{"id":"https://openalex.org/W4255920058","doi":"https://doi.org/10.1002/0471142905.hg1303s11","title":"Ex Vivo and In Vivo Gene Delivery to the Brain","display_name":"Ex Vivo and In Vivo Gene Delivery to the Brain","publication_year":1996,"publication_date":"1996-11-01","ids":{"openalex":"https://openalex.org/W4255920058","doi":"https://doi.org/10.1002/0471142905.hg1303s11"},"language":"en","primary_location":{"id":"doi:10.1002/0471142905.hg1303s11","doi":"https://doi.org/10.1002/0471142905.hg1303s11","is_oa":false,"landing_page_url":"https://doi.org/10.1002/0471142905.hg1303s11","pdf_url":null,"source":{"id":"https://openalex.org/S2764932843","display_name":"Current Protocols in Human Genetics","issn_l":"1934-8258","issn":["1934-8258","1934-8266"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-70"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Protocols in Human Genetics","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5037996429","display_name":"Jaana Suhonen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1307098950","display_name":"Salk Institute for Biological Studies","ror":"https://ror.org/03xez1567","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1307098950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jaana Suhonen","raw_affiliation_strings":["The Salk Institute, La Jolla, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Salk Institute, La Jolla, California","institution_ids":["https://openalex.org/I1307098950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109934923","display_name":"Jasodhara Ray","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1307098950","display_name":"Salk Institute for Biological Studies","ror":"https://ror.org/03xez1567","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1307098950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jasodhara Ray","raw_affiliation_strings":["The Salk Institute, La Jolla, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Salk Institute, La Jolla, California","institution_ids":["https://openalex.org/I1307098950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018145632","display_name":"Ulrike Bl\u00f6mer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1307098950","display_name":"Salk Institute for Biological Studies","ror":"https://ror.org/03xez1567","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1307098950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ulrike Bl\u00f6mer","raw_affiliation_strings":["The Salk Institute, La Jolla, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Salk Institute, La Jolla, California","institution_ids":["https://openalex.org/I1307098950"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5072968010","display_name":"Fred H. Gage","orcid":"https://orcid.org/0000-0002-0938-4106","observed_orcids":["https://orcid.org/0000-0002-0938-4106"]},"institutions":[{"id":"https://openalex.org/I1307098950","display_name":"Salk Institute for Biological Studies","ror":"https://ror.org/03xez1567","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1307098950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Fred H. Gage","raw_affiliation_strings":["The Salk Institute, La Jolla, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Salk Institute, La Jolla, California","institution_ids":["https://openalex.org/I1307098950"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I1307098950"],"apc_list":{"value":5050,"currency":"USD","value_usd":5050},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.37398767,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"11","issue":"1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.0052999998442828655,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11872","display_name":"Barrier Structure and Function Studies","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gene-delivery-to-the-brain","display_name":"gene delivery to the brain","score":0.8930000066757202},{"id":"https://openalex.org/keywords/ex-vivo-gene-transfer","display_name":"ex vivo gene transfer","score":0.8050000071525574},{"id":"https://openalex.org/keywords/recombinant-viral-vectors","display_name":"recombinant viral vectors","score":0.9070000052452087},{"id":"https://openalex.org/keywords/brain-sectioning","display_name":"brain sectioning","score":0.7860000133514404},{"id":"https://openalex.org/keywords/rat-brain","display_name":"rat brain","score":0.7620000243186951}],"concepts":[{"id":"https://openalex.org/C26291073","wikidata":"https://www.wikidata.org/wiki/Q310484","display_name":"Ex