{"id":"https://openalex.org/W4253316675","doi":"https://doi.org/10.21203/rs.3.rs-324394/v1","title":"Extracellular Vesicles-based Pre-Targeting Strategy Enables Multi-Modal Imaging of Orthotopic Colon Cancer and Image-Guided Surgery","display_name":"Extracellular Vesicles-based Pre-Targeting Strategy Enables Multi-Modal Imaging of Orthotopic Colon Cancer and Image-Guided Surgery","publication_year":2021,"publication_date":"2021-03-18","ids":{"openalex":"https://openalex.org/W4253316675","doi":"https://doi.org/10.21203/rs.3.rs-324394/v1"},"language":"en","primary_location":{"id":"doi:10.21203/rs.3.rs-324394/v1","doi":"https://doi.org/10.21203/rs.3.rs-324394/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-324394/v1","pdf_url":"https://www.researchsquare.com/article/rs-324394/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.researchsquare.com/article/rs-324394/latest.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5045648694","display_name":"Rui Fang An","orcid":"https://orcid.org/0000-0001-6609-7317","observed_orcids":["https://orcid.org/0000-0001-6609-7317"]},"institutions":[{"id":"https://openalex.org/I47720641","display_name":"Huazhong University of Science and Technology","ror":"https://ror.org/00p991c53","country_code":"CN","type":"education","lineage":["https://openalex.org/I47720641"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Rui An","raw_affiliation_strings":["Union Hosptical, Tongji Medical Colledge, Huazhong University of Science and Technology"],"raw_orcid":"https://orcid.org/0000-0001-6609-7317","affiliations":[{"raw_affiliation_string":"Union Hosptical, Tongji Medical Colledge, Huazhong University of Science and Technology","institution_ids":["https://openalex.org/I47720641"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055473059","display_name":"Boping Jing","orcid":"https://orcid.org/0000-0001-8664-201X","observed_orcids":["https://orcid.org/0000-0001-8664-201X"]},"institutions":[{"id":"https://openalex.org/I4210129222","display_name":"Wuhan Union Hospital","ror":"https://ror.org/0371fqr87","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210129222"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Boping Jing","raw_affiliation_strings":["Wuhan Union Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wuhan Union Hospital","institution_ids":["https://openalex.org/I4210129222"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022909271","display_name":"Ruijie Qian","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210129222","display_name":"Wuhan Union Hospital","ror":"https://ror.org/0371fqr87","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210129222"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ruijie Qian","raw_affiliation_strings":["Wuhan Union Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wuhan Union Hospital","institution_ids":["https://openalex.org/I4210129222"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016526230","display_name":"Dawei Jiang","orcid":"https://orcid.org/0000-0002-4072-0075","observed_orcids":["https://orcid.org/0000-0002-4072-0075"]},"institutions":[{"id":"https://openalex.org/I4210129222","display_name":"Wuhan Union Hospital","ror":"https://ror.org/0371fqr87","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210129222"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Dawei Jiang","raw_affiliation_strings":["Wuhan Union Hospital","Wuhan Union Hospital Yongkang Gai Wuhan Union Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wuhan Union Hospital","institution_ids":["https://openalex.org/I4210129222"]},{"raw_affiliation_string":"Wuhan Union Hospital Yongkang Gai Wuhan Union Hospital","institution_ids":["https://openalex.org/I4210129222"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067881552","display_name":"Yongkang Gai","orcid":"https://orcid.org/0000-0001-6766-5240","observed_orcids":["https://orcid.org/0000-0001-6766-5240"]},"institutions":[{"id":"https://openalex.org/I4210129222","display_name":"Wuhan Union Hospital","ror":"https://ror.org/0371fqr87","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210129222"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yongkang Gai","raw_affiliation_strings":["Wuhan Union Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wuhan Union Hospital","institution_ids":["https://openalex.org/I4210129222"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100412034","display_name":"Zhen Liu","orcid":"https://orcid.org/0000-0002-1886-6457","observed_orcids":["https://orcid.org/0000-0002-1886-6457","https://orcid.org/0000-0002-7548-1115"]},"institutions":[{"id":"https://openalex.org/I4210129222","display_name":"Wuhan Union Hospital","ror":"https://ror.org/0371fqr87","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210129222"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhen Liu","raw_affiliation_strings":["Wuhan Union Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wuhan Union Hospital","institution_ids":["https://openalex.org/I4210129222"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047606978","display_name":"Feng Guo","orcid":"https://orcid.org/0000-0003-0882-5296","observed_orcids":["https://orcid.org/0000-0003-0882-5296"]},"institutions":[{"id":"https://openalex.org/I4210129222","display_name":"Wuhan Union Hospital","ror":"https://ror.org/0371fqr87","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210129222"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Feng