{"id":"https://openalex.org/W4253991771","doi":"https://doi.org/10.3410/f.727317193.793555803","title":"Faculty Opinions recommendation of Novel surface features for automated detection of focal cortical dysplasias in paediatric epilepsy.","display_name":"Faculty Opinions recommendation of Novel surface features for automated detection of focal cortical dysplasias in paediatric epilepsy.","publication_year":2019,"publication_date":"2019-01-29","ids":{"openalex":"https://openalex.org/W4253991771","doi":"https://doi.org/10.3410/f.727317193.793555803"},"language":"en","primary_location":{"id":"doi:10.3410/f.727317193.793555803","doi":"https://doi.org/10.3410/f.727317193.793555803","is_oa":false,"landing_page_url":"https://doi.org/10.3410/f.727317193.793555803","pdf_url":null,"source":{"id":"https://openalex.org/S4363604054","display_name":"Faculty Opinions \u2013 Post-Publication Peer Review of the Biomedical Literature","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Faculty Opinions \u2013 Post-Publication Peer Review of the Biomedical Literature","raw_type":"dataset"},"volume":null,"type":"peer-review","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5037746759","display_name":"Robert Greenwood","orcid":"https://orcid.org/0000-0002-6231-0253","observed_orcids":["https://orcid.org/0000-0002-6231-0253"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Robert Greenwood","raw_affiliation_strings":["Department of Neurology, University of North Carolina School of Medicine, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, University of North Carolina School of Medicine, USA","institution_ids":["https://openalex.org/I114027177"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5037746759"],"corresponding_institution_ids":["https://openalex.org/I114027177"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10094","display_name":"Epilepsy research and treatment","score":0.5853999853134155,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10094","display_name":"Epilepsy research and treatment","score":0.5853999853134155,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10052","display_name":"Medical Image Segmentation Techniques","score":0.09790000319480896,"subfield":{"id":"https://openalex.org/subfields/1707","display_name":"Computer Vision and Pattern Recognition"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12552","display_name":"Fetal and Pediatric Neurological Disorders","score":0.046300001442432404,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/focal-cortical-dysplasia","display_name":"focal cortical dysplasia","score":1.0},{"id":"https://openalex.org/keywords/pediatric-epilepsy","display_name":"pediatric epilepsy","score":0.9480000138282776},{"id":"https://openalex.org/keywords/drug-resistant-epilepsy","display_name":"drug-resistant epilepsy","score":0.9480000138282776},{"id":"https://openalex.org/keywords/automatic-lesion-detection","display_name":"automated lesion detection","score":0.8899999856948853},{"id":"https://openalex.org/keywords/cortical-morphometry","display_name":"cortical morphometry","score":0.6949999928474426},{"id":"https://openalex.org/keywords/hemispheric-asymmetry","display_name":"hemispheric lateralization","score":0.968999981880188},{"id":"https://openalex.org/keywords/neural-network-classifier","display_name":"neural network classifier","score":0.7789999842643738},{"id":"https://openalex.org/keywords/structural-mri","display_name":"structural MRI","score":0.7289999723434448},{"id":"https://openalex.org/keywords/cortical-development","display_name":"cortical development","score":0.7229999899864197}],"concepts":[{"id":"https://openalex.org/C2778186239","wikidata":"https://www.wikidata.org/wiki/Q41571","display_name":"Epilepsy","level":2,"score":0.7692179083824158},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4137308895587921},{"id":"https://openalex.org/C19527891","wikidata":"https://www.wikidata.org/wiki/Q1120908","display_name":"Medical physics","level":1,"score":0.37029770016670227},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.35908186435699463},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.3526447117328644},{"id":"https://openalex.org/C2522767166","wikidata":"https://www.wikidata.org/wiki/Q2374463","display_name":"Data science","level":1,"score":0.3349604904651642},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.3313804268836975}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.3410/f.727317193.793555803","doi":"https://doi.org/10.3410/f.727317193.793555803","is_oa":false,"landing_page_url":"https://doi.org/10.3410/f.727317193.793555803","pdf_url":null,"source":{"id":"https://openalex.org/S4363604054","display_name":"Faculty Opinions \u2013 Post-Publication Peer Review of the Biomedical Literature","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Faculty Opinions \u2013 Post-Publication Peer Review of the Biomedical