{"id":"https://openalex.org/W4255138787","doi":"https://doi.org/10.1001/archopht.1990.01070110050024","title":"A Randomized Trial of Sorbinil, an Aldose Reductase Inhibitor, in Diabetic Retinopathy","display_name":"A Randomized Trial of Sorbinil, an Aldose Reductase Inhibitor, in Diabetic Retinopathy","publication_year":1990,"publication_date":"1990-09-01","ids":{"openalex":"https://openalex.org/W4255138787","doi":"https://doi.org/10.1001/archopht.1990.01070110050024","pmid":"https://pubmed.ncbi.nlm.nih.gov/2119168"},"language":"en","primary_location":{"id":"doi:10.1001/archopht.1990.01070110050024","doi":"https://doi.org/10.1001/archopht.1990.01070110050024","is_oa":false,"landing_page_url":"https://doi.org/10.1001/archopht.1990.01070110050024","pdf_url":null,"source":{"id":"https://openalex.org/S80523760","display_name":"Archives of Ophthalmology","issn_l":"0003-9950","issn":["0003-9950","1538-3601"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core"],"host_organization":"https://openalex.org/P4310320259","host_organization_name":"American Medical Association","host_organization_lineage":["https://openalex.org/P4310320259"],"host_organization_lineage_names":["American Medical Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of Ophthalmology","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W4255138787"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.4159,"has_fulltext":false,"cited_by_count":228,"citation_normalized_percentile":{"value":0.89623772,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"108","issue":"9","first_page":"1234","last_page":"1234"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12533","display_name":"Aldose Reductase and Taurine","score":0.7124000191688538,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12533","display_name":"Aldose Reductase and Taurine","score":0.7124000191688538,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10170","display_name":"Retinal Diseases and Treatments","score":0.2831999957561493,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11142","display_name":"Advanced Glycation End Products research","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/1308","display_name":"Clinical Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sorbinil","display_name":"sorbinil","score":0.9980000257492065},{"id":"https://openalex.org/keywords/aldose-reductase-inhibitors","display_name":"aldose reductase inhibitors","score":0.9089999794960022},{"id":"https://openalex.org/keywords/diabetic-retinopathy","display_name":"diabetic retinopathy","score":1.0},{"id":"https://openalex.org/keywords/type-1-diabetes","display_name":"type 1 diabetes","score":0.9490000009536743},{"id":"https://openalex.org/keywords/retinopathy-progression","display_name":"retinopathy progression","score":0.847000002861023},{"id":"https://openalex.org/keywords/microaneurysms","display_name":"microaneurysms","score":0.968999981880188},{"id":"https://openalex.org/keywords/drug-safety","display_name":"drug safety","score":0.5899999737739563},{"id":"https://openalex.org/keywords/hypersensitivity","display_name":"hypersensitivity","score":0.6959999799728394}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.928495466709137},{"id":"https://openalex.org/C512399662","wikidata":"https://www.wikidata.org/wiki/Q3505712","display_name":"Family medicine","level":1,"score":0.4402260184288025},{"id":"https://openalex.org/C108516343","wikidata":"https://www.wikidata.org/wiki/Q189553","display_name":"Otorhinolaryngology","level":2,"score":0.42754003405570984},{"id":"https://openalex.org/C16568411","wikidata":"https://www.wikidata.org/wiki/Q83042","display_name":"Neurology","level":2,"score":0.4139016270637512},{"id":"https://openalex.org/C118487528","wikidata":"https://www.wikidata.org/wiki/Q161437","display_name":"Ophthalmology","level":1,"score":0.3834517002105713},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.26621755957603455}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000449","descriptor_name":"Aldehyde Reductase","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D000783","descriptor_name":"Aneurysm","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D003930","descriptor_name":"Diabetic Retinopathy","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D003930","descriptor_name":"Diabetic Retinopathy","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D004361","descriptor_name":"Drug