{"id":"https://openalex.org/W4254469451","doi":"https://doi.org/10.1016/j.euroneuro.2019.09.210","title":"P.164 Safety and pharmacokinetic study of inhaled Esketamine after a multiple dose in healthy volunteers","display_name":"P.164 Safety and pharmacokinetic study of inhaled Esketamine after a multiple dose in healthy volunteers","publication_year":2019,"publication_date":"2019-12-01","ids":{"openalex":"https://openalex.org/W4254469451","doi":"https://doi.org/10.1016/j.euroneuro.2019.09.210"},"language":"en","primary_location":{"id":"doi:10.1016/j.euroneuro.2019.09.210","doi":"https://doi.org/10.1016/j.euroneuro.2019.09.210","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.euroneuro.2019.09.210","pdf_url":null,"source":{"id":"https://openalex.org/S168041952","display_name":"European Neuropsychopharmacology","issn_l":"0924-977X","issn":["0924-977X","1873-7862"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Neuropsychopharmacology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5085668440","display_name":"Sylwia Janowska","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210096162","display_name":"Celon Pharma (Poland)","ror":"https://ror.org/00y35qw13","country_code":"PL","type":"company","lineage":["https://openalex.org/I4210096162"]}],"countries":["PL"],"is_corresponding":true,"raw_author_name":"S. Janowska","raw_affiliation_strings":["Celon Pharma SA, Clinical Department, Lomianki, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Celon Pharma SA, Clinical Department, Lomianki, Poland","institution_ids":["https://openalex.org/I4210096162"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056772996","display_name":"Ewa Tratkiewicz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210096162","display_name":"Celon Pharma (Poland)","ror":"https://ror.org/00y35qw13","country_code":"PL","type":"company","lineage":["https://openalex.org/I4210096162"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"E. Tratkiewicz","raw_affiliation_strings":["Celon Pharma SA, R&D Centre, Lomianki, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Celon Pharma SA, R&D Centre, Lomianki, Poland","institution_ids":["https://openalex.org/I4210096162"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036599898","display_name":"Miko\u0142aj Mat\u0142oka","orcid":"https://orcid.org/0000-0001-9891-1838","observed_orcids":["https://orcid.org/0000-0001-9891-1838"]},"institutions":[{"id":"https://openalex.org/I4210096162","display_name":"Celon Pharma (Poland)","ror":"https://ror.org/00y35qw13","country_code":"PL","type":"company","lineage":["https://openalex.org/I4210096162"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"M. Matloka","raw_affiliation_strings":["Celon Pharma SA, R&D Centre, Lomianki, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Celon Pharma SA, R&D Centre, Lomianki, Poland","institution_ids":["https://openalex.org/I4210096162"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086408216","display_name":"P. Perko","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210096162","display_name":"Celon Pharma (Poland)","ror":"https://ror.org/00y35qw13","country_code":"PL","type":"company","lineage":["https://openalex.org/I4210096162"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"P. Perko","raw_affiliation_strings":["Celon Pharma SA, R&D Centre, Lomianki, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Celon Pharma SA, R&D Centre, Lomianki, Poland","institution_ids":["https://openalex.org/I4210096162"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027675202","display_name":"M. Gaciarz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210096162","display_name":"Celon Pharma (Poland)","ror":"https://ror.org/00y35qw13","country_code":"PL","type":"company","lineage":["https://openalex.org/I4210096162"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"M. Gaciarz","raw_affiliation_strings":["Celon Pharma SA, R&D Centre, Lomianki, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Celon Pharma SA, R&D Centre, Lomianki, Poland","institution_ids":["https://openalex.org/I4210096162"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5074594600","display_name":"Maciej Wieczorek","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210096162","display_name":"Celon Pharma (Poland)","ror":"https://ror.org/00y35qw13","country_code":"PL","type":"company","lineage":["https://openalex.org/I4210096162"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"M. Wieczorek","raw_affiliation_strings":["Celon Pharma SA, R&D Centre, Lomianki, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Celon Pharma SA, R&D