{"id":"https://openalex.org/W4253116052","doi":"https://doi.org/10.1200/jco.2004.22.14_suppl.8056","title":"A double blind, parallel, placebo controlled, dose ranging study on efficacy and safety of oral clodronate in cancer induced osteolysis measured by biochemical markers of bone resorption","display_name":"A double blind, parallel, placebo controlled, dose ranging study on efficacy and safety of oral clodronate in cancer induced osteolysis measured by biochemical markers of bone resorption","publication_year":2004,"publication_date":"2004-07-15","ids":{"openalex":"https://openalex.org/W4253116052","doi":"https://doi.org/10.1200/jco.2004.22.14_suppl.8056"},"language":"en","primary_location":{"id":"doi:10.1200/jco.2004.22.14_suppl.8056","doi":"https://doi.org/10.1200/jco.2004.22.14_suppl.8056","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2004.22.14_suppl.8056","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"J. E. Brown","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800150677","display_name":"Western General Hospital","ror":"https://ror.org/009kr6r15","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1324252669","https://openalex.org/I2800150677"]},{"id":"https://openalex.org/I2801838318","display_name":"Institut Jules Bordet","ror":"https://ror.org/05e8s8534","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I2801838318"]},{"id":"https://openalex.org/I2802526638","display_name":"Ninewells Hospital","ror":"https://ror.org/039c6rk82","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2800860831","https://openalex.org/I2802526638"]},{"id":"https://openalex.org/I91136226","display_name":"University of Sheffield","ror":"https://ror.org/05krs5044","country_code":"GB","type":"education","lineage":["https://openalex.org/I91136226"]}],"countries":["BE","GB"],"is_corresponding":false,"raw_author_name":"J. E. Brown","raw_affiliation_strings":["University of Sheffield, Sheffield, United Kingdom; Ninewells Hospital & Medical School, Dundee, United Kingdom; Institut Jules Bordet, Brussels, Belgium; Western General Hospital, Edinburgh, United Kingdom; Beaston Oncology Centre, Glasgow, United Kingdom; Schering OY, Helsinki, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Sheffield, Sheffield, United Kingdom; Ninewells Hospital & Medical School, Dundee, United Kingdom; Institut Jules Bordet, Brussels, Belgium; Western General Hospital, Edinburgh, United Kingdom; Beaston Oncology Centre, Glasgow, United Kingdom; Schering OY, Helsinki, Finland","institution_ids":["https://openalex.org/I2800150677","https://openalex.org/I2801838318","https://openalex.org/I2802526638","https://openalex.org/I91136226"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037004738","display_name":"Eugene Vincent McCloskey","orcid":"https://orcid.org/0000-0003-0177-8140","observed_orcids":["https://orcid.org/0000-0003-0177-8140"]},"institutions":[{"id":"https://openalex.org/I2800150677","display_name":"Western General Hospital","ror":"https://ror.org/009kr6r15","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1324252669","https://openalex.org/I2800150677"]},{"id":"https://openalex.org/I2801838318","display_name":"Institut Jules Bordet","ror":"https://ror.org/05e8s8534","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I2801838318"]},{"id":"https://openalex.org/I2802526638","display_name":"Ninewells Hospital","ror":"https://ror.org/039c6rk82","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2800860831","https://openalex.org/I2802526638"]},{"id":"https://openalex.org/I91136226","display_name":"University of Sheffield","ror":"https://ror.org/05krs5044","country_code":"GB","type":"education","lineage":["https://openalex.org/I91136226"]}],"countries":["BE","GB"],"is_corresponding":false,"raw_author_name":"E. McCloskey","raw_affiliation_strings":["University of Sheffield, Sheffield, United Kingdom; Ninewells Hospital & Medical School, Dundee, United Kingdom; Institut Jules Bordet, Brussels, Belgium; Western General Hospital, Edinburgh, United Kingdom; Beaston Oncology Centre, Glasgow, United Kingdom; Schering OY, Helsinki, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Sheffield, Sheffield, United Kingdom; Ninewells Hospital & Medical School, Dundee, United Kingdom; Institut Jules Bordet, Brussels, Belgium; Western General Hospital, Edinburgh, United Kingdom; Beaston Oncology Centre, Glasgow, United Kingdom; Schering OY, Helsinki, Finland","institution_ids":["https://openalex.org/I2800150677","https://openalex.org/I2801838318","https://openalex.org/I2802526638","https://openalex.org/I91136226"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111818190","display_name":"J Dewar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800150677","display_name":"Western General Hospital","ror":"https://ror.org/009kr6r15","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1324252669","https://openalex.org/I2800150677"]},{"id":"https://openalex.org/I2801838318","display_name":"Institut