{"id":"https://openalex.org/W42592348","doi":"https://doi.org/10.1096/fasebj.23.1_supplement.524.18","title":"Control of breast cancer by dietary alpha\u2010lactalbumin is mediated by regulation of retinoid metabolism and signaling","display_name":"Control of breast cancer by dietary alpha\u2010lactalbumin is mediated by regulation of retinoid metabolism and signaling","publication_year":2009,"publication_date":"2009-04-01","ids":{"openalex":"https://openalex.org/W42592348","doi":"https://doi.org/10.1096/fasebj.23.1_supplement.524.18","mag":"42592348"},"language":"en","primary_location":{"id":"doi:10.1096/fasebj.23.1_supplement.524.18","doi":"https://doi.org/10.1096/fasebj.23.1_supplement.524.18","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.23.1_supplement.524.18","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5085598699","display_name":"Somdutta Sinha Roy","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I118073183","display_name":"Meharry Medical College","ror":"https://ror.org/00k63dq23","country_code":"US","type":"education","lineage":["https://openalex.org/I118073183"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Somdutta Sinha Roy","raw_affiliation_strings":["Cancer Biology Meharry Medical College Nashville TN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Biology Meharry Medical College Nashville TN","institution_ids":["https://openalex.org/I118073183"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113713369","display_name":"Michael W. Scha\u0308ffer","orcid":"https://orcid.org/0009-0003-7381-3053","observed_orcids":["https://orcid.org/0009-0003-7381-3053"]},"institutions":[{"id":"https://openalex.org/I118073183","display_name":"Meharry Medical College","ror":"https://ror.org/00k63dq23","country_code":"US","type":"education","lineage":["https://openalex.org/I118073183"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael W Sch\u00e4ffer","raw_affiliation_strings":["Cancer Biology Meharry Medical College Nashville TN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Biology Meharry Medical College Nashville TN","institution_ids":["https://openalex.org/I118073183"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112520459","display_name":"Shyamali Mukherjee","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I118073183","display_name":"Meharry Medical College","ror":"https://ror.org/00k63dq23","country_code":"US","type":"education","lineage":["https://openalex.org/I118073183"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shyamali Mukherjee","raw_affiliation_strings":["Cancer Biology Meharry Medical College Nashville TN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Biology Meharry Medical College Nashville TN","institution_ids":["https://openalex.org/I118073183"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103404831","display_name":"Salil K. Das","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I118073183","display_name":"Meharry Medical College","ror":"https://ror.org/00k63dq23","country_code":"US","type":"education","lineage":["https://openalex.org/I118073183"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Salil K Das","raw_affiliation_strings":["Cancer Biology Meharry Medical College Nashville TN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Biology Meharry Medical College Nashville TN","institution_ids":["https://openalex.org/I118073183"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I118073183"],"apc_list":{"value":3740,"currency":"USD","value_usd":3740},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.00354307,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"23","issue":"S1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11559","display_name":"Retinoids in leukemia and cellular processes","score":0.9750999808311462,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11559","display_name":"Retinoids in leukemia and cellular processes","score":0.9750999808311462,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.0017999999690800905,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10866","display_name":"Nutritional Studies and Diet","score":0.0015999999595806003,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.7390000224113464},{"id":"https://openalex.org/keywords/alpha-lactalbumin","display_name":"alpha-lactalbumin","score":0.9290000200271606},{"id":"https://openalex.org/keywords/whey-protein","display_name":"whey protein","score":0.871999979019165},{"id":"https://openalex.org/keywords/casein","display_name":"casein","score":0.7450000047683716},{"id":"https://openalex.org/keywords/dietary-protein","display_name":"dietary protein","score":0.7870000004768372},{"id":"https://openalex.org/keywords/vitamin-a-metabolism","display_name":"vitamin A metabolism","score":0.9779999852180481},{"id":"https://openalex.org/keywords/retinoic-acid","display_name":"retinoic acid","score":0.921999990940094},{"id":"https://openalex.org/keywords/retinol","display_name":"retinol","score":0.9760000109672546},{"id":"https://openalex.org/keywords/retinyl-palmitate","display_name":"retinyl palmitate","score":0.9990000128746033},{"id":"https://openalex.org/keywords/retinoid-binding-proteins","display_name":"retinoid-binding proteins","score":0.8090000152587891},{"id":"https://openalex.org/keywords/crabp2","display_name":"CRABP2","score":0.9980000257492065},{"id":"https://openalex.org/keywords/lecithin-retinol-acyltransferase","display_name":"LRAT","score":0.9700000286102295},{"id":"https://openalex.org/keywords/retinoic-acid-receptor","display_name":"retinoic acid receptor","score":0.828000009059906},{"id":"https://openalex.org/keywords/retinoid-x-receptor","display_name":"retinoid X receptor","score":0.9909999966621399},{"id":"https://openalex.org/keywords/dmba-induced-tumors","display_name":"DMBA-induced tumors","score":0.8650000095367432},{"id":"https://openalex.org/keywords/tumor-grade","display_name":"tumor