{"id":"https://openalex.org/W4253160941","doi":"https://doi.org/10.1517/14656566.9.10.1773","title":"Arsenic trioxide","display_name":"Arsenic trioxide","publication_year":2008,"publication_date":"2008-06-21","ids":{"openalex":"https://openalex.org/W4253160941","doi":"https://doi.org/10.1517/14656566.9.10.1773","pmid":"https://pubmed.ncbi.nlm.nih.gov/18570609"},"language":"en","primary_location":{"id":"doi:10.1517/14656566.9.10.1773","doi":"https://doi.org/10.1517/14656566.9.10.1773","is_oa":false,"landing_page_url":"https://doi.org/10.1517/14656566.9.10.1773","pdf_url":null,"source":{"id":"https://openalex.org/S52020611","display_name":"Expert Opinion on Pharmacotherapy","issn_l":"1465-6566","issn":["1465-6566","1744-7666"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Expert Opinion on Pharmacotherapy","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5085360755","display_name":"Mark Robert Litzow","orcid":"https://orcid.org/0000-0002-9816-6302","observed_orcids":["https://orcid.org/0000-0002-9816-6302"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Mark R Litzow","raw_affiliation_strings":["Mayo Clinic, Division of Hematology, 200 First Street SW, Rochester, MN 55905, USA. litzow.mark@mayo.edu","+1 507 266 4972","Mayo Clinic, Division of Hematology, 200 First Street SW, Rochester, MN 55905, USA +1 507 284 5362"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Clinic, Division of Hematology, 200 First Street SW, Rochester, MN 55905, USA. litzow.mark@mayo.edu","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"+1 507 266 4972","institution_ids":[]},{"raw_affiliation_string":"Mayo Clinic, Division of Hematology, 200 First Street SW, Rochester, MN 55905, USA +1 507 284 5362","institution_ids":["https://openalex.org/I1330342723"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5085360755"],"corresponding_institution_ids":["https://openalex.org/I1330342723"],"apc_list":null,"apc_paid":null,"fwci":0.4712,"has_fulltext":false,"cited_by_count":45,"citation_normalized_percentile":{"value":0.40356789,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"9","issue":"10","first_page":"1773","last_page":"1785"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11559","display_name":"Retinoids in leukemia and cellular processes","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11559","display_name":"Retinoids in leukemia and cellular processes","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10710","display_name":"Arsenic contamination and mitigation","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2304","display_name":"Environmental Chemistry"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/arsenic-trioxide","display_name":"arsenic trioxide","score":1.0},{"id":"https://openalex.org/keywords/acute-promyelocytic-leukemia","display_name":"acute promyelocytic leukemia","score":0.902999997138977},{"id":"https://openalex.org/keywords/mechanism-of-action","display_name":"mechanism of action","score":0.8349999785423279},{"id":"https://openalex.org/keywords/relapsed-leukemia","display_name":"relapsed leukemia","score":0.6790000200271606},{"id":"https://openalex.org/keywords/anticancer-drug-development","display_name":"anticancer drug development","score":0.5619999766349792},{"id":"https://openalex.org/keywords/clinical-trials","display_name":"clinical trials","score":0.5019999742507935}],"concepts":[{"id":"https://openalex.org/C2780386689","wikidata":"https://www.wikidata.org/wiki/Q7739","display_name":"Arsenic trioxide","level":3,"score":0.9813005924224854},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9098342657089233},{"id":"https://openalex.org/C2776601000","wikidata":"https://www.wikidata.org/wiki/Q612108","display_name":"Acute promyelocytic