{"id":"https://openalex.org/W42539734","doi":null,"title":"Human papillomavirus infection and anal carcinoma. Retrospective analysis by in situ hybridization and the polymerase chain reaction.","display_name":"Human papillomavirus infection and anal carcinoma. Retrospective analysis by in situ hybridization and the polymerase chain reaction.","publication_year":1992,"publication_date":"1992-06-01","ids":{"openalex":"https://openalex.org/W42539734","mag":"42539734","pmid":"https://pubmed.ncbi.nlm.nih.gov/1318640","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1886536"},"language":"en","primary_location":{"id":"pmh:oai:pubmedcentral.nih.gov:1886536","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1886536","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Pathol","raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1886536","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101499569","display_name":"Sherif R. Zaki","orcid":"https://orcid.org/0000-0001-6605-4536","observed_orcids":["https://orcid.org/0000-0001-6605-4536"]},"institutions":[{"id":"https://openalex.org/I1289490764","display_name":"Centers for Disease Control and Prevention","ror":"https://ror.org/042twtr12","country_code":"US","type":"government","lineage":["https://openalex.org/I1289490764","https://openalex.org/I1299022934"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S R Zaki","raw_affiliation_strings":["Division of Viral Diseases, Center for Disease Control, Atlanta, GA 30333"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Viral Diseases, Center for Disease Control, Atlanta, GA 30333","institution_ids":["https://openalex.org/I1289490764"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059706142","display_name":"Randy L. Judd","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R Judd","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041168480","display_name":"Lisa M. Coffield","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"L M Coffield","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109324450","display_name":"Patricia W. Greer","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P Greer","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073351088","display_name":"F Rolston","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"F Rolston","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5110273083","display_name":"Bruce Lee Evatt","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"B L Evatt","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.0678,"has_fulltext":false,"cited_by_count":111,"citation_normalized_percentile":{"value":0.85081471,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"140","issue":"6","first_page":"1345","last_page":"55"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10146","display_name":"Cervical Cancer and HPV Research","score":0.9434000253677368,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10146","display_name":"Cervical Cancer and HPV Research","score":0.9434000253677368,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13110","display_name":"Colorectal and Anal Carcinomas","score":0.05400000140070915,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10685","display_name":"Viral-associated cancers and disorders","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/human-papillomavirus","display_name":"human papillomavirus","score":0.9890000224113464},{"id":"https://openalex.org/keywords/anal-squamous-cell-carcinoma","display_name":"anal squamous cell carcinoma","score":0.9779999852180481},{"id":"https://openalex.org/keywords/hpv-16","display_name":"HPV16","score":0.6700000166893005},{"id":"https://openalex.org/keywords/hpv-18","display_name":"HPV 18","score":0.9800000190734863},{"id":"https://openalex.org/keywords/hpv-31","display_name":"HPV 31","score":0.6779999732971191},{"id":"https://openalex.org/keywords/hpv35","display_name":"HPV35","score":0.9100000262260437},{"id":"https://openalex.org/keywords/hpv-51","display_name":"HPV51","score":0.9679999947547913},{"id":"https://openalex.org/keywords/hpv-33","display_name":"HPV 33","score":0.8489999771118164},{"id":"https://openalex.org/keywords/hpv-genotyping","display_name":"HPV genotyping","score":0.640999972820282},{"id":"https://openalex.org/keywords/hpv-testing","display_name":"HPV testing","score":0.6359999775886536},{"id":"https://openalex.org/keywords/carcinogenesis","display_name":"carcinogenesis","score":0.6869999766349792},{"id":"https://openalex.org/keywords/formalin-fixed-paraffin-embedded-tissue","display_name":"formalin-fixed paraffin-embedded tissue","score":0.824999988079071}],"concepts":[{"id":"https://openalex.org/C49105822","wikidata":"https://www.wikidata.org/wiki/Q176996","display_name":"Polymerase chain reaction","level":3,"score":0.8165601491928101},{"id":"https://openalex.org/C81439078","wikidata":"https://www.wikidata.org/wiki/Q2304142","display_name":"In situ hybridization","level":4,"score":0.693535566329956},{"id":"https://openalex.org/C160798450","wikidata":"https://www.wikidata.org/wiki/Q4230870","display_name":"Concordance","level":2,"score":0.6438726782798767},{"id":"https://openalex.org/C2781209916","wikidata":"https://www.wikidata.org/wiki/Q3215756","display_name":"Typing","level":2,"score":0.583885908126831},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5030006766319275},{"id":"https://openalex.org/C2777661416","wikidata":"https://www.wikidata.org/wiki/Q1035645","display_name":"Carcinoma in situ","level":3,"score":0.4833326041698456},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.4816933572292328},{"id":"https://openalex.org/C2776270601","wikidata":"https://www.wikidata.org/wiki/Q9055203","display_name":"Papillomaviridae","level":4,"score":0.45807358622550964},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.416968435049057},{"id":"https://openalex.org/C2777546739","wikidata":"https://www.wikidata.org/wiki/Q33525","display_name":"Carcinoma","level":2,"score":0.4018833339214325},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3768230974674225},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.29043009877204895},{"id":"https://openalex.org/C2778220009","wikidata":"https://www.wikidata.org/wiki/Q160105","display_name":"Cervical