{"id":"https://openalex.org/W4253572085","doi":"https://doi.org/10.1210/endo.151.2.9997","title":"Additive Effect of Polymorphisms in the IL-6, LTA, and TNF-\u03b1 Genes and Plasma Fatty Acid Level Modulate Risk for the Metabolic Syndrome and Its Components","display_name":"Additive Effect of Polymorphisms in the IL-6, LTA, and TNF-\u03b1 Genes and Plasma Fatty Acid Level Modulate Risk for the Metabolic Syndrome and Its Components","publication_year":2010,"publication_date":"2010-02-01","ids":{"openalex":"https://openalex.org/W4253572085","doi":"https://doi.org/10.1210/endo.151.2.9997"},"language":"en","primary_location":{"id":"doi:10.1210/endo.151.2.9997","doi":"https://doi.org/10.1210/endo.151.2.9997","is_oa":false,"landing_page_url":"https://doi.org/10.1210/endo.151.2.9997","pdf_url":null,"source":{"id":"https://openalex.org/S157527038","display_name":"Endocrinology","issn_l":"0013-7227","issn":["0013-7227","1945-7170"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrinology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5036449746","display_name":"Catherine M. Phillips","orcid":"https://orcid.org/0000-0003-4916-4463","observed_orcids":["https://orcid.org/0000-0003-4916-4463"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Catherine M. Phillips","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063002416","display_name":"Louisa Goumidi","orcid":"https://orcid.org/0000-0003-4164-8471","observed_orcids":["https://orcid.org/0000-0003-4164-8471"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Louisa Goumidi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016135322","display_name":"Sandrine Bertrais","orcid":"https://orcid.org/0000-0001-7388-0916","observed_orcids":["https://orcid.org/0000-0001-7388-0916"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sandrine Bertrais","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078392652","display_name":"Jane F. Ferguson","orcid":"https://orcid.org/0000-0001-6896-1025","observed_orcids":["https://orcid.org/0000-0001-6896-1025"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jane F. Ferguson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042447376","display_name":"Martyn R. Field","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Martyn R. Field","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Enda D. Kelly","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Enda D. Kelly","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048899740","display_name":"John Mehegan","orcid":"https://orcid.org/0000-0002-4229-3599","observed_orcids":["https://orcid.org/0000-0002-4229-3599"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"John Mehegan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036791650","display_name":"Gina Marie Peloso","orcid":"https://orcid.org/0000-0002-5355-8636","observed_orcids":["https://orcid.org/0000-0002-5355-8636"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gina M. Peloso","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059560495","display_name":"L. Adrienne Cupples","orcid":"https://orcid.org/0000-0003-0273-7965","observed_orcids":["https://orcid.org/0000-0003-0273-7965"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"L. Adrienne Cupples","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Jian Shen","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jian Shen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018093575","display_name":"Jos\u00e9 Mar\u00eda Ordov\u00e1s","orcid":"https://orcid.org/0000-0002-7581-5680","observed_orcids":["https://orcid.org/0000-0002-7581-5680"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jose M. Ordovas","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035245724","display_name":"Ross McManus","orcid":"https://orcid.org/0000-0002-0529-9617","observed_orcids":["https://orcid.org/0000-0002-0529-9617"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ross McManus","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043541421","display_name":"Serge Her\u00e7berg","orcid":"https://orcid.org/0000-0002-3168-1350","observed_orcids":["https://orcid.org/0000-0002-3168-1350"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Serge Hercberg","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113778437","display_name":"Henri Portugal","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Henri Portugal","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066285906","display_name":"Denis Lairon","orcid":"https://orcid.org/0000-0001-9941-3742","observed_orcids":["https://orcid.org/0000-0001-9941-3742"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Denis Lairon","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082897489","display_name":"Richard Planells","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Richard Planells","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5023335967","display_name":"Helen M. Roche","orcid":"https://orcid.org/0000-0002-0628-3318","observed_orcids":["https://orcid.org/0000-0002-0628-3318"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Helen M. Roche","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3750,"currency":"USD","value_usd":3750},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.52452945,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"151","issue":"2","first_page":"840","last_page":"840"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10528","display_name":"Adipokines, Inflammation, and Metabolic Diseases","score":0.8984000086784363,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10528","display_name":"Adipokines, Inflammation, and Metabolic Diseases","score":0.8984000086784363,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13984","display_name":"Nutrition, Genetics, and Disease","score":0.06120000034570694,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.018300000578165054,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/metabolic-syndrome","display_name":"metabolic syndrome","score":0.9950000047683716},{"id":"https://openalex.org/keywords/il-6-gene-polymorphism","display_name":"IL-6 