{"id":"https://openalex.org/W42563337","doi":"https://doi.org/10.1161/circ.118.suppl_18.s_1137-c","title":"Abstract 5063: Cardiovascular Effects of Transdermal Testosterone in Postmenopausal Women","display_name":"Abstract 5063: Cardiovascular Effects of Transdermal Testosterone in Postmenopausal Women","publication_year":2008,"publication_date":"2008-10-28","ids":{"openalex":"https://openalex.org/W42563337","doi":"https://doi.org/10.1161/circ.118.suppl_18.s_1137-c","mag":"42563337"},"language":"en","primary_location":{"id":"doi:10.1161/circ.118.suppl_18.s_1137-c","doi":"https://doi.org/10.1161/circ.118.suppl_18.s_1137-c","is_oa":false,"landing_page_url":"https://doi.org/10.1161/circ.118.suppl_18.s_1137-c","pdf_url":null,"source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5087977641","display_name":"Cristiana Vitale","orcid":"https://orcid.org/0000-0003-1111-9894","observed_orcids":["https://orcid.org/0000-0003-1111-9894"]},"institutions":[{"id":"https://openalex.org/I4387155925","display_name":"IRCCS San Raffaele Roma","ror":"https://ror.org/006x48140","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210153126","https://openalex.org/I4387155925"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"C Vitale","raw_affiliation_strings":["IRCCS San Raffaele rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IRCCS San Raffaele rome, Italy","institution_ids":["https://openalex.org/I4387155925"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077323159","display_name":"Peter D. Collins","orcid":"https://orcid.org/0000-0002-3377-3160","observed_orcids":["https://orcid.org/0000-0002-3377-3160"]},"institutions":[{"id":"https://openalex.org/I4210096640","display_name":"Royal Brompton Hospital","ror":"https://ror.org/00cv4n034","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2800036501","https://openalex.org/I4210096640"]},{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"P Collins","raw_affiliation_strings":["Imperial College London, Royal Brompton Hosp, london, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Imperial College London, Royal Brompton Hosp, london, United Kingdom","institution_ids":["https://openalex.org/I4210096640","https://openalex.org/I47508984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021125403","display_name":"Giuseppe Marazzi","orcid":"https://orcid.org/0000-0003-2852-5610","observed_orcids":["https://orcid.org/0000-0003-2852-5610"]},"institutions":[{"id":"https://openalex.org/I4387155925","display_name":"IRCCS San Raffaele Roma","ror":"https://ror.org/006x48140","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210153126","https://openalex.org/I4387155925"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"G Marazzi","raw_affiliation_strings":["IRCCS San Raffaele, rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IRCCS San Raffaele, rome, Italy","institution_ids":["https://openalex.org/I4387155925"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064706121","display_name":"Giuseppe Caminiti","orcid":"https://orcid.org/0000-0001-7820-567X","observed_orcids":["https://orcid.org/0000-0001-7820-567X"]},"institutions":[{"id":"https://openalex.org/I4387155925","display_name":"IRCCS San Raffaele Roma","ror":"https://ror.org/006x48140","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210153126","https://openalex.org/I4387155925"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"G Caminiti","raw_affiliation_strings":["IRCCS San Raffaele, rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IRCCS San Raffaele, rome, Italy","institution_ids":["https://openalex.org/I4387155925"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001121658","display_name":"Imran Lodhi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"I Lodhi","raw_affiliation_strings":["Duke Univ, Mason, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Duke Univ, Mason, OH","institution_ids":["https://openalex.org/I170897317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071402126","display_name":"Cynthia A. Rodenberg","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C A Rodenberg","raw_affiliation_strings":["Duke Univ, Mason, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Duke Univ, Mason, OH","institution_ids":["https://openalex.org/I170897317"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108248007","display_name":"Giuseppe Massimo Claudio Rosano","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210096640","display_name":"Royal Brompton Hospital","ror":"https://ror.org/00cv4n034","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2800036501","https://openalex.org/I4210096640"]},{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"G M Rosano","raw_affiliation_strings":["Imperial College London, Royal Brompton