{"id":"https://openalex.org/W4253664583","doi":"https://doi.org/10.21203/rs.3.rs-687053/v1","title":"Photobiomodulation Therapy Prevents Dysgeusia Chemotherapy-Induced in Breast Cancer Women Treated with Doxorubicin Plus Cyclophosphamide: A Triple-Blinded, Randomized, Placebo-Controlled Clinical Trial","display_name":"Photobiomodulation Therapy Prevents Dysgeusia Chemotherapy-Induced in Breast Cancer Women Treated with Doxorubicin Plus Cyclophosphamide: A Triple-Blinded, Randomized, Placebo-Controlled Clinical Trial","publication_year":2021,"publication_date":"2021-08-20","ids":{"openalex":"https://openalex.org/W4253664583","doi":"https://doi.org/10.21203/rs.3.rs-687053/v1"},"language":"en","primary_location":{"id":"doi:10.21203/rs.3.rs-687053/v1","doi":"https://doi.org/10.21203/rs.3.rs-687053/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-687053/v1","pdf_url":"https://www.researchsquare.com/article/rs-687053/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.researchsquare.com/article/rs-687053/latest.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5054528500","display_name":"Malta C\u00e1ssia Emanuella N\u00f3brega","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I243754102","display_name":"Universidade Federal do Cear\u00e1","ror":"https://ror.org/03srtnf24","country_code":"BR","type":"education","lineage":["https://openalex.org/I243754102"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Malta C\u00e1ssia Emanuella N\u00f3brega","raw_affiliation_strings":["Federal University of Ceara: Universidade Federal do Ceara"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Federal University of Ceara: Universidade Federal do Ceara","institution_ids":["https://openalex.org/I243754102"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083149827","display_name":"Anna Clara Arag\u00e3o Matos Carlos","orcid":"https://orcid.org/0000-0002-6296-2956","observed_orcids":["https://orcid.org/0000-0002-6296-2956"]},"institutions":[{"id":"https://openalex.org/I4210122181","display_name":"Unichristus","ror":"https://ror.org/02kt6vs55","country_code":"BR","type":"education","lineage":["https://openalex.org/I4210122181"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Anna Clara Arag\u00e3o Matos Carlos","raw_affiliation_strings":["Unichristus: Centro Universitario Christus"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Unichristus: Centro Universitario Christus","institution_ids":["https://openalex.org/I4210122181"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013468310","display_name":"Manuele Carine Maciel de Alencar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210114510","display_name":"Hospital Haroldo Jua\u00e7aba","ror":"https://ror.org/01pg9bv14","country_code":"BR","type":"healthcare","lineage":["https://openalex.org/I4210114510"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Manuele Carine Maciel de Alencar","raw_affiliation_strings":["Cancer Institute of Ceara: Instituto do Cancer do Ceara"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Institute of Ceara: Instituto do Cancer do Ceara","institution_ids":["https://openalex.org/I4210114510"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069433415","display_name":"Eveline Fernandes Alves e Silva","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210114510","display_name":"Hospital Haroldo Jua\u00e7aba","ror":"https://ror.org/01pg9bv14","country_code":"BR","type":"healthcare","lineage":["https://openalex.org/I4210114510"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Eveline Fernandes Alves e Silva","raw_affiliation_strings":["Cancer Institute of Ceara: Instituto do Cancer do Ceara"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Institute of Ceara: Instituto do Cancer do Ceara","institution_ids":["https://openalex.org/I4210114510"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040563495","display_name":"Victor Bruno Caitano Nogueira","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210114510","display_name":"Hospital Haroldo Jua\u00e7aba","ror":"https://ror.org/01pg9bv14","country_code":"BR","type":"healthcare","lineage":["https://openalex.org/I4210114510"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Victor