{"id":"https://openalex.org/W4255035631","doi":"https://doi.org/10.1067/mcp.2001.118867","title":"Effect of grapefruit juice on digoxin pharmacokinetics in humans","display_name":"Effect of grapefruit juice on digoxin pharmacokinetics in humans","publication_year":2001,"publication_date":"2001-10-01","ids":{"openalex":"https://openalex.org/W4255035631","doi":"https://doi.org/10.1067/mcp.2001.118867","mag":"1988641769","pmid":"https://pubmed.ncbi.nlm.nih.gov/11673746"},"language":"en","primary_location":{"id":"doi:10.1067/mcp.2001.118867","doi":"https://doi.org/10.1067/mcp.2001.118867","is_oa":false,"landing_page_url":"https://doi.org/10.1067/mcp.2001.118867","pdf_url":null,"source":{"id":"https://openalex.org/S159852663","display_name":"Clinical Pharmacology & Therapeutics","issn_l":"0009-9236","issn":["0009-9236","1085-8733","1532-6535"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Pharmacology & Therapeutics","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5039307785","display_name":"Laurent Becquemont","orcid":"https://orcid.org/0000-0003-3477-8956","observed_orcids":["https://orcid.org/0000-0003-3477-8956"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"L Becquemont","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5039307785"],"corresponding_institution_ids":[],"apc_list":{"value":4410,"currency":"USD","value_usd":4410},"apc_paid":null,"fwci":9.9404,"has_fulltext":false,"cited_by_count":236,"citation_normalized_percentile":{"value":0.98984537,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"70","issue":"4","first_page":"311","last_page":"316"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.7265999913215637,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.7265999913215637,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.2660999894142151,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11908","display_name":"Protein Interaction Studies and Fluorescence Analysis","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/grapefruit-juice","display_name":"grapefruit juice","score":1.0},{"id":"https://openalex.org/keywords/digoxin","display_name":"digoxin","score":0.996999979019165},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.8289999961853027},{"id":"https://openalex.org/keywords/drug-interactions","display_name":"drug interactions","score":0.8690000176429749},{"id":"https://openalex.org/keywords/p-glycoprotein-inhibition","display_name":"P-glycoprotein inhibition","score":0.9629999995231628},{"id":"https://openalex.org/keywords/mdr1-c3435t-polymorphism","display_name":"MDR1 C3435T polymorphism","score":0.9110000133514404},{"id":"https://openalex.org/keywords/bioavailability","display_name":"bioavailability","score":0.9559999704360962},{"id":"https://openalex.org/keywords/renal-clearance","display_name":"renal clearance","score":0.7789999842643738},{"id":"https://openalex.org/keywords/food-drug-interactions","display_name":"food-drug interactions","score":0.7160000205039978}],"concepts":[{"id":"https://openalex.org/C2776773239","wikidata":"https://www.wikidata.org/wiki/Q1138468","display_name":"Grapefruit juice","level":3,"score":0.9398925304412842},{"id":"https://openalex.org/C2777707475","wikidata":"https://www.wikidata.org/wiki/Q422222","display_name":"Digoxin","level":3,"score":0.8875932097434998},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.7286508083343506},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.6440259218215942},{"id":"https://openalex.org/C3018968983","wikidata":"https://www.wikidata.org/wiki/Q8492","display_name":"Fruit juice","level":2,"score":0.43463048338890076},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4223829507827759},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.36309537291526794},{"id":"https://openalex.org/C31903555","wikidata":"https://www.wikidata.org/wiki/Q1637030","display_name":"Food science","level":1,"score":0.27797073125839233},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.17666727304458618},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.04330900311470032}],"mesh":[{"descriptor_ui":"D001628","descriptor_name":"Beverages","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002957","descriptor_name":"Citrus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004077","descriptor_name":"Digoxin","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011110","descriptor_name":"Polymorphism, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018565","descriptor_name":"Food-Drug Interactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018592","descriptor_name":"Cross-Over Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019540","descriptor_name":"Area Under Curve","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020168","descriptor_name":"ATP Binding Cassette Transporter, Subfamily B, Member 1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020168","descriptor_name":"ATP Binding Cassette Transporter, Subfamily B, Member 