Tolerance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005500","descriptor_name":"Follow-Up Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007093","descriptor_name":"Imidazoles","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D007093","descriptor_name":"Imidazoles","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012171","descriptor_name":"Retinal Vessels","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D013401","descriptor_name":"Sugar Alcohol Dehydrogenases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D015337","descriptor_name":"Multicenter Studies as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016009","descriptor_name":"Chi-Square Distribution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016032","descriptor_name":"Randomized Controlled Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D048289","descriptor_name":"Imidazolidines","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1001/archopht.1990.01070110050024","doi":"https://doi.org/10.1001/archopht.1990.01070110050024","is_oa":false,"landing_page_url":"https://doi.org/10.1001/archopht.1990.01070110050024","pdf_url":null,"source":{"id":"https://openalex.org/S80523760","display_name":"Archives of Ophthalmology","issn_l":"0003-9950","issn":["0003-9950","1538-3601"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core"],"host_organization":"https://openalex.org/P4310320259","host_organization_name":"American Medical Association","host_organization_lineage":["https://openalex.org/P4310320259"],"host_organization_lineage_names":["American Medical Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of Ophthalmology","raw_type":"journal-article"},{"id":"pmid:2119168","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2119168","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of ophthalmology (Chicago, Ill. : 1960)","raw_type":"Clinical Trial"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/randomized-controlled-trial","display_name":"Randomized Controlled Trial"},{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1970384279","https://openalex.org/W2077750860","https://openalex.org/W1974176582","https://openalex.org/W1985484796","https://openalex.org/W2004178308","https://openalex.org/W203429344","https://openalex.org/W4235943758","https://openalex.org/W1964389921","https://openalex.org/W2161727220","https://openalex.org/W2014591096"],"abstract_inverted_index":{"A":[0],"total":[1],"of":[2,34,39,80,123,140,152,167,174,200],"497":[3],"patients":[4,40,125,193],"aged":[5],"18":[6],"to":[7,16,22,195],"56":[8],"years":[9,18,158],"with":[10,97,171,182],"insulin-dependent":[11,172],"diabetes":[12,173],"mellitus":[13],"for":[14,31,156],"1":[15],"15":[17],"were":[19],"randomly":[20],"assigned":[21,126,194],"take":[23,196],"oral":[24],"sorbinil":[25,67,90,127,147],"or":[26,52],"placebo":[27,73,95],"and":[28,69,106],"followed":[29],"up":[30],"a":[32,84,129,150,160,183,198],"median":[33],"41":[35],"months.":[36,136],"The":[37,78],"percentage":[38],"whose":[41],"retinopathy":[42,168],"severity":[43],"grade":[44],"at":[45,83,101,114,149],"maximum":[46,116],"follow-up":[47,117],"had":[48],"worsened":[49],"by":[50],"two":[51,61],"more":[53],"levels":[54],"was":[55],"not":[56,113],"significantly":[57],"different":[58],"between":[59],"the":[60,66,72,89,94,115,124,133,138,165,189],"treatment":[62],"groups":[63],"(28%":[64],"in":[65,71,88,93,132,169,188],"group":[68,91],"32%":[70],"group,":[74,96],"P":[75],"=":[76,104,109,119],".344).":[77],"number":[79],"microaneurysms":[81],"increased":[82],"slightly":[85,184],"slower":[86,185],"rate":[87,187],"than":[92],"statistically":[98],"significant":[99],"differences":[100],"21":[102],"(P":[103,108,118],".046)":[105],"30":[107],".039)":[110],"months":[111],"but":[112],".156).":[120],"About":[121],"7%":[122],"developed":[128],"hypersensitivity":[130],"reaction":[131],"first":[134],"3":[135,157],"On":[137],"basis":[139],"these":[141],"results,":[142],"it":[143],"is":[144],"unlikely":[145],"that":[146],"administered":[148],"dosage":[151],"250":[153],"mg":[154],"daily":[155],"has":[159],"clinically":[161],"important":[162],"effect":[163],"on":[164],"course":[166],"adults":[170],"moderate":[175],"duration.":[176],"Our":[177],"data":[178],"are":[179],"consistent,":[180],"however,":[181],"progression":[186],"microaneurysm":[190],"count":[191],"among":[192],"sorbinil,":[197],"finding":[199],"uncertain":[201],"clinical":[202],"importance.":[203]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":10},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":10}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2022-05-12T00:00:00"}