Bruno Caitano Nogueira","raw_affiliation_strings":["Cancer Institute of Ceara: Instituto do Cancer do Ceara"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Institute of Ceara: Instituto do Cancer do Ceara","institution_ids":["https://openalex.org/I4210114510"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100603121","display_name":"Ana Paula Negreiros Nunes Alves","orcid":"https://orcid.org/0000-0002-5090-6877","observed_orcids":["https://orcid.org/0000-0002-5090-6877"]},"institutions":[{"id":"https://openalex.org/I243754102","display_name":"Universidade Federal do Cear\u00e1","ror":"https://ror.org/03srtnf24","country_code":"BR","type":"education","lineage":["https://openalex.org/I243754102"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Ana Paula Negreiros Nunes Alves","raw_affiliation_strings":["UFC: Universidade Federal do Ceara"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UFC: Universidade Federal do Ceara","institution_ids":["https://openalex.org/I243754102"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034976961","display_name":"F\u00e1bio Figueiredo Chaves","orcid":"https://orcid.org/0000-0001-5343-7802","observed_orcids":["https://orcid.org/0000-0001-5343-7802"]},"institutions":[{"id":"https://openalex.org/I4210114510","display_name":"Hospital Haroldo Jua\u00e7aba","ror":"https://ror.org/01pg9bv14","country_code":"BR","type":"healthcare","lineage":["https://openalex.org/I4210114510"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"F\u00e1bio Figueiredo Chaves","raw_affiliation_strings":["Cancer Institute of Ceara: Instituto do Cancer do Ceara"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Institute of Ceara: Instituto do Cancer do Ceara","institution_ids":["https://openalex.org/I4210114510"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036880708","display_name":"Jos\u00e9 Fernando Bastos de Moura","orcid":"https://orcid.org/0000-0002-2544-9846","observed_orcids":["https://orcid.org/0000-0002-2544-9846"]},"institutions":[{"id":"https://openalex.org/I4210114510","display_name":"Hospital Haroldo Jua\u00e7aba","ror":"https://ror.org/01pg9bv14","country_code":"BR","type":"healthcare","lineage":["https://openalex.org/I4210114510"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Jos\u00e9 Fernando Bastos de Moura","raw_affiliation_strings":["Cancer Institute of Ceara: Instituto do Cancer do Ceara"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Institute of Ceara: Instituto do Cancer do Ceara","institution_ids":["https://openalex.org/I4210114510"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5014569708","display_name":"Paulo Goberl\u00e2nio de Barros Silva","orcid":"https://orcid.org/0000-0002-1513-9027","observed_orcids":["https://orcid.org/0000-0002-1513-9027"]},"institutions":[{"id":"https://openalex.org/I243754102","display_name":"Universidade Federal do Cear\u00e1","ror":"https://ror.org/03srtnf24","country_code":"BR","type":"education","lineage":["https://openalex.org/I243754102"]}],"countries":["BR"],"is_corresponding":true,"raw_author_name":"Paulo Goberl\u00e2nio Barros Silva","raw_affiliation_strings":["Federal University of Ceara: Universidade Federal do Ceara"],"raw_orcid":"https://orcid.org/0000-0002-1513-9027","affiliations":[{"raw_affiliation_string":"Federal University of Ceara: Universidade Federal do Ceara","institution_ids":["https://openalex.org/I243754102"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5014569708"],"corresponding_institution_ids":["https://openalex.org/I243754102"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":3,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12198","display_name":"Oral health in cancer treatment","score":0.486299991607666,"subfield":{"id":"https://openalex.org/subfields/3500","display_name":"General Dentistry"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12198","display_name":"Oral health in cancer treatment","score":0.486299991607666,"subfield":{"id":"https://openalex.org/subfields/3500","display_name":"General Dentistry"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11566","display_name":"Laser Applications in Dentistry and