{"id":"https://openalex.org/W4254762009","doi":"https://doi.org/10.1158/1538-7445.sabcs18-ct192","title":"Abstract CT192: Entrectinib in locally advanced or metastatic ROS1 fusion-positive non-small cell lung cancer (NSCLC): Integrated analysis of ALKA-372-001, STARTRK-1 and STARTRK-2","display_name":"Abstract CT192: Entrectinib in locally advanced or metastatic ROS1 fusion-positive non-small cell lung cancer (NSCLC): Integrated analysis of ALKA-372-001, STARTRK-1 and STARTRK-2","publication_year":2019,"publication_date":"2019-07-01","ids":{"openalex":"https://openalex.org/W4254762009","doi":"https://doi.org/10.1158/1538-7445.sabcs18-ct192"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.sabcs18-ct192","doi":"https://doi.org/10.1158/1538-7445.sabcs18-ct192","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.sabcs18-ct192","pdf_url":null,"source":{"id":"https://openalex.org/S59378366","display_name":"Clinical Trials","issn_l":"1740-7745","issn":["1740-7745","1740-7753"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Trials","raw_type":"proceedings-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5063199354","display_name":"Alexander Edward Dela Cruz Drilon","orcid":"https://orcid.org/0000-0001-6806-9061","observed_orcids":["https://orcid.org/0000-0001-6806-9061"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alexander Drilon","raw_affiliation_strings":["Thoracic Oncology Service, Division of Solid Tumor Oncology, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Thoracic Oncology Service, Division of Solid Tumor Oncology, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087836238","display_name":"Fabrice Barl\u00e9si","orcid":"https://orcid.org/0000-0001-5793-3539","observed_orcids":["https://orcid.org/0000-0001-5793-3539"]},"institutions":[{"id":"https://openalex.org/I21491767","display_name":"Aix-Marseille Universit\u00e9","ror":"https://ror.org/035xkbk20","country_code":"FR","type":"education","lineage":["https://openalex.org/I21491767"]},{"id":"https://openalex.org/I4210087487","display_name":"Assistance Publique H\u00f4pitaux de Marseille","ror":"https://ror.org/002cp4060","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I21491767","https://openalex.org/I4210087487"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Fabrice Barlesi","raw_affiliation_strings":["Aix Marseille University, Assistance Publique-H\u00f4pitaux de Marseille, Marseille, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Aix Marseille University, Assistance Publique-H\u00f4pitaux de Marseille, Marseille, France","institution_ids":["https://openalex.org/I21491767","https://openalex.org/I4210087487"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009935310","display_name":"Filippo de Braud","orcid":"https://orcid.org/0000-0003-0103-730X","observed_orcids":["https://orcid.org/0000-0003-0103-730X"]},"institutions":[{"id":"https://openalex.org/I189158943","display_name":"University of Milan","ror":"https://ror.org/00wjc7c48","country_code":"IT","type":"education","lineage":["https://openalex.org/I189158943"]},{"id":"https://openalex.org/I4210156707","display_name":"Fondazione IRCCS Istituto Nazionale dei Tumori","ror":"https://ror.org/05dwj7825","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210153126","https://openalex.org/I4210156707"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Filippo De Braud","raw_affiliation_strings":["Department of Medical Oncology, Fondazione IRCCS Istituto Nazionale dei Tumori, and Department of Medical Oncology, University of Milan, Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, Fondazione IRCCS Istituto Nazionale dei Tumori, and Department of Medical Oncology, University of Milan, Milan, Italy","institution_ids":["https://openalex.org/I189158943","https://openalex.org/I4210156707"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064697305","display_name":"Byoung Chul Cho","orcid":"https://orcid.org/0000-0002-5562-270X","observed_orcids":["https://orcid.org/0000-0002-5562-270X"]},"institutions":[{"id":"https://openalex.org/I4405258038","display_name":"Yonsei Cancer Hospital","ror":"https://ror.org/0005vby86","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I193775966","https://openalex.org/I2799970807","https://openalex.org/I4210160791","https://openalex.org/I4405258038"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Byoung