gene polymorphism","score":0.8500000238418579},{"id":"https://openalex.org/keywords/tnf-gene-polymorphism","display_name":"TNF gene polymorphism","score":0.9190000295639038},{"id":"https://openalex.org/keywords/plasma-fatty-acids","display_name":"plasma fatty acids","score":0.7210000157356262},{"id":"https://openalex.org/keywords/polyunsaturated-to-saturated-fat-ratio","display_name":"polyunsaturated to saturated fat ratio","score":0.8799999952316284},{"id":"https://openalex.org/keywords/fat-intake","display_name":"dietary fat intake","score":0.7609999775886536},{"id":"https://openalex.org/keywords/fasting-hyperglycemia","display_name":"fasting hyperglycemia","score":0.859000027179718},{"id":"https://openalex.org/keywords/systolic-blood-pressure","display_name":"systolic blood pressure","score":0.8899999856948853},{"id":"https://openalex.org/keywords/abdominal-obesity","display_name":"abdominal obesity","score":0.996999979019165},{"id":"https://openalex.org/keywords/genetic-susceptibility","display_name":"genetic susceptibility","score":0.6740000247955322},{"id":"https://openalex.org/keywords/cytokine-gene-polymorphisms","display_name":"cytokine gene polymorphisms","score":0.574999988079071},{"id":"https://openalex.org/keywords/gene-diet-interaction","display_name":"gene-diet interaction","score":0.5249999761581421}],"concepts":[{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7599235773086548},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.757183313369751},{"id":"https://openalex.org/C2780578515","wikidata":"https://www.wikidata.org/wiki/Q657193","display_name":"Metabolic syndrome","level":3,"score":0.7314776182174683},{"id":"https://openalex.org/C543025807","wikidata":"https://www.wikidata.org/wiki/Q61476","display_name":"Fatty acid","level":2,"score":0.5052347779273987},{"id":"https://openalex.org/C17991360","wikidata":"https://www.wikidata.org/wiki/Q21173843","display_name":"Tumor necrosis factor alpha","level":2,"score":0.5044623613357544},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.49957823753356934},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.401456356048584},{"id":"https://openalex.org/C511355011","wikidata":"https://www.wikidata.org/wiki/Q12174","display_name":"Obesity","level":2,"score":0.40109044313430786},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.36670535802841187},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3564545512199402},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.22745543718338013}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1210/endo.151.2.9997","doi":"https://doi.org/10.1210/endo.151.2.9997","is_oa":false,"landing_page_url":"https://doi.org/10.1210/endo.151.2.9997","pdf_url":null,"source":{"id":"https://openalex.org/S157527038","display_name":"Endocrinology","issn_l":"0013-7227","issn":["0013-7227","1945-7170"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrinology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9940000176429749}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2163197436","https://openalex.org/W2588968258","https://openalex.org/W2908960115","https://openalex.org/W2938076614","https://openalex.org/W2123712092","https://openalex.org/W3085137020","https://openalex.org/W2106672539","https://openalex.org/W1969175028","https://openalex.org/W1482643326","https://openalex.org/W2029800502"],"abstract_inverted_index":{"Context:":[0],"Cytokine":[1],"polymorphisms":[2,34],"and":[3,31,38,64,77,89,111,124,138,176,221],"dietary":[4,48],"fat":[5,49,190],"composition":[6],"may":[7],"influence":[8],"the":[9,12,20,25,71,130,136,147,197,206],"risk":[10,37,99,140,145,204],"of":[11,19,47,74,129,146,205],"metabolic":[13],"syndrome":[14],"(MetS).":[15],"Objective:":[16],"The":[17],"objective":[18],"study":[21,73],"was":[22],"to":[23,188],"determine":[24],"relationship":[26],"between":[27],"lymphotoxin-\u03b1":[28],"(LTA),":[29],"TNF-\u03b1,":[30],"IL-6":[32,60,131],"gene":[33],"with":[35,120],"MetS":[36,75,98,148,207],"investigate":[39],"whether":[40],"plasma":[41,65],"fatty":[42,66],"acid":[43],"composition,":[44],"a":[45],"biomarker":[46],"intake,":[50],"modulated":[51],"these":[52,193],"associations.":[53],"Design:":[54],"Polymorphisms":[55],"(LTA":[56],"rs915654,":[57],"TNF-\u03b1":[58,90,139],"rs1800629,":[59],"rs1800797),":[61],"biochemical":[62],"measurements,":[63],"acids":[67],"were":[68],"determined":[69],"in":[70,196],"LIPGENE-SU.VI.MAX":[72],"cases":[76],"matched":[78],"controls":[79],"(n":[80],"=":[81,109,117,154,163,174,184,213],"1754).":[82],"Results:LTA":[83],"rs915654":[84],"minor":[85],"A":[86,125],"allele":[87,94,126],"carriers":[88,142],"rs1800629":[91],"major":[92],"G":[93],"homozygotes":[95,123],"had":[96,201],"increased":[97,144],"[odds":[100],"ratio":[101,191],"(OR)":[102],"1.37":[103],"(confidence":[104],"interval":[105],"[CI]":[106],"1.12-1.66),":[107],"P":[108,116,153,162,173,183,212],"0.002":[110],"OR":[112],"1.35":[113],"(CI":[114,151,160,171,181,210],"1.08-1.70),":[115],"0.009]":[118],"compared":[119],"their":[121],"TT":[122],"carriers.":[127],"Possession":[128],"rs1800797":[132],"GG":[133],"genotype":[134,141],"by":[135],"LTA":[137],"further":[143],"[OR":[149,158,169,179,208],"2.10":[150],"1.19-3.71)":[152],"0.009],":[155],"fasting":[156,215],"hyperglycemia":[157],"2.65":[159],"1.12-6.28),":[161],"0.027],":[164],"high":[165,217],"systolic":[166,218],"blood":[167,219],"pressure":[168],"1.99":[170],"1.07-3.72),":[172],"0.03],":[175],"abdominal":[177,222],"obesity":[178,223],"1.52":[180],"1.01-2.28),":[182],"0.04].":[185],"Plasma":[186],"polyunsaturated":[187],"saturated":[189],"exacerbated":[192],"effects;":[194],"subjects":[195],"lowest":[198],"50th":[199],"percentile":[200],"even":[202],"greater":[203],"4.40":[209],"1.55-12.45),":[211],"0.005],":[214],"hyperglycemia,":[216],"pressure,":[220],"(P":[224],"<":[225],"0.05).":[226]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2019,"cited_by_count":1}],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2022-05-12T00:00:00"}