{"id":"https://openalex.org/W4256634634","doi":"https://doi.org/10.3410/f.736963101.793567815","title":"Faculty Opinions recommendation of Single-cell transcriptomics of the naked mole-rat reveals unexpected features of mammalian immunity.","display_name":"Faculty Opinions recommendation of Single-cell transcriptomics of the naked mole-rat reveals unexpected features of mammalian immunity.","publication_year":2019,"publication_date":"2019-11-26","ids":{"openalex":"https://openalex.org/W4256634634","doi":"https://doi.org/10.3410/f.736963101.793567815"},"language":"en","primary_location":{"id":"doi:10.3410/f.736963101.793567815","doi":"https://doi.org/10.3410/f.736963101.793567815","is_oa":true,"landing_page_url":"https://doi.org/10.3410/f.736963101.793567815","pdf_url":"https://facultyopinions.com/download/736963101","source":{"id":"https://openalex.org/S4363604054","display_name":"Faculty Opinions \u2013 Post-Publication Peer Review of the Biomedical Literature","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Faculty Opinions \u2013 Post-Publication Peer Review of the Biomedical Literature","raw_type":"dataset"},"volume":null,"type":"peer-review","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://facultyopinions.com/download/736963101","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5028596003","display_name":"Sarah Amalia Teichmann","orcid":"https://orcid.org/0000-0002-6294-6366","observed_orcids":["https://orcid.org/0000-0002-6294-6366"]},"institutions":[{"id":"https://openalex.org/I2802476451","display_name":"Wellcome Sanger Institute","ror":"https://ror.org/05cy4wa09","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I2802476451","https://openalex.org/I87048295"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Sarah Teichmann","raw_affiliation_strings":["Wellcome Sanger Institute, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wellcome Sanger Institute, UK","institution_ids":["https://openalex.org/I2802476451"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5019953572","display_name":"Tzachi Hagai","orcid":"https://orcid.org/0000-0002-4575-6624","observed_orcids":["https://orcid.org/0000-0002-4575-6624"]},"institutions":[{"id":"https://openalex.org/I1303153112","display_name":"European Bioinformatics Institute","ror":"https://ror.org/02catss52","country_code":"GB","type":"facility","lineage":["https://openalex.org/I1303153112","https://openalex.org/I4210138560"]},{"id":"https://openalex.org/I2802476451","display_name":"Wellcome Sanger Institute","ror":"https://ror.org/05cy4wa09","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I2802476451","https://openalex.org/I87048295"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Tzachi Hagai","raw_affiliation_strings":["EMBL-European Bioinformatics Institute & Wellcome Trust Sanger Institute, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"EMBL-European Bioinformatics Institute & Wellcome Trust Sanger Institute, UK","institution_ids":["https://openalex.org/I1303153112","https://openalex.org/I2802476451"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10676","display_name":"Genetics, Aging, and Longevity in Model Organisms","score":0.6371999979019165,"subfield":{"id":"https://openalex.org/subfields/1302","display_name":"Aging"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10676","display_name":"Genetics, Aging, and Longevity in Model Organisms","score":0.6371999979019165,"subfield":{"id":"https://openalex.org/subfields/1302","display_name":"Aging"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.1542000025510788,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.035100001841783524,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/naked-mole-rat","display_name":"naked mole-rat","score":1.0},{"id":"https://openalex.org/keywords/tumor-surveillance","display_name":"tumor surveillance","score":0.8659999966621399},{"id":"https://openalex.org/keywords/granulocytes","display_name":"granulocytes","score":0.6980000138282776},{"id":"https://openalex.org/keywords/lipopolysaccharide-response","display_name":"lipopolysaccharide