{"id":"https://openalex.org/W4253399239","doi":"https://doi.org/10.22533/at.ed.0702023045","title":"AVALIA\u00c7\u00c3O DA PROTE\u00cdNA ANTI-INFLAMAT\u00d3RIA ANEXINA A1 EM MODELO DE DOEN\u00c7A PULMONAR OBSTRUTIVA CR\u00d4NICA INDUZIDA POR EXPOSI\u00c7\u00c3O \u00c0 FUMA\u00c7A DO CIGARRO","display_name":"AVALIA\u00c7\u00c3O DA PROTE\u00cdNA ANTI-INFLAMAT\u00d3RIA ANEXINA A1 EM MODELO DE DOEN\u00c7A PULMONAR OBSTRUTIVA CR\u00d4NICA INDUZIDA POR EXPOSI\u00c7\u00c3O \u00c0 FUMA\u00c7A DO CIGARRO","publication_year":2020,"publication_date":"2020-04-23","ids":{"openalex":"https://openalex.org/W4253399239","doi":"https://doi.org/10.22533/at.ed.0702023045"},"language":"pt","primary_location":{"id":"doi:10.22533/at.ed.0702023045","doi":"https://doi.org/10.22533/at.ed.0702023045","is_oa":false,"landing_page_url":"https://doi.org/10.22533/at.ed.0702023045","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Ci\u00eancias da Sa\u00fade: Teoria e Interven\u00e7\u00e3o 2","raw_type":"book-chapter"},"volume":{"id":"https://openalex.org/W4244247989","display_name":"Ci\u00eancias da Sa\u00fade: Teoria e Interven\u00e7\u00e3o 2"},"type":"book-chapter","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/11449/148959","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5054843565","display_name":"Lucas Possebon","orcid":"https://orcid.org/0000-0002-7065-526X","observed_orcids":["https://orcid.org/0000-0002-7065-526X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lucas Possebon","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082477094","display_name":"Sara de Souza Costa","orcid":"https://orcid.org/0000-0002-9359-5482","observed_orcids":["https://orcid.org/0000-0002-9359-5482"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sara de Souza Costa","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017074855","display_name":"Helena Ribeiro Souza","orcid":"https://orcid.org/0000-0002-5645-9123","observed_orcids":["https://orcid.org/0000-0002-5645-9123"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Helena Ribeiro Souza","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016976211","display_name":"Ariane Harumi Yoshikawa","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ariane Harumi Yoshikawa","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015209751","display_name":"Melina Mizusaki Iyomasa-Pilon","orcid":"https://orcid.org/0000-0001-8312-7143","observed_orcids":["https://orcid.org/0000-0001-8312-7143"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Melina Mizusaki Iyomasa-Pilon","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058720078","display_name":"S\u00f4nia Maria Oliani","orcid":"https://orcid.org/0000-0003-0918-2130","observed_orcids":["https://orcid.org/0000-0003-0918-2130"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sonia Maria Oliani","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5089595575","display_name":"Ana Paula Girol","orcid":"https://orcid.org/0000-0002-8760-8945","observed_orcids":["https://orcid.org/0000-0002-8760-8945"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ana Paula Girol","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"41","last_page":"61"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10143","display_name":"Chronic Obstructive Pulmonary Disease (COPD) Research","score":0.5404999852180481,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10143","display_name":"Chronic Obstructive Pulmonary Disease (COPD) Research","score":0.5404999852180481,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12030","display_name":"S100 Proteins and Annexins","score":0.38179999589920044,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.004699999932199717,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/annexin-a1","display_name":"annexin A1","score":0.8980000019073486},{"id":"https://openalex.org/keywords/ac2-26-peptide","display_name":"Ac2-26 peptide","score":0.8820000290870667},{"id":"https://openalex.org/keywords/chronic-obstructive-pulmonary-disease","display_name":"chronic obstructive pulmonary disease","score":0.8989999890327454},{"id":"https://openalex.org/keywords/cigarette-smoke-exposure","display_name":"cigarette smoke exposure","score":0.8939999938011169},{"id":"https://openalex.org/keywords/anti-inflammatory-therapy","display_name":"anti-inflammatory therapy","score":0.824999988079071},{"id":"https://openalex.org/keywords/airway-inflammation","display_name":"airway