{"id":"https://openalex.org/W4254903935","doi":"https://doi.org/10.1117/12.384228","title":"Two-photon excitation laser scanning microscopy of rabbit nasal septal cartilage following Nd:YAG-laser-mediated stress relaxation","display_name":"Two-photon excitation laser scanning microscopy of rabbit nasal septal cartilage following Nd:YAG-laser-mediated stress relaxation","publication_year":2000,"publication_date":"2000-04-27","ids":{"openalex":"https://openalex.org/W4254903935","doi":"https://doi.org/10.1117/12.384228"},"language":"en","primary_location":{"id":"doi:10.1117/12.384228","doi":"https://doi.org/10.1117/12.384228","is_oa":true,"landing_page_url":"https://doi.org/10.1117/12.384228","pdf_url":"https://www.spiedigitallibrary.org/conference-proceedings-of-spie/3921/0000/Two-photon-excitation-laser-scanning-microscopy-of-rabbit-nasal-septal/10.1117/12.384228.pdf","source":{"id":"https://openalex.org/S183492911","display_name":"Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE","issn_l":"0277-786X","issn":["0277-786X","1996-756X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1"],"host_organization":"https://openalex.org/P4310315543","host_organization_name":"SPIE","host_organization_lineage":["https://openalex.org/P4310315543"],"host_organization_lineage_names":["SPIE"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"SPIE Proceedings","raw_type":"proceedings-article"},"volume":null,"type":"conference-paper","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.spiedigitallibrary.org/conference-proceedings-of-spie/3921/0000/Two-photon-excitation-laser-scanning-microscopy-of-rabbit-nasal-septal/10.1117/12.384228.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5043185575","display_name":"Charlton C. Kim","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]},{"id":"https://openalex.org/I4210133819","display_name":"Beckman Laser Institute and Medical Clinic","ror":"https://ror.org/03bfp2076","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210133819"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Charlton C. Kim","raw_affiliation_strings":["Yale Univ. School of Medicine and Beckman Laser Institute and Medical Clinic (United States)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Yale Univ. School of Medicine and Beckman Laser Institute and Medical Clinic (United States)","institution_ids":["https://openalex.org/I32971472","https://openalex.org/I4210133819"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002316468","display_name":"Vincent P. Wallace","orcid":"https://orcid.org/0000-0003-3814-5400","observed_orcids":["https://orcid.org/0000-0003-3814-5400"]},"institutions":[{"id":"https://openalex.org/I4210133819","display_name":"Beckman Laser Institute and Medical Clinic","ror":"https://ror.org/03bfp2076","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210133819"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vincent P. Wallace","raw_affiliation_strings":["Beckman Laser Institute and Medical Clinic (United Kingdom)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beckman Laser Institute and Medical Clinic (United Kingdom)","institution_ids":["https://openalex.org/I4210133819"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062796910","display_name":"Mariah L. Coleno","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210133819","display_name":"Beckman Laser Institute and Medical Clinic","ror":"https://ror.org/03bfp2076","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210133819"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mariah L. Coleno","raw_affiliation_strings":["Beckman Laser Institute and Medical Clinic (United States)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beckman Laser Institute and Medical Clinic (United States)","institution_ids":["https://openalex.org/I4210133819"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083475350","display_name":"Xavier Dao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210133819","display_name":"Beckman Laser Institute and Medical Clinic","ror":"https://ror.org/03bfp2076","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210133819"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xavier Dao","raw_affiliation_strings":["Beckman Laser Institute and Medical Clinic (United States)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beckman Laser Institute and Medical Clinic (United States)","institution_ids":["https://openalex.org/I4210133819"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089747606","display_name":"Bruce J. Tromberg","orcid":"https://orcid.org/0000-0002-7481-7975","observed_orcids":["https://orcid.org/0000-0002-7481-7975"]},"institutions":[{"id":"https://openalex.org/I4210133819","display_name":"Beckman Laser Institute and Medical Clinic","ror":"https://ror.org/03bfp2076","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210133819"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bruce J. Tromberg","raw_affiliation_strings":["Beckman Laser Institute and Medical Clinic (United States)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beckman Laser Institute and Medical Clinic (United