{"id":"https://openalex.org/W4256089689","doi":"https://doi.org/10.1177/117693510500100108","title":"Assessing the Statistical Significance of the Achieved Classification Error of Classifiers Constructed using Serum Peptide Profiles, and a Prescription for Random Sampling Repeated Studies for Massive High-Throughput Genomic and Proteomic Studies","display_name":"Assessing the Statistical Significance of the Achieved Classification Error of Classifiers Constructed using Serum Peptide Profiles, and a Prescription for Random Sampling Repeated Studies for Massive High-Throughput Genomic and Proteomic Studies","publication_year":2005,"publication_date":"2005-01-01","ids":{"openalex":"https://openalex.org/W4256089689","doi":"https://doi.org/10.1177/117693510500100108","mag":"2157723599","pmid":"https://pubmed.ncbi.nlm.nih.gov/19305632","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2657655"},"language":"en","primary_location":{"id":"doi:10.1177/117693510500100108","doi":"https://doi.org/10.1177/117693510500100108","is_oa":true,"landing_page_url":"https://doi.org/10.1177/117693510500100108","pdf_url":null,"source":{"id":"https://openalex.org/S55012689","display_name":"Cancer Informatics","issn_l":"1176-9351","issn":["1176-9351"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Informatics","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1177/117693510500100108","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5017169505","display_name":"James Lyons\u2010Weiler","orcid":"https://orcid.org/0000-0001-9343-7508","observed_orcids":["https://orcid.org/0000-0001-9343-7508"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]},{"id":"https://openalex.org/I4210128526","display_name":"UPMC Hillman Cancer Center","ror":"https://ror.org/03bw34a45","country_code":"US","type":"facility","lineage":["https://openalex.org/I170201317","https://openalex.org/I4210128526"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James Lyons-Weiler","raw_affiliation_strings":["Department of Pathology, Cancer Biomarkers Laboratory, Center for Pathology Informatics, Benedum Oncology Informatics Center, University of Pittsburgh","University of Pittsburgh Cancer Institute University of Pittsburgh, University of Pittsburgh"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Cancer Biomarkers Laboratory, Center for Pathology Informatics, Benedum Oncology Informatics Center, University of Pittsburgh","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"University of Pittsburgh Cancer Institute University of Pittsburgh, University of Pittsburgh","institution_ids":["https://openalex.org/I4210128526"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025981389","display_name":"Richard C. Pelikan","orcid":"https://orcid.org/0000-0001-9674-7341","observed_orcids":["https://orcid.org/0000-0001-9674-7341"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Richard Pelikan","raw_affiliation_strings":["Department of Computer Science, University of Pittsburgh"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Computer Science, University of Pittsburgh","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061896236","display_name":"J Zeh Herbert","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]},{"id":"https://openalex.org/I4210128526","display_name":"UPMC Hillman Cancer Center","ror":"https://ror.org/03bw34a45","country_code":"US","type":"facility","lineage":["https://openalex.org/I170201317","https://openalex.org/I4210128526"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J Zeh Herbert","raw_affiliation_strings":["Department of Surgery, University of Pittsburgh","University of Pittsburgh Cancer Institute University of Pittsburgh, University of Pittsburgh"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, University of Pittsburgh","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"University of Pittsburgh Cancer Institute University of Pittsburgh, University of Pittsburgh","institution_ids":["https://openalex.org/I4210128526"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021037951","display_name":"David Clement Whitcomb","orcid":"https://orcid.org/0000-0002-4462-1410","observed_orcids":["https://orcid.org/0000-0002-4462-1410"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]},{"id":"https://openalex.org/I4210128526","display_name":"UPMC Hillman Cancer Center","ror":"https://ror.org/03bw34a45","country_code":"US","type":"facility","lineage":["https://openalex.org/I170201317","https://openalex.org/I4210128526"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David