{"id":"https://openalex.org/W426080813","doi":"https://doi.org/10.1212/wnl.84.14_supplement.p4.141","title":"Diabetes, Obesity And Diagnosis Of Amyotrophic Lateral Sclerosis: A Population-Based Study (P4.141)","display_name":"Diabetes, Obesity And Diagnosis Of Amyotrophic Lateral Sclerosis: A Population-Based Study (P4.141)","publication_year":2015,"publication_date":"2015-04-06","ids":{"openalex":"https://openalex.org/W426080813","doi":"https://doi.org/10.1212/wnl.84.14_supplement.p4.141","mag":"426080813"},"language":"en","primary_location":{"id":"doi:10.1212/wnl.84.14_supplement.p4.141","doi":"https://doi.org/10.1212/wnl.84.14_supplement.p4.141","is_oa":false,"landing_page_url":"https://doi.org/10.1212/wnl.84.14_supplement.p4.141","pdf_url":null,"source":{"id":"https://openalex.org/S79704628","display_name":"Neurology","issn_l":"0028-3878","issn":["0028-3878","1526-632X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5021008013","display_name":"Marianthi\u2010Anna Kioumourtzoglou","orcid":"https://orcid.org/0000-0001-5710-4992","observed_orcids":["https://orcid.org/0000-0001-5710-4992"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marianthi-Anna Kioumourtzoglou","raw_affiliation_strings":["Harvard School of Public Health Boston MA United States","3Harvard School of Public Health Boston MA United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Harvard School of Public Health Boston MA United States","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"3Harvard School of Public Health Boston MA United States","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091526885","display_name":"Ran Shmuel Rotem","orcid":"https://orcid.org/0000-0002-8378-3287","observed_orcids":["https://orcid.org/0000-0002-8378-3287"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ran Rotem","raw_affiliation_strings":["Harvard School of Public Health Boston MA United States","3Harvard School of Public Health Boston MA United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Harvard School of Public Health Boston MA United States","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"3Harvard School of Public Health Boston MA United States","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004313058","display_name":"Ryan M. Seals","orcid":"https://orcid.org/0000-0003-0622-9001","observed_orcids":["https://orcid.org/0000-0003-0622-9001"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ryan Seals","raw_affiliation_strings":["Harvard School of Public Health Boston MA United States","3Harvard School of Public Health Boston MA United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Harvard School of Public Health Boston MA United States","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"3Harvard School of Public Health Boston MA United States","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013251164","display_name":"Ole Gredal","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801941904","display_name":"Bispebjerg Hospital","ror":"https://ror.org/00td68a17","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2801941904","https://openalex.org/I2802567020"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Ole Gredal","raw_affiliation_strings":["Bispeberg Hosp/Dept Of Neuro Copenhagen  Denmark","1Bispeberg Hosp/Dept Of Neuro Copenhagen Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bispeberg Hosp/Dept Of Neuro Copenhagen  Denmark","institution_ids":["https://openalex.org/I2801941904"]},{"raw_affiliation_string":"1Bispeberg Hosp/Dept Of Neuro Copenhagen Denmark","institution_ids":["https://openalex.org/I2801941904"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023722191","display_name":"Johnni Hansen","orcid":"https://orcid.org/0000-0002-9342-2725","observed_orcids":["https://orcid.org/0000-0002-9342-2725"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Johnni Hansen","raw_affiliation_strings":["Institute of Cancer Epidemiology Copenhagen  Denmark","5Institute of Cancer Epidemiology Copenhagen Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Cancer Epidemiology Copenhagen  Denmark","institution_ids":[]},{"raw_affiliation_string":"5Institute of Cancer Epidemiology Copenhagen Denmark","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5086410623","display_name":"Marc G. Weisskopf","orcid":"https://orcid.org/0000-0003-4513-9834","observed_orcids":["https://orcid.org/0000-0003-4513-9834"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Marc Weisskopf","raw_affiliation_strings":["HSPH Boston MA United States","4HSPH Boston MA United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"HSPH Boston MA United States","institution_ids":[]},{"raw_affiliation_string":"4HSPH Boston MA United States","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.00652418,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"84","issue":"14_supplement","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10855","display_name":"Amyotrophic Lateral Sclerosis Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10855","display_name":"Amyotrophic Lateral Sclerosis Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11735","display_name":"Peripheral Neuropathies and