{"id":"https://openalex.org/W4254550758","doi":"https://doi.org/10.1016/s0021-9258(19)30856-7","title":"STO-609, a specific inhibitor of the Ca2+/calmodulin-dependent protein kinase kinase.","display_name":"STO-609, a specific inhibitor of the Ca2+/calmodulin-dependent protein kinase kinase.","publication_year":2003,"publication_date":"2003-02-01","ids":{"openalex":"https://openalex.org/W4254550758","doi":"https://doi.org/10.1016/s0021-9258(19)30856-7"},"language":"en","primary_location":{"id":"doi:10.1016/s0021-9258(19)30856-7","doi":"https://doi.org/10.1016/s0021-9258(19)30856-7","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0021-9258(19)30856-7","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1016/s0021-9258(19)30856-7","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5078658497","display_name":"Hiroshi Tokumitsu","orcid":"https://orcid.org/0000-0002-2193-6794","observed_orcids":["https://orcid.org/0000-0002-2193-6794"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hiroshi Tokumitsu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086354882","display_name":"Hiroyuki Inuzuka","orcid":"https://orcid.org/0000-0002-4892-0047","observed_orcids":["https://orcid.org/0000-0002-4892-0047"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hiroyuki Inuzuka","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100976228","display_name":"Yumi Ishikawa","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yumi Ishikawa","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5105414024","display_name":"Masahiko Ikeda","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Masahiko Ikeda","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042913262","display_name":"Ikutaro Saji","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ikutaro Saji","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5028305352","display_name":"Ry\u014dji Kobayashi","orcid":"https://orcid.org/0000-0002-3937-0856","observed_orcids":["https://orcid.org/0000-0002-3937-0856"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ryoji Kobayashi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":0.0,"has_fulltext":false,"cited_by_count":15,"citation_normalized_percentile":{"value":0.32875972,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"278","issue":"6","first_page":"4368","last_page":"4368"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.926800012588501,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.926800012588501,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13971","display_name":"Synthesis and Biological Activity","score":0.016300000250339508,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10274","display_name":"Synthesis and biological activity","score":0.00860000029206276,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sto-609","display_name":"STO-609","score":1.0},{"id":"https://openalex.org/keywords/chemical-synthesis","display_name":"chemical synthesis","score":0.7020000219345093},{"id":"https://openalex.org/keywords/kinase-inhibition","display_name":"kinase inhibition","score":0.3569999933242798}],"concepts":[{"id":"https://openalex.org/C2776923262","wikidata":"https://www.wikidata.org/wiki/Q412316","display_name":"Isoquinoline","level":2,"score":0.9350954294204712},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.8408335447311401},{"id":"https://openalex.org/C2776673659","wikidata":"https://www.wikidata.org/wiki/Q47512","display_name":"Acetic acid","level":2,"score":0.7027269005775452},{"id":"https://openalex.org/C2779074116","wikidata":"https://www.wikidata.org/wiki/Q134856","display_name":"Carboxylic acid","level":2,"score":0.4739637076854706},{"id":"https://openalex.org/C94412978","wikidata":"https://www.wikidata.org/wiki/Q103135","display_name":"Hydrolysis","level":2,"score":0.4213348627090454},{"id":"https://openalex.org/C13965031","wikidata":"https://www.wikidata.org/wiki/Q243545","display_name":"Nuclear