cancer","level":3,"score":0.21629318594932556},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.21617373824119568},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.09652972221374512},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D001005","descriptor_name":"Anus Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D002294","descriptor_name":"Carcinoma, Squamous Cell","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009693","descriptor_name":"Nucleic Acid Hybridization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014412","descriptor_name":"Tumor Virus Infections","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D016133","descriptor_name":"Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D027383","descriptor_name":"Papillomaviridae","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"pmh:oai:pubmedcentral.nih.gov:1886536","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1886536","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Pathol","raw_type":"Text"},{"id":"pmid:1318640","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1318640","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American journal of pathology","raw_type":"Journal Article"},{"id":"mag:42539734","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1318640","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:1886536","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1886536","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Pathol","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":45,"referenced_works":["https://openalex.org/W19254763","https://openalex.org/W79384053","https://openalex.org/W82698608","https://openalex.org/W163813882","https://openalex.org/W190015672","https://openalex.org/W952083443","https://openalex.org/W1500130815","https://openalex.org/W1562340509","https://openalex.org/W1657284351","https://openalex.org/W1854767509","https://openalex.org/W1911489264","https://openalex.org/W1967960141","https://openalex.org/W1969353948","https://openalex.org/W1969652801","https://openalex.org/W1976051908","https://openalex.org/W1979661897","https://openalex.org/W1979946419","https://openalex.org/W1983095670","https://openalex.org/W1985623864","https://openalex.org/W1998031082","https://openalex.org/W2003990673","https://openalex.org/W2015910388","https://openalex.org/W2024113708","https://openalex.org/W2032118018","https://openalex.org/W2035732039","https://openalex.org/W2038500217","https://openalex.org/W2047480444","https://openalex.org/W2060728092","https://openalex.org/W2060786724","https://openalex.org/W2085267728","https://openalex.org/W2087162682","https://openalex.org/W2109527410","https://openalex.org/W2112967311","https://openalex.org/W2148128258","https://openalex.org/W2160438825","https://openalex.org/W2170385036","https://openalex.org/W2171006571","https://openalex.org/W2193387564","https://openalex.org/W2284296097","https://openalex.org/W2312750407","https://openalex.org/W2312922488","https://openalex.org/W2322736405","https://openalex.org/W2402944231","https://openalex.org/W2403493016","https://openalex.org/W2416534240"],"related_works":["https://openalex.org/W2403493016","https://openalex.org/W2069562669","https://openalex.org/W1959508910","https://openalex.org/W1978865341","https://openalex.org/W2160438825","https://openalex.org/W2148128258","https://openalex.org/W2416534240","https://openalex.org/W2338276009","https://openalex.org/W2412027947","https://openalex.org/W1562427299"],"abstract_inverted_index":{"To":[0],"examine":[1],"the":[2,14,17,93,99,105,111,114,128,203,214],"association":[3],"of":[4,43,50,77,110,116,123,127,172,180,189,216],"human":[5],"papillomavirus":[6],"(HPV)":[7],"infection":[8],"with":[9,53,202],"anal":[10,54,217],"squamous":[11],"cell":[12],"carcinoma,":[13],"authors":[15],"applied":[16],"highly":[18],"sensitive":[19],"polymerase":[20],"chain":[21],"reaction":[22],"(PCR)":[23],"and":[24,72,101,137,145,175,196],"in":[25,34,47,207,213],"situ":[26],"hybridization":[27],"(ISH)":[28],"techniques":[29],"to":[30,104,120],"detect":[31],"HPV":[32,44,64,85,112,132,140,151,155,159,163,167,171,182],"DNA":[33],"formalin-fixed,":[35],"paraffin-embedded":[36],"tissues":[37],"from":[38,75],"18":[39,51],"patients.":[40],"The":[41],"presence":[42],"types":[45,65],"16/18":[46],"3":[48],"(16.7%)":[49],"patients":[52,80,118],"carcinoma":[55],"was":[56,96,185],"found,":[57],"using":[58,98,134],"a":[59,178],"colorimetric":[60],"ISH":[61,90,195],"technique":[62],"for":[63,84,139],"6,":[66,141,152],"11,":[67,142,156],"16,":[68,143,160,210],"18,":[69,144,164],"31,":[70,86],"35,":[71,87],"51.":[73],"Results":[74],"one":[76],"these":[78],"three":[79,181],"were":[81,192],"also":[82],"positive":[83,117,193],"51":[88],"by":[89,194],"techniques.":[91],"When":[92],"same":[94],"series":[95],"analyzed":[97],"PCR":[100,125,197],"consensus":[102],"primers":[103,136],"L1":[106],"open":[107],"reading":[108],"frame":[109],"genomes,":[113],"frequency":[115],"rose":[119],"14":[121,129],"(77.8%)":[122],"18.":[124],"analysis":[126],"lesions":[130],"containing":[131],"DNA,":[133],"type-specific":[135],"probes":[138],"33,":[146,168],"showed":[147],"that":[148,191,205],"1":[149,153,161,165,176],"contained":[150,154,158,162,166,170,177],"4":[157],"5":[169],"unclassified":[173],"type(s),":[174],"mixture":[179],"types.":[183],"There":[184],"concordance":[186],"between":[187],"typing":[188],"cases":[190],"methods.":[198],"These":[199],"data":[200],"agree":[201],"concept":[204],"HPV,":[206],"particular":[208],"type":[209],"is":[211],"implicated":[212],"pathogenesis":[215],"cancer.":[218]},"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":6}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