Chul Cho","raw_affiliation_strings":["Division of Medical Oncology, Yonsei Cancer Center, Seoul, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Medical Oncology, Yonsei Cancer Center, Seoul, Republic of Korea","institution_ids":["https://openalex.org/I4405258038"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034739279","display_name":"Myung\u2010Ju Ahn","orcid":"https://orcid.org/0000-0002-5740-9654","observed_orcids":["https://orcid.org/0000-0002-5740-9654","https://orcid.org/0000-0002-5376-5109"]},"institutions":[{"id":"https://openalex.org/I2802194831","display_name":"Samsung Medical Center","ror":"https://ror.org/05a15z872","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I2250650973","https://openalex.org/I2802194831"]},{"id":"https://openalex.org/I848706","display_name":"Sungkyunkwan University","ror":"https://ror.org/04q78tk20","country_code":"KR","type":"education","lineage":["https://openalex.org/I848706"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Myung-Ju Ahn","raw_affiliation_strings":["Division of Hematology-Oncology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology-Oncology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea","institution_ids":["https://openalex.org/I2802194831","https://openalex.org/I848706"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031031537","display_name":"Salvatore Siena","orcid":"https://orcid.org/0000-0002-2681-2846","observed_orcids":["https://orcid.org/0000-0002-2681-2846"]},"institutions":[{"id":"https://openalex.org/I189158943","display_name":"University of Milan","ror":"https://ror.org/00wjc7c48","country_code":"IT","type":"education","lineage":["https://openalex.org/I189158943"]},{"id":"https://openalex.org/I4210094195","display_name":"Azienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda","ror":"https://ror.org/00htrxv69","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210094195"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Salvatore Siena","raw_affiliation_strings":["Niguarda Cancer Center, Grande Ospedale Metropolitano Niguarda, and Department of Oncology and Hemato-Oncology, Universit\u00e0 degli Studi di Milano, Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Niguarda Cancer Center, Grande Ospedale Metropolitano Niguarda, and Department of Oncology and Hemato-Oncology, Universit\u00e0 degli Studi di Milano, Milan, Italy","institution_ids":["https://openalex.org/I189158943","https://openalex.org/I4210094195"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080991347","display_name":"Matthew Krebs","orcid":"https://orcid.org/0000-0001-7540-3064","observed_orcids":["https://orcid.org/0000-0001-7540-3064"]},"institutions":[{"id":"https://openalex.org/I28407311","display_name":"University of Manchester","ror":"https://ror.org/027m9bs27","country_code":"GB","type":"education","lineage":["https://openalex.org/I28407311"]},{"id":"https://openalex.org/I4210133995","display_name":"The Christie NHS Foundation Trust","ror":"https://ror.org/03v9efr22","country_code":"GB","type":"funder","lineage":["https://openalex.org/I4210133995"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Matthew G. Krebs","raw_affiliation_strings":["Division of Cancer Sciences, The University of Manchester and The Christie NHS Foundation Trust, Manchester, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cancer Sciences, The University of Manchester and The Christie NHS Foundation Trust, Manchester, United Kingdom","institution_ids":["https://openalex.org/I28407311","https://openalex.org/I4210133995"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112421072","display_name":"Chia\u2010Chi Lin","orcid":"https://orcid.org/0000-0002-2573-5789","observed_orcids":["https://orcid.org/0000-0002-2573-5789","https://orcid.org/0009-0006-5084-0819"]},"institutions":[{"id":"https://openalex.org/I16733864","display_name":"National Taiwan University","ror":"https://ror.org/05bqach95","country_code":"TW","type":"education","lineage":["https://openalex.org/I16733864"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Chia-Chi Lin","raw_affiliation_strings":["Department of