Medicine","score":0.47049999237060547,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11785","display_name":"Nausea and vomiting management","score":0.0044999998062849045,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/low-level-laser-therapy","display_name":"low-level laser therapy","score":0.9819999933242798},{"id":"https://openalex.org/keywords/dysgeusia","display_name":"dysgeusia","score":0.9610000252723694},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.9259999990463257},{"id":"https://openalex.org/keywords/doxorubicin","display_name":"doxorubicin","score":0.8600000143051147},{"id":"https://openalex.org/keywords/cyclophosphamide","display_name":"cyclophosphamide","score":0.9990000128746033},{"id":"https://openalex.org/keywords/red-laser","display_name":"red laser","score":0.5839999914169312},{"id":"https://openalex.org/keywords/infrared-laser","display_name":"infrared laser","score":0.9580000042915344},{"id":"https://openalex.org/keywords/quality-of-life","display_name":"quality of life","score":0.8629999756813049},{"id":"https://openalex.org/keywords/oral-mucositis","display_name":"oral mucositis","score":0.8349999785423279},{"id":"https://openalex.org/keywords/anorexia","display_name":"anorexia","score":0.8050000071525574},{"id":"https://openalex.org/keywords/cachexia","display_name":"cachexia","score":0.949999988079071},{"id":"https://openalex.org/keywords/weight-loss","display_name":"weight loss","score":0.6919999718666077},{"id":"https://openalex.org/keywords/chemotherapy-side-effects","display_name":"chemotherapy side effects","score":0.578000009059906}],"concepts":[{"id":"https://openalex.org/C2777054765","wikidata":"https://www.wikidata.org/wiki/Q6402731","display_name":"Dysgeusia","level":3,"score":0.8164873123168945},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8156855702400208},{"id":"https://openalex.org/C2776755627","wikidata":"https://www.wikidata.org/wiki/Q408524","display_name":"Cyclophosphamide","level":3,"score":0.7540842294692993},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.640393853187561},{"id":"https://openalex.org/C2781303535","wikidata":"https://www.wikidata.org/wiki/Q18936","display_name":"Doxorubicin","level":3,"score":0.6214114427566528},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.6186236143112183},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.5336709022521973},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.49115821719169617},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.47619855403900146},{"id":"https://openalex.org/C2780110267","wikidata":"https://www.wikidata.org/wiki/Q7843332","display_name":"Triple-negative breast cancer","level":4,"score":0.4680347740650177},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.46061110496520996},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4470142424106598},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.42141789197921753},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.0957212746143341},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.08564776182174683},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.06319484114646912}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.21203/rs.3.rs-687053/v1","doi":"https://doi.org/10.21203/rs.3.rs-687053/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-687053/v1","pdf_url":"https://www.researchsquare.com/article/rs-687053/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.21203/rs.3.rs-687053/v1","doi":"https://doi.org/10.21203/rs.3.rs-687053/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-687053/v1","pdf_url":"https://www.researchsquare.com/article/rs-687053/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[{"display_name":"Randomized Controlled