{"id":"https://openalex.org/W4253997177","doi":"https://doi.org/10.31234/osf.io/vurk5","title":"Transcriptional Changes Before and After Forgetting of a Long-Term Sensitization Memory in Aplysia californica","display_name":"Transcriptional Changes Before and After Forgetting of a Long-Term Sensitization Memory in Aplysia californica","publication_year":2018,"publication_date":"2018-08-08","ids":{"openalex":"https://openalex.org/W4253997177","doi":"https://doi.org/10.31234/osf.io/vurk5"},"language":"en","primary_location":{"id":"doi:10.31234/osf.io/vurk5","doi":"https://doi.org/10.31234/osf.io/vurk5","is_oa":true,"landing_page_url":"https://doi.org/10.31234/osf.io/vurk5","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"},"volume":null,"type":"preprint","indexed_in":["crossref","datacite"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.31234/osf.io/vurk5","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5018297979","display_name":"Robert J Calin-Jageman","orcid":"https://orcid.org/0000-0002-9837-6529","observed_orcids":["https://orcid.org/0000-0002-9837-6529"]},"institutions":[{"id":"https://openalex.org/I189917405","display_name":"Dominican University","ror":"https://ror.org/01qww1p93","country_code":"US","type":"education","lineage":["https://openalex.org/I189917405"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Robert Calin-Jageman","raw_affiliation_strings":["Neuroscience Program, Dominican University, 7900 West Division Street, River Forest, IL 60305"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neuroscience Program, Dominican University, 7900 West Division Street, River Forest, IL 60305","institution_ids":["https://openalex.org/I189917405"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5075481670","display_name":"Irina E. Calin\u2010Jageman","orcid":"https://orcid.org/0000-0002-2529-4223","observed_orcids":["https://orcid.org/0000-0002-2529-4223"]},"institutions":[{"id":"https://openalex.org/I189917405","display_name":"Dominican University","ror":"https://ror.org/01qww1p93","country_code":"US","type":"education","lineage":["https://openalex.org/I189917405"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Irina Calin-Jageman","raw_affiliation_strings":["Dominican University 7900 West Division Street River Forest, IL 60305 708.524.6596","Neuroscience Program, Dominican University, 7900 West Division Street, River Forest, IL 60305"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dominican University 7900 West Division Street River Forest, IL 60305 708.524.6596","institution_ids":["https://openalex.org/I189917405"]},{"raw_affiliation_string":"Neuroscience Program, Dominican University, 7900 West Division Street, River Forest, IL 60305","institution_ids":["https://openalex.org/I189917405"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5018297979"],"corresponding_institution_ids":["https://openalex.org/I189917405"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10448","display_name":"Memory and Neural Mechanisms","score":0.9692000150680542,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10448","display_name":"Memory and Neural Mechanisms","score":0.9692000150680542,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.021299999207258224,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10423","display_name":"Neurobiology and Insect Physiology Research","score":0.004800000227987766,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/forgetting","display_name":"forgetting","score":0.9490000009536743},{"id":"https://openalex.org/keywords/long-term-memory","display_name":"long-term memory","score":0.7419999837875366},{"id":"https://openalex.org/keywords/siphon-withdrawal-reflex","display_name":"siphon withdrawal reflex","score":0.8659999966621399},{"id":"https://openalex.org/keywords/aplysia-californica","display_name":"Aplysia californica","score":0.9480000138282776},{"id":"https://openalex.org/keywords/gene-expression","display_name":"gene expression","score":0.7289999723434448},{"id":"https://openalex.org/keywords/transcriptome","display_name":"transcriptome","score":0.6430000066757202},{"id":"https://openalex.org/keywords/memory-traces","display_name":"memory traces","score":0.6899999976158142},{"id":"https://openalex.org/keywords/memory-decay","display_name":"memory