vivo","level":3,"score":0.8804957866668701},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.6817981600761414},{"id":"https://openalex.org/C135983454","wikidata":"https://www.wikidata.org/wiki/Q2790163","display_name":"Gene delivery","level":4,"score":0.5848594307899475},{"id":"https://openalex.org/C102230213","wikidata":"https://www.wikidata.org/wiki/Q430117","display_name":"Transgene","level":3,"score":0.5717402100563049},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5580628514289856},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4929497241973877},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4177218973636627},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.38118740916252136},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.36209115386009216},{"id":"https://openalex.org/C111599444","wikidata":"https://www.wikidata.org/wiki/Q213901","display_name":"Genetic enhancement","level":3,"score":0.3320726156234741},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.13900542259216309},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.13269343972206116}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1002/0471142905.hg1303s11","doi":"https://doi.org/10.1002/0471142905.hg1303s11","is_oa":false,"landing_page_url":"https://doi.org/10.1002/0471142905.hg1303s11","pdf_url":null,"source":{"id":"https://openalex.org/S2764932843","display_name":"Current Protocols in Human Genetics","issn_l":"1934-8258","issn":["1934-8258","1934-8266"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-70"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Protocols in Human Genetics","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.504800021648407,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":28,"referenced_works":["https://openalex.org/W126651838","https://openalex.org/W290667714","https://openalex.org/W1774646573","https://openalex.org/W1968960126","https://openalex.org/W1983924189","https://openalex.org/W1994042895","https://openalex.org/W1994078063","https://openalex.org/W1998046435","https://openalex.org/W1998567805","https://openalex.org/W2005789317","https://openalex.org/W2009761723","https://openalex.org/W2022196880","https://openalex.org/W2028477896","https://openalex.org/W2029820461","https://openalex.org/W2038036971","https://openalex.org/W2047876948","https://openalex.org/W2047945439","https://openalex.org/W2050927126","https://openalex.org/W2064616917","https://openalex.org/W2067379696","https://openalex.org/W2068029268","https://openalex.org/W2071971522","https://openalex.org/W2073765832","https://openalex.org/W2082157013","https://openalex.org/W2083430062","https://openalex.org/W2114689164","https://openalex.org/W2117198101","https://openalex.org/W4245757319"],"related_works":["https://openalex.org/W2046805678","https://openalex.org/W2064616917","https://openalex.org/W48059278","https://openalex.org/W1994051931","https://openalex.org/W2008551004","https://openalex.org/W2169431513","https://openalex.org/W1966948468","https://openalex.org/W1974871382","https://openalex.org/W2964078581","https://openalex.org/W1510561167"],"abstract_inverted_index":{"Abstract":[0],"This":[1,90],"unit":[2,91],"describes":[3],"methods":[4,36],"for":[5,10,84,95,108],"grafting":[6,67],"genetically":[7],"modified":[8],"cells":[9,28,62,70],"ex":[11,47],"vivo":[12,30,48],"delivery":[13,23],"of":[14,24,40,50,61,68,77,88,105,110,114,121],"specific":[15],"genes":[16],"into":[17,71],"the":[18,38,44,54,69,72,100],"rat":[19],"brain":[20,27,73],"and":[21,107],"direct":[22],"transgenes":[25],"to":[26,53,66,74,98,103],"in":[29,43,63],"using":[31],"recombinant":[32],"viral":[33],"vectors.":[34],"These":[35],"assess":[37],"function":[39],"a":[41,78,85,115],"gene":[42,51],"brain.":[45],"The":[46],"approach":[49],"transfer":[52],"nervous":[55],"system":[56],"depends":[57],"on":[58],"genetic":[59],"manipulation":[60],"vitro":[64],"prior":[65,102],"enable":[75],"production":[76],"transgene":[79],"at":[80],"physiologically":[81],"significant":[82],"levels":[83],"long":[86],"period":[87],"time.":[89],"also":[92,125],"includes":[93],"procedures":[94],"transcardial":[96],"perfusion":[97],"fix":[99],"tissue":[101,122],"analysis":[104],"expression":[106],"sectioning":[109],"brains":[111],"by":[112],"use":[113],"freezing":[116],"sledge":[117],"microtome.":[118],"Thionine":[119],"staining":[120],"sections":[123],"is":[124],"described.":[126]},"counts_by_year":[{"year":2017,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2022-05-12T00:00:00"}