Disorders","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/amyotrophic-lateral-sclerosis","display_name":"amyotrophic lateral sclerosis","score":1.0},{"id":"https://openalex.org/keywords/diabetes-mellitus","display_name":"diabetes mellitus","score":0.8510000109672546},{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.9879999756813049},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.9179999828338623},{"id":"https://openalex.org/keywords/type-1-diabetes","display_name":"type 1 diabetes","score":0.8830000162124634},{"id":"https://openalex.org/keywords/vascular-risk-factors","display_name":"vascular risk factors","score":0.8970000147819519},{"id":"https://openalex.org/keywords/protective-association","display_name":"protective association","score":0.6729999780654907},{"id":"https://openalex.org/keywords/age-at-diabetes-diagnosis","display_name":"age at diabetes diagnosis","score":0.5600000023841858}],"concepts":[{"id":"https://openalex.org/C2780596555","wikidata":"https://www.wikidata.org/wiki/Q206901","display_name":"Amyotrophic lateral sclerosis","level":3,"score":0.9556410312652588},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8074379563331604},{"id":"https://openalex.org/C511355011","wikidata":"https://www.wikidata.org/wiki/Q12174","display_name":"Obesity","level":2,"score":0.6081448197364807},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.6010624170303345},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.5261515974998474},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3415106534957886},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.15567132830619812},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.11608695983886719},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.07430288195610046}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1212/wnl.84.14_supplement.p4.141","doi":"https://doi.org/10.1212/wnl.84.14_supplement.p4.141","is_oa":false,"landing_page_url":"https://doi.org/10.1212/wnl.84.14_supplement.p4.141","pdf_url":null,"source":{"id":"https://openalex.org/S79704628","display_name":"Neurology","issn_l":"0028-3878","issn":["0028-3878","1526-632X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1585186077","https://openalex.org/W4366352001","https://openalex.org/W2058662184","https://openalex.org/W2754373622","https://openalex.org/W4389437834","https://openalex.org/W2024208999","https://openalex.org/W7096237319","https://openalex.org/W1183572567","https://openalex.org/W3091082500","https://openalex.org/W2947441081"],"abstract_inverted_index":{"OBJECTIVE:":[0],"Assess":[1],"the":[2,17,24,52,138,141,172,201,207],"association":[3,122,174,186,208,225],"between":[4,78,123,209,226],"diabetes,":[5,236],"obesity":[6,111,188],"and":[7,57,80,82,93,101,125,211,230,232],"diagnosis":[8],"of":[9,55,222],"amyotrophic":[10],"lateral":[11],"sclerosis":[12],"(ALS),":[13],"using":[14,69,113],"data":[15,70],"from":[16,71],"Danish":[18,73],"National":[19],"Registers.":[20],"BACKGROUND:":[21],"ALS":[22,58,77,88,106,126,145,212,231],"is":[23,44,200,241],"most":[25],"common":[26],"motor":[27],"neuron":[28],"disorder.":[29],"Several":[30],"vascular":[31,50,227],"risk":[32,39,47,228],"factors":[33,229],"have":[34,59],"been":[35,60],"associated":[36,107],"with":[37,76,108,171,176,219],"decreased":[38],"for":[40,49,86,105,129,144,187,243],"ALS.":[41,244],"Although":[42],"diabetes":[43,56,109,124,130,166,210],"also":[45,180],"a":[46,65,120,159,182,223],"factor":[48],"disease,":[51],"few":[53],"studies":[54],"inconsistent.":[61],"DESIGN/METHODS:":[62],"We":[63,95,118,151,179],"conducted":[64],"population-based":[66],"case-control":[67],"study,":[68],"3,650":[72],"residents":[74],"diagnosed":[75],"1982":[79],"2009,":[81],"365,000":[83],"controls":[84],"(100":[85],"each":[87],"case),":[89],"matched":[90],"on":[91],"age":[92,163,168],"sex.":[94],"calculated":[96],"adjusted":[97],"odds":[98],"ratios":[99],"(OR)":[100],"confidence":[102],"intervals":[103],"(CI)":[104],"or":[110,167],"diagnosis,":[112],"conditional":[114],"logistic":[115],"regressions.":[116],"RESULTS:":[117],"found":[119],"protective":[121,173,224,242],"diagnosis.":[127,213],"Specifically,":[128],"admissions":[131,189],"at":[132,164,169],"least":[133],"three":[134],"years":[135],"prior":[136],"to":[137,205],"index":[139],"date,":[140],"estimated":[142],"OR":[143],"was":[146],"0.59":[147],"(95[percnt]":[148],"CI:":[149],"0.45-0.77).":[150],"observed":[152,181],"no":[153],"effect":[154],"modification":[155,161],"by":[156,162],"gender,":[157],"but":[158,237],"significant":[160],"first":[165,202],"ALS,":[170],"stronger":[175],"increasing":[177],"age.":[178],"protective,":[183],"albeit":[184],"insignificant,":[185],"(OR":[190],"=":[191],"0.72;":[192],"95[percnt]CI:":[193],"0.50-1.02).":[194],"CONCLUSIONS:":[195],"To":[196],"our":[197],"knowledge,":[198],"this":[199],"nationwide":[203],"study":[204],"investigate":[206],"Our":[214],"findings":[215],"are":[216],"in":[217],"agreement":[218],"previous":[220],"reports":[221],"suggest":[233],"type":[234,239],"2":[235],"not":[238],"1,":[240],"Study":[245],"Supported":[246],"by:":[247],"5R01":[248],"ES019188-02,":[249],"NIH":[250],"T32":[251],"ES007069":[252]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}