decay","score":0.3050000071525574}],"concepts":[{"id":"https://openalex.org/C7149132","wikidata":"https://www.wikidata.org/wiki/Q1377840","display_name":"Forgetting","level":2,"score":0.9127540588378906},{"id":"https://openalex.org/C2778178740","wikidata":"https://www.wikidata.org/wiki/Q136564","display_name":"Aplysia","level":2,"score":0.8267344236373901},{"id":"https://openalex.org/C100660578","wikidata":"https://www.wikidata.org/wiki/Q18733","display_name":"Recall","level":2,"score":0.7219457626342773},{"id":"https://openalex.org/C28093023","wikidata":"https://www.wikidata.org/wiki/Q175168","display_name":"Engram","level":2,"score":0.7083934545516968},{"id":"https://openalex.org/C2776217527","wikidata":"https://www.wikidata.org/wiki/Q944828","display_name":"Sensitization","level":2,"score":0.6359332799911499},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5545580983161926},{"id":"https://openalex.org/C24590219","wikidata":"https://www.wikidata.org/wiki/Q18601","display_name":"Long-term memory","level":3,"score":0.548420786857605},{"id":"https://openalex.org/C48455012","wikidata":"https://www.wikidata.org/wiki/Q2892593","display_name":"Memory consolidation","level":3,"score":0.5415220260620117},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.5307953953742981},{"id":"https://openalex.org/C180747234","wikidata":"https://www.wikidata.org/wiki/Q23373","display_name":"Cognitive psychology","level":1,"score":0.4864194393157959},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.30438122153282166},{"id":"https://openalex.org/C2781161787","wikidata":"https://www.wikidata.org/wiki/Q48360","display_name":"Hippocampus","level":2,"score":0.2632189989089966}],"mesh":[],"locations_count":6,"locations":[{"id":"doi:10.31234/osf.io/vurk5","doi":"https://doi.org/10.31234/osf.io/vurk5","is_oa":true,"landing_page_url":"https://doi.org/10.31234/osf.io/vurk5","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"},{"id":"pmh:oai:share.osf.io:461E5-990-924","doi":null,"is_oa":false,"landing_page_url":"http://doi.org/10.31234/OSF.IO/VURK5","pdf_url":null,"source":{"id":"https://openalex.org/S4306401687","display_name":"PsyArXiv (OSF Preprints)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2799848540","host_organization_name":"Center for Open Science","host_organization_lineage":["https://openalex.org/I2799848540"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"preprint"},{"id":"pmh:oai:share.osf.io:E001F-AE8-AAE","doi":null,"is_oa":false,"landing_page_url":"http://api.osf.io/v2/nodes/deq5g/","pdf_url":null,"source":{"id":"https://openalex.org/S4306401127","display_name":"OSF Preprints (OSF Preprints)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2799848540","host_organization_name":"Center for Open Science","host_organization_lineage":["https://openalex.org/I2799848540"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"project"},{"id":"pmh:oai:share.osf.io:a722dc70-d63d-43cb-b012-2f19b13dc947","doi":null,"is_oa":true,"landing_page_url":"https://osf.io/vurk5","pdf_url":null,"source":{"id":"https://openalex.org/S4306401687","display_name":"PsyArXiv (OSF Preprints)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2799848540","host_organization_name":"Center for Open Science","host_organization_lineage":["https://openalex.org/I2799848540"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Preprint"},{"id":"pmh:oai:share.osf.io:e9125992-3c95-4dde-b906-5283e2d46cfe","doi":null,"is_oa":false,"landing_page_url":"https://osf.io/deq5g","pdf_url":null,"source":{"id":"https://openalex.org/S4306401127","display_name":"OSF Preprints (OSF Preprints)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2799848540","host_organization_name":"Center for Open Science","host_organization_lineage":["https://openalex.org/I2799848540"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Project"},{"id":"doi:10.17605/osf.io/deq5g","doi":"https://doi.org/10.17605/osf.io/deq5g","is_oa":true,"landing_page_url":"https://doi.org/10.17605/osf.io/deq5g","pdf_url":null,"source":{"id":"https://openalex.org/S7407050956","display_name":"Open Science Framework","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2799848540","host_organization_name":"Center for Open Science","host_organization_lineage":["https://openalex.org/I2799848540"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"}],"best_oa_location":{"id":"doi:10.31234/osf.io/vurk5","doi":"https://doi.org/10.31234/osf.io/vurk5","is_oa":true,"landing_page_url":"https://doi.org/10.31234/osf.io/vurk5","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321026","display_name":"Ministry of Earth Sciences","ror":"https://ror.org/013cf5k59"},{"id":"https://openalex.org/F4320322724","display_name":"Ministry of