grade","score":0.7409999966621399}],"concepts":[{"id":"https://openalex.org/C2775954498","wikidata":"https://www.wikidata.org/wiki/Q420418","display_name":"Retinoid","level":4,"score":0.6619083881378174},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.6441614627838135},{"id":"https://openalex.org/C2776142715","wikidata":"https://www.wikidata.org/wiki/Q193970","display_name":"Casein","level":2,"score":0.616595447063446},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5853018760681152},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.581338107585907},{"id":"https://openalex.org/C2781121885","wikidata":"https://www.wikidata.org/wiki/Q425517","display_name":"Retinoic acid","level":3,"score":0.5763219594955444},{"id":"https://openalex.org/C2777326149","wikidata":"https://www.wikidata.org/wiki/Q7316807","display_name":"Retinyl palmitate","level":4,"score":0.5685868263244629},{"id":"https://openalex.org/C178617795","wikidata":"https://www.wikidata.org/wiki/Q14897677","display_name":"Alpha-lactalbumin","level":3,"score":0.5198515057563782},{"id":"https://openalex.org/C68863886","wikidata":"https://www.wikidata.org/wiki/Q1799818","display_name":"Lactalbumin","level":2,"score":0.4924353063106537},{"id":"https://openalex.org/C64943373","wikidata":"https://www.wikidata.org/wiki/Q2651003","display_name":"Alpha (finance)","level":4,"score":0.4801573157310486},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4754179120063782},{"id":"https://openalex.org/C2778938436","wikidata":"https://www.wikidata.org/wiki/Q5205596","display_name":"DMBA","level":4,"score":0.45752015709877014},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.4217590391635895},{"id":"https://openalex.org/C2779573558","wikidata":"https://www.wikidata.org/wiki/Q424976","display_name":"Retinol","level":3,"score":0.3664090633392334},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3553442060947418},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.34795525670051575},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.31681329011917114},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.28189629316329956},{"id":"https://openalex.org/C2776940978","wikidata":"https://www.wikidata.org/wiki/Q34956","display_name":"Vitamin","level":2,"score":0.19587934017181396},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.1433761715888977},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.134172260761261},{"id":"https://openalex.org/C2775944032","wikidata":"https://www.wikidata.org/wiki/Q22907659","display_name":"Patient satisfaction","level":2,"score":0.0},{"id":"https://openalex.org/C49453240","wikidata":"https://www.wikidata.org/wiki/Q1592163","display_name":"Construct validity","level":3,"score":0.0},{"id":"https://openalex.org/C159110408","wikidata":"https://www.wikidata.org/wiki/Q121176","display_name":"Nursing","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1096/fasebj.23.1_supplement.524.18","doi":"https://doi.org/10.1096/fasebj.23.1_supplement.524.18","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.23.1_supplement.524.18","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729},{"id":"https://metadata.un.org/sdg/2","display_name":"Zero hunger","score":0.5666999816894531}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8600000143051147}],"study_designs":[],"awards":[{"id":"https://openalex.org/G8210486615","display_name":null,"funder_award_id":"62415","funder_id":"https://openalex.org/F4320308625","funder_display_name":"Flight Attendant Medical Research Institute"}],"funders":[{"id":"https://openalex.org/F4320308625","display_name":"Flight Attendant Medical Research Institute","ror":"https://ror.org/00ybhm522"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W164494182","https://openalex.org/W1705782855","https://openalex.org/W1994337372","https://openalex.org/W2021433043","https://openalex.org/W2128226272","https://openalex.org/W2521832449","https://openalex.org/W3172213187","https://openalex.org/W1561848337","https://openalex.org/W2101767009","https://openalex.org/W1910538594"],"abstract_inverted_index":{"Dietary":[0],"protein":[1,53],"is":[2,13],"a":[3,71],"significant":[4],"factor":[5],"in":[6,27,40,109,118,131,141],"breast":[7,28],"cancer":[8,29,32,63],"control.":[9,30],"However,":[10,120],"no":[11],"information":[12],"available":[14],"concerning":[15],"the":[16,21,65,83,121,132,142],"effects":[17],"of":[18,23,38,73,93,123,152,158],"\u00e1\u2010lactalbumin":[19,51],"on":[20,44],"expression":[22,151],"certain":[24],"genes":[25],"involved":[26],"Breast":[31],"was":[33,128],"developed":[34],"by":[35,181],"gavage":[36],"administration":[37],"DMBA":[39],"female":[41],"rats,":[42],"maintained":[43],"AIN\u201076A":[45],"diet":[46],"with":[47],"either":[48],"casein":[49,66,143],"or":[50],"as":[52],"source":[54],"for":[55],"120":[56],"days.":[57],"The":[58,91,150],"whey":[59,84,133],"group":[60,69,85,134,144],"had":[61,70,86],"less":[62,130],"than":[64,139],"group.":[67],"Casein":[68],"mixture":[72],"grade":[74,76,79,88],"I,":[75,163],"II":[77],"and":[78,99,112,126,147,156,167,170],"III":[80],"tumors":[81],"whereas":[82],"mostly":[87],"I":[89],"tumor.":[90],"levels":[92,114],"retinoic":[94],"acid":[95],"(RA),":[96],"retinol":[97],"(ROH)":[98],"retinyl":[100],"palmitate":[101],"(RP)":[102],"were":[103,115],"44,":[104],"430,":[105],"606":[106],"\u00b5g/g,":[107],"respectively":[108],"control":[110],"tissue,":[111],"their":[113],"significantly":[116,129],"reduced":[117],"tumors.":[119],"decrease":[122],"RA,":[124],"ROH":[125],"RP":[127],"(77,":[135],"48,":[136],"45%,":[137],"respectively)":[138],"that":[140],"(84.5%,":[145],"69.5%":[146],"54.6%,":[148],"respectively).":[149],"various":[153],"binding":[154],"proteins":[155],"mediators":[157],"retinoid":[159],"action":[160],"like,":[161],"CRBP":[162],"CRABP":[164],"II,":[165],"LRAT":[166],"nuclear":[168],"RAR":[169],"RXR":[171],"receptors":[172],"also":[173],"show":[174],"similar":[175],"variation":[176],"among":[177],"these":[178],"groups.":[179],"(Supported":[180],"FAMRI":[182],"Clinical":[183],"Innovator":[184],"Award":[185],"#":[186],"62415)":[187]},"counts_by_year":[],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2016-06-24T00:00:00"}