Jules Bordet","ror":"https://ror.org/05e8s8534","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I2801838318"]},{"id":"https://openalex.org/I2802526638","display_name":"Ninewells Hospital","ror":"https://ror.org/039c6rk82","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2800860831","https://openalex.org/I2802526638"]},{"id":"https://openalex.org/I91136226","display_name":"University of Sheffield","ror":"https://ror.org/05krs5044","country_code":"GB","type":"education","lineage":["https://openalex.org/I91136226"]}],"countries":["BE","GB"],"is_corresponding":false,"raw_author_name":"J. A. Dewar","raw_affiliation_strings":["University of Sheffield, Sheffield, United Kingdom; Ninewells Hospital & Medical School, Dundee, United Kingdom; Institut Jules Bordet, Brussels, Belgium; Western General Hospital, Edinburgh, United Kingdom; Beaston Oncology Centre, Glasgow, United Kingdom; Schering OY, Helsinki, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Sheffield, Sheffield, United Kingdom; Ninewells Hospital & Medical School, Dundee, United Kingdom; Institut Jules Bordet, Brussels, Belgium; Western General Hospital, Edinburgh, United Kingdom; Beaston Oncology Centre, Glasgow, United Kingdom; Schering OY, Helsinki, Finland","institution_ids":["https://openalex.org/I2800150677","https://openalex.org/I2801838318","https://openalex.org/I2802526638","https://openalex.org/I91136226"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110271682","display_name":"J.J. Body","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800150677","display_name":"Western General Hospital","ror":"https://ror.org/009kr6r15","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1324252669","https://openalex.org/I2800150677"]},{"id":"https://openalex.org/I2801838318","display_name":"Institut Jules Bordet","ror":"https://ror.org/05e8s8534","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I2801838318"]},{"id":"https://openalex.org/I2802526638","display_name":"Ninewells Hospital","ror":"https://ror.org/039c6rk82","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2800860831","https://openalex.org/I2802526638"]},{"id":"https://openalex.org/I91136226","display_name":"University of Sheffield","ror":"https://ror.org/05krs5044","country_code":"GB","type":"education","lineage":["https://openalex.org/I91136226"]}],"countries":["BE","GB"],"is_corresponding":false,"raw_author_name":"J.-J. Body","raw_affiliation_strings":["University of Sheffield, Sheffield, United Kingdom; Ninewells Hospital & Medical School, Dundee, United Kingdom; Institut Jules Bordet, Brussels, Belgium; Western General Hospital, Edinburgh, United Kingdom; Beaston Oncology Centre, Glasgow, United Kingdom; Schering OY, Helsinki, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Sheffield, Sheffield, United Kingdom; Ninewells Hospital & Medical School, Dundee, United Kingdom; Institut Jules Bordet, Brussels, Belgium; Western General Hospital, Edinburgh, United Kingdom; Beaston Oncology Centre, Glasgow, United Kingdom; Schering OY, Helsinki, Finland","institution_ids":["https://openalex.org/I2800150677","https://openalex.org/I2801838318","https://openalex.org/I2802526638","https://openalex.org/I91136226"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007286394","display_name":"David Cameron","orcid":"https://orcid.org/0000-0002-2717-7979","observed_orcids":["https://orcid.org/0000-0002-2717-7979","https://orcid.org/0000-0001-6097-2256"]},"institutions":[{"id":"https://openalex.org/I2800150677","display_name":"Western General Hospital","ror":"https://ror.org/009kr6r15","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1324252669","https://openalex.org/I2800150677"]},{"id":"https://openalex.org/I2801838318","display_name":"Institut Jules Bordet","ror":"https://ror.org/05e8s8534","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I2801838318"]},{"id":"https://openalex.org/I2802526638","display_name":"Ninewells Hospital","ror":"https://ror.org/039c6rk82","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2800860831","https://openalex.org/I2802526638"]},{"id":"https://openalex.org/I91136226","display_name":"University of Sheffield","ror":"https://ror.org/05krs5044","country_code":"GB","type":"education","lineage":["https://openalex.org/I91136226"]}],"countries":["BE","GB"],"is_corresponding":false,"raw_author_name":"D. A. Cameron","raw_affiliation_strings":["University of Sheffield, Sheffield, United Kingdom; Ninewells Hospital & Medical School, Dundee, United Kingdom; Institut Jules Bordet, Brussels, Belgium; Western General Hospital, Edinburgh, United Kingdom; Beaston Oncology Centre, Glasgow, United Kingdom; Schering OY, Helsinki, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Sheffield, Sheffield, United Kingdom; Ninewells Hospital & Medical School, Dundee, United Kingdom; Institut Jules Bordet, Brussels, Belgium; Western General