inflammation","score":0.6869999766349792},{"id":"https://openalex.org/keywords/bronchoalveolar-lavage","display_name":"bronchoalveolar lavage","score":0.8259999752044678},{"id":"https://openalex.org/keywords/inflammatory-cells","display_name":"inflammatory cells","score":0.6629999876022339},{"id":"https://openalex.org/keywords/cytokines","display_name":"cytokines","score":0.9259999990463257},{"id":"https://openalex.org/keywords/lung-histopathology","display_name":"lung histopathology","score":0.6209999918937683},{"id":"https://openalex.org/keywords/emphysema","display_name":"emphysema","score":0.628000020980835},{"id":"https://openalex.org/keywords/rats","display_name":"rats","score":0.3659999966621399},{"id":"https://openalex.org/keywords/hemoglobin","display_name":"hemoglobin","score":0.41499999165534973},{"id":"https://openalex.org/keywords/blood-pressure","display_name":"blood pressure","score":0.621999979019165},{"id":"https://openalex.org/keywords/atherosclerosis","display_name":"atherosclerosis","score":0.46299999952316284},{"id":"https://openalex.org/keywords/airway-hyperresponsiveness","display_name":"airway hyperresponsiveness","score":0.4569999873638153}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.33445507287979126}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.22533/at.ed.0702023045","doi":"https://doi.org/10.22533/at.ed.0702023045","is_oa":false,"landing_page_url":"https://doi.org/10.22533/at.ed.0702023045","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Ci\u00eancias da Sa\u00fade: Teoria e Interven\u00e7\u00e3o 2","raw_type":"book-chapter"},{"id":"pmh:oai:americanae.aecid.es:1756844","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/11449/148959","pdf_url":null,"source":{"id":"https://openalex.org/S4306400786","display_name":"Americanae (AECID Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"reponame:Reposit\u00f3rio Institucional da UNESP","raw_type":"info:eu-repo/semantics/masterThesis"},{"id":"pmh:oai:repositorio.unesp.br:11449/148959","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/11449/148959","pdf_url":null,"source":{"id":"https://openalex.org/S4306402641","display_name":"LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Cient\u00edficas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4383465926","host_organization_name":"LA Referencia","host_organization_lineage":["https://openalex.org/I4383465926"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"instacron:UNESP","raw_type":"info:eu-repo/semantics/masterThesis"}],"best_oa_location":{"id":"pmh:oai:americanae.aecid.es:1756844","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/11449/148959","pdf_url":null,"source":{"id":"https://openalex.org/S4306400786","display_name":"Americanae (AECID Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"reponame:Reposit\u00f3rio Institucional da UNESP","raw_type":"info:eu-repo/semantics/masterThesis"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7120806946","https://openalex.org/W7120901681","https://openalex.org/W7061043796","https://openalex.org/W2887746380","https://openalex.org/W3161525010","https://openalex.org/W7119327714","https://openalex.org/W7120629210","https://openalex.org/W7120332339","https://openalex.org/W2205436868","https://openalex.org/W2969824331"],"abstract_inverted_index":{"O":[0,122],"processo":[1,455],"inflamat\u00f3rio":[2,456],"causado":[3,457],"pelo":[4],"tabagismo":[5],"est\u00e1":[6],"relacionado":[7],"a":[8,25,141,167,180,442],"diferentes":[9],"tipos":[10],"de":[11,54,81,96,110,194,209,219,240,261,314,331,362,374,420,451],"doen\u00e7as":[12,472],"como":[13,253],"enfisema":[14],"pulmonar,":[15],"doen\u00e7a":[16],"pulmonar":[17,182],"obstrutiva":[18],"cr\u00f4nica":[19],"(DPOC)":[20],"e":[21,70,76,95,106,137,165,173,189,200,212,221,223,227,233,249,282,289,303,316,338,349,356,365,370,376,388,393,401,422,424,429,464],"aterosclerose.":[22],"Neste":[23],"cen\u00e1rio,":[24],"prote\u00edna":[26,50],"anti-inflamat\u00f3ria":[27],"AnxA1":[28],"pode":[29],"representar":[30],"uma":[31],"alternativa":[32],"terap\u00eautica.":[33],"Por":[34],"essas":[35],"raz\u00f5es,":[36],"o":[37,73,116,151,202,214,327,411,414,454,469],"objetivo":[38],"da":[39,49,92,133,156,187,243,247,295,357,418],"pesquisa":[40],"foi":[41,125,183,309],"avaliar":[42,140],"os":[43,224,230,336],"efeitos":[44],"do":[45,135,143,175,