States)","institution_ids":["https://openalex.org/I4210133819"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5023034578","display_name":"Brian J. F. Wong","orcid":"https://orcid.org/0000-0001-6318-7384","observed_orcids":["https://orcid.org/0000-0001-6318-7384"]},"institutions":[{"id":"https://openalex.org/I4210133819","display_name":"Beckman Laser Institute and Medical Clinic","ror":"https://ror.org/03bfp2076","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210133819"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brian J. Wong","raw_affiliation_strings":["Beckman Laser Institute and Medical Clinic (United States)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beckman Laser Institute and Medical Clinic (United States)","institution_ids":["https://openalex.org/I4210133819"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.67,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.86315789,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"3921","issue":null,"first_page":"331","last_page":"339"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11566","display_name":"Laser Applications in Dentistry and Medicine","score":0.9110999703407288,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11566","display_name":"Laser Applications in Dentistry and Medicine","score":0.9110999703407288,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10957","display_name":"Photodynamic Therapy Research Studies","score":0.007699999958276749,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":0.006599999964237213,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/septal-cartilage","display_name":"septal cartilage","score":0.8460000157356262},{"id":"https://openalex.org/keywords/hyaline-cartilage","display_name":"hyaline cartilage","score":0.9350000023841858},{"id":"https://openalex.org/keywords/nd-yag-laser-irradiation","display_name":"Nd:YAG laser irradiation","score":0.8830000162124634},{"id":"https://openalex.org/keywords/two-photon-microscopy","display_name":"two-photon microscopy","score":0.7260000109672546},{"id":"https://openalex.org/keywords/surface-temperature","display_name":"surface temperature","score":0.6499999761581421},{"id":"https://openalex.org/keywords/diffuse-reflectance","display_name":"diffuse reflectance","score":0.7789999842643738},{"id":"https://openalex.org/keywords/cell-membrane-lysis","display_name":"cell membrane lysis","score":0.6859999895095825}],"concepts":[{"id":"https://openalex.org/C2780550940","wikidata":"https://www.wikidata.org/wiki/Q502730","display_name":"Cartilage","level":2,"score":0.7857238054275513},{"id":"https://openalex.org/C520434653","wikidata":"https://www.wikidata.org/wiki/Q38867","display_name":"Laser","level":2,"score":0.7061854600906372},{"id":"https://openalex.org/C111337013","wikidata":"https://www.wikidata.org/wiki/Q2737837","display_name":"Irradiation","level":2,"score":0.6992174983024597},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.5216988921165466},{"id":"https://openalex.org/C2780024818","wikidata":"https://www.wikidata.org/wiki/Q2014564","display_name":"Hyaline cartilage","level":5,"score":0.47034743428230286},{"id":"https://openalex.org/C91881484","wikidata":"https://www.wikidata.org/wiki/Q191807","display_name":"Fluorescence","level":2,"score":0.4557577669620514},{"id":"https://openalex.org/C147080431","wikidata":"https://www.wikidata.org/wiki/Q1074953","display_name":"Microscopy","level":2,"score":0.44368940591812134},{"id":"https://openalex.org/C169274487","wikidata":"https://www.wikidata.org/wiki/Q840211","display_name":"Fluorescence microscope","level":3,"score":0.4415796399116516},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4125731587409973},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.37341582775115967},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.3527078628540039},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.2925568222999573},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.2919342517852783},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.283603698015213},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.13318821787834167},{"id":"https://openalex.org/C2776164576","wikidata":"https://www.wikidata.org/wiki/Q62736","display_name":"Osteoarthritis","level":3,"score":0.12820404767990112},{"id":"https://openalex.org/C3020332539","wikidata":"https://www.wikidata.org/wiki/Q2014564","display_name":"Articular cartilage","level":4,"score":0.1191704273223877},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.10381191968917847},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C185544564","wikidata":"https://www.wikidata.org/wiki/Q81197","display_name":"Nuclear physics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1117/12.384228","doi":"https://doi.org/10.1117/12.384228","is_oa":true,"landing_page_url":"https://doi.org/10.1117/12.384228","pdf_url":"https://www.spiedigitallibrary.org/conference-proceedings-of-spie/3921/0000/Two-photon-excitation-laser-scanning-microscopy-of-rabbit-nasal-septal/10.1117/12.384228.pdf","source":{"id":"https://openalex.org/S183492911","display_name":"Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE","issn_l":"0277-786X","issn":["0277-786X","1996-756X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1"],"host_organization":"https://openalex.org/P4310315543","host_organization_name":"SPIE","host_organization_lineage":["https://openalex.org/P4310315543"],"host_organization_lineage_names":["SPIE"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"SPIE