Hospital, Edinburgh, United Kingdom; Beaston Oncology Centre, Glasgow, United Kingdom; Schering OY, Helsinki, Finland","institution_ids":["https://openalex.org/I2800150677","https://openalex.org/I2801838318","https://openalex.org/I2802526638","https://openalex.org/I91136226"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111986454","display_name":"O. Prakash Purohit","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800150677","display_name":"Western General Hospital","ror":"https://ror.org/009kr6r15","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1324252669","https://openalex.org/I2800150677"]},{"id":"https://openalex.org/I2801838318","display_name":"Institut Jules Bordet","ror":"https://ror.org/05e8s8534","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I2801838318"]},{"id":"https://openalex.org/I2802526638","display_name":"Ninewells Hospital","ror":"https://ror.org/039c6rk82","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2800860831","https://openalex.org/I2802526638"]},{"id":"https://openalex.org/I91136226","display_name":"University of Sheffield","ror":"https://ror.org/05krs5044","country_code":"GB","type":"education","lineage":["https://openalex.org/I91136226"]}],"countries":["BE","GB"],"is_corresponding":false,"raw_author_name":"O. P.-K. Purohit","raw_affiliation_strings":["University of Sheffield, Sheffield, United Kingdom; Ninewells Hospital & Medical School, Dundee, United Kingdom; Institut Jules Bordet, Brussels, Belgium; Western General Hospital, Edinburgh, United Kingdom; Beaston Oncology Centre, Glasgow, United Kingdom; Schering OY, Helsinki, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Sheffield, Sheffield, United Kingdom; Ninewells Hospital & Medical School, Dundee, United Kingdom; Institut Jules Bordet, Brussels, Belgium; Western General Hospital, Edinburgh, United Kingdom; Beaston Oncology Centre, Glasgow, United Kingdom; Schering OY, Helsinki, Finland","institution_ids":["https://openalex.org/I2800150677","https://openalex.org/I2801838318","https://openalex.org/I2802526638","https://openalex.org/I91136226"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111740830","display_name":"Adrian N Harnett","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800150677","display_name":"Western General Hospital","ror":"https://ror.org/009kr6r15","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1324252669","https://openalex.org/I2800150677"]},{"id":"https://openalex.org/I2801838318","display_name":"Institut Jules Bordet","ror":"https://ror.org/05e8s8534","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I2801838318"]},{"id":"https://openalex.org/I2802526638","display_name":"Ninewells Hospital","ror":"https://ror.org/039c6rk82","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2800860831","https://openalex.org/I2802526638"]},{"id":"https://openalex.org/I91136226","display_name":"University of Sheffield","ror":"https://ror.org/05krs5044","country_code":"GB","type":"education","lineage":["https://openalex.org/I91136226"]}],"countries":["BE","GB"],"is_corresponding":false,"raw_author_name":"A. Harnett","raw_affiliation_strings":["University of Sheffield, Sheffield, United Kingdom; Ninewells Hospital & Medical School, Dundee, United Kingdom; Institut Jules Bordet, Brussels, Belgium; Western General Hospital, Edinburgh, United Kingdom; Beaston Oncology Centre, Glasgow, United Kingdom; Schering OY, Helsinki, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Sheffield, Sheffield, United Kingdom; Ninewells Hospital & Medical School, Dundee, United Kingdom; Institut Jules Bordet, Brussels, Belgium; Western General Hospital, Edinburgh, United Kingdom; Beaston Oncology Centre, Glasgow, United Kingdom; Schering OY, Helsinki, Finland","institution_ids":["https://openalex.org/I2800150677","https://openalex.org/I2801838318","https://openalex.org/I2802526638","https://openalex.org/I91136226"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026865923","display_name":"Riitta T\u00e4htel\u00e4","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800150677","display_name":"Western General Hospital","ror":"https://ror.org/009kr6r15","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1324252669","https://openalex.org/I2800150677"]},{"id":"https://openalex.org/I2801838318","display_name":"Institut Jules Bordet","ror":"https://ror.org/05e8s8534","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I2801838318"]},{"id":"https://openalex.org/I2802526638","display_name":"Ninewells Hospital","ror":"https://ror.org/039c6rk82","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2800860831","https://openalex.org/I2802526638"]},{"id":"https://openalex.org/I91136226","display_name":"University of Sheffield","ror":"https://ror.org/05krs5044","country_code":"GB","type":"education","lineage":["https://openalex.org/I91136226"]}],"countries":["BE","GB"],"is_corresponding":false,"raw_author_name":"R. Tahtela","raw_affiliation_strings":["University