{"id":"https://openalex.org/W4256546048","doi":"https://doi.org/10.3410/f.1017192.202582","title":"Faculty Opinions recommendation of Inactivation of Icmt inhibits transformation by oncogenic K-Ras and B-Raf.","display_name":"Faculty Opinions recommendation of Inactivation of Icmt inhibits transformation by oncogenic K-Ras and B-Raf.","publication_year":2004,"publication_date":"2004-02-14","ids":{"openalex":"https://openalex.org/W4256546048","doi":"https://doi.org/10.3410/f.1017192.202582"},"language":"en","primary_location":{"id":"doi:10.3410/f.1017192.202582","doi":"https://doi.org/10.3410/f.1017192.202582","is_oa":false,"landing_page_url":"https://doi.org/10.3410/f.1017192.202582","pdf_url":null,"source":{"id":"https://openalex.org/S4363604054","display_name":"Faculty Opinions \u2013 Post-Publication Peer Review of the Biomedical Literature","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Faculty Opinions \u2013 Post-Publication Peer Review of the Biomedical Literature","raw_type":"dataset"},"volume":null,"type":"peer-review","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5064063895","display_name":"Channing J. Der","orcid":"https://orcid.org/0000-0002-7751-2747","observed_orcids":["https://orcid.org/0000-0002-7751-2747"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Channing Der","raw_affiliation_strings":["Department of Pharmacology, The University of North Carolina at Chapel Hill, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, The University of North Carolina at Chapel Hill, USA","institution_ids":["https://openalex.org/I114027177"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5064063895"],"corresponding_institution_ids":["https://openalex.org/I114027177"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.6723999977111816,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.6723999977111816,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11533","display_name":"Melanoma and MAPK Pathways","score":0.06989999860525131,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12104","display_name":"Protein Tyrosine Phosphatases","score":0.030899999663233757,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/icmt","display_name":"IcmT","score":0.8939999938011169},{"id":"https://openalex.org/keywords/isoprenylcysteine-carboxyl-methyltransferase","display_name":"isoprenylcysteine carboxyl methyltransferase","score":0.7490000128746033},{"id":"https://openalex.org/keywords/oncogenic-kras","display_name":"oncogenic KRAS","score":0.8199999928474426},{"id":"https://openalex.org/keywords/braf","display_name":"BRAF","score":0.8930000066757202},{"id":"https://openalex.org/keywords/ras-signaling","display_name":"Ras signaling","score":0.30799999833106995},{"id":"https://openalex.org/keywords/oncogenic-transformation","display_name":"oncogenic transformation","score":0.7459999918937683},{"id":"https://openalex.org/keywords/protein-prenylation","display_name":"protein prenylation","score":0.6850000023841858}],"concepts":[{"id":"https://openalex.org/C204241405","wikidata":"https://www.wikidata.org/wiki/Q461499","display_name":"Transformation (genetics)","level":3,"score":0.5905320048332214},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4781540334224701},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4127289354801178},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3550143837928772},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.32084500789642334},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2576141953468323},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2367618978023529},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.20311444997787476}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.3410/f.1017192.202582","doi":"https://doi.org/10.3410/f.1017192.202582","is_oa":false,"landing_page_url":"https://doi.org/10.3410/f.1017192.202582","pdf_url":null,"source":{"id":"https://openalex.org/S4363604054","display_name":"Faculty Opinions \u2013 Post-Publication Peer Review of the Biomedical Literature","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Faculty Opinions \u2013 Post-Publication Peer Review of the Biomedical Literature","raw_type":"dataset"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2112532834","https://openalex.org/W2046427109"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-08-18T07:49:30.821534","created_date":"2022-05-12T00:00:00"}
