{"id":"https://openalex.org/W4255403286","doi":"https://doi.org/10.2331/suisan.44.21","title":null,"display_name":null,"publication_year":1978,"publication_date":"1978-01-01","ids":{"openalex":"https://openalex.org/W4255403286","doi":"https://doi.org/10.2331/suisan.44.21"},"language":"en","primary_location":{"id":"doi:10.2331/suisan.44.21","doi":"https://doi.org/10.2331/suisan.44.21","is_oa":true,"landing_page_url":"https://doi.org/10.2331/suisan.44.21","pdf_url":"https://www.jstage.jst.go.jp/article/suisan1932/44/1/44_1_21/_pdf","source":{"id":"https://openalex.org/S4210186241","display_name":"NIPPON SUISAN GAKKAISHI","issn_l":"0021-5392","issn":["0021-5392","1349-998X"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["dongbi-c","jufo-1","norway-1","poland-20","russia-white-list-4"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"NIPPON SUISAN GAKKAISHI","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.jstage.jst.go.jp/article/suisan1932/44/1/44_1_21/_pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109529241","display_name":"Riichi Kusuda","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I77063589","display_name":"K\u014dchi University","ror":"https://ror.org/01xxp6985","country_code":"JP","type":"education","lineage":["https://openalex.org/I77063589"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Riich KUSUDA","raw_affiliation_strings":["\u9ad8\u77e5\u5927\u5b66\u8fb2\u5b66\u90e8\u683d\u57f9\u6f01\u696d\u5b66\u79d1"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"\u9ad8\u77e5\u5927\u5b66\u8fb2\u5b66\u90e8\u683d\u57f9\u6f01\u696d\u5b66\u79d1","institution_ids":["https://openalex.org/I77063589"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Kenji KAWAI","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210124961","display_name":"Kyoto Biken Laboratories (Japan)","ror":"https://ror.org/02wz7nx80","country_code":"JP","type":"company","lineage":["https://openalex.org/I4210124961"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kenji KAWAI","raw_affiliation_strings":["\u5fae\u751f\u7269\u5316\u5b66\u7814\u7a76\u6240"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"\u5fae\u751f\u7269\u5316\u5b66\u7814\u7a76\u6240","institution_ids":["https://openalex.org/I4210124961"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111731962","display_name":"Yasuhiko JO","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yasuhiko JO","raw_affiliation_strings":["\u5fb3\u5cf6\u770c\u6c34\u7523\u8a66\u9a13\u5834"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"\u5fb3\u5cf6\u770c\u6c34\u7523\u8a66\u9a13\u5834","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005868938","display_name":"Tomoharu AKIZUKI","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tomoharu AKIZUKI","raw_affiliation_strings":["\u5fb3\u5cf6\u770c\u6c34\u7523\u8a66\u9a13\u5834"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"\u5fb3\u5cf6\u770c\u6c34\u7523\u8a66\u9a13\u5834","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068565247","display_name":"Minoru FUKUNAGA","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Minoru FUKUNAGA","raw_affiliation_strings":["\u5fb3\u5cf6\u770c\u6c34\u7523\u8a66\u9a13\u5834"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"\u5fb3\u5cf6\u770c\u6c34\u7523\u8a66\u9a13\u5834","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5011834873","display_name":"\u5b50\u4e4b\u52a9 \u5c0f\u7af9","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nenosuke KOTAKE","raw_affiliation_strings":["\u5fb3\u5cf6\u770c\u6c34\u7523\u8a66\u9a13\u5834"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"\u5fb3\u5cf6\u770c\u6c34\u7523\u8a66\u9a13\u5834","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.171,"has_fulltext":true,"cited_by_count":18,"citation_normalized_percentile":{"value":0.51666499,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"44","issue":"1","first_page":"21","last_page":"25"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10506","display_name":"Aquaculture disease management and microbiota","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10506","display_name":"Aquaculture disease management and microbiota","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11684","display_name":"Vibrio bacteria research studies","score":0.002099999925121665,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11688","display_name":"Microbial infections and disease research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/vibriosis","display_name":"vibriosis","score":0.8809999823570251},{"id":"https://openalex.org/keywords/ayu","display_name":"Plecoglossus altivelis","score":0.9950000047683716},{"id":"https://openalex.org/keywords/vibrio-anguillarum","display_name":"Vibrio anguillarum","score":0.972000002861023},{"id":"https://openalex.org/keywords/oral-vaccine","display_name":"oral vaccine","score":0.8180000185966492},{"id":"https://openalex.org/keywords/sonication","display_name":"sonication","score":0.828000009059906},{"id":"https://openalex.org/keywords/heat-treatment-food-and-biological-processing","display_name":"heat treatment (food and biological processing)","score":0.5740000009536743},{"id":"https://openalex.org/keywords/incomplete-freund-s-adjuvant","display_name":"incomplete Freund's adjuvant","score":0.984000027179718},{"id":"https://openalex.org/keywords/fish-disease-control","display_name":"fish disease control","score":0.5569999814033508},{"id":"https://openalex.org/keywords/booster-vaccination","display_name":"booster