C Whitcomb","raw_affiliation_strings":["Departments of Medicine, Cell Biology & Physiology, and Human Genetics, University of Pittsburgh","University of Pittsburgh Cancer Institute University of Pittsburgh, University of Pittsburgh"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Medicine, Cell Biology & Physiology, and Human Genetics, University of Pittsburgh","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"University of Pittsburgh Cancer Institute University of Pittsburgh, University of Pittsburgh","institution_ids":["https://openalex.org/I4210128526"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031959583","display_name":"David E Malehorn","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]},{"id":"https://openalex.org/I4210128526","display_name":"UPMC Hillman Cancer Center","ror":"https://ror.org/03bw34a45","country_code":"US","type":"facility","lineage":["https://openalex.org/I170201317","https://openalex.org/I4210128526"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David E Malehorn","raw_affiliation_strings":["Clinical Proteomics Facility, University of Pittsburgh","University of Pittsburgh Cancer Institute University of Pittsburgh, University of Pittsburgh"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Proteomics Facility, University of Pittsburgh","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"University of Pittsburgh Cancer Institute University of Pittsburgh, University of Pittsburgh","institution_ids":["https://openalex.org/I4210128526"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114017213","display_name":"William L. Bigbee","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]},{"id":"https://openalex.org/I4210128526","display_name":"UPMC Hillman Cancer Center","ror":"https://ror.org/03bw34a45","country_code":"US","type":"facility","lineage":["https://openalex.org/I170201317","https://openalex.org/I4210128526"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William L Bigbee","raw_affiliation_strings":["Clinical Proteomics Facility, University of Pittsburgh","University of Pittsburgh Cancer Institute University of Pittsburgh, University of Pittsburgh"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Proteomics Facility, University of Pittsburgh","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"University of Pittsburgh Cancer Institute University of Pittsburgh, University of Pittsburgh","institution_ids":["https://openalex.org/I4210128526"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5012461386","display_name":"Milo\u0161 Hauskrecht","orcid":"https://orcid.org/0000-0002-7818-0633","observed_orcids":["https://orcid.org/0000-0002-7818-0633"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]},{"id":"https://openalex.org/I4210128526","display_name":"UPMC Hillman Cancer Center","ror":"https://ror.org/03bw34a45","country_code":"US","type":"facility","lineage":["https://openalex.org/I170201317","https://openalex.org/I4210128526"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Milos Hauskrecht","raw_affiliation_strings":["Department of Computer Science, University of Pittsburgh","University of Pittsburgh Cancer Institute University of Pittsburgh, University of Pittsburgh"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Computer Science, University of Pittsburgh","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"University of Pittsburgh Cancer Institute University of Pittsburgh, University of Pittsburgh","institution_ids":["https://openalex.org/I4210128526"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":2650,"currency":"USD","value_usd":2650},"apc_paid":{"value":2650,"currency":"USD","value_usd":2650},"fwci":1.2389,"has_fulltext":false,"cited_by_count":19,"citation_normalized_percentile":{"value":0.76313321,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"1","issue":null,"first_page":"117693510500100","last_page":"117693510500100"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.5770999789237976,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.5770999789237976,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10519","display_name":"Advanced Proteomics Techniques and Applications","score":0.35740000009536743,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10836","display_name":"Metabolomics and Mass Spectrometry Studies","score":0.007600000128149986,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/permutation-tests","display_name":"permutation