Hosp, london, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Imperial College London, Royal Brompton Hosp, london, Italy","institution_ids":["https://openalex.org/I4210096640","https://openalex.org/I47508984"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"118","issue":"suppl_18","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11146","display_name":"Hormonal and reproductive studies","score":0.7476000189781189,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11146","display_name":"Hormonal and reproductive studies","score":0.7476000189781189,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10694","display_name":"Menopause: Health Impacts and Treatments","score":0.2502000033855438,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10459","display_name":"Sexual function and dysfunction studies","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/transdermal-testosterone","display_name":"transdermal testosterone","score":0.9330000281333923},{"id":"https://openalex.org/keywords/testosterone-patch","display_name":"testosterone patch","score":0.6919999718666077},{"id":"https://openalex.org/keywords/postmenopausal-women","display_name":"postmenopausal women","score":0.984000027179718},{"id":"https://openalex.org/keywords/cardiovascular-safety","display_name":"cardiovascular safety","score":0.9110000133514404},{"id":"https://openalex.org/keywords/cardiovascular-risk-factors","display_name":"cardiovascular risk factors","score":0.7020000219345093},{"id":"https://openalex.org/keywords/hypoactive-sexual-desire-disorder","display_name":"hypoactive sexual desire disorder","score":0.8289999961853027},{"id":"https://openalex.org/keywords/hormone-replacement-therapy","display_name":"hormone replacement therapy","score":0.9599999785423279},{"id":"https://openalex.org/keywords/stroke","display_name":"stroke","score":0.45500001311302185},{"id":"https://openalex.org/keywords/myocardial-infarction","display_name":"myocardial infarction","score":1.0},{"id":"https://openalex.org/keywords/venous-thromboembolism","display_name":"venous thromboembolism","score":1.0},{"id":"https://openalex.org/keywords/hdl-cholesterol","display_name":"HDL cholesterol","score":0.8009999990463257},{"id":"https://openalex.org/keywords/ldl-cholesterol","display_name":"LDL cholesterol","score":0.9639999866485596},{"id":"https://openalex.org/keywords/lipoproteins","display_name":"lipoproteins","score":0.5899999737739563},{"id":"https://openalex.org/keywords/blood-pressure","display_name":"blood pressure","score":0.527999997138977},{"id":"https://openalex.org/keywords/lipoprotein-a","display_name":"lipoprotein(a)","score":0.32100000977516174},{"id":"https://openalex.org/keywords/menopause","display_name":"menopause","score":0.35499998927116394}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9549801349639893},{"id":"https://openalex.org/C2780159708","wikidata":"https://www.wikidata.org/wiki/Q17003363","display_name":"Hormone replacement therapy (female-to-male)","level":3,"score":0.6902626752853394},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.6521172523498535},{"id":"https://openalex.org/C2779279991","wikidata":"https://www.wikidata.org/wiki/Q6058681","display_name":"Testosterone (patch)","level":2,"score":0.5298264622688293},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5209932923316956},{"id":"https://openalex.org/C2910557164","wikidata":"https://www.wikidata.org/wiki/Q177708","display_name":"Surgical Menopause","level":3,"score":0.49560534954071045},{"id":"https://openalex.org/C2778270857","wikidata":"https://www.wikidata.org/wiki/Q2723972","display_name":"Lipid profile","level":3,"score":0.4695513844490051},{"id":"https://openalex.org/C203092338","wikidata":"https://www.wikidata.org/wiki/Q1340863","display_name":"Clinical endpoint","level":3,"score":0.43234074115753174},{"id":"https://openalex.org/C205679159","wikidata":"https://www.wikidata.org/wiki/Q3375179","display_name":"Transdermal","level":2,"score":0.4278278648853302},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.42764484882354736},{"id":"https://openalex.org/C61511704","wikidata":"https://www.wikidata.org/wiki/Q1671857","display_name":"Incidence (geometry)","level":2,"score":0.42596665024757385},{"id":"https://openalex.org/C500558357","wikidata":"https://www.wikidata.org/wiki/Q12152","display_name":"Myocardial