Education, India","ror":"https://ror.org/048xjjh50"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":58,"referenced_works":["https://openalex.org/W272873588","https://openalex.org/W1178553251","https://openalex.org/W1496228533","https://openalex.org/W1525053110","https://openalex.org/W1546952499","https://openalex.org/W1603366607","https://openalex.org/W1731056190","https://openalex.org/W1752618202","https://openalex.org/W1915026028","https://openalex.org/W1937980604","https://openalex.org/W1966286636","https://openalex.org/W1969761972","https://openalex.org/W1976557365","https://openalex.org/W1989994517","https://openalex.org/W2008588148","https://openalex.org/W2012686486","https://openalex.org/W2014041564","https://openalex.org/W2014733063","https://openalex.org/W2016743088","https://openalex.org/W2027685064","https://openalex.org/W2029252387","https://openalex.org/W2030303981","https://openalex.org/W2031409236","https://openalex.org/W2038608009","https://openalex.org/W2040145197","https://openalex.org/W2040751411","https://openalex.org/W2042249753","https://openalex.org/W2045431709","https://openalex.org/W2059174580","https://openalex.org/W2059527510","https://openalex.org/W2069458358","https://openalex.org/W2070734605","https://openalex.org/W2074623278","https://openalex.org/W2079092260","https://openalex.org/W2081098333","https://openalex.org/W2081863440","https://openalex.org/W2089524009","https://openalex.org/W2113594310","https://openalex.org/W2132002199","https://openalex.org/W2135627436","https://openalex.org/W2135911361","https://openalex.org/W2144742521","https://openalex.org/W2148791309","https://openalex.org/W2155105030","https://openalex.org/W2160697532","https://openalex.org/W2199586356","https://openalex.org/W2402139709","https://openalex.org/W2514991315","https://openalex.org/W2744751690","https://openalex.org/W2754643671","https://openalex.org/W2761768825","https://openalex.org/W2765830037","https://openalex.org/W2769400708","https://openalex.org/W2790487467","https://openalex.org/W2802752559","https://openalex.org/W4230399697","https://openalex.org/W7095830387","https://openalex.org/W7097005763"],"related_works":["https://openalex.org/W7134259052","https://openalex.org/W2771322314","https://openalex.org/W7221912209","https://openalex.org/W2885422961","https://openalex.org/W6962810000","https://openalex.org/W4235159708","https://openalex.org/W2045431709","https://openalex.org/W2014041564","https://openalex.org/W3162834244","https://openalex.org/W2754643671"],"abstract_inverted_index":{"This":[0],"is":[1,123,218],"a":[2,5,52,88,198,211],"pre-print":[3],"of":[4,11,87,98,112,119,137,139,152,161,194,200,214],"paper":[6],"now":[7],"published":[8],"in":[9,92,181,187],"Neurobiology":[10],"Learning":[12],"and":[13,63,84,167,209],"Memory:":[14],"https://doi.org/10.1016/j.nlm.2018.09.007":[15],"Most":[16],"long-term":[17,89],"memories":[18],"are":[19,72,171],"forgotten,":[20],"becoming":[21],"progressively":[22],"less":[23],"likely":[24],"to":[25,51,67],"be":[26],"recalled.":[27],"Still,":[28],"some":[29],"memory":[30,38,53,91,122,189,217],"fragments":[31],"may":[32],"persist":[33,42],"beyond":[34,149],"forgetting,":[35],"as":[36,145],"savings":[37,104,121],"(easier":[39],"relearning)":[40],"can":[41],"long":[43],"after":[44,165],"recall":[45,62,111],"has":[46],"become":[47],"impossible.":[48],"What":[49],"happens":[50],"trace":[54],"during":[55],"forgetting":[56,86],"that":[57,81,108],"makes":[58],"it":[59],"inaccessible":[60],"for":[61,173],"yet":[64],"still":[65,124,157],"effective":[66],"spark":[68],"easier":[69],"re-learning?":[70],"We":[71,106,196],"addressing":[73],"this":[74],"question":[75],"by":[76],"tracking":[77,203],"the":[78,93,135,150,188],"transcriptional":[79],"changes":[80,180,206],"accompany":[82],"learning":[83],"then":[85],"sensitization":[90,113,208,216],"tail-elicited":[94],"siphon":[95],"withdrawal":[96],"reflex":[97],"Aplysia":[99],"californica.":[100],"First,":[101],"we":[102,133,142],"tracked":[103,134],"memory.":[105],"found":[107],"even":[109],"though":[110],"fades":[114],"completely":[115],"within":[116,191],"1":[117,176,192],"week":[118],"training,":[120],"robustly":[125],"expressed":[126],"at":[127,174],"2":[128,163],"weeks":[129,164],"post":[130],"training.":[131,195],"Next,":[132],"time-course":[136],"regulation":[138,160],"11":[140],"transcripts":[141,156],"previously":[143],"identified":[144],"potentially":[146],"being":[147],"regulated":[148,172],"decay":[151],"recall.":[153],"Remarkably,":[154],"3":[155],"show":[158],"strong":[159],"expression":[162,183,205],"training":[166],"an":[168],"additional":[169],"4":[170],"least":[175],"week.":[177],"These":[178],"long-lasting":[179],"gene":[182,204],"always":[184],"began":[185],"early":[186],"process,":[190],"day":[193],"present":[197],"synthesis":[199],"our":[201],"results":[202],"accompanying":[207],"provide":[210],"testable":[212],"model":[213],"how":[215],"forgotten.":[219]},"counts_by_year":[],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2022-05-12T00:00:00"}
