{"id":"https://openalex.org/W4254573007","doi":"https://doi.org/10.1002/chem.201405210","title":"Total Synthesis of the Anti\u2010inflammatory and Pro\u2010resolving Lipid Mediator MaR1n\u22123 DPA Utilizing an sp3\u2013sp3 Negishi Cross\u2010Coupling Reaction","display_name":"Total Synthesis of the Anti\u2010inflammatory and Pro\u2010resolving Lipid Mediator MaR1n\u22123 DPA Utilizing an sp3\u2013sp3 Negishi Cross\u2010Coupling Reaction","publication_year":2014,"publication_date":"2014-09-24","ids":{"openalex":"https://openalex.org/W4254573007","doi":"https://doi.org/10.1002/chem.201405210"},"language":"en","primary_location":{"id":"doi:10.1002/chem.201405210","doi":"https://doi.org/10.1002/chem.201405210","is_oa":true,"landing_page_url":"https://doi.org/10.1002/chem.201405210","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/chem.201405210","source":{"id":"https://openalex.org/S68911691","display_name":"Chemistry - A European Journal","issn_l":"0947-6539","issn":["0947-6539","1521-3765"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemistry \u2013 A European Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/chem.201405210","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5020429231","display_name":"J\u00f8rn Eivind Tungen","orcid":"https://orcid.org/0000-0002-6522-9661","observed_orcids":["https://orcid.org/0000-0002-6522-9661"]},"institutions":[{"id":"https://openalex.org/I184942183","display_name":"University of Oslo","ror":"https://ror.org/01xtthb56","country_code":"NO","type":"education","lineage":["https://openalex.org/I184942183"]}],"countries":["NO"],"is_corresponding":false,"raw_author_name":"J\u00f8rn Eivind Tungen","raw_affiliation_strings":["School of Pharmacy, Department of Pharmaceutical Chemistry, University of Oslo, PO Box 1068 Blindern, 0316 Oslo (Norway)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Pharmacy, Department of Pharmaceutical Chemistry, University of Oslo, PO Box 1068 Blindern, 0316 Oslo (Norway)","institution_ids":["https://openalex.org/I184942183"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066971675","display_name":"Marius Aursnes","orcid":"https://orcid.org/0000-0002-9960-0254","observed_orcids":["https://orcid.org/0000-0002-9960-0254"]},"institutions":[{"id":"https://openalex.org/I184942183","display_name":"University of Oslo","ror":"https://ror.org/01xtthb56","country_code":"NO","type":"education","lineage":["https://openalex.org/I184942183"]}],"countries":["NO"],"is_corresponding":false,"raw_author_name":"Marius Aursnes","raw_affiliation_strings":["School of Pharmacy, Department of Pharmaceutical Chemistry, University of Oslo, PO Box 1068 Blindern, 0316 Oslo (Norway)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Pharmacy, Department of Pharmaceutical Chemistry, University of Oslo, PO Box 1068 Blindern, 0316 Oslo (Norway)","institution_ids":["https://openalex.org/I184942183"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061453586","display_name":"Jesmond Dalli","orcid":"https://orcid.org/0000-0001-6328-3640","observed_orcids":["https://orcid.org/0000-0001-6328-3640"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jesmond Dalli","raw_affiliation_strings":["Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Harvard Institutes of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, 02115 (USA)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Harvard Institutes of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, 02115 (USA)","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087105572","display_name":"Hildur H. Arnardottir","orcid":"https://orcid.org/0000-0002-5163-3946","observed_orcids":["https://orcid.org/0000-0002-5163-3946"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hildur Arnardottir","raw_affiliation_strings":["Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Harvard Institutes of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, 02115 (USA)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Harvard Institutes of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, 02115 (USA)","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029525374","display_name":"Charles Nicholas Serhan","orcid":"https://orcid.org/0000-0003-4627-8545","observed_orcids":["https://orcid.org/0000-0003-4627-8545"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Charles Nicholas Serhan","raw_affiliation_strings":["Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Harvard Institutes of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, 02115 (USA)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Harvard Institutes of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, 02115 (USA)","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5064427328","display_name":"Trond Vidar Hansen","orcid":"https://orcid.org/0000-0001-5239-9920","observed_orcids":["https://orcid.org/0000-0001-5239-9920"]},"institutions":[{"id":"https://openalex.org/I184942183","display_name":"University of Oslo","ror":"https://ror.org/01xtthb56","country_code":"NO","type":"education","lineage":["https://openalex.org/I184942183"]}],"countries":["NO"],"is_corresponding":true,"raw_author_name":"Trond Vidar Hansen","raw_affiliation_strings":["School of Pharmacy, Department of Pharmaceutical Chemistry, University of Oslo, PO Box 1068 Blindern, 0316 Oslo (Norway)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Pharmacy, Department of Pharmaceutical Chemistry, University of Oslo, PO Box 1068 Blindern, 0316 Oslo (Norway)","institution_ids":["https://openalex.org/I184942183"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5064427328"],"corresponding_institution_ids":["https://openalex.org/I184942183"],"apc_list":{"value":4640,"currency":"USD","value_usd":4640},"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.3938424,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"20","issue":"45","first_page":"14537","last_page":"14537"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10548","display_name":"Catalytic Cross-Coupling Reactions","score":0.7368000149726868,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10548","display_name":"Catalytic Cross-Coupling Reactions","score":0.7368000149726868,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10387","display_name":"Fatty Acid Research and Health","score":0.20029999315738678,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10013","display_name":"Asymmetric Synthesis and Catalysis","score":0.008700000122189522,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/total-synthesis","display_name":"total synthesis","score":0.7250000238418579},{"id":"https://openalex.org/keywords/anti-inflammatory-lipid-mediators","display_name":"anti-inflammatory lipid mediators","score":0.6349999904632568},{"id":"https://openalex.org/keywords/specialized-pro-resolving-mediators","display_name":"specialized pro-resolving mediators","score":0.9229999780654907},{"id":"https://openalex.org/keywords/negishi-coupling","display_name":"Negishi coupling","score":0.9350000023841858},{"id":"https://openalex.org/keywords/palladium-catalysis","display_name":"palladium catalysis","score":0.8830000162124634},{"id":"https://openalex.org/keywords/ipr-ligand","display_name":"IPr ligand","score":0.6729999780654907},{"id":"https://openalex.org/keywords/eicosanoids","display_name":"eicosanoids","score":0.5}],"concepts":[{"id":"https://openalex.org/C71866858","wikidata":"https://www.wikidata.org/wiki/Q902756","display_name":"Negishi coupling","level":3,"score":0.9374958276748657},{"id":"https://openalex.org/C131584629","wikidata":"https://www.wikidata.org/wiki/Q4308705","display_name":"Coupling (piping)","level":2,"score":0.4894393980503082},{"id":"https://openalex.org/C2993838110","wikidata":"https://www.wikidata.org/wiki/Q494230","display_name":"Medical school","level":2,"score":0.44513261318206787},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.40568485856056213},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.34694916009902954},{"id":"https://openalex.org/C512399662","wikidata":"https://www.wikidata.org/wiki/Q3505712","display_name":"Family medicine","level":1,"score":0.33445316553115845},{"id":"https://openalex.org/C161790260","wikidata":"https://www.wikidata.org/wiki/Q82264","display_name":"Catalysis","level":2,"score":0.3231162130832672},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.2656443417072296},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.24615713953971863},{"id":"https://openalex.org/C509550671","wikidata":"https://www.wikidata.org/wiki/Q126945","display_name":"Medical education","level":1,"score":0.21758466958999634},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.10205331444740295},{"id":"https://openalex.org/C78519656","wikidata":"https://www.wikidata.org/wiki/Q101333","display_name":"Mechanical engineering","level":1,"score":0.09537944197654724}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1002/chem.201405210","doi":"https://doi.org/10.1002/chem.201405210","is_oa":true,"landing_page_url":"https://doi.org/10.1002/chem.201405210","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/chem.201405210","source":{"id":"https://openalex.org/S68911691","display_name":"Chemistry - A European Journal","issn_l":"0947-6539","issn":["0947-6539","1521-3765"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemistry \u2013 A European Journal","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1002/chem.201405210","doi":"https://doi.org/10.1002/chem.201405210","is_oa":true,"landing_page_url":"https://doi.org/10.1002/chem.201405210","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/chem.201405210","source":{"id":"https://openalex.org/S68911691","display_name":"Chemistry - A European Journal","issn_l":"0947-6539","issn":["0947-6539","1521-3765"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemistry \u2013 A European Journal","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4254573007.pdf","grobid_xml":"https://content.openalex.org/works/W4254573007.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2108711501","https://openalex.org/W2962056889","https://openalex.org/W2065630525","https://openalex.org/W2054474846","https://openalex.org/W4244984430","https://openalex.org/W2953003432","https://openalex.org/W2952686718","https://openalex.org/W4235736939","https://openalex.org/W2084734428","https://openalex.org/W2510163210"],"abstract_inverted_index":{"Abstract":[0],"Invited":[1],"for":[2],"the":[3,11,39,50,54,58],"cover":[4],"of":[5,10,13,19,31,42,57],"this":[6],"issue":[7],"are":[8],"members":[9],"groups":[12],"Professors":[14],"Trond":[15],"V.":[16],"Hansen,":[17],"University":[18],"Oslo":[20],"and":[21],"Charles":[22],"N.":[23],"Serhan,":[24],"Brigham":[25],"&":[26],"Women\u2019s":[27],"Hospital,":[28],"Harvard":[29,33],"Institute":[30],"Medicine,":[32],"Medical":[34],"School.":[35],"The":[36],"image":[37],"depicts":[38],"successful":[40],"application":[41],"an":[43],"sp3\u2013sp3":[44],"Pd\u2010catalyzed":[45],"Negishi":[46],"cross\u2010coupling":[47],"reaction":[48],"using":[49],"PEPPSI\u2122\u2010IPr":[51],"catalyst.":[52],"Read":[53],"full":[55],"text":[56],"article":[59],"at":[60],"10.1002/chem.201404721":[61],".":[62]},"counts_by_year":[],"updated_date":"2026-10-08T09:06:37.294493","created_date":"2022-05-12T00:00:00"}