chemistry","level":1,"score":0.4165293872356415},{"id":"https://openalex.org/C2779485729","wikidata":"https://www.wikidata.org/wiki/Q210385","display_name":"Pyridine","level":2,"score":0.41351208090782166},{"id":"https://openalex.org/C155647269","wikidata":"https://www.wikidata.org/wiki/Q243455","display_name":"Medicinal chemistry","level":1,"score":0.412598580121994},{"id":"https://openalex.org/C188027245","wikidata":"https://www.wikidata.org/wiki/Q750446","display_name":"Polymer chemistry","level":1,"score":0.2997473478317261},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.23655912280082703}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/s0021-9258(19)30856-7","doi":"https://doi.org/10.1016/s0021-9258(19)30856-7","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0021-9258(19)30856-7","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1016/s0021-9258(19)30856-7","doi":"https://doi.org/10.1016/s0021-9258(19)30856-7","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0021-9258(19)30856-7","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3118459755","https://openalex.org/W2089160906","https://openalex.org/W2584088828","https://openalex.org/W362982246","https://openalex.org/W2077918159","https://openalex.org/W2365386791","https://openalex.org/W2313730328","https://openalex.org/W7213408389","https://openalex.org/W2092395326","https://openalex.org/W6945184521"],"abstract_inverted_index":{"The":[0,115],"chemical":[1],"name":[2],"of":[3,49,66,72,83,113,119,162],"STO-609":[4,92,103],"presented":[5],"in":[6,77,87,109],"this":[7],"paper":[8],"was":[9,56,61],"inappropriate.":[10],"It":[11],"should":[12,25,46,146,152],"be":[13,147,153],"7H-benzimidazo[2,1-a]benz[de]isoquinoline-7-one-3-carboxylic":[14,30],"acid.":[15],"Page":[16,37,135],"15816,":[17],"the":[18,64,120,160,163],"first":[19],"line":[20],"under":[21,41,142],"\u201cResults":[22],"and":[23,117,132,140,149],"Discussion\u201d":[24],"read:":[26,47],"\u201cWe":[27],"have":[28],"synthesized":[29,57],"acid":[31,51,81,100,107],"(STO-609,":[32,52],"Fig.":[33],"1A)":[34],"\u2026":[35],"\u201d":[36],"15814,":[38],"paragraph":[39],"2":[40],"\u201cExperimental":[42,143],"Procedures\u201d:":[43,144],"Corrected":[44],"sentences":[45],"\u201cSynthesis":[48],"STO-609\u20147H-Benzimidazo[2,1-a]benz[de]isoquinoline-7-one-3-carboxylic":[50],"Mr":[53],"=":[54],"314.29)":[55],"as":[58,93,104],"follows.":[59],"3-Bromo-7H-benzimidazo[2,1-a]benz[de]isoquinoline-7-one":[60],"prepared":[62],"by":[63,80,125],"method":[65],"Nakaya":[67],"et":[68],"al.":[69],"(37).":[70],"Reaction":[71],"3-bromo-7H-benzimidazo[2,1-a]benz[de]isoquinoline-7-one":[73],"with":[74,85],"cuprous":[75],"cyanide":[76],"pyridine,":[78],"followed":[79],"hydrolysis":[82],"3-cyano-7H-benzimidazo[2,1-a]benz[de]isoquinoline-7-one":[84],"H2SO4":[86],"aqueous":[88],"acetic":[89,99,106],"acid,":[90],"yielded":[91,101],"a":[94,110],"yellow":[95],"solid.":[96],"Recrystallization":[97],"from":[98],"pure":[102],"an":[105],"adduct":[108],"molar":[111],"ratio":[112],"1:1.":[114],"structure":[116],"purity":[118],"synthetic":[121],"compound":[122],"were":[123],"confirmed":[124],"1H":[126],"NMR,":[127],"electrospray":[128],"ionization":[129],"mass":[130],"spectroscopy,":[131],"elemental":[133],"analysis.\u201d":[134],"15815,":[136],"paragraphs":[137],"3,":[138],"5,":[139],"6":[141],"\u201c\u03bcmol/min/mg\u201d":[145],"\u201cnmol/min/mg\u201d":[148],"also":[150],"\u201cmmol/min/mg\u201d":[151],"\u201c\u03bcmol/min/mg.\u201d":[154],"These":[155],"changes":[156],"do":[157],"not":[158],"affect":[159],"conclusions":[161],"paper.":[164]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":3}],"updated_date":"2026-10-08T09:06:37.294493","created_date":"2022-05-12T00:00:00"}