284,307,354,382,384,407,426,445,462],"pept\u00eddeo":[46,74,152,415,446],"mim\u00e9tico":[47,447],"Ac2-26":[48,448],"AnxA1,":[51,363],"em":[52,60,88,318,399],"modelo":[53,450],"tabagismo.":[55,475],"Ratas":[56],"Wistar":[57],"foram":[58,86,147,163,191,198,271,340],"divididas":[59],"3":[61],"grupos":[62,80],"(n=10/grupo):":[63],"expostos":[64,83,107],"ao":[65,84,159,474],"fumo":[66,85],"n\u00e3o":[67,437],"tratados":[68,71],"(F)":[69],"com":[72,150,320,413],"(F+Ac2-26)":[75],"controles":[77],"(C).":[78],"Os":[79,196],"animais":[82,145,197,368,436],"colocados":[87],"um":[89,114],"equipamento":[90],"espec\u00edfico":[91],"Unidade":[93],"Did\u00e1tica":[94],"Pesquisa":[97],"Experimental":[98],"(UDPE)":[99],"das":[100,256,471],"Faculdades":[101],"Integradas":[102],"Padre":[103],"Albino":[104],"(FIPA),":[105],"\u00e0":[108,460],"queima":[109],"10":[111],"cigarros":[112],"comerciais,":[113],"ap\u00f3s":[115,326],"outro,":[117],"2x/dia,":[118],"por":[119,185,259],"5":[120],"semanas.":[121],"grupo":[123,264,298,344,391],"C":[124,348,369,400],"mantido":[126],"no":[127,171,263,287,293,297,343,380,390,449],"mesmo":[128],"regime,":[129],"por\u00e9m":[130],"na":[131,312],"aus\u00eancia":[132],"fuma\u00e7a":[134,461],"cigarro":[136,463],"tratamento.":[138,328],"Para":[139],"efic\u00e1cia":[142],"Ac2-26,":[144],"F+Ac2-26":[146,302],"administrados":[148],"intraperitonealmente":[149],"(1mg/kg),":[153],"1x/dia,":[154],"antes":[155],"primeira":[157],"exposi\u00e7\u00e3o":[158,459],"cigarro.":[160],"As":[161,235,275,351,372],"ratas":[162],"pesadas":[164],"tiveram":[166],"press\u00e3o":[168,244],"arterial":[169],"aferida":[170],"in\u00edcio":[172],"final":[174],"experimento.":[176],"No":[177],"per\u00edodo":[178],"final,":[179],"ventila\u00e7\u00e3o":[181,250],"verificada":[184],"meio":[186],"pletismografia":[188],"tamb\u00e9m":[190],"realizadas":[192],"imagens":[193,260],"raios-X.":[195],"eutanasiados":[199],"coletados":[201],"lavado":[203],"bronco":[204],"alveolar":[205],"(LBA)":[206],"para":[207,216,229,468],"quantifica\u00e7\u00f5es":[208,330],"c\u00e9lulas":[210,324,332],"inflamat\u00f3rias":[211,333],"citocinas,":[213],"sangue":[215,408],"dosagens":[217,373,405],"bioqu\u00edmicas":[218,406],"citocinas":[220,375],"hemoglobina":[222,421],"\u00f3rg\u00e3os,":[225],"pulm\u00e3o":[226,288,355],"traqueia,":[228],"estudos":[231],"histopatol\u00f3gicos":[232],"imuno-histoqu\u00edmicos.":[234],"an\u00e1lises":[236,276,306,352],"fisiol\u00f3gicas":[237],"mostraram":[238,278,359,409],"perda":[239,290],"peso,":[241],"aumento":[242,283,311,379,417],"arterial,":[245],"redu\u00e7\u00f5es":[246],"frequ\u00eancia":[248],"pulmonares,":[251],"bem":[252],"altera\u00e7\u00f5es":[254],"macrosc\u00f3picas":[255],"dimens\u00f5es":[257],"pulmonares":[258],"raio-X":[262],"F.":[265],"Enquanto,":[266],"nos":[267,334,367,395],"F+Ac2-26,":[268],"esses":[269],"valores":[270],"semelhantes":[272],"aos":[273,347,435],"controles.":[274],"histopatol\u00f3gicas":[277],"maiores":[279],"espa\u00e7os":[280],"intra-alveolares":[281],"tecido":[285],"linfoide":[286],"dos":[291],"c\u00edlios":[292],"epit\u00e9lio":[294],"traqueia":[296,358],"F":[299,345,392],"comparado":[300,346],"as":[301,404],"C.":[304],"Nas":[305,329],"LBA,":[308],"observado":[310],"quantidade":[313],"linf\u00f3citos":[315],"macr\u00f3fagos":[317,337],"F,":[319],"redu\u00e7\u00e3o":[321,394,425],"significante":[322],"dessas":[323],"promovida":[325],"tecidos,":[335],"mast\u00f3citos":[339],"observados":[341],"aumentados":[342],"F+Ac2-26.":[350,371,402],"imuno-histoqu\u00edmicas":[353],"menor":[360],"express\u00e3o":[361],"COX-2":[364],"MMP-9":[366],"quimiocina":[377],"indicaram":[378],"sobrenadante":[381],"macerado":[383],"pulm\u00e3o,":[385],"plasma":[386],"sangu\u00edneo":[387],"LBA":[389],"n\u00edveis":[396],"desses":[397],"mediadores":[398],"Ainda,":[403],"que":[410],"tratamento":[412,470],"ocasionou":[416],"concentra\u00e7\u00e3o":[419],"glicose":[423],"colesterol":[427],"total":[428],"transaminase":[430],"glut\u00e2mico":[431],"oxalac\u00e9tica":[432],"(TGO)":[433],"comparados":[434],"tratados.":[438],"Nossos":[439],"resultados":[440],"evidenciaram":[441],"a\u00e7\u00e3o":[443],"protetora":[444],"DPOC,":[452],"atenuando":[453],"pela":[458],"abre":[465],"novas":[466],"perspectivas":[467],"relacionadas":[473]},"counts_by_year":[],"updated_date":"2026-10-10T09:11:00.788812","created_date":"2022-05-12T00:00:00"}