tests","score":0.5559999942779541},{"id":"https://openalex.org/keywords/cancer-classification","display_name":"cancer classification","score":0.7369999885559082},{"id":"https://openalex.org/keywords/early-cancer-detection","display_name":"early cancer detection","score":0.7200000286102295},{"id":"https://openalex.org/keywords/proteomic-profiling","display_name":"proteomic profiling","score":0.4659999907016754}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6183292865753174},{"id":"https://openalex.org/C95623464","wikidata":"https://www.wikidata.org/wiki/Q1096149","display_name":"Classifier (UML)","level":2,"score":0.5880417227745056},{"id":"https://openalex.org/C169258074","wikidata":"https://www.wikidata.org/wiki/Q245748","display_name":"Random forest","level":2,"score":0.5321995615959167},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.465353786945343},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.45333629846572876},{"id":"https://openalex.org/C2777526511","wikidata":"https://www.wikidata.org/wiki/Q691543","display_name":"Pace","level":2,"score":0.4456346035003662},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.43567946553230286},{"id":"https://openalex.org/C97931131","wikidata":"https://www.wikidata.org/wiki/Q5282087","display_name":"Discriminative model","level":2,"score":0.4295884966850281},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.4147379696369171},{"id":"https://openalex.org/C205649164","wikidata":"https://www.wikidata.org/wiki/Q1071","display_name":"Geography","level":0,"score":0.0},{"id":"https://openalex.org/C13280743","wikidata":"https://www.wikidata.org/wiki/Q131089","display_name":"Geodesy","level":1,"score":0.0}],"mesh":[],"locations_count":8,"locations":[{"id":"doi:10.1177/117693510500100108","doi":"https://doi.org/10.1177/117693510500100108","is_oa":true,"landing_page_url":"https://doi.org/10.1177/117693510500100108","pdf_url":null,"source":{"id":"https://openalex.org/S55012689","display_name":"Cancer Informatics","issn_l":"1176-9351","issn":["1176-9351"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Informatics","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:1414765","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2657655","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:2657655","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2657655","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Inform","raw_type":"Text"},{"id":"pmid:19305632","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19305632","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer informatics","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.160.7273","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.160.7273","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www3.cs.pitt.edu/~milos/research/Cancer-Informatics-2005.pdf","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:b422028e553e41f3ac8b918e9988db22","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/b422028e553e41f3ac8b918e9988db22","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Cancer Informatics, Vol 1, Pp 53-77 (2005)","raw_type":"article"},{"id":"pmh:oai:doaj.org/article:f1ffb17a904847d884c07b47eeb79054","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/f1ffb17a904847d884c07b47eeb79054","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Cancer Informatics, Vol 1 (2005)","raw_type":"article"},{"id":"mag:2157723599","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19305632","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"doi:10.1177/117693510500100108","doi":"https://doi.org/10.1177/117693510500100108","is_oa":true,"landing_page_url":"https://doi.org/10.1177/117693510500100108","pdf_url":null,"source":{"id":"https://openalex.org/S55012689","display_name":"Cancer Informatics","issn_l":"1176-9351","issn":["1176-9351"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Informatics","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8371999859809875}],"study_designs":[],"awards":[{"id":"https://openalex.org/G7338161738","display_name":"Serum Proteomic Biomarkers for Colon & Pancreatic