Oncology, National Taiwan University, Taipei, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, National Taiwan University, Taipei, Taiwan","institution_ids":["https://openalex.org/I16733864"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Tom John","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210158799","display_name":"Olivia Newton-John Cancer Wellness & Research Centre","ror":"https://ror.org/04t908e09","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I4210158799"]},{"id":"https://openalex.org/I4210163497","display_name":"Austin Health","ror":"https://ror.org/05dbj6g52","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I4210163497"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Tom John","raw_affiliation_strings":["Dept Medical Oncology, Austin Health, Olivia-Newton John Cancer Institute, Heidelberg, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept Medical Oncology, Austin Health, Olivia-Newton John Cancer Institute, Heidelberg, Australia","institution_ids":["https://openalex.org/I4210158799","https://openalex.org/I4210163497"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063823247","display_name":"Daniel S.W. Tan","orcid":"https://orcid.org/0000-0002-6514-6786","observed_orcids":["https://orcid.org/0000-0002-6514-6786"]},"institutions":[{"id":"https://openalex.org/I4210137145","display_name":"National Cancer Centre Singapore","ror":"https://ror.org/03bqk3e80","country_code":"SG","type":"healthcare","lineage":["https://openalex.org/I4210137145"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Daniel SW Tan","raw_affiliation_strings":["Division of Medical Oncology, National Cancer Centre, Singapore, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Medical Oncology, National Cancer Centre, Singapore, Singapore","institution_ids":["https://openalex.org/I4210137145"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067259938","display_name":"Takashi Seto","orcid":"https://orcid.org/0000-0002-2960-4364","observed_orcids":["https://orcid.org/0000-0002-2960-4364"]},"institutions":[{"id":"https://openalex.org/I4210093709","display_name":"National Hospital Organization Kyushu Cancer Center","ror":"https://ror.org/00mce9b34","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210093709","https://openalex.org/I4210137409"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takashi Seto","raw_affiliation_strings":["Department of Thoracic Oncology, National Kyushu Cancer Center, Fukuoka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Thoracic Oncology, National Kyushu Cancer Center, Fukuoka, Japan","institution_ids":["https://openalex.org/I4210093709"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054931755","display_name":"Rafa\u0142 Dziadziuszko","orcid":"https://orcid.org/0000-0001-8080-9843","observed_orcids":["https://orcid.org/0000-0001-8080-9843"]},"institutions":[{"id":"https://openalex.org/I75124487","display_name":"Gda\u0144sk Medical University","ror":"https://ror.org/019sbgd69","country_code":"PL","type":"education","lineage":["https://openalex.org/I75124487"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Rafal Dziadziuszko","raw_affiliation_strings":["Department of Oncology and Radiotherapy, Medical University of Gdansk, Gdansk, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology and Radiotherapy, Medical University of Gdansk, Gdansk, Poland","institution_ids":["https://openalex.org/I75124487"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012989377","display_name":"Hendrik\u2010Tobias Arkenau","orcid":"https://orcid.org/0000-0002-2015-1549","observed_orcids":["https://orcid.org/0000-0002-2015-1549","https://orcid.org/0000-0003-0372-0540"]},"institutions":[{"id":"https://openalex.org/I172427033","display_name":"Sarah Cannon Research Institute","ror":"https://ror.org/03cp5cj42","country_code":"GB","type":"education","lineage":["https://openalex.org/I172427033"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Hendrick-Tobias Arkenau","raw_affiliation_strings":["Sarah Cannon Research Institute, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sarah Cannon Research Institute, London, United Kingdom","institution_ids":["https://openalex.org/I172427033"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074506844","display_name":"Christian