Proceedings","raw_type":"proceedings-article"}],"best_oa_location":{"id":"doi:10.1117/12.384228","doi":"https://doi.org/10.1117/12.384228","is_oa":true,"landing_page_url":"https://doi.org/10.1117/12.384228","pdf_url":"https://www.spiedigitallibrary.org/conference-proceedings-of-spie/3921/0000/Two-photon-excitation-laser-scanning-microscopy-of-rabbit-nasal-septal/10.1117/12.384228.pdf","source":{"id":"https://openalex.org/S183492911","display_name":"Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE","issn_l":"0277-786X","issn":["0277-786X","1996-756X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1"],"host_organization":"https://openalex.org/P4310315543","host_organization_name":"SPIE","host_organization_lineage":["https://openalex.org/P4310315543"],"host_organization_lineage_names":["SPIE"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"SPIE Proceedings","raw_type":"proceedings-article"},"sustainable_development_goals":[{"score":0.46810001134872437,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G271587875","display_name":"OPTIMIZATION OF LASER MEDIATED CARTILAGE RESHAPING","funder_award_id":"K23DC000170","funder_id":"https://openalex.org/F4320337352","funder_display_name":"National Institute on Deafness and Other Communication Disorders"},{"id":"https://openalex.org/G8876996369","display_name":null,"funder_award_id":"N00014","funder_id":"https://openalex.org/F4320337345","funder_display_name":"Office of Naval Research"}],"funders":[{"id":"https://openalex.org/F4320306084","display_name":"U.S. Department of Energy","ror":"https://ror.org/01bj3aw27"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337345","display_name":"Office of Naval Research","ror":"https://ror.org/00rk2pe57"},{"id":"https://openalex.org/F4320337352","display_name":"National Institute on Deafness and Other Communication Disorders","ror":"https://ror.org/04mhx6838"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4254903935.pdf","grobid_xml":"https://content.openalex.org/works/W4254903935.grobid-xml"},"referenced_works_count":3,"referenced_works":["https://openalex.org/W1549475994","https://openalex.org/W2017349409","https://openalex.org/W7046438096"],"related_works":["https://openalex.org/W2079032681","https://openalex.org/W2035303128","https://openalex.org/W1966049687","https://openalex.org/W2010837856","https://openalex.org/W1971650076","https://openalex.org/W2123492751","https://openalex.org/W2115132905","https://openalex.org/W2074912713","https://openalex.org/W2058090200","https://openalex.org/W2065102341"],"abstract_inverted_index":{"Laser":[0],"irradiation":[1,49],"of":[2,76,107,135,149,152,175],"hyaline":[3],"cartilage":[4,30,70],"result":[5],"in":[6,24,85,126,130,159,171,177],"stable":[7],"shape":[8],"changes":[9,23],"due":[10],"to":[11,98,114],"temperature":[12,75],"dependent":[13],"stress":[14,52],"relaxation.":[15],"In":[16,180],"this":[17],"study,":[18],"we":[19],"determined":[20],"the":[21,100,104,131,150,162,167,178,182],"structural":[22],"chondrocytes":[25,108],"within":[26],"rabbit":[27],"nasal":[28],"septal":[29],"tissue":[31,160,169],"over":[32],"a":[33,37,72,92],"12-day":[34],"period":[35],"using":[36],"two-photon":[38],"laser":[39,45,48,67,119,153],"scanning":[40],"microscope":[41],"(TPM)":[42],"following":[43,118,123,146,156],"Nd:YAG":[44],"irradiation.":[46,82],"During":[47],"surface":[50,74],"temperature,":[51],"relaxation,":[53],"and":[54,121,141,173,189],"diffuse":[55],"reflectance,":[56],"were":[57,109],"measured":[58],"dynamically.":[59],"Each":[60],"specimen":[61],"received":[62],"one":[63],"or":[64,133],"two":[65],"sequential":[66],"exposures.":[68],"The":[69],"reached":[71],"peak":[73],"about":[77],"61":[78],"degrees":[79],"C":[80],"during":[81],"Cartilage":[83],"denatured":[84],"50":[86],"percent":[87],"EtOH":[88],"was":[89,96,137],"used":[90],"as":[91],"positive":[93,183],"control.":[94],"TPM":[95],"performed":[97],"detect":[99],"fluorescence":[101,136,176],"emission":[102],"from":[103],"chondrocytes.":[105],"Images":[106],"obtained":[110],"at":[111],"depths":[112],"up":[113],"150":[115],"microns,":[116],"immediately":[117,145],"exposure,":[120,147],"also":[122],"12":[124],"days":[125,158],"culture.":[127],"Few":[128],"differences":[129],"pattern":[132],"intensity":[134,172],"observed":[138],"between":[139],"controls":[140],"irradiated":[142,163],"specimens":[143,164],"imaged":[144],"regardless":[148],"number":[151],"pulses.":[154],"However,":[155],"twelve":[157],"culture,":[161],"increase,":[165],"whereas":[166],"native":[168],"diminishes,":[170],"distribution":[174],"cytoplasm.":[179],"contrast,":[181],"control":[184],"shows":[185],"only":[186],"extracellular":[187],"matrices":[188],"empty":[190],"lacuna,":[191],"feature":[192],"consistent":[193],"with":[194],"cell":[195],"membrane":[196],"lysis.":[197]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2022-05-12T00:00:00"}