infarction","level":2,"score":0.4165405035018921},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.4133340120315552},{"id":"https://openalex.org/C2778562196","wikidata":"https://www.wikidata.org/wiki/Q177708","display_name":"Menopause","level":2,"score":0.39176449179649353},{"id":"https://openalex.org/C29456083","wikidata":"https://www.wikidata.org/wiki/Q1221899","display_name":"Gynecology","level":1,"score":0.3750874996185303},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.26115882396698},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1161/circ.118.suppl_18.s_1137-c","doi":"https://doi.org/10.1161/circ.118.suppl_18.s_1137-c","is_oa":false,"landing_page_url":"https://doi.org/10.1161/circ.118.suppl_18.s_1137-c","pdf_url":null,"source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2578898452","https://openalex.org/W2081224239","https://openalex.org/W2079958673","https://openalex.org/W3204082116","https://openalex.org/W1928081212","https://openalex.org/W7133435522","https://openalex.org/W1964055379","https://openalex.org/W4366595004","https://openalex.org/W2559114406","https://openalex.org/W2089648710"],"abstract_inverted_index":{"Testosterone":[0],"Transdermal":[1],"Patch":[2],"(TTP)":[3],"has":[4],"been":[5],"developed":[6],"for":[7],"the":[8,21,38,46,108,145,214,237,245,272,287,294,350],"treatment":[9,215],"of":[10,25,37,50,75,107,161,244,271,293,352],"postmeno-pausal":[11],"women":[12,28,77],"(PMW)":[13],"with":[14,58,138,362],"hypoactive":[15],"sexual":[16],"desire":[17],"disorder":[18],"(HSDD).":[19],"Since":[20],"cardiovascular":[22],"(CV)":[23],"effects":[24],"testosterone":[26],"in":[27,56,65,89,131,150,220,247,274,308,318,325,335,356],"are":[29],"still":[30],"unclear":[31],"we":[32],"conducted":[33,128],"a":[34,173,242,326],"pooled":[35],"analysis":[36],"large":[39],"phase":[40,91],"III":[41,92],"clinical":[42,96,337],"program":[43],"to":[44,185],"evaluate":[45],"efficacy":[47],"and":[48,117,153,166,201,208,230,253,270,303,311,315,330,346,359],"safety":[49],"300":[51],"\u03bcg/day":[52],"TTP,":[53],"alone":[54,170],"or":[55,67,134,171,190,363],"association":[57],"hormone":[59],"replacement":[60],"therapy":[61,334],"(HRT),":[62],"versus":[63],"placebo":[64,188,309],"surgical":[66,133,358],"natural":[68,135],"PMW.":[69,136],"Design":[70],"&":[71],"Methods:":[72],"A":[73],"total":[74],"2795":[76,181],"aged":[78],"between":[79],"26":[80],"\u201370":[81],"years":[82],"(mean":[83],"age":[84],"52(SD=6.8)":[85],"years)":[86],"were":[87,142,157,183,203,211,234,306],"included":[88,114],"5":[90],"randomized,":[93],"double-blind,":[94],"placebo-controlled":[95,291],"trials":[97,338],"(treatment":[98],"duration":[99],"range":[100],"24":[101,252,279],"\u2013":[102],"52":[103,254,284],"weeks)":[104],"as":[105,172],"part":[106],"TTP":[109,191,250,263,277,329,333],"Clinical":[110],"program.":[111],"4":[112,297],"studies":[113],"PMW":[115,182,361],"(natural":[116],"surgical,":[118],"two":[119],"each":[120],"respectively)":[121],"receiving":[122,320,328],"HRT":[123],"while":[124],"1":[125,316],"study":[126,238],"was":[127,177,196],"without":[129,364],"HRT,":[130],"either":[132,187],"Women":[137],"known":[139],"CV":[140,154,175,221,299,343,354],"disorders":[141],"excluded":[143],"from":[144,148,241],"studies.":[146],"Changes":[147],"baseline":[149,209],"standard":[151],"metabolic":[152],"risk":[155,222,344,351],"factors":[156,223],"compared.":[158],"The":[159,180,206],"incidence":[160],"stroke,":[162],"myocardial":[163],"infarction":[164],"(MI)":[165],"venous":[167],"thromboembolism":[168],"(VTE)":[169],"composite":[174],"endpoint":[176],"assessed.":[178],"Results:":[179],"randomized":[184],"receive":[186],"(n=1297)":[189],"(n=1498).":[192],"Baseline":[193],"mean":[194,258,265],"BMI":[195],"27":[197],"kg/m2":[198],"(SD=5.3":[199],"kg/m2)":[200],"56%":[202],"naturally":[204,360],"menopausal.":[205],"demographic":[207],"parameters":[210],"similar":[212],"among":[213],"groups.":[216],"No":[217],"significant":[218],"changes":[219],"(Total":[224],"Cholesterol,":[225],"Triglycerides,":[226],"Insulin,":[227],"Glucose,":[228],"Systolic":[229],"Diastolic":[231],"Blood":[232],"Pressure)":[233],"detected":[235],"during":[236],"period,":[239],"apart":[240],"blunting":[243],"increases":[246],"HDL-C":[248],"by":[249,276],"at":[251,278,283],"weeks":[255],"(Placebo":[256],"52-week":[257,264],"change":[259,266,349],"2.59":[260],"mg/dl":[261],"vs.":[262],"1.20":[267],"mg/dl,":[268],"p<0.005)":[269],"decrease":[273],"LDL-C":[275],"(p<0.05),":[280],"but":[281],"not":[282,340,348],"weeks.":[285],"During":[286],"double-blind":[288],"(24":[289],"weeks),":[290],"period":[292],"combined":[295],"studies,":[296],"major":[298,353],"events":[300,355],"(2":[301,313],"MIs":[302,314],"2":[304],"strokes)":[305],"reported":[307],"patients":[310],"3":[312],"stroke)":[317],"those":[319],"TTP.":[321],"One":[322],"VTE":[323],"occurred":[324],"patient":[327],"HRT.":[331,366],"Conclusion:":[332],"these":[336,357],"did":[339,347],"adversely":[341],"affect":[342],"profile":[345],"concomitant":[365]},"counts_by_year":[],"updated_date":"2026-10-22T18:32:59.640997","created_date":"2016-06-24T00:00:00"}