Diego Rolfo","orcid":"https://orcid.org/0000-0002-7860-8417","observed_orcids":["https://orcid.org/0000-0002-7860-8417"]},"institutions":[{"id":"https://openalex.org/I126744593","display_name":"University of Maryland, Baltimore","ror":"https://ror.org/04rq5mt64","country_code":"US","type":"education","lineage":["https://openalex.org/I126744593"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christian Rolfo","raw_affiliation_strings":["Greenebaum Comprehensive Cancer Center, Maryland University, Baltimore, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Greenebaum Comprehensive Cancer Center, Maryland University, Baltimore, MD","institution_ids":["https://openalex.org/I126744593"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110844442","display_name":"J\u00fcrgen Wolf","orcid":"https://orcid.org/0000-0001-8833-8812","observed_orcids":["https://orcid.org/0000-0001-8833-8812"]},"institutions":[{"id":"https://openalex.org/I4210153755","display_name":"University Hospital Cologne","ror":"https://ror.org/05mxhda18","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210153755"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"J\u00fcrgen Wolf","raw_affiliation_strings":["Center for Integrated Oncology K\u00f6ln-Bonn, University Hospital of Cologne, Cologne, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Integrated Oncology K\u00f6ln-Bonn, University Hospital of Cologne, Cologne, Germany","institution_ids":["https://openalex.org/I4210153755"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052597823","display_name":"Chenglin Ye","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183934855","display_name":"Genentech","ror":"https://ror.org/04gndp242","country_code":"US","type":"company","lineage":["https://openalex.org/I118019719","https://openalex.org/I129302853","https://openalex.org/I183934855"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chenglin Ye","raw_affiliation_strings":["Genentech, South San Francisco, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genentech, South San Francisco, CA","institution_ids":["https://openalex.org/I183934855"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113882339","display_name":"Todd Riehl","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183934855","display_name":"Genentech","ror":"https://ror.org/04gndp242","country_code":"US","type":"company","lineage":["https://openalex.org/I118019719","https://openalex.org/I129302853","https://openalex.org/I183934855"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Todd Riehl","raw_affiliation_strings":["Genentech, South San Francisco, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genentech, South San Francisco, CA","institution_ids":["https://openalex.org/I183934855"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066041178","display_name":"Susan Eng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183934855","display_name":"Genentech","ror":"https://ror.org/04gndp242","country_code":"US","type":"company","lineage":["https://openalex.org/I118019719","https://openalex.org/I129302853","https://openalex.org/I183934855"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Susan Eng","raw_affiliation_strings":["Genentech, South San Francisco, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genentech, South San Francisco, CA","institution_ids":["https://openalex.org/I183934855"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5034705456","display_name":"Robert Charles Doebele","orcid":"https://orcid.org/0000-0001-6728-6857","observed_orcids":["https://orcid.org/0000-0001-6728-6857"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Robert C. Doebele","raw_affiliation_strings":["University of Colorado, Aurora, CO"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Colorado, Aurora, CO","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":11,"institutions_distinct_count":21,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4150,"currency":"USD","value_usd":4150},"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"CT192","last_page":"CT192"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12334","display_name":"Lung Cancer Research Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10202","display_name":"Lung