leukemia","level":4,"score":0.7422635555267334},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.4879586100578308},{"id":"https://openalex.org/C502230775","wikidata":"https://www.wikidata.org/wiki/Q871","display_name":"Arsenic","level":2,"score":0.4834493100643158},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.4732511639595032},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.4588703513145447},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.45368894934654236},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.36058536171913147},{"id":"https://openalex.org/C16005928","wikidata":"https://www.wikidata.org/wiki/Q171171","display_name":"Dermatology","level":1,"score":0.3467099666595459},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C2781121885","wikidata":"https://www.wikidata.org/wiki/Q425517","display_name":"Retinoic acid","level":3,"score":0.0},{"id":"https://openalex.org/C191897082","wikidata":"https://www.wikidata.org/wiki/Q11467","display_name":"Metallurgy","level":1,"score":0.0},{"id":"https://openalex.org/C199539241","wikidata":"https://www.wikidata.org/wiki/Q7748","display_name":"Law","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.0},{"id":"https://openalex.org/C17744445","wikidata":"https://www.wikidata.org/wiki/Q36442","display_name":"Political science","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000077237","descriptor_name":"Arsenic Trioxide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D001152","descriptor_name":"Arsenicals","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D001152","descriptor_name":"Arsenicals","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D001152","descriptor_name":"Arsenicals","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D002986","descriptor_name":"Clinical Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010087","descriptor_name":"Oxides","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D010087","descriptor_name":"Oxides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D010087","descriptor_name":"Oxides","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D012008","descriptor_name":"Recurrence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015473","descriptor_name":"Leukemia, Promyelocytic, Acute","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1517/14656566.9.10.1773","doi":"https://doi.org/10.1517/14656566.9.10.1773","is_oa":false,"landing_page_url":"https://doi.org/10.1517/14656566.9.10.1773","pdf_url":null,"source":{"id":"https://openalex.org/S52020611","display_name":"Expert Opinion on Pharmacotherapy","issn_l":"1465-6566","issn":["1465-6566","1744-7666"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Expert Opinion on Pharmacotherapy","raw_type":"journal-article"},{"id":"pmid:18570609","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18570609","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Expert opinion on pharmacotherapy","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":107,"referenced_works":["https://openalex.org/W66419860","https://openalex.org/W87759113","https://openalex.org/W134636856","https://openalex.org/W246344969","https://openalex.org/W570370693","https://openalex.org/W1503457234","https://openalex.org/W1541929695","https://openalex.org/W1554600230","https://openalex.org/W1692919389","https://openalex.org/W1874426991","https://openalex.org/W1931891535","https://openalex.org/W1965141571","https://openalex.org/W1965388358","https://openalex.org/W1965948236","https://openalex.org/W1967415817","https://openalex.org/W1971017479","https://openalex.org/W1974839297","https://openalex.org/W1977691781","https://openalex.org/W1977783851","https://openalex.org/W1979256395","https://openalex.org/W1979259746","https://openalex.org/W1981044274","https://openalex.org/W1982961577","https://openalex.org/W1988080543","https://openalex.org/W1991406325","https://openalex.org/W1992304316","https://openalex.org/W1995369623","https://openalex.org/W1995745847","https://openalex.org/W2004978917","https://openalex.org/W2007039736","https://openalex.org/W2007819295","https://openalex.org/W2011140047","https://openalex.org/W2017075730","https://openalex.org/W2026035187","https://openalex.org/W2027113610","https://openalex.org/W2029309882","https://openalex.org/W2029439010","https://openalex.org/W2032744013","https://openalex.org/W2033109685","https://openalex.org/W2034377752","https://openalex.org/W2035817692","https://