh:oai:digitalcommons.odu.edu:hms_fac_pubs-1043","doi":"https://doi.org/10.5923/j.diabetes.20130203.02","is_oa":true,"landing_page_url":"https://digitalcommons.odu.edu/hms_fac_pubs/43","pdf_url":"https://digitalcommons.odu.edu/hms_fac_pubs/43","source":{"id":"https://openalex.org/S4377196314","display_name":"ODU Digital Commons (Old Dominion University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I81365321","host_organization_name":"Old Dominion University","host_organization_lineage":["https://openalex.org/I81365321"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Human Movement Studies & Special Education Faculty Publications","raw_type":"article"},"sustainable_development_goals":[{"score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/randomized-controlled-trial","display_name":"Randomized Controlled Trial"},{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W42639007.pdf","grobid_xml":"https://content.openalex.org/works/W42639007.grobid-xml"},"referenced_works_count":38,"referenced_works":["https://openalex.org/W1480866078","https://openalex.org/W1593625319","https://openalex.org/W1908277406","https://openalex.org/W1973259490","https://openalex.org/W1988010651","https://openalex.org/W1993253729","https://openalex.org/W2005840034","https://openalex.org/W2020343018","https://openalex.org/W2021848217","https://openalex.org/W2022526433","https://openalex.org/W2027061140","https://openalex.org/W2027915363","https://openalex.org/W2029535496","https://openalex.org/W2043358394","https://openalex.org/W2044437167","https://openalex.org/W2046005854","https://openalex.org/W2046645679","https://openalex.org/W2049453065","https://openalex.org/W2055988844","https://openalex.org/W2071646553","https://openalex.org/W2085663109","https://openalex.org/W2086677877","https://openalex.org/W2088014624","https://openalex.org/W2089644365","https://openalex.org/W2101811518","https://openalex.org/W2105454690","https://openalex.org/W2111205134","https://openalex.org/W2115218756","https://openalex.org/W2121405025","https://openalex.org/W2121786223","https://openalex.org/W2124533805","https://openalex.org/W2125209003","https://openalex.org/W2134995526","https://openalex.org/W2147942713","https://openalex.org/W2156098150","https://openalex.org/W2166127907","https://openalex.org/W2173441688","https://openalex.org/W2274421275"],"related_works":["https://openalex.org/W2182677981","https://openalex.org/W6912945765","https://openalex.org/W2046005854","https://openalex.org/W4383646709","https://openalex.org/W2979184618","https://openalex.org/W4386771008","https://openalex.org/W4377224868","https://openalex.org/W4403614263","https://openalex.org/W4385737961","https://openalex.org/W4312788394"],"abstract_inverted_index":{"The":[0,99],"purpose":[1],"of":[2,10,59,86,108],"this":[3],"investigation":[4],"was":[5],"to":[6,41,69,95,114],"evaluate":[7],"the":[8],"effect":[9],"melatonin":[11,42,140],"on":[12,90],"glycemic":[13,146],"control":[14,147],"and":[15,79,144],"oxidative":[16],"stress":[17],"(OS)":[18],"in":[19,51,101,132,148],"adults":[20,149],"with":[21,28,150],"type":[22],"2":[23],"diabetes":[24],"(T2D).":[25],"Fourteen":[26],"subjects":[27],"T2D":[29],"(10":[30],"female,":[31],"4":[32],"male;":[33],"52.5":[34],"\u00b1":[35],"5.0":[36],"years)":[37],"were":[38,130],"randomly":[39],"assigned":[40],"(MEL)":[43],"or":[44,61,136],"placebo":[45,64],"groups":[46],"(PLA)":[47,65],"for":[48,118,123],"42":[49,77],"days,":[50,78],"a":[52,84,105],"crossover":[53],"design.":[54],"Subjects":[55],"ingested":[56],"10":[57],"mg":[58],"MEL":[60,91,111,119],"an":[62],"identical":[63],"30":[66],"minutes":[67],"prior":[68],"sleep.":[70],"Fasting":[71],"blood":[72],"draws":[73],"occurred":[74],"at":[75],"baseline,":[76],"84":[80],"days.":[81],"Plasma":[82],"malondialdehyde,":[83],"marker":[85],"OS,":[87],"significantly":[88],"decreased":[89],"(-6.25\u00b12.10":[92],"nmol/ml)":[93],"compared":[94,113],"PLA":[96,115],"(0.72\u00b13.30,":[97],"p=0.028).":[98],"change":[100],"hemoglobin":[102],"A1c":[103],"showed":[104],"total":[106],"improvement":[107],"0.33%":[109],"following":[110],"supplementation":[112],"(-0.24\u00b10.23":[116],"%":[117,122],"vs.":[120],"0.09\u00b10.21":[121],"PLA,":[124],"p=0.01),":[125],"although":[126],"no":[127],"significant":[128],"changes":[129],"noted":[131],"fasting":[133],"plasma":[134],"glucose":[135],"lipid":[137],"levels.":[138],"Daily":[139],"may":[141],"diminish":[142],"OS":[143],"enhance":[145],"T2D.":[151]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-10-12T09:40:04.860316","created_date":"2016-06-24T00:00:00"}