Centre, Lomianki, Poland","institution_ids":["https://openalex.org/I4210096162"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5085668440"],"corresponding_institution_ids":["https://openalex.org/I4210096162"],"apc_list":{"value":3000,"currency":"USD","value_usd":3000},"apc_paid":null,"fwci":0.1958,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.49336341,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":92,"max":95},"biblio":{"volume":"29","issue":null,"first_page":"S127","last_page":"S128"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.0860000029206276,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.0860000029206276,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12547","display_name":"Pharmaceutical studies and practices","score":0.07249999791383743,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11071","display_name":"Treatment of Major Depression","score":0.06930000334978104,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/esketamine","display_name":"esketamine","score":0.9639999866485596},{"id":"https://openalex.org/keywords/repeated-dosing","display_name":"repeated dosing","score":0.8019999861717224},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.8489999771118164},{"id":"https://openalex.org/keywords/drug-safety","display_name":"drug safety","score":0.8899999856948853},{"id":"https://openalex.org/keywords/healthy-volunteers","display_name":"healthy volunteers","score":0.5339999794960022},{"id":"https://openalex.org/keywords/regulatory-t-cells","display_name":"regulatory T cells","score":0.6269999742507935},{"id":"https://openalex.org/keywords/interleukin-2-therapy","display_name":"interleukin-2 therapy","score":0.9290000200271606},{"id":"https://openalex.org/keywords/chronic-graft-versus-host-disease","display_name":"chronic graft-versus-host disease","score":0.9269999861717224},{"id":"https://openalex.org/keywords/pd-1","display_name":"PD-1","score":0.9879999756813049},{"id":"https://openalex.org/keywords/treg-homeostasis","display_name":"Treg homeostasis","score":0.8600000143051147},{"id":"https://openalex.org/keywords/stat5-phosphorylation","display_name":"STAT5 phosphorylation","score":0.7480000257492065},{"id":"https://openalex.org/keywords/treg-apoptosis","display_name":"Treg apoptosis","score":0.6800000071525574},{"id":"https://openalex.org/keywords/immune-tolerance","display_name":"immune tolerance","score":0.503000020980835}],"concepts":[{"id":"https://openalex.org/C2779727006","wikidata":"https://www.wikidata.org/wiki/Q426188","display_name":"FOXP3","level":3,"score":0.7354733943939209},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6819263696670532},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5840293169021606},{"id":"https://openalex.org/C2778296632","wikidata":"https://www.wikidata.org/wiki/Q1550619","display_name":"Regulatory T cell","level":5,"score":0.48622336983680725},{"id":"https://openalex.org/C2779972918","wikidata":"https://www.wikidata.org/wiki/Q1194520","display_name":"Graft-versus-host disease","level":3,"score":0.442465215921402},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.41484397649765015},{"id":"https://openalex.org/C79484868","wikidata":"https://www.wikidata.org/wiki/Q5971673","display_name":"IL-2 receptor","level":4,"score":0.4046521782875061},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.3727725148200989},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.36966389417648315},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.35447758436203003},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2694675326347351}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/j.euroneuro.2019.09.210","doi":"https://doi.org/10.1016/j.euroneuro.2019.09.210","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.euroneuro.2019.09.210","pdf_url":null,"source":{"id":"https://openalex.org/S168041952","display_name":"European Neuropsychopharmacology","issn_l":"0924-977X","issn":["0924-977X","1873-7862"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Neuropsychopharmacology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":5,"referenced_works":["https://openalex.org/W2103255996","https://openalex.org/W2128918664","https://openalex.org/W2330587564","https://openalex.org/W2779386549","https://openalex.org/W2912505514"],"related_works":["https://openalex.org/W2397817666","https://openalex.org/W656754184","https://openalex.org/W2585738255","https://openalex.org/W2552435202","https://openalex.org/W2509235510","https://openalex.org/W4405043831","https://openalex.org/W2049808194","https://openalex.org/W2555193107","https://openalex.org/W2548653188","https://openalex.org/W3003037882"],"abstract_inverted_index":null,"counts_by_year":[{"year":2021,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2022-05-12T00:00:00"}