response","score":0.9229999780654907},{"id":"https://openalex.org/keywords/innate-immunity","display_name":"innate immunity","score":0.4359999895095825},{"id":"https://openalex.org/keywords/healthspan","display_name":"healthspan","score":0.6380000114440918},{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.5360000133514404},{"id":"https://openalex.org/keywords/comparative-genomics","display_name":"comparative genomics","score":0.7570000290870667},{"id":"https://openalex.org/keywords/immune-system-evolution","display_name":"immune system evolution","score":0.5699999928474426}],"concepts":[{"id":"https://openalex.org/C124815738","wikidata":"https://www.wikidata.org/wiki/Q41509","display_name":"Mole","level":2,"score":0.7290129065513611},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.5776273012161255},{"id":"https://openalex.org/C2779341262","wikidata":"https://www.wikidata.org/wiki/Q182581","display_name":"Immunity","level":3,"score":0.5738300085067749},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.42665889859199524},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4195128083229065},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.24513936042785645},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2222842574119568},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.18949255347251892},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.14606568217277527},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.143196702003479}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.3410/f.736963101.793567815","doi":"https://doi.org/10.3410/f.736963101.793567815","is_oa":true,"landing_page_url":"https://doi.org/10.3410/f.736963101.793567815","pdf_url":"https://facultyopinions.com/download/736963101","source":{"id":"https://openalex.org/S4363604054","display_name":"Faculty Opinions \u2013 Post-Publication Peer Review of the Biomedical Literature","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Faculty Opinions \u2013 Post-Publication Peer Review of the Biomedical Literature","raw_type":"dataset"}],"best_oa_location":{"id":"doi:10.3410/f.736963101.793567815","doi":"https://doi.org/10.3410/f.736963101.793567815","is_oa":true,"landing_page_url":"https://doi.org/10.3410/f.736963101.793567815","pdf_url":"https://facultyopinions.com/download/736963101","source":{"id":"https://openalex.org/S4363604054","display_name":"Faculty Opinions \u2013 Post-Publication Peer Review of the Biomedical Literature","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Faculty Opinions \u2013 Post-Publication Peer Review of the Biomedical Literature","raw_type":"dataset"},"sustainable_development_goals":[{"score":0.8048999905586243,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4256634634.pdf","grobid_xml":"https://content.openalex.org/works/W4256634634.grobid-xml"},"referenced_works_count":55,"referenced_works":["https://openalex.org/W1217705870","https://openalex.org/W1484434143","https://openalex.org/W1494964088","https://openalex.org/W1507573241","https://openalex.org/W1513618424","https://openalex.org/W1900937478","https://openalex.org/W1967773296","https://openalex.org/W1977099733","https://openalex.org/W1984689597","https://openalex.org/W1992749367","https://openalex.org/W2007249445","https://openalex.org/W2010457001","https://openalex.org/W2012959412","https://openalex.org/W2013131472","https://openalex.org/W2013435992","https://openalex.org/W2017066841","https://openalex.org/W2029157767","https://openalex.org/W2052940639","https://openalex.org/W2055043387","https://openalex.org/W2071010503","https://openalex.org/W2097392849","https://openalex.org/W2103017472","https://openalex.org/W2116562617","https://openalex.org/W2124784812","https://openalex.org/W2129916363","https://openalex.org/W2137986897","https://openalex.org/W2140258573","https://openalex.org/W2145025818","https://openalex.org/W2150048134","https://openalex.org/W2158714788","https://openalex.org/W2165912888","https://openalex.org/W2166186418","https://openalex.org/W2169456326","https://openalex.org/W2221432805","https://openalex.org/W2347163170","https://openalex.org/W2488424576","https://openalex.org/W2726273547","https://openalex.org/W2742273126","https://openalex.org/W2766437506","https://openalex.org/W2766641567","https://openalex.org/W2775503072","https://openalex.org/W2784960881","https://openalex.org/W2794480084","https://openalex.org/W2795652047","https://openalex.org/W2799839529","https://openalex.org/W2889326414","https://openalex.org/W2894687190","https://openalex.org/W2899566169","https://openalex.org/W2945792041","https://openalex.org/W2950595506","https://openalex.org/W2951506174","https://openalex.org/W3099862724","https://openalex.org/W4232805347","https://openalex.org/W4232948727","https://openalex.org/W4300009529"],"related_works":["https://openalex.org/W2990981753","https://openalex.org/W2996659250","https://openalex.org/W3193875077","https://openalex.org/W6976876612","https://openalex.org/W2901212199","https://openalex.org/W6977237101","https://openalex.org/W3039623904","https://openalex.org/W2899566169","https://openalex.org/W6958582924","https://openalex.org/W6920729662"],"abstract_inverted_index":{"The":[0],"immune":[1,66,91,115],"system":[2,67,92,116],"comprises":[3],"a":[4,23,120,127],"complex":[5],"network":[6],"of":[7,68,93,101,188,196],"specialized":[8],"cells":[9],"that":[10,64,73,100,112,125,137,152,161,175],"protects":[11],"against":[12],"infection,":[13],"eliminates":[14],"cancerous":[15],"cells,":[16],"and":[17,30,52,78,96],"regulates":[18],"tissue":[19],"repair,":[20],"thus":[21,183],"serving":[22],"critical":[24],"role":[25],"in":[26,83,166],"homeostasis,":[27],"health":[28,205],"span,":[29],"life":[31,41],"span.The":[32],"subterranean-dwelling":[33],"naked":[34],"mole-rat":[35],"(NM-R;":[36],"Heterocephalus":[37],"glaber)":[38],"exhibits":[39],"prolonged":[40],"span":[42],"relative":[43],"to":[44,99,107,178,202],"its":[45,203],"body":[46],"size,":[47],"is":[48,117],"unusually":[49],"cancer":[50,76],"resistant,":[51],"manifests":[53],"few":[54],"physiological":[55],"or":[56],"molecular":[57],"changes":[58],"with":[59],"advancing":[60],"age.We":[61],"therefore":[62],"hypothesized":[63],"the":[65,80,90,94,102,108,113,153,172],"NM-Rs":[69,138],"evolved":[70],"unique":[71],"features":[72],"confer":[74],"enhanced":[75],"immunosurveillance":[77],"prevent":[79],"age-associated":[81],"decline":[82],"homeostasis.Using":[84],"single-cell":[85],"RNA-sequencing":[86],"(scRNA-seq)":[87],"we":[88,110,134,170],"mapped":[89],"NM-R":[95,114,154,182],"compared":[97],"it":[98],"short-lived,":[103],"cancer-prone":[104],"mouse.In":[105],"contrast":[106],"mouse,":[109],"find":[111,136],"characterized":[118],"by":[119],"high":[121],"myeloid-tolymphoid":[122],"cell":[123,132,164],"ratio":[124],"includes":[126],"novel,":[128],"lipopolysaccharide":[129],"(LPS)-responsive,":[130],"granulocyte":[131],"subset.Surprisingly,":[133],"also":[135],"lack":[139],"canonical":[140],"natural":[141],"killer":[142],"(NK)":[143],"cells.Our":[144],"comparative":[145],"genomics":[146],"analyses":[147],"support":[148],"this":[149,179],"finding,":[150],"showing":[151],"genome":[155],"lacks":[156],"an":[157,192],"expanded":[158],"gene":[159],"family":[160],"controls":[162],"NK":[163],"function":[165],"several":[167],"other":[168],"species.Furthermore,":[169],"reconstructed":[171],"evolutionary":[173],"history":[174],"likely":[176],"led":[177],"genomic":[180],"state.The":[181],"challenges":[184],"our":[185],"current":[186],"understanding":[187],"mammalian":[189],"immunity,":[190],"favoring":[191],"atypical,":[193],"myeloid-biased":[194],"mode":[195],"innate":[197],"immunosurveillance,":[198],"which":[199],"may":[200],"contribute":[201],"remarkable":[204],"span.":[206]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2022-05-12T00:00:00"}
