{"id":"https://openalex.org/W4254934232","doi":"https://doi.org/10.1074/jbc.a111.234641","title":"Gephyrin regulates GABAergic and glutamatergic synaptic transmission in hippocampal cell cultures.","display_name":"Gephyrin regulates GABAergic and glutamatergic synaptic transmission in hippocampal cell cultures.","publication_year":2011,"publication_date":"2011-08-26","ids":{"openalex":"https://openalex.org/W4254934232","doi":"https://doi.org/10.1074/jbc.a111.234641","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3162465"},"language":"en","primary_location":{"id":"doi:10.1074/jbc.a111.234641","doi":"https://doi.org/10.1074/jbc.a111.234641","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.a111.234641","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1074/jbc.a111.234641","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5026991143","display_name":"Zeynep Kasap Varley","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Zeynep Kasap Varley","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002076744","display_name":"Rocco Pizzarelli","orcid":"https://orcid.org/0000-0003-0662-0887","observed_orcids":["https://orcid.org/0000-0003-0662-0887"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rocco Pizzarelli","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048358856","display_name":"Roberta Antonelli","orcid":"https://orcid.org/0000-0001-6884-7847","observed_orcids":["https://orcid.org/0000-0001-6884-7847"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Roberta Antonelli","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Stefka H. Stancheva","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Stefka H. Stancheva","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077167110","display_name":"Matthias Kneussel","orcid":"https://orcid.org/0000-0003-4900-366X","observed_orcids":["https://orcid.org/0000-0003-4900-366X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Matthias Kneussel","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054923894","display_name":"Enrico Cherubini","orcid":"https://orcid.org/0000-0002-1183-2772","observed_orcids":["https://orcid.org/0000-0002-1183-2772"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Enrico Cherubini","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5042384891","display_name":"Paola Zacchi","orcid":"https://orcid.org/0000-0001-8944-5652","observed_orcids":["https://orcid.org/0000-0001-8944-5652"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Paola Zacchi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":0.2306,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.47409847,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"286","issue":"35","first_page":"31062","last_page":"31062"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11772","display_name":"Genetics and Neurodevelopmental Disorders","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gephyrin","display_name":"gephyrin","score":0.996999979019165},{"id":"https://openalex.org/keywords/gabaergic-transmission","display_name":"GABAergic neurotransmission","score":0.8859999775886536},{"id":"https://openalex.org/keywords/glutamatergic-neurotransmission","display_name":"glutamatergic neurotransmission","score":1.0},{"id":"https://openalex.org/keywords/hippocampal-neurons","display_name":"hippocampal neurons","score":0.8199999928474426},{"id":"https://openalex.org/keywords/intrabodies","display_name":"intrabodies","score":0.6809999942779541},{"id":"https://openalex.org/keywords/vgat","display_name":"vesicular GABA transporter","score":0.8349999785423279},{"id":"https://openalex.org/keywords/neuroligin-2","display_name":"neuroligin-2","score":0.9990000128746033},{"id":"https://openalex.org/keywords/neurexin","display_name":"neurexin","score":0.8510000109672546},{"id":"https://openalex.org/keywords/presynaptic-inhibition","display_name":"presynaptic inhibition","score":0.5400000214576721},{"id":"https://openalex.org/keywords/gaba-a-receptor","display_name":"GABAA receptor","score":0.5339999794960022},{"id":"https://openalex.org/keywords/glycine-receptor","display_name":"glycine receptor","score":0.7630000114440918},{"id":"https://openalex.org/keywords/paired-pulse-ratio","display_name":"paired-pulse ratio","score":0.5669999718666077},{"id":"https://openalex.org/keywords/neurotransmitter-release","display_name":"neurotransmitter release","score":0.5210000276565552}],"concepts":[{"id":"https://openalex.org/C2777969728","wikidata":"https://www.wikidata.org/wiki/Q1270676","display_name":"Gephyrin","level":5,"score":0.981258749961853},{"id":"https://openalex.org/C2780648746","wikidata":"https://www.wikidata.org/wiki/Q28208871","display_name":"Glutamatergic","level":4,"score":0.671637773513794},{"id":"https://openalex.org/C2779790309","wikidata":"https://www.wikidata.org/wiki/Q4316446","display_name":"Neuroligin","level":4,"score":0.6447844505310059},{"id":"https://openalex.org/C2779177108","wikidata":"https://www.wikidata.org/wiki/Q18356742","display_name":"GABAergic","level":3,"score":0.6352421045303345},{"id":"https://openalex.org/C17077164","wikidata":"https://www.wikidata.org/wiki/Q1185869","display_name":"Inhibitory