Cancer","funder_award_id":"U01CA084968","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":53,"referenced_works":["https://openalex.org/W1484966362","https://openalex.org/W1501040652","https://openalex.org/W1554663460","https://openalex.org/W1560724230","https://openalex.org/W1594735475","https://openalex.org/W1879822879","https://openalex.org/W1976927254","https://openalex.org/W1979354511","https://openalex.org/W1985354563","https://openalex.org/W1989666771","https://openalex.org/W1994326152","https://openalex.org/W1994642659","https://openalex.org/W1994888855","https://openalex.org/W1995945562","https://openalex.org/W2000305974","https://openalex.org/W2018840890","https://openalex.org/W2038818175","https://openalex.org/W2041120394","https://openalex.org/W2048183930","https://openalex.org/W2049549441","https://openalex.org/W2051830951","https://openalex.org/W2064990216","https://openalex.org/W2071389756","https://openalex.org/W2072284219","https://openalex.org/W2074466695","https://openalex.org/W2102342618","https://openalex.org/W2105494575","https://openalex.org/W2108725536","https://openalex.org/W2108728387","https://openalex.org/W2110298216","https://openalex.org/W2117897510","https://openalex.org/W2119908867","https://openalex.org/W2119934595","https://openalex.org/W2120789186","https://openalex.org/W2124181495","https://openalex.org/W2127314075","https://openalex.org/W2130213158","https://openalex.org/W2134389439","https://openalex.org/W2139212933","https://openalex.org/W2144227498","https://openalex.org/W2156909104","https://openalex.org/W2157825442","https://openalex.org/W2161371306","https://openalex.org/W2161959113","https://openalex.org/W2169182264","https://openalex.org/W2170545355","https://openalex.org/W3106889297","https://openalex.org/W3193477162","https://openalex.org/W4238306122","https://openalex.org/W4247934745","https://openalex.org/W4256631986","https://openalex.org/W4321375892","https://openalex.org/W4388297464"],"related_works":["https://openalex.org/W7099256916","https://openalex.org/W7099538641","https://openalex.org/W2104377150","https://openalex.org/W7100584354","https://openalex.org/W1994888855","https://openalex.org/W228362181","https://openalex.org/W2564714439","https://openalex.org/W2114117605","https://openalex.org/W1994710495","https://openalex.org/W1540602938"],"abstract_inverted_index":{"Peptide":[0],"profiles":[1],"generated":[2],"using":[3],"SELDI/MALDI":[4],"time":[5],"of":[6,14,27,47,49,80,96,112,142,177,189,198,207],"flight":[7],"mass":[8],"spectrometry":[9],"provide":[10],"a":[11,60,74,132,196,212,217],"promising":[12],"source":[13],"patient-specific":[15],"information":[16],"with":[17,38,109,119,152],"high":[18],"potential":[19],"impact":[20],"on":[21,86,99,115,195],"the":[22,78,81,87,93,97,110,113,116,138,171],"early":[23],"detection":[24],"and":[25,29,41,52,103,156],"classification":[26,50,76,154,190],"cancer":[28],"other":[30,175],"diseases.":[31],"The":[32,90,140,202],"new":[33],"profiling":[34],"technology":[35],"comes,":[36],"however,":[37],"numerous":[39],"challenges":[40],"concerns.":[42],"Particularly":[43],"important":[44],"are":[45,107],"concerns":[46],"reproducibility":[48],"results":[51,191,203],"their":[53],"significance.":[54],"In":[55],"this":[56],"work":[57],"we":[58,192],"describe":[59],"computational":[61],"validation":[62],"framework,":[63],"called":[64],"PACE":[65,143,162,184],"(Permutation-Achieved":[66],"Classification":[67,83],"Error),":[68],"that":[69,131,146,205,214],"lets":[70],"us":[71],"assess,":[72],"for":[73],"given":[75],"model,":[77],"significance":[79,188],"Achieved":[82],"Error":[84],"(ACE)":[85],"profile":[88],"data.":[89,139],"framework":[91],"compares":[92],"performance":[94],"statistic":[95],"classifier":[98,114],"true":[100],"data":[101,118,200],"samples":[102],"checks":[104],"if":[105],"these":[106,208],"consistent":[108],"behavior":[111],"same":[117],"randomly":[120],"reassigned":[121],"class":[122],"labels.":[123],"A":[124],"statistically":[125,218],"significant":[126,219],"ACE":[127],"increases":[128],"our":[129],"belief":[130],"discriminative":[133],"signal":[134,213],"was":[135],"found":[136],"in":[137,170],"advantage":[141],"analysis":[144,163,185],"is":[145,157],"it":[147],"can":[148],"be":[149],"easily":[150],"combined":[151],"any":[153],"model":[155],"relatively":[158],"easy":[159],"to":[160,186,216],"interpret.":[161],"does":[164],"not":[165],"protect":[166],"researchers":[167],"against":[168],"confounding":[169],"experimental":[172],"design,":[173],"or":[174,179],"sources":[176],"systematic":[178],"random":[180],"error.":[181],"We":[182],"use":[183],"assess":[187],"have":[193],"achieved":[194],"number":[197],"published":[199],"sets.":[201],"show":[204],"many":[206],"datasets":[209],"indeed":[210],"possess":[211],"leads":[215],"ACE.":[220]},"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2022-05-12T00:00:00"}
