{"id":"https://openalex.org/W4254833474","doi":"https://doi.org/10.1158/1538-7445.epso16-b07","title":"Abstract B07: Visualization of the mechanisms of metastasis within a biomimetic engineered tumor microenvironment encompassing a perfusable cylindrical 3D microvessel","display_name":"Abstract B07: Visualization of the mechanisms of metastasis within a biomimetic engineered tumor microenvironment encompassing a perfusable cylindrical 3D microvessel","publication_year":2017,"publication_date":"2017-01-15","ids":{"openalex":"https://openalex.org/W4254833474","doi":"https://doi.org/10.1158/1538-7445.epso16-b07"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.epso16-b07","doi":"https://doi.org/10.1158/1538-7445.epso16-b07","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.epso16-b07","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5048578102","display_name":"Andrew D. Wong","orcid":"https://orcid.org/0000-0001-8693-6421","observed_orcids":["https://orcid.org/0000-0001-8693-6421"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrew D. Wong","raw_affiliation_strings":["Johns Hopkins University, Baltimore, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Johns Hopkins University, Baltimore, MD","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071589099","display_name":"Vanesa L. Silvestri","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vanesa Silvestri","raw_affiliation_strings":["Johns Hopkins University, Baltimore, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Johns Hopkins University, Baltimore, MD","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084041667","display_name":"Andrew J. Ewald","orcid":"https://orcid.org/0000-0002-1964-0740","observed_orcids":["https://orcid.org/0000-0002-1964-0740"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrew J. Ewald","raw_affiliation_strings":["Johns Hopkins University, Baltimore, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Johns Hopkins University, Baltimore, MD","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5042538449","display_name":"Peter C. Searson","orcid":"https://orcid.org/0000-0002-5417-0828","observed_orcids":["https://orcid.org/0000-0002-5417-0828"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peter C. Searson","raw_affiliation_strings":["Johns Hopkins University, Baltimore, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Johns Hopkins University, Baltimore, MD","institution_ids":["https://openalex.org/I145311948"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I145311948"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"77","issue":"2_Supplement","first_page":"B07","last_page":"B07"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.7490000128746033,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.7490000128746033,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.07609999924898148,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.062199998646974564,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/metastasis","display_name":"metastasis","score":0.9430000185966492},{"id":"https://openalex.org/keywords/intravasation","display_name":"intravasation","score":0.9309999942779541},{"id":"https://openalex.org/keywords/tumor-invasion","display_name":"tumor invasion","score":0.8560000061988831},{"id":"https://openalex.org/keywords/endothelial-barrier","display_name":"endothelial barrier","score":0.5289999842643738},{"id":"https://openalex.org/keywords/extracellular-matrix","display_name":"extracellular matrix","score":0.7239999771118164},{"id":"https://openalex.org/keywords/mda-mb-231-cells","display_name":"MDA-MB-231 cells","score":0.9269999861717224},{"id":"https://openalex.org/keywords/shear-stress","display_name":"shear stress","score":0.902999997138977},{"id":"https://openalex.org/keywords/tumor-cell-adhesion","display_name":"tumor cell adhesion","score":0.8880000114440918},{"id":"https://openalex.org/keywords/tumor-vasculature","display_name":"tumor vasculature","score":0.6079999804496765},{"id":"https://openalex.org/keywords/cell-division","display_name":"cell division","score":0.3089999854564667}],"concepts":[{"id":"https://openalex.org/C2778050619","wikidata":"https://www.wikidata.org/wiki/Q6058567","display_name":"Intravasation","level":4,"score":0.9957646131515503},{"id":"https://openalex.org/C2776436680","wikidata":"https://www.wikidata.org/wiki/Q1632335","display_name":"Microvessel","level":3,"score":0.787796676158905},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.5382269620895386},{"id":"https://openalex.org/C181104049","wikidata":"https://www.wikidata.org/wiki/Q11936292","display_name":"Mechanotransduction","level":2,"score":0.502713680267334},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.4570893943309784},{"id":"https://openalex.org/C2776107976","wikidata":"https://www.wikidata.org/wiki/Q1786433","display_name":"Tumor