postsynaptic potential","level":2,"score":0.6110098361968994},{"id":"https://openalex.org/C200170125","wikidata":"https://www.wikidata.org/wiki/Q969316","display_name":"Neurotransmission","level":3,"score":0.5756010413169861},{"id":"https://openalex.org/C148762608","wikidata":"https://www.wikidata.org/wiki/Q3748185","display_name":"Hippocampal formation","level":2,"score":0.5256196856498718},{"id":"https://openalex.org/C35599011","wikidata":"https://www.wikidata.org/wiki/Q426887","display_name":"Glycine receptor","level":4,"score":0.5183395147323608},{"id":"https://openalex.org/C53645450","wikidata":"https://www.wikidata.org/wiki/Q907093","display_name":"Scaffold protein","level":3,"score":0.5065740346908569},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.47923043370246887},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4515314996242523},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.39629608392715454},{"id":"https://openalex.org/C112592302","wikidata":"https://www.wikidata.org/wiki/Q1207387","display_name":"Excitatory postsynaptic potential","level":3,"score":0.3929426968097687},{"id":"https://openalex.org/C61174792","wikidata":"https://www.wikidata.org/wiki/Q420510","display_name":"Glutamate receptor","level":3,"score":0.32082152366638184},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.2805884778499603},{"id":"https://openalex.org/C2777756961","wikidata":"https://www.wikidata.org/wiki/Q620730","display_name":"Glycine","level":3,"score":0.19916024804115295},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1533057689666748},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.09963321685791016},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.06511837244033813}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1074/jbc.a111.234641","doi":"https://doi.org/10.1074/jbc.a111.234641","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.a111.234641","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2175415","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3162465","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3162465","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3162465/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Biol Chem","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1074/jbc.a111.234641","doi":"https://doi.org/10.1074/jbc.a111.234641","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.a111.234641","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.428600013256073,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7217685241","https://openalex.org/W7216821508","https://openalex.org/W2047223588","https://openalex.org/W3034812137","https://openalex.org/W1947718130","https://openalex.org/W2025553361","https://openalex.org/W2044440341","https://openalex.org/W2060100216","https://openalex.org/W2094183469","https://openalex.org/W7095486870"],"abstract_inverted_index":{"Gephyrin":[0],"Regulates":[1],"GABAergic":[2],"and":[3,24,49,87,104,120,136],"Glutamatergic":[4],"Synaptic":[5],"Transmission":[6],"in":[7,58,67,81,88,130,137],"Hippocampal":[8],"Cell":[9],"CulturesJournal":[10],"of":[11,64,133],"Biological":[12],"ChemistryVol.":[13],"286Issue":[14],"23PreviewGephyrin":[15],"is":[16],"a":[17,44,61,78,92,127],"scaffold":[18],"protein":[19,42,93],"essential":[20],"for":[21],"stabilizing":[22],"glycine":[23],"GABAA":[25],"receptors":[26],"at":[27],"inhibitory":[28],"synapses.":[29],"Here,":[30],"recombinant":[31],"intrabodies":[32],"against":[33],"gephyrin":[34],"(scFv-gephyrin)":[35],"were":[36],"used":[37],"to":[38],"assess":[39],"whether":[40],"this":[41],"exerts":[43],"transynaptic":[45],"action":[46],"on":[47],"GABA":[48,65,85],"glutamate":[50],"release.":[51],"Pair":[52],"recordings":[53],"from":[54],"interconnected":[55],"hippocampal":[56],"cells":[57],"culture":[59],"revealed":[60],"reduced":[62],"probability":[63],"release":[66],"scFv-gephyrin-transfected":[68],"neurons":[69],"compared":[70],"with":[71,77,96],"controls.":[72],"This":[73],"effect":[74],"was":[75],"associated":[76],"significant":[79],"decrease":[80],"VGAT,":[82],"the":[83,99,102,131,138],"vesicular":[84],"transporter,":[86],"neuroligin":[89],"2":[90],"(NLG2),":[91],"that,":[94],"interacting":[95],"neurexins,":[97],"ensures":[98],"cross-talk":[100],"between":[101],"post-":[103],"presynaptic":[105],"sites.":[106],"Full-Text":[107],"PDF":[108],"Open":[109],"Access":[110],"VOLUME":[111],"286":[112],"(2011)":[113],"PAGES":[114],"20942\u201320951":[115],"PAGE":[116],"20949:":[117],"Lines":[118],"16":[119],"17":[121],"under":[122],"\u201cDiscussion\u201d":[123],"should":[124],"read":[125],"\u201cby":[126],"clear":[128],"increase":[129],"number":[132],"transmitter":[134],"failures":[135],"PPR":[139],"\u2026":[140],"\u201d":[141]},"counts_by_year":[{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2022-05-12T00:00:00"}