Cancer Diagnosis and Treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/entrectinib","display_name":"entrectinib","score":0.9929999709129333},{"id":"https://openalex.org/keywords/brain-metastases","display_name":"brain metastases","score":0.7799999713897705},{"id":"https://openalex.org/keywords/intracranial-response","display_name":"intracranial response","score":0.8679999709129333},{"id":"https://openalex.org/keywords/central-nervous-system-penetration","display_name":"CNS penetration","score":0.7210000157356262},{"id":"https://openalex.org/keywords/treatment-related-adverse-events","display_name":"treatment-related adverse events","score":0.6840000152587891},{"id":"https://openalex.org/keywords/overall-response-rate","display_name":"overall response rate","score":0.6290000081062317},{"id":"https://openalex.org/keywords/progression-free-survival","display_name":"progression-free survival","score":0.875},{"id":"https://openalex.org/keywords/alk-inhibitor-resistance","display_name":"ALK inhibitor resistance","score":0.4429999887943268},{"id":"https://openalex.org/keywords/alk-positive-non-small-cell-lung-cancer","display_name":"ALK-positive non-small cell lung cancer","score":0.49300000071525574}],"concepts":[{"id":"https://openalex.org/C2775999482","wikidata":"https://www.wikidata.org/wiki/Q18031208","display_name":"ROS1","level":4,"score":0.7626734375953674},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7269436120986938},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6274319291114807},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.6111807227134705},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.5599718689918518},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.5090529322624207},{"id":"https://openalex.org/C203092338","wikidata":"https://www.wikidata.org/wiki/Q1340863","display_name":"Clinical endpoint","level":3,"score":0.47515058517456055},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.42144647240638733},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.40790241956710815},{"id":"https://openalex.org/C2781182431","wikidata":"https://www.wikidata.org/wiki/Q356033","display_name":"Adenocarcinoma","level":3,"score":0.1752314567565918},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.sabcs18-ct192","doi":"https://doi.org/10.1158/1538-7445.sabcs18-ct192","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.sabcs18-ct192","pdf_url":null,"source":{"id":"https://openalex.org/S59378366","display_name":"Clinical Trials","issn_l":"1740-7745","issn":["1740-7745","1740-7753"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Trials","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.6000000238418579}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2939418306","https://openalex.org/W4234415355","https://openalex.org/W4229972308","https://openalex.org/W3135209648","https://openalex.org/W2995220921","https://openalex.org/W2921982658","https://openalex.org/W3088110133","https://openalex.org/W4389430282","https://openalex.org/W4225123144","https://openalex.org/W4402558380"],"abstract_inverted_index":{"Background":[0],"Entrectinib":[1,32,348,363,417],"is":[2,349,364],"a":[3,89,369],"potent":[4],"inhibitor":[5],"of":[6,61,112,125,158,200,207,245,432,440],"ROS1":[7,29,77,85,90,99,105,190,256,355,423],"(in":[8],"addition":[9],"to":[10,13,236],"TRKA/B/C),":[11],"designed":[12],"effectively":[14],"penetrate":[15],"the":[16,37,114,189,249,441],"central":[17,141],"nervous":[18],"system":[19],"(CNS);":[20],"brain":[21],"metastases":[22],"are":[23],"common":[24],"in":[25,36,42,70,175,182,205,241,334,352,418],"patients":[26,71,83,103,119,176,183,253,302,314,335,353],"with":[27,39,72,84,104,120,177,184,210,254,306,315,336,354,360],"advanced":[28,74,420],"fusion-positive":[30,78,106,257,356,424],"NSCLC.":[31],"achieves":[33],"therapeutic":[34],"levels":[35],"CNS":[38,186,307,317,361],"antitumor":[40],"activity":[41],"multiple":[43],"intracranial":[44,170,179,323,332,338],"tumor":[45],"models.":[46],"We":[47],"present":[48],"an":[49,178,337],"updated":[50],"integrated":[51,115],"safety":[52,371],"and":[53,134,156,243,295,305,330,367,435],"efficacy":[54,116],"analysis":[55,81,117,431],"from":[56],