openalex.org/W2038319519","https://openalex.org/W2039699322","https://openalex.org/W2040872477","https://openalex.org/W2042208740","https://openalex.org/W2043195965","https://openalex.org/W2044994704","https://openalex.org/W2045410500","https://openalex.org/W2045561705","https://openalex.org/W2045849246","https://openalex.org/W2046705094","https://openalex.org/W2046818057","https://openalex.org/W2047385837","https://openalex.org/W2053875306","https://openalex.org/W2055182902","https://openalex.org/W2058305307","https://openalex.org/W2061049714","https://openalex.org/W2061415456","https://openalex.org/W2070009086","https://openalex.org/W2074118757","https://openalex.org/W2074133288","https://openalex.org/W2076426515","https://openalex.org/W2079325913","https://openalex.org/W2082267009","https://openalex.org/W2083529200","https://openalex.org/W2084025561","https://openalex.org/W2084599114","https://openalex.org/W2084930093","https://openalex.org/W2085736557","https://openalex.org/W2093210814","https://openalex.org/W2094911226","https://openalex.org/W2095357364","https://openalex.org/W2096971694","https://openalex.org/W2099603517","https://openalex.org/W2104769714","https://openalex.org/W2107719605","https://openalex.org/W2109685720","https://openalex.org/W2110944752","https://openalex.org/W2113138587","https://openalex.org/W2114736068","https://openalex.org/W2116845799","https://openalex.org/W2121529913","https://openalex.org/W2122181070","https://openalex.org/W2122620029","https://openalex.org/W2122906481","https://openalex.org/W2123222392","https://openalex.org/W2123724074","https://openalex.org/W2129662445","https://openalex.org/W2133918059","https://openalex.org/W2142423276","https://openalex.org/W2144217577","https://openalex.org/W2145492248","https://openalex.org/W2146450867","https://openalex.org/W2146712309","https://openalex.org/W2164476317","https://openalex.org/W2165008927","https://openalex.org/W2166687484","https://openalex.org/W2171035085","https://openalex.org/W2184391500","https://openalex.org/W2242790540","https://openalex.org/W2271053812","https://openalex.org/W2314037093","https://openalex.org/W2401071456","https://openalex.org/W2547679356","https://openalex.org/W2562442463","https://openalex.org/W2979549906","https://openalex.org/W4249204451"],"related_works":["https://openalex.org/W2111279921","https://openalex.org/W97451159","https://openalex.org/W2179987098","https://openalex.org/W2592281590","https://openalex.org/W2353741893","https://openalex.org/W2417783687","https://openalex.org/W2062188579","https://openalex.org/W2064116421","https://openalex.org/W2207991208","https://openalex.org/W2375378305"],"abstract_inverted_index":{"BACKGROUND:":[0],"The":[1],"ancient":[2],"drug,":[3],"arsenic,":[4],"has":[5,20,77],"remarkable":[6],"efficacy":[7],"in":[8,27,46,81,88],"the":[9,36,47,82,89,101,113],"treatment":[10,48,90],"of":[11,24,35,38,40,49,59,64,71,84,91,104,115],"relapsed":[12],"acute":[13],"promyelocytic":[14],"leukemia":[15],"(APL)":[16],"and":[17,42,51,62],"this":[18],"success":[19],"led":[21],"to":[22,95,100],"exploration":[23],"its":[25,44,79],"use":[26],"other":[28,52,92],"malignancies.":[29],"OBJECTIVE:":[30],"To":[31],"provide":[32],"an":[33],"overview":[34],"mechanism":[37],"action":[39],"arsenic":[41,75,107],"summarize":[43],"development":[45],"APL":[50],"malignant":[53],"disorders.":[54],"METHODS:":[55],"A":[56,69],"20-year":[57],"search":[58],"MEDLINE,":[60],"EMBASE":[61],"Web":[63],"Science":[65],"was":[66],"conducted.":[67],"RESULTS/CONCLUSIONS:":[68],"series":[70],"clinical":[72,102],"trials":[73],"with":[74],"trioxide":[76,108],"confirmed":[78],"benefit":[80],"therapy":[83,109],"APL.":[85],"Its":[86],"role":[87],"malignancies":[93],"remains":[94],"be":[96],"determined.":[97],"Careful":[98],"attention":[99],"management":[103],"patients":[105],"on":[106],"can":[110],"significantly":[111],"lessen":[112],"risk":[114],"major":[116],"side":[117],"effects.":[118]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":5}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2022-05-12T00:00:00"}