Literature","raw_type":"dataset"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":50,"referenced_works":["https://openalex.org/W1545396860","https://openalex.org/W1601352055","https://openalex.org/W1755973449","https://openalex.org/W1900111192","https://openalex.org/W1915947444","https://openalex.org/W1920738063","https://openalex.org/W1966424459","https://openalex.org/W1967083130","https://openalex.org/W1967471947","https://openalex.org/W1989986335","https://openalex.org/W1999555857","https://openalex.org/W2002693366","https://openalex.org/W2010917685","https://openalex.org/W2021225636","https://openalex.org/W2021453748","https://openalex.org/W2031191642","https://openalex.org/W2035282286","https://openalex.org/W2036226049","https://openalex.org/W2037689983","https://openalex.org/W2055132316","https://openalex.org/W2057298051","https://openalex.org/W2063176769","https://openalex.org/W2070424142","https://openalex.org/W2072021035","https://openalex.org/W2073514374","https://openalex.org/W2074904157","https://openalex.org/W2079227251","https://openalex.org/W2088198702","https://openalex.org/W2092307234","https://openalex.org/W2095512333","https://openalex.org/W2102089433","https://openalex.org/W2103954178","https://openalex.org/W2105727230","https://openalex.org/W2107448081","https://openalex.org/W2110208125","https://openalex.org/W2120731293","https://openalex.org/W2125043543","https://openalex.org/W2125807833","https://openalex.org/W2126402194","https://openalex.org/W2135894834","https://openalex.org/W2139925805","https://openalex.org/W2143463042","https://openalex.org/W2151130155","https://openalex.org/W2160413897","https://openalex.org/W2160609984","https://openalex.org/W2168905703","https://openalex.org/W2342015317","https://openalex.org/W2607718182","https://openalex.org/W4235184801","https://openalex.org/W4240721737"],"related_works":["https://openalex.org/W2567150859","https://openalex.org/W2610734459","https://openalex.org/W2164755360","https://openalex.org/W1536516579","https://openalex.org/W4402970961","https://openalex.org/W2125807833","https://openalex.org/W2798181793","https://openalex.org/W2766683605","https://openalex.org/W4415010845","https://openalex.org/W2755934158"],"abstract_inverted_index":{"Focal":[0],"cortical":[1,8,38,83,95,119,136,202,226,266],"dysplasia":[2],"is":[3,22,53],"a":[4,55,69,73,86,170,212],"congenital":[5],"abnormality":[6],"of":[7,14,36,68,82,113,172,197,247,261],"development":[9,84],"and":[10,60,105,140,194,199,264],"the":[11,65,128,195,233,258],"leading":[12],"cause":[13],"surgically":[15],"remediable":[16],"drug-resistant":[17],"epilepsy":[18,156,253],"in":[19,40,85,135,204,250],"children.Post-surgical":[20],"outcome":[21],"improved":[23,34],"by":[24],"presurgical":[25],"lesion":[26],"detection":[27,35],"on":[28,220],"structural":[29,259],"MRI.Automated":[30],"computational":[31],"techniques":[32],"have":[33,43],"focal":[37,80,155],"dysplasias":[39,203],"adults":[41],"but":[42],"not":[44],"yet":[45],"been":[46],"effective":[47],"when":[48,216,230],"applied":[49],"to":[50,57,63,78,90,187,232,244,257],"developing":[51],"brains.There":[52],"therefore":[54],"need":[56],"develop":[58],"reliable":[59],"sensitive":[61],"methods":[62,125,240],"address":[64],"particular":[66],"challenges":[67],"paediatric":[70,87,206,252],"cohort.We":[71],"developed":[72],"classifier":[74,146,189],"using":[75,149,169,191,235],"surface-based":[76],"features":[77,109,193,238],"identify":[79],"abnormalities":[81],"cohort.In":[88],"addition":[89],"established":[91,192,198,237],"measures,":[92],"such":[93,116,126],"as":[94,117,121,123,127,254,256],"thickness,":[96],"grey-white":[97],"matter":[98],"blurring,":[99],"FLAIR":[100],"signal":[101,138],"intensity,":[102,139],"sulcal":[103],"depth":[104],"curvature,":[106],"our":[107,205,221],"novel":[108,200,217],"included":[110],"complementary":[111],"metrics":[112],"surface":[114],"morphology":[115],"local":[118,133,225],"deformation":[120],"well":[122,255],"post-processing":[124],"\"doughnut\"":[129],"method":[130],"-which":[131],"quantifies":[132],"variability":[134],"morphometry/MRI":[137],"per-vertex":[141],"interhemispheric":[142],"asymmetry.A":[143],"neural":[144],"network":[145],"was":[147,185],"trained":[148],"data":[150],"from":[151],"22":[152],"patients":[153],"with":[154,211],"(mean":[157,176],"age":[158,177],"=":[159,178],"12.1":[160],"\u00b1":[161,180],"3.9,":[162],"9":[163],"females),":[164],"after":[165],"intra-and":[166],"inter-subject":[167],"normalisation":[168],"population":[171],"28":[173],"healthy":[174,263],"controls":[175],"14.6":[179],"3.1,":[181],"11":[182],"females).Leave-one-out":[183],"cross-validation":[184],"used":[186],"quantify":[188],"sensitivity":[190,214,234],"combination":[196],"features.Focal":[201],"cohort":[207],"were":[208,228],"correctly":[209],"identified":[210],"higher":[213],"(73%)":[215],"features,":[218],"based":[219],"approach":[222],"for":[223],"detecting":[224],"changes,":[227],"included,":[229],"compared":[231],"only":[236],"(59%).These":[239],"may":[241],"be":[242],"applicable":[243],"aiding":[245],"identification":[246],"subtle":[248],"lesions":[249],"medication-resistant":[251],"analysis":[260],"both":[262],"abnormal":[265],"development.":[267]},"counts_by_year":[],"updated_date":"2026-10-12T09:40:04.860316","created_date":"2022-05-12T00:00:00"}