microenvironment","level":3,"score":0.45188626646995544},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.42553460597991943},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.41432642936706543},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.4080744981765747},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.39765581488609314},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3931977450847626},{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.3649216592311859},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3531606197357178},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.32844361662864685},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2601735293865204},{"id":"https://openalex.org/C3020616263","wikidata":"https://www.wikidata.org/wiki/Q1216998","display_name":"Tumor cells","level":2,"score":0.16503053903579712},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.10195347666740417}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.epso16-b07","doi":"https://doi.org/10.1158/1538-7445.epso16-b07","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.epso16-b07","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8048999905586243,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2592864734","https://openalex.org/W2040422822","https://openalex.org/W2756104372","https://openalex.org/W2087496074","https://openalex.org/W7161100802","https://openalex.org/W4409440515","https://openalex.org/W2783342489","https://openalex.org/W2591764905","https://openalex.org/W3093803443","https://openalex.org/W2010839383"],"abstract_inverted_index":{"Abstract":[0],"Metastasis":[1],"is":[2,74,90,163,193],"responsible":[3],"for":[4],"the":[5,14,20,34,122,169,205,214,224,236,254,274],"majority":[6],"of":[7,13,54,99,115,133,155,253,256,273],"cancer":[8,119],"related":[9],"deaths;":[10],"however,":[11],"many":[12],"biological":[15],"and":[16,25,38,56,80,113,124,141,179,189,198,217,227,280],"physical":[17],"details":[18,132],"surrounding":[19,68],"critical":[21,233],"steps":[22,234],"(e.g.":[23],"invasion":[24,55,112],"intravasation)":[26],"are":[27],"largely":[28],"unknown,":[29],"in":[30,36,51,78,208,235,283],"part":[31],"due":[32],"to":[33,231],"difficulty":[35],"recapitulating":[37],"visualizing":[39],"these":[40,45],"dynamic":[41],"processes.":[42],"To":[43],"elucidate":[44],"mechanisms,":[46],"we":[47,108,129,150,175,203,219],"have":[48,109],"developed":[49],"an":[50,64,69],"vitro":[52],"model":[53],"intravasation":[57,114,134,156,192],"that":[58,89,184,190],"comprises":[59],"tumor":[60,138,144,158,173,199,210,225,262],"cells":[61,84,120,139,211],"embedded":[62],"within":[63,258],"extracellular":[65],"matrix":[66],"(ECM)":[67],"engineered":[70,261],"microvessel.":[71,269],"The":[72],"microvessel":[73,123],"cylindrical,":[75],"150":[76],"\u03bcm":[77],"diameter,":[79],"lined":[81],"with":[82,213],"endothelial":[83],"forming":[85],"a":[86,96,152,259,265],"functional":[87],"barrier":[88],"maintained":[91],"under":[92],"constant":[93],"perfusion":[94],"at":[95,168],"shear":[97,196],"stress":[98,197],"2-8":[100],"dyne":[101],"cm-2.":[102],"Using":[103],"this":[104],"biomimetic":[105,260],"tumor-microvessel":[106],"platform,":[107],"previously":[110],"visualized":[111],"single":[116,137,148],"MDA-MB-231":[117],"breast":[118],"into":[121,126,161],"escape":[125],"flow.":[127],"Here,":[128],"present":[130],"mechanistic":[131],"from":[135,181],"both":[136],"(MDA-MB-231)":[140],"mouse":[142],"mammary":[143],"organoids":[145],"(MMTV-PyMT).":[146],"For":[147,172],"cells,":[149],"observe":[151],"mitosis-mediated":[153],"mechanism":[154],"where":[157],"cell":[159,166,200],"entry":[160],"flow":[162],"prefaced":[164],"by":[165,195],"division":[167],"ECM-vessel":[170],"interface.":[171],"organoids,":[174],"see":[176],"vascular":[177],"deformation":[178],"destabilization":[180],"growing":[182],"tumors":[183],"impinge":[185],"upon":[186],"proximal":[187],"vessels,":[188],"bulk":[191],"mediated":[194],"adhesion.":[201],"As":[202],"characterize":[204],"various":[206],"ways":[207],"which":[209],"interact":[212],"vessel":[215],"endothelium":[216],"intravasate,":[218],"can":[220],"explore":[221],"strategies":[222],"involving":[223],"vasculature":[226],"clinically":[228],"relevant":[229],"drugs":[230],"inhibit":[232],"metastatic":[237],"cascade.":[238],"Citation":[239],"Format:":[240],"Andrew":[241,246],"D.":[242],"Wong,":[243],"Vanesa":[244],"Silvestri,":[245],"J.":[247],"Ewald,":[248],"Peter":[249],"C.":[250],"Searson.":[251],"Visualization":[252],"mechanisms":[255],"metastasis":[257],"microenvironment":[263],"encompassing":[264],"perfusable":[266],"cylindrical":[267],"3D":[268],"[abstract].":[270],"In:":[271],"Proceedings":[272],"AACR":[275],"Special":[276],"Conference":[277],"on":[278],"Engineering":[279],"Physical":[281],"Sciences":[282],"Oncology;":[284],"2016":[285],"Jun":[286],"25-28;":[287],"Boston,":[288],"MA.":[289],"Philadelphia":[290],"(PA):":[291],"AACR;":[292],"Cancer":[293],"Res":[294],"2017;77(2":[295],"Suppl):Abstract":[296],"nr":[297],"B07.":[298]},"counts_by_year":[],"updated_date":"2026-07-14T23:27:15.235271","created_date":"2022-05-12T00:00:00"}