{"id":"https://openalex.org/W4256587330","doi":"https://doi.org/10.4324/9781003074984-16","title":"The Ethics of Translating High-Throughput Science into Clinical Practice","display_name":"The Ethics of Translating High-Throughput Science into Clinical Practice","publication_year":2020,"publication_date":"2020-08-26","ids":{"openalex":"https://openalex.org/W4256587330","doi":"https://doi.org/10.4324/9781003074984-16"},"language":"en","primary_location":{"id":"doi:10.4324/9781003074984-16","doi":"https://doi.org/10.4324/9781003074984-16","is_oa":false,"landing_page_url":"https://doi.org/10.4324/9781003074984-16","pdf_url":null,"source":{"id":"https://openalex.org/S4306463855","display_name":"Routledge eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310319847","host_organization_name":"Routledge","host_organization_lineage":["https://openalex.org/P4310319847","https://openalex.org/P4310320547"],"host_organization_lineage_names":["Routledge","Taylor & Francis"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Ethical Challenges of Emerging Medical Technologies","raw_type":"book-chapter"},"volume":{"id":"https://openalex.org/W3080953855","display_name":"The Ethical Challenges of Emerging Medical Technologies"},"type":"book-chapter","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5022685497","display_name":"Pilar N. Ossorio","orcid":"https://orcid.org/0000-0002-3495-7375","observed_orcids":["https://orcid.org/0000-0002-3495-7375"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Pilar N. Ossorio","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5022685497"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.64867606,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"203","last_page":"204"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10582","display_name":"Ethics in Clinical Research","score":0.6464999914169312,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10582","display_name":"Ethics in Clinical Research","score":0.6464999914169312,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11636","display_name":"Artificial Intelligence in Healthcare and Education","score":0.19619999825954437,"subfield":{"id":"https://openalex.org/subfields/2718","display_name":"Health Informatics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13417","display_name":"Biomedical Ethics and Regulation","score":0.05050000175833702,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/research-ethics","display_name":"research ethics","score":0.6230000257492065},{"id":"https://openalex.org/keywords/big-data-science","display_name":"big data science","score":0.6449999809265137},{"id":"https://openalex.org/keywords/clinical-translation","display_name":"clinical translation","score":0.5360000133514404},{"id":"https://openalex.org/keywords/dna-sequencing","display_name":"DNA sequencing","score":0.5899999737739563},{"id":"https://openalex.org/keywords/imputation","display_name":"imputation","score":0.746999979019165},{"id":"https://openalex.org/keywords/missing-data","display_name":"missing data","score":0.9010000228881836},{"id":"https://openalex.org/keywords/machine-learning","display_name":"machine learning","score":0.9890000224113464},{"id":"https://openalex.org/keywords/model-validation","display_name":"model validation","score":0.8360000252723694},{"id":"https://openalex.org/keywords/research-ethics-committees","display_name":"research ethics committees","score":0.7879999876022339},{"id":"https://openalex.org/keywords/food-and-drug-administration","display_name":"Food and Drug Administration","score":0.7400000095367432},{"id":"https://openalex.org/keywords/human-trials","display_name":"human trials","score":0.6259999871253967},{"id":"https://openalex.org/keywords/predictive-model","display_name":"prediction model","score":0.49900001287460327}],"concepts":[{"id":"https://openalex.org/C157764524","wikidata":"https://www.wikidata.org/wiki/Q1383412","display_name":"Throughput","level":3,"score":0.6711447834968567},{"id":"https://openalex.org/C55587333","wikidata":"https://www.wikidata.org/wiki/Q1133029","display_name":"Engineering ethics","level":1,"score":0.5104143023490906},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4407254755496979},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.20788687467575073},{"id":"https://openalex.org/C76155785","wikidata":"https://www.wikidata.org/wiki/Q418","display_name":"Telecommunications","level":1,"score":0.06303766369819641},{"id":"https://openalex.org/C555944384","wikidata":"https://www.wikidata.org/wiki/Q249","display_name":"Wireless","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.4324/9781003074984-16","doi":"https://doi.org/10.4324/9781003074984-16","is_oa":false,"landing_page_url":"https://doi.org/10.4324/9781003074984-16","pdf_url":null,"source":{"id":"https://openalex.org/S4306463855","display_name":"Routledge eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310319847","host_organization_name":"Routledge","host_organization_lineage":["https://openalex.org/P4310319847","https://openalex.org/P4310320547"],"host_organization_lineage_names":["Routledge","Taylor & Francis"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Ethical Challenges of Emerging Medical Technologies","raw_type":"book-chapter"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.504800021648407,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3094336210","https://openalex.org/W2603644021","https://openalex.org/W2945734510","https://openalex.org/W2502154895","https://openalex.org/W6992575386","https://openalex.org/W7212229308","https://openalex.org/W2970921286","https://openalex.org/W2466406540","https://openalex.org/W2153863538","https://openalex.org/W3087750143"],"abstract_inverted_index":{"Biomedical":[0],"research":[1,46],"is":[2,12],"increasingly":[3],"data":[4,10,59,73],"intensive":[5],"and":[6,8,28,45,51,82,86,97,101,120,132],"computational,":[7],"\u201cbig":[9],"science\u201d":[11],"migrating":[13],"into":[14],"the":[15,53,64,80,99,107,111,114],"clinical":[16],"arena.":[17],"Teaching":[18],"hospitals":[19],"are":[20,136],"making":[21],"substantial":[22],"investments":[23],"in":[24,57],"DNA":[25],"sequencing":[26,35],"capacity,":[27],"some":[29,124],"now":[30],"advertise":[31],"their":[32],"use":[33],"of":[34,66,92],"to":[36,49,94,98,128,139],"help":[37],"guide":[38],"medical":[39],"treatment.":[40],"Institutional":[41],"review":[42],"boards":[43],"(IRBs)":[44],"ethicists":[47],"need":[48,123],"understand":[50],"evaluate":[52],"analytical":[54,95],"approaches":[55,77],"used":[56],"big":[58],"research.":[60],"Consider,":[61],"for":[62],"instance,":[63],"phenomenon":[65],"imputation,":[67],"which":[68],"involves":[69],"computationally":[70],"inferring":[71],"missing":[72],"points.":[74],"Novel":[75],"programming":[76],"may":[78],"challenge":[79],"Food":[81],"Drug":[83],"Administration,":[84],"IRBs,":[85],"ethicists.":[87],"Machine":[88],"learning":[89],"adds":[90],"layers":[91],"complexity":[93],"processes":[96],"ethical":[100],"regulatory":[102],"issues.":[103],"In":[104],"machine":[105],"learning,":[106],"program,":[108],"rather":[109],"than":[110],"programmer,":[112],"builds":[113],"predictive":[115],"model.":[116],"Computational":[117],"scientists,":[118],"ethicists,":[119],"regulators":[121],"will":[122],"agreement":[125],"on":[126],"how":[127],"validate":[129],"these":[130],"models":[131],"determine":[133],"when":[134],"they":[135],"robust":[137],"enough":[138],"enter":[140],"human":[141],"trials.":[142]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2022-05-12T00:00:00"}