Trial","id":"https://openalex.org/study-designs/randomized-controlled-trial"},{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4253664583.pdf","grobid_xml":"https://content.openalex.org/works/W4253664583.grobid-xml"},"referenced_works_count":31,"referenced_works":["https://openalex.org/W175449331","https://openalex.org/W281867321","https://openalex.org/W1966844003","https://openalex.org/W2021792184","https://openalex.org/W2037350881","https://openalex.org/W2076668534","https://openalex.org/W2095197048","https://openalex.org/W2099706887","https://openalex.org/W2129462855","https://openalex.org/W2130722096","https://openalex.org/W2141015207","https://openalex.org/W2158334747","https://openalex.org/W2299095302","https://openalex.org/W2301380784","https://openalex.org/W2310338326","https://openalex.org/W2579854084","https://openalex.org/W2794260504","https://openalex.org/W2800387198","https://openalex.org/W2807196262","https://openalex.org/W2907689032","https://openalex.org/W2938772886","https://openalex.org/W2939344663","https://openalex.org/W2962003939","https://openalex.org/W2988550965","https://openalex.org/W2989643829","https://openalex.org/W3026068952","https://openalex.org/W3045093101","https://openalex.org/W3093574223","https://openalex.org/W3116216897","https://openalex.org/W4210547897","https://openalex.org/W4242962671"],"related_works":["https://openalex.org/W7001115300","https://openalex.org/W4412391565","https://openalex.org/W7120423150","https://openalex.org/W4365811131","https://openalex.org/W2988550965","https://openalex.org/W2900039699","https://openalex.org/W7126468993","https://openalex.org/W7164183414","https://openalex.org/W4388421056","https://openalex.org/W7130374793"],"abstract_inverted_index":{"Abstract":[0],"Purpose":[1],"To":[2],"evaluate":[3],"the":[4,69,90,102,112,151,154,183,198,226,231],"effectiveness":[5],"of":[6,74,77,101,176,200,237],"photobiomodulation":[7],"(PBMT)":[8],"in":[9,12],"preventing":[10],"dysgeusia":[11],"breast":[13,33,240],"cancer":[14,34,241],"patients":[15,35,40,139,238],"treated":[16,36,50,84,242],"with":[17,37,51,85,239,243],"doxorubicin-cyclophosphamide":[18],"(AC).":[19],"Methods":[20],"This":[21],"is":[22],"a":[23,47,158],"phase":[24],"II,":[25],"randomized,":[26],"triple-blind,":[27],"placebo-controlled":[28],"clinical":[29],"trial":[30],"involving":[31],"112":[32],"AC.":[38,177,244],"The":[39,95,126,178],"were":[41,65,124,128],"divided":[42],"equally":[43],"into":[44],"two":[45],"groups:":[46],"test":[48],"group":[49,83,156,185],"2":[52],"J":[53,58],"red":[54],"laser":[55,60],"and":[56,79,93,97,107,111,120,133,143,165,193,218,229,235],"3":[57],"infrared":[59],"on":[61,68,71,256],"21":[62],"points":[63],"that":[64],"symmetrically":[66],"distributed":[67],"tongue":[70],"day":[72],"0":[73],"four":[75,174],"cycles":[76,175],"AC,":[78],"an":[80],"equal":[81],"placebo":[82,155],"simulated":[86],"PBMT":[87,138,184,194,224],"to":[88],"blind":[89],"patient,":[91],"evaluator,":[92],"statistician.":[94],"clinicopathological":[96],"sociodemographic":[98],"data,":[99],"results":[100],"hematological":[103],"tests,":[104],"taste":[105,109,145,227],"test,":[106],"subjective":[108,144],"analysis,":[110],"QoL,":[113],"ECOG":[114,160],"performance":[115],"status,":[116],"body":[117],"mass":[118],"index,":[119],"other":[121,152],"side":[122],"effects":[123],"recorded.":[125],"data":[127],"analyzed":[129],"using":[130],"ANOVA-RM/Bonferroni,":[131],"Friedman/Dunn,":[132],"chi-square/Fisher's":[134],"exact":[135],"tests.":[136],"Results":[137],"showed":[140,157],"less":[141],"objective":[142],"loss":[146,169,228],"(p":[147,162,170,186,202,206,210,215,220],"<":[148,171,187,207],"0.05).":[149],"On":[150],"hand,":[153],"higher":[159],"status":[161,234],"=":[163,203,211,216,221],"0.037)":[164],"more":[166],"significant":[167],"weight":[168],"0.001)":[172],"after":[173],"QoL":[179,236],"was":[180],"significantly":[181],"higherin":[182],"0.05)":[188],"at":[189],"all":[190],"assessment":[191],"periods,":[192],"treatment":[195],"also":[196],"reduced":[197,225],"incidence":[199],"cachexia":[201],"0.020),":[204,217],"anorexia":[205],"0.001),":[208],"diarrhea":[209],"0.040),":[212],"oral":[213],"mucositis":[214],"vomiting":[219],"0.008).":[222],"Conclusion":[223],"improved":[230],"overall":[232],"health":[233],"Trial":[245],"registration":[246],":":[247],"Brazilian":[248],"Clinical":[249],"Trials":[250],"Registry":[251],"(www.ensaiosclinicos.gov.br)":[252],"approval":[253],"numberRBR-9qnm34y,":[254],"registered":[255],"01/05/2021":[257]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1}],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2022-05-12T00:00:00"}