Guo","raw_affiliation_strings":["Wuhan Union Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wuhan Union Hospital","institution_ids":["https://openalex.org/I4210129222"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051544202","display_name":"Sen Ren","orcid":"https://orcid.org/0000-0002-3674-885X","observed_orcids":["https://orcid.org/0000-0002-3674-885X"]},"institutions":[{"id":"https://openalex.org/I4210129222","display_name":"Wuhan Union Hospital","ror":"https://ror.org/0371fqr87","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210129222"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Sen Ren","raw_affiliation_strings":["Wuhan Union Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wuhan Union Hospital","institution_ids":["https://openalex.org/I4210129222"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054261528","display_name":"Yu Jie Gao","orcid":"https://orcid.org/0009-0003-9397-695X","observed_orcids":["https://orcid.org/0009-0003-9397-695X"]},"institutions":[{"id":"https://openalex.org/I4210129222","display_name":"Wuhan Union Hospital","ror":"https://ror.org/0371fqr87","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210129222"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yu Gao","raw_affiliation_strings":["Wuhan Union Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wuhan Union Hospital","institution_ids":["https://openalex.org/I4210129222"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5080642996","display_name":"Xiaoli Lan","orcid":"https://orcid.org/0000-0002-7263-7399","observed_orcids":["https://orcid.org/0000-0002-7263-7399"]},"institutions":[{"id":"https://openalex.org/I4210129222","display_name":"Wuhan Union Hospital","ror":"https://ror.org/0371fqr87","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210129222"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaoli Lan","raw_affiliation_strings":["Wuhan Union Hospital","Wuhan Union Hospital Research"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wuhan Union Hospital","institution_ids":["https://openalex.org/I4210129222"]},{"raw_affiliation_string":"Wuhan Union Hospital Research","institution_ids":["https://openalex.org/I4210129222"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5045648694"],"corresponding_institution_ids":["https://openalex.org/I47720641"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10773","display_name":"Extracellular vesicles in disease","score":0.7300000190734863,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10773","display_name":"Extracellular vesicles in disease","score":0.7300000190734863,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10782","display_name":"Nanoplatforms for cancer theranostics","score":0.21459999680519104,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.012199999764561653,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/extracellular-vesicles","display_name":"extracellular vesicles","score":0.9959999918937683},{"id":"https://openalex.org/keywords/colon-cancer","display_name":"colon cancer","score":0.9440000057220459},{"id":"https://openalex.org/keywords/image-guided-surgery","display_name":"image-guided surgery","score":0.8379999995231628},{"id":"https://openalex.org/keywords/pretargeting","display_name":"pretargeting","score":0.7549999952316284},{"id":"https://openalex.org/keywords/pet-ct-imaging","display_name":"PET/CT imaging","score":0.781000018119812},{"id":"https://openalex.org/keywords/near-infrared-fluorescence-imaging","display_name":"near-infrared fluorescence imaging","score":0.9829999804496765},{"id":"https://openalex.org/keywords/adipose-derived-stem-cells","display_name":"adipose-derived stem cells","score":0.902999997138977},{"id":"https://openalex.org/keywords/click-chemistry","display_name":"click chemistry","score":0.7049999833106995},{"id":"https://openalex.org/keywords/nanoprobes","display_name":"nanoprobes","score":0.6549999713897705},{"id":"https://openalex.org/keywords/multimodal-imaging","display_name":"multimodal imaging","score":0.7689999938011169},{"id":"https://openalex.org/keywords/tumor-resection","display_name":"tumor resection","score":0.503000020980835},{"id":"https://openalex.org/keywords/orthotopic-tumor-model","display_name":"orthotopic tumor model","score":0.7379999756813049}],"concepts":[{"id":"https://openalex.org/C2992929900","wikidata":"https://www.wikidata.org/wiki/Q21097485","display_name":"Extracellular vesicles","level":2,"score":0.689075767993927},{"id":"https://openalex.org/C71139939","wikidata":"https://www.wikidata.org/wiki/Q910194","display_name":"Modal","level":2,"score":0.5856723785400391},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.5669111013412476},{"id":"https://openalex.org/C31601959","wikidata":"https://www.wikidata.org/wiki/Q931309","display_name":"Medical imaging","level":2,"score":0.43595921993255615},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4043227732181549},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.40004944801330566},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.3209803104400635},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.19805589318275452},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.1810545027256012},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.16735374927520752},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.15706273913383484},{"id":"https://openalex.org/C188027245","wikidata":"https://www.wikidata.org/wiki/Q750446","display_name":"Polymer