"three":[57],"Phase":[58],"I/II":[59],"studies":[60],"entrectinib":[62],"(ALKA-372-001":[63],"[EudraCT":[64],"2012-000148-88],":[65],"STARTRK-1":[66,434],"[NCT02097810],":[67],"STARTRK-2":[68,436],"[NCT02568267])":[69],"locally":[73,419],"or":[75,239,421],"metastatic":[76,422],"NSCLCs.Methods":[79],"The":[80,98],"included":[82,102,118],"inhibitor-na\u00efve":[86],"NSCLC":[87,107],"harboring":[88],"fusion":[91],"identified":[92],"via":[93],"nucleic":[94],"acid-based":[95],"diagnostic":[96],"platforms.":[97],"safety-evaluable":[100,191],"population":[101,192,251],"who":[108],"received":[109],"\u22651":[110],"dose":[111,237],"entrectinib;":[113],"at":[121,131,194,211,310],"least":[122,195,212],"6":[123],"months":[124],"follow-up.":[126],"Tumor":[127],"assessments":[128],"were":[129,229],"done":[130],"week":[132],"4":[133],"every":[135],"8":[136],"weeks":[137],"thereafter.":[138],"Blinded":[139],"independent":[140],"review":[142],"(BICR),":[143],"RECIST":[144],"v1.1":[145],"was":[146,203,270,325,341],"performed.":[147],"Primary":[148],"endpoints":[149],"by":[150,215],"BICR:":[151],"overall":[152],"response":[153,159,339],"rate":[154],"(ORR)":[155],"duration":[157],"(DOR).":[160],"Key":[161],"secondary":[162],"endpoints:":[163,169],"progression-free":[164],"survival":[165],"(PFS),":[166],"safety.":[167],"Additional":[168],"ORR":[171,269,324],"(complete/partial":[172],"responses),":[173],"DOR":[174,333],"response,":[180],"PFS":[181],"baseline":[185,316],"disease.Results":[187],"In":[188,248,313],"(n=134),":[193],"one":[196,213],"treatment-related":[197],"AE":[198],"(TRAE)":[199],"any":[201],"grade":[202,217,219,222,225,231],"seen":[204],"93%":[206],"patients.":[208],"Patients":[209],"TRAE":[214],"highest":[216],"were:":[218],"1/2,":[220],"59%;":[221],"3,":[223],"31%;":[224],"4,":[226],"4%.":[227],"There":[228],"no":[230],"5":[232],"TRAEs.":[233],"TRAEs":[234],"led":[235],"reduction":[238],"discontinuation":[240],"34%":[242],"5%":[244],"patients,":[246],"respectively.":[247,312],"efficacy-evaluable":[250],"(n=53":[252],"treatment-na\u00efve,":[255],"NSCLC;":[258],"median":[259,331],"age":[260],"53":[261],"years,":[262],"64%":[263],"female,":[264],"59%":[265],"never":[266],"smokers),":[267],"BICR-assessed":[268,280,288],"77%":[271],"(95%":[272,284,292,298,327,344],"CI":[273,285,293,299,328,345],"64-88),":[274],"complete":[275],"responses":[276],"n=3":[277],"(6%).":[278],"Median":[279,287],"DOR:":[281],"25":[282],"mo":[283,291,297,343],"11-35).":[286],"PFS:":[289],"26":[290],"16-37)":[294],"14":[296],"5-NR)":[300],"for":[301,444],"without":[303],"(n=30)":[304],"disease":[308,318],"(n=23)":[309],"baseline,":[311],"(per":[319],"BICR":[320],"assessment,":[321],"n=20),":[322],"55%":[326],"32-77)":[329],"(n=11)":[340],"13":[342],"6-not":[346],"reached).Conclusion":[347],"highly":[350],"active":[351],"NSCLC,":[357],"including":[358],"those":[359],"disease.":[362],"well":[365],"tolerated":[366],"has":[368],"manageable":[370],"profile.Citation":[372],"Format:":[373],"Alexander":[374],"Drilon,":[375],"Fabrice":[376],"Barlesi,":[377],"Filippo":[378],"De":[379],"Braud,":[380],"Byoung":[381],"Chul":[382],"Cho,":[383],"Myung-Ju":[384],"Ahn,":[385],"Salvatore":[386],"Siena,":[387],"Matthew":[388],"G.":[389],"Krebs,":[390],"Chia-Chi":[391],"Lin,":[392],"Tom":[393],"John,":[394],"Daniel":[395],"SW":[396],"Tan,":[397],"Takashi":[398],"Seto,":[399],"Rafal":[400],"Dziadziuszko,":[401],"Hendrick-Tobias":[402],"Arkenau,":[403],"Christian":[404],"Rolfo,":[405],"J\u00fcrgen":[406],"Wolf,":[407],"Chenglin":[408],"Ye,":[409],"Todd":[410],"Riehl,":[411],"Susan":[412],"Eng,":[413],"Robert":[414],"C.":[415],"Doebele.":[416],"non-small":[425],"cell":[426],"lung":[427],"cancer":[428],"(NSCLC):":[429],"Integrated":[430],"ALKA-372-001,":[433],"[abstract].":[437],"In:":[438],"Proceedings":[439],"American":[442],"Association":[443],"Cancer":[445,459],"Research":[446],"Annual":[447],"Meeting":[448],"2019;":[449],"2019":[450],"Mar":[451],"29-Apr":[452],"3;":[453],"Atlanta,":[454],"GA.":[455],"Philadelphia":[456],"(PA):":[457],"AACR;":[458],"Res":[460],"2019;79(13":[461],"Suppl):Abstract":[462],"nr":[463],"CT192.":[464]},"counts_by_year":[],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2022-05-12T00:00:00"}