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1067/mcp.2001.118867","doi":"https://doi.org/10.1067/mcp.2001.118867","is_oa":false,"landing_page_url":"https://doi.org/10.1067/mcp.2001.118867","pdf_url":null,"source":{"id":"https://openalex.org/S159852663","display_name":"Clinical Pharmacology & Therapeutics","issn_l":"0009-9236","issn":["0009-9236","1085-8733","1532-6535"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Pharmacology & Therapeutics","raw_type":"journal-article"},{"id":"pmid:11673746","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11673746","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical pharmacology and therapeutics","raw_type":"Clinical Trial"},{"id":"mag:1988641769","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11673746","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9922999739646912}],"study_designs":[{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":28,"referenced_works":["https://openalex.org/W1523397215","https://openalex.org/W1578896110","https://openalex.org/W1787076927","https://openalex.org/W1875260420","https://openalex.org/W1972291181","https://openalex.org/W1990732193","https://openalex.org/W1994301337","https://openalex.org/W1995742773","https://openalex.org/W1997520975","https://openalex.org/W1999021046","https://openalex.org/W2015500397","https://openalex.org/W2022545732","https://openalex.org/W2033767311","https://openalex.org/W2054458932","https://openalex.org/W2060716969","https://openalex.org/W2061864878","https://openalex.org/W2076025389","https://openalex.org/W2076491064","https://openalex.org/W2084152024","https://openalex.org/W2099891679","https://openalex.org/W2117927958","https://openalex.org/W2126310184","https://openalex.org/W2127645257","https://openalex.org/W2138275432","https://openalex.org/W2166931842","https://openalex.org/W2169949296","https://openalex.org/W2318934741","https://openalex.org/W2334067891"],"related_works":["https://openalex.org/W2012253880","https://openalex.org/W2080675242","https://openalex.org/W2897749673","https://openalex.org/W6885059904","https://openalex.org/W571435653","https://openalex.org/W2000069832","https://openalex.org/W2105555971","https://openalex.org/W2013205914","https://openalex.org/W1581481291","https://openalex.org/W2472382982"],"abstract_inverted_index":{"OBJECTIVES:":[0],"Grapefruit":[1,103],"juice":[2,28,72,104,160,195],"is":[3],"responsible":[4],"for":[5],"drug":[6,113,221],"interactions":[7],"mediated":[8],"by":[9,52,227],"intestinal":[10],"cytochrome":[11],"P4503A4":[12],"inhibition":[13,17,211],"and":[14,149,177],"possibly":[15],"P-glycoprotein":[16,35,53,89,202,210],"in":[18,61,98,139,189,220],"enterocytes.":[19],"Our":[20],"main":[21],"objective":[22,39],"was":[23,40,50,91,135],"to":[24,41,94,130,146,153,215],"determine":[25,42],"whether":[26,43],"grapefruit":[27,71,159,194,208],"alters":[29],"the":[30,44,47,68,77,110,119,122,140],"bioavailability":[31],"of":[32,46,70,79,84,116,229],"digoxin,":[33],"a":[34,80,136,217],"substrate.":[36],"The":[37,88,162,186],"secondary":[38],"magnitude":[45],"pharmacokinetic":[48,180],"interaction":[49],"influenced":[51],"genetic":[54,96],"polymorphism.":[55],"METHODS:":[56],"Twelve":[57],"healthy":[58],"volunteers":[59],"participated":[60],"this":[62],"open":[63],"randomized":[64],"crossover":[65],"study":[66],"comparing":[67],"effect":[69,108],"consumption":[73],"(versus":[74],"water)":[75],"on":[76,109],"pharmacokinetics":[78,191],"single":[81],"oral":[82],"dose":[83],"digoxin":[85,117,141,163,179,190,230],"(0.5":[86],"mg).":[87],"genotype":[90,176],"determined":[92],"according":[93],"MDR1":[95,174],"polymorphism":[97],"exon":[99],"26":[100],"(C3435T).":[101],"RESULTS:":[102],"had":[105],"no":[106],"significant":[107],"maximum":[111],"plasma":[112,123],"concentration":[114],"(C(max))":[115],"or":[118],"area":[120],"under":[121],"concentration-time":[124],"curve":[125],"(AUC)":[126],"from":[127,143,150],"time":[128,144,151],"zero":[129,145,152],"48":[131],"hours.":[132],"However,":[133],"there":[134],"9%":[137],"increase":[138],"AUC":[142],"4":[147],"hours":[148,155],"24":[154],"(P":[156],"=.01)":[157],"during":[158,168,193],"administration.":[161],"renal":[164],"clearance":[165],"remained":[166],"unchanged":[167],"both":[169],"periods.":[170],"No":[171],"relationship":[172],"between":[173],"C3435T":[175],"early":[178],"changes":[181,188],"could":[182],"be":[183],"detected.":[184],"CONCLUSION:":[185],"modest":[187],"observed":[192],"ingestion":[196],"do":[197],"not":[198,213],"support":[199],"an":[200],"important":[201],"inhibition.":[203],"Under":[204],"our":[205],"experimental":[206],"conditions,":[207],"juice-mediated":[209],"does":[212],"appear":[214],"play":[216],"relevant":[218],"role":[219],"interactions,":[222],"at":[223],"least":[224],"when":[225],"assessed":[226],"use":[228],"disposition":[231],"kinetics.":[232]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":8},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":11},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":7},{"year":2012,"cited_by_count":10}],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2022-05-12T00:00:00"}