vaccination","score":0.6880000233650208},{"id":"https://openalex.org/keywords/fish-mortality","display_name":"fish mortality","score":0.37700000405311584}],"concepts":[{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.6386473178863525},{"id":"https://openalex.org/C2994288365","wikidata":"https://www.wikidata.org/wiki/Q642906","display_name":"Plecoglossus altivelis","level":3,"score":0.6228480935096741},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.5887584090232849},{"id":"https://openalex.org/C22070199","wikidata":"https://www.wikidata.org/wiki/Q192995","display_name":"Vaccination","level":2,"score":0.5644766688346863},{"id":"https://openalex.org/C2777863537","wikidata":"https://www.wikidata.org/wiki/Q357896","display_name":"Adjuvant","level":2,"score":0.5610429048538208},{"id":"https://openalex.org/C180032290","wikidata":"https://www.wikidata.org/wiki/Q1664296","display_name":"Inoculation","level":2,"score":0.5465904474258423},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5151287317276001},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.4923027753829956},{"id":"https://openalex.org/C2781348184","wikidata":"https://www.wikidata.org/wiki/Q7924678","display_name":"Vibrio anguillarum","level":4,"score":0.42805641889572144},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.3997649550437927},{"id":"https://openalex.org/C2909208804","wikidata":"https://www.wikidata.org/wiki/Q127282","display_name":"Fish <Actinopterygii>","level":2,"score":0.31205958127975464},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3106061816215515},{"id":"https://openalex.org/C2776154503","wikidata":"https://www.wikidata.org/wiki/Q753490","display_name":"Vibrio","level":3,"score":0.2955667972564697},{"id":"https://openalex.org/C505870484","wikidata":"https://www.wikidata.org/wiki/Q180538","display_name":"Fishery","level":1,"score":0.11684966087341309},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.2331/suisan.44.21","doi":"https://doi.org/10.2331/suisan.44.21","is_oa":true,"landing_page_url":"https://doi.org/10.2331/suisan.44.21","pdf_url":"https://www.jstage.jst.go.jp/article/suisan1932/44/1/44_1_21/_pdf","source":{"id":"https://openalex.org/S4210186241","display_name":"NIPPON SUISAN GAKKAISHI","issn_l":"0021-5392","issn":["0021-5392","1349-998X"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["dongbi-c","jufo-1","norway-1","poland-20","russia-white-list-4"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"NIPPON SUISAN GAKKAISHI","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.2331/suisan.44.21","doi":"https://doi.org/10.2331/suisan.44.21","is_oa":true,"landing_page_url":"https://doi.org/10.2331/suisan.44.21","pdf_url":"https://www.jstage.jst.go.jp/article/suisan1932/44/1/44_1_21/_pdf","source":{"id":"https://openalex.org/S4210186241","display_name":"NIPPON SUISAN GAKKAISHI","issn_l":"0021-5392","issn":["0021-5392","1349-998X"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["dongbi-c","jufo-1","norway-1","poland-20","russia-white-list-4"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"NIPPON SUISAN GAKKAISHI","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4255403286.pdf","grobid_xml":"https://content.openalex.org/works/W4255403286.grobid-xml"},"referenced_works_count":1,"referenced_works":["https://openalex.org/W1560093572"],"related_works":[],"abstract_inverted_index":{"Efficacy":[0],"of":[1,4,9,26,54,61,65,73,101,119,121,127,138,150],"four":[2,52,155],"kinds":[3,53],"oral":[5],"vaccine":[6,55],"for":[7,129,146,154],"control":[8],"vibriosis":[10,27],"in":[11,28,103,135,141,170,183],"cultured":[12],"ayu":[13],"(Plecoglossus":[14],"altivelis)":[15],"was":[16,30,43,75,106,112,152,160,163],"investigated.Nutrient":[17],"broth":[18],"inoculated":[19],"with":[20,32,38,48],"Vibrio":[21],"anguillarum,":[22],"the":[23,82,104,147,171],"etiological":[24],"agent":[25],"ayu,":[29],"incubated":[31],"shaking.Cells":[33],"were":[34,56,96,168,176],"harvested":[35],"and":[36,91,93,157],"inactivated":[37],"formalin.The":[39],"bacterine":[40,90,110,123],"thus":[41],"prepared":[42],"ultrasonicated,":[44],"heated":[45,109],"or":[46],"mixed":[47],"Freund":[49],"incomplete":[50],"adjuvant.These":[51],"administered":[57,115,161],"at":[58,116,124],"a":[59,117,125],"level":[60,118,126],"0.4g":[62],"wet":[63],"weight":[64],"cells":[66],"per":[67,70],"kg":[68],"body-weight":[69],"day.The":[71],"efficacy":[72,149],"vaccination":[74,151],"tested":[76],"by":[77],"expos":[78],"ing":[79],"fish":[80],"to":[81,143,178],"bacteria":[83],"discharged":[84],"from":[85],"artificially":[86],"infected":[87],"ayu.The":[88],"formalin-killed":[89,92,122],"ultrasonicated":[94],"becterine":[95],"highly":[97],"effective,":[98],"but":[99],"production":[100],"antibody":[102],"blood":[105],"not":[107],"observed.The":[108],"also":[111],"effective":[113],"when":[114,158],"4.0g.Administration":[120],"4.0g":[128],"more":[130],"than":[131],"2":[132],"weeks":[133],"resulted":[134],"low":[136],"mortality":[137],"about":[139,144],"10%":[140],"contrast":[142],"90%":[145],"controls.This":[148],"maintained":[153],"weeks,":[156],"booster":[159],"it":[162],"prolonged":[164],"further.Though":[165],"many":[166],"antigens":[167,175],"contained":[169],"bacterine,":[172],"heat":[173],"resistant":[174],"considered":[177],"play":[179],"an":[180],"important":[181],"role":[182],"protection":[184],"against":[185],"vibrio":[186],"infection.":[187]},"counts_by_year":[{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-15T10:00:46.086208","created_date":"2022-05-12T00:00:00"}