chemistry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.21203/rs.3.rs-324394/v1","doi":"https://doi.org/10.21203/rs.3.rs-324394/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-324394/v1","pdf_url":"https://www.researchsquare.com/article/rs-324394/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.21203/rs.3.rs-324394/v1","doi":"https://doi.org/10.21203/rs.3.rs-324394/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-324394/v1","pdf_url":"https://www.researchsquare.com/article/rs-324394/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9763000011444092}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3296361681","display_name":null,"funder_award_id":"81873904","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G657857762","display_name":null,"funder_award_id":"82071966","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4253316675.pdf","grobid_xml":"https://content.openalex.org/works/W4253316675.grobid-xml"},"referenced_works_count":20,"referenced_works":["https://openalex.org/W1882802785","https://openalex.org/W1953486725","https://openalex.org/W1977692564","https://openalex.org/W1987462949","https://openalex.org/W2008117298","https://openalex.org/W2060473298","https://openalex.org/W2178935826","https://openalex.org/W2274058631","https://openalex.org/W2413772475","https://openalex.org/W2433297226","https://openalex.org/W2585035491","https://openalex.org/W2757000254","https://openalex.org/W2768241957","https://openalex.org/W2806552206","https://openalex.org/W2920968291","https://openalex.org/W2974786109","https://openalex.org/W2975244376","https://openalex.org/W2997857961","https://openalex.org/W3011486277","https://openalex.org/W3024278242"],"related_works":["https://openalex.org/W6958214443","https://openalex.org/W6902072775","https://openalex.org/W7112944091","https://openalex.org/W4313545320","https://openalex.org/W3118968579","https://openalex.org/W4403545914","https://openalex.org/W2222643713","https://openalex.org/W4388575760","https://openalex.org/W4309914120","https://openalex.org/W4381510213"],"abstract_inverted_index":{"Abstract":[0],"BackgroudColon":[1],"cancer":[2,51,71,214,246],"contributes":[3],"to":[4,42,48,127,137],"high":[5],"mortality":[6],"rates":[7],"as":[8,265],"the":[9,96,100,108,146,151,159,167,176,190,211,223],"result":[10],"of":[11,69,99,169,187,244,262],"incomplete":[12],"resection":[13],"in":[14,66,72,141],"tumor":[15,128,177,224,227],"surgery.":[16,250],"Multimodal":[17],"imaging":[18,140,161,208,243],"can":[19],"provide":[20],"preoperative":[21,217],"evaluation":[22],"and":[23,57,62,85,107,145,158,189,206,226,247],"intraoperative":[24],"image-guiding.":[25],"As":[26],"biocompatible":[27],"nanocarriers,":[28],"extracellular":[29,45,101,120,263],"vesicles":[30,76,88,102,121,264],"hold":[31],"great":[32],"promise":[33],"for":[34,241,259],"multimodal":[35],"imaging.":[36],"In":[37],"this":[38,235,253],"study,":[39],"we":[40],"aim":[41],"synthesized":[43],"an":[44],"vesicles-based":[46],"nanoprobe":[47,237],"visualize":[49],"colon":[50,70,213,245],"with":[52],"positron-emission":[53],"tomography/computed":[54],"tomography":[55],"(PET/CT)":[56],"near-infrared":[58],"fluorescence":[59],"(NIRF)":[60],"imaging,":[61,222],"investigated":[63],"its":[64],"utility":[65],"image-guided":[67,249],"surgery":[68],"animal":[73],"models.":[74],"ResultsExtracellular":[75],"were":[77,89,103],"successfully":[78],"isolated":[79],"from":[80],"adipose-derived":[81],"stem":[82],"cells":[83],"(ADSCs),":[84],"their":[86],"membrane":[87],"observed":[90],"under":[91],"TEM.":[92],"DLS":[93],"detected":[94],"that":[95,119,150,175,203],"hydrodynamic":[97],"diameters":[98],"approximately":[104],"140":[105],"nm":[106],"zeta":[109],"potential":[110],"was":[111,135,155,163],"\u22127.93":[112],"\u00b1":[113],"0.24":[114],"mV.":[115],"Confocal":[116],"microscopy":[117],"showed":[118,149,174,202],"had":[122,178],"a":[123,256],"strong":[124],"binding":[125],"ability":[126],"cells.":[129],"A":[130],"click":[131],"chemistry-based":[132],"pre-targeting":[133,153],"strategy":[134],"used":[136],"achieve":[138],"PET":[139,143],"vivo.":[142],"images":[144,173,180],"biodistribution":[147],"results":[148],"best":[152,160],"time":[154,162,183],"20":[156,195],"h,":[157],"2":[164],"h":[165,196],"after":[166,185,197],"injection":[168],"68Ga-L-NETA-DBCO.":[170],"The":[171],"NIRF":[172,207,221,248],"clear":[179],"at":[181,194],"all":[182],"points":[184],"administration":[186],"nanoparticles":[188],"Tumor/Muscle":[191],"ratio":[192],"peaked":[193],"injection.":[198],"Our":[199],"data":[200],"also":[201],"both":[204],"PET/CT":[205],"clearly":[209,231],"visualized":[210],"orthotopic":[212],"models,":[215],"providing":[216],"evaluation.":[218],"Under":[219],"real-time":[220],"location":[225],"boundary":[228],"could":[229],"be":[230,239],"observed.":[232],"ConclusionsIn":[233],"brief,":[234],"novel":[236],"may":[238],"useful":[240],"multi-modal":[242],"More":[251],"importantly,":[252],"study":[254],"provides":[255],"new":[257],"possibility":[258],"clinical":[260],"application":[261],"nanocarriers.":[266]},"counts_by_year":[{"year":2021,"cited_by_count":1}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2022-05-12T00:00:00"}
