{"id":"https://openalex.org/W4254256388","doi":"https://doi.org/10.1201/9781003066897-1","title":"Historical Perspective","display_name":"Historical Perspective","publication_year":2020,"publication_date":"2020-07-08","ids":{"openalex":"https://openalex.org/W4254256388","doi":"https://doi.org/10.1201/9781003066897-1"},"language":"en","primary_location":{"id":"doi:10.1201/9781003066897-1","doi":"https://doi.org/10.1201/9781003066897-1","is_oa":false,"landing_page_url":"https://doi.org/10.1201/9781003066897-1","pdf_url":null,"source":{"id":"https://openalex.org/S4306463075","display_name":"CRC Press eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310320584","host_organization_name":"CRC Press","host_organization_lineage":["https://openalex.org/P4310320584","https://openalex.org/P4310320547"],"host_organization_lineage_names":["CRC Press","Taylor & Francis"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Photodynamic Therapy","raw_type":"book-chapter"},"volume":{"id":"https://openalex.org/W1566667731","display_name":"Photodynamic Therapy"},"type":"book-chapter","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5010197450","display_name":"Thomas J. Dougherty","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Thomas J. Dougherty","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112040346","display_name":"Barbara W. Henderson","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Barbara W. Henderson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102478208","display_name":"Samuel Schwartz","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Samuel Schwartz","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056910382","display_name":"James W. Winkelman","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"James W. Winkelman","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5005744329","display_name":"Richard L. Lipson","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Richard L. Lipson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.0814,"has_fulltext":false,"cited_by_count":15,"citation_normalized_percentile":{"value":0.83515284,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":95},"biblio":{"volume":null,"issue":null,"first_page":"1","last_page":"16"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10957","display_name":"Photodynamic Therapy Research Studies","score":0.9824000000953674,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10957","display_name":"Photodynamic Therapy Research Studies","score":0.9824000000953674,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12441","display_name":"Porphyrin Metabolism and Disorders","score":0.012299999594688416,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10782","display_name":"Nanoplatforms for cancer theranostics","score":0.0017999999690800905,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/porphyrins","display_name":"porphyrins","score":0.8870000243186951},{"id":"https://openalex.org/keywords/hematoporphyrin","display_name":"hematoporphyrin","score":0.9589999914169312},{"id":"https://openalex.org/keywords/tumor-localization","display_name":"tumor localization","score":0.6869999766349792},{"id":"https://openalex.org/keywords/ionizing-radiation","display_name":"ionizing radiation","score":0.7059999704360962},{"id":"https://openalex.org/keywords/tissue-type","display_name":"tissue type","score":0.8650000095367432}],"concepts":[{"id":"https://openalex.org/C12713177","wikidata":"https://www.wikidata.org/wiki/Q1900281","display_name":"Perspective (graphical)","level":2,"score":0.5950173735618591},{"id":"https://openalex.org/C95457728","wikidata":"https://www.wikidata.org/wiki/Q309","display_name":"History","level":0,"score":0.3591907024383545},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3099783658981323},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.14445149898529053}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1201/9781003066897-1","doi":"https://doi.org/10.1201/9781003066897-1","is_oa":false,"landing_page_url":"https://doi.org/10.1201/9781003066897-1","pdf_url":null,"source":{"id":"https://openalex.org/S4306463075","display_name":"CRC Press eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310320584","host_organization_name":"CRC Press","host_organization_lineage":["https://openalex.org/P4310320584","https://openalex.org/P4310320547"],"host_organization_lineage_names":["CRC Press","Taylor & Francis"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Photodynamic Therapy","raw_type":"book-chapter"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.46810001134872437,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1514356464","https://openalex.org/W2041717033","https://openalex.org/W93702113","https://openalex.org/W109200951","https://openalex.org/W2412119709","https://openalex.org/W2052807753","https://openalex.org/W2014290896","https://openalex.org/W2014135258","https://openalex.org/W2423138750","https://openalex.org/W2415496327"],"abstract_inverted_index":{"The":[0,140],"1950s":[1],"began":[2],"with":[3,33,57],"studies":[4,92],"on":[5,100,130],"porphyrin":[6,133,135,141],"uptake":[7],"by":[8,52,80,120],"mouse":[9],"tumors.":[10,25],"With":[11],"partial":[12],"purification,":[13],"surprisingly,":[14],"the":[15,20,37,45,54,65,76,111],"hematoporphyrin-rich":[16],"fractions":[17],"were":[18,50],"among":[19],"poorest":[21],"localizers":[22],"in":[23,70,95,115,118],"tested":[24],"Interestingly,":[26],"too,":[27],"Mann":[28],"Chemical":[29],"Co.":[30,123],"supplied":[31],"us":[32],"evaporated":[34],"residue":[35],"from":[36,64],"HCl":[38,55,67],"mother":[39],"liquor":[40],"remaining":[41],"after":[42],"removal":[43],"of":[44,60,89,103,113],"crystalline":[46],"\"hematoporphyrin\"":[47],"hydrochloride.":[48],"Porphyrins":[49,63],"precipitated":[51],"neutralizing":[53],"extracts":[56],"an":[58],"excess":[59],"sodium":[61],"acetate.":[62],"5%":[66],"fraction":[68],"localized":[69],"tumors":[71],"much":[72],"better":[73],"than":[74],"did":[75],"purified":[77],"HP":[78],"extracted":[79],"1%":[81],"HCl.":[82],"A":[83,97],"general":[84],"review":[85],"and":[86,106,137],"preliminary":[87],"report":[88],"our":[90],"human":[91],"was":[93,108],"published":[94],"1955.":[96],"national":[98],"\"Conference":[99],"Some":[101],"Relationships":[102],"Porphyrins,":[104],"Tumors,":[105],"Radiosensitivity\"":[107],"held":[109],"at":[110],"University":[112],"Minnesota":[114],"1956,":[116],"sponsored":[117],"part":[119],"Merck":[121],"&":[122],"Response":[124],"to":[125],"ionizing":[126],"radiation":[127],"depends":[128],"heavily":[129],"three":[131],"factors:":[132],"dose,":[134],"type,":[136],"tissue":[138],"type.":[139],"dose":[142],"is":[143],"particularly":[144],"critical.":[145]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2022-05-12T00:00:00"}