of Sheffield, Sheffield, United Kingdom; Ninewells Hospital & Medical School, Dundee, United Kingdom; Institut Jules Bordet, Brussels, Belgium; Western General Hospital, Edinburgh, United Kingdom; Beaston Oncology Centre, Glasgow, United Kingdom; Schering OY, Helsinki, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Sheffield, Sheffield, United Kingdom; Ninewells Hospital & Medical School, Dundee, United Kingdom; Institut Jules Bordet, Brussels, Belgium; Western General Hospital, Edinburgh, United Kingdom; Beaston Oncology Centre, Glasgow, United Kingdom; Schering OY, Helsinki, Finland","institution_ids":["https://openalex.org/I2800150677","https://openalex.org/I2801838318","https://openalex.org/I2802526638","https://openalex.org/I91136226"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074727283","display_name":"M. Kurkilahti","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800150677","display_name":"Western General Hospital","ror":"https://ror.org/009kr6r15","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1324252669","https://openalex.org/I2800150677"]},{"id":"https://openalex.org/I2801838318","display_name":"Institut Jules Bordet","ror":"https://ror.org/05e8s8534","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I2801838318"]},{"id":"https://openalex.org/I2802526638","display_name":"Ninewells Hospital","ror":"https://ror.org/039c6rk82","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2800860831","https://openalex.org/I2802526638"]},{"id":"https://openalex.org/I91136226","display_name":"University of Sheffield","ror":"https://ror.org/05krs5044","country_code":"GB","type":"education","lineage":["https://openalex.org/I91136226"]}],"countries":["BE","GB"],"is_corresponding":false,"raw_author_name":"M. Kurkilahti","raw_affiliation_strings":["University of Sheffield, Sheffield, United Kingdom; Ninewells Hospital & Medical School, Dundee, United Kingdom; Institut Jules Bordet, Brussels, Belgium; Western General Hospital, Edinburgh, United Kingdom; Beaston Oncology Centre, Glasgow, United Kingdom; Schering OY, Helsinki, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Sheffield, Sheffield, United Kingdom; Ninewells Hospital & Medical School, Dundee, United Kingdom; Institut Jules Bordet, Brussels, Belgium; Western General Hospital, Edinburgh, United Kingdom; Beaston Oncology Centre, Glasgow, United Kingdom; Schering OY, Helsinki, Finland","institution_ids":["https://openalex.org/I2800150677","https://openalex.org/I2801838318","https://openalex.org/I2802526638","https://openalex.org/I91136226"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5112862080","display_name":"Rob Coleman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800150677","display_name":"Western General Hospital","ror":"https://ror.org/009kr6r15","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1324252669","https://openalex.org/I2800150677"]},{"id":"https://openalex.org/I2801838318","display_name":"Institut Jules Bordet","ror":"https://ror.org/05e8s8534","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I2801838318"]},{"id":"https://openalex.org/I2802526638","display_name":"Ninewells Hospital","ror":"https://ror.org/039c6rk82","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2800860831","https://openalex.org/I2802526638"]},{"id":"https://openalex.org/I91136226","display_name":"University of Sheffield","ror":"https://ror.org/05krs5044","country_code":"GB","type":"education","lineage":["https://openalex.org/I91136226"]}],"countries":["BE","GB"],"is_corresponding":false,"raw_author_name":"R. E. Coleman","raw_affiliation_strings":["University of Sheffield, Sheffield, United Kingdom; Ninewells Hospital & Medical School, Dundee, United Kingdom; Institut Jules Bordet, Brussels, Belgium; Western General Hospital, Edinburgh, United Kingdom; Beaston Oncology Centre, Glasgow, United Kingdom; Schering OY, Helsinki, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Sheffield, Sheffield, United Kingdom; Ninewells Hospital & Medical School, Dundee, United Kingdom; Institut Jules Bordet, Brussels, Belgium; Western General Hospital, Edinburgh, United Kingdom; Beaston Oncology Centre, Glasgow, United Kingdom; Schering OY, Helsinki, Finland","institution_ids":["https://openalex.org/I2800150677","https://openalex.org/I2801838318","https://openalex.org/I2802526638","https://openalex.org/I91136226"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"22","issue":"14_suppl","first_page":"8056","last_page":"8056"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11221","display_name":"Bone health and treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11221","display_name":"Bone health and treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10071","display_name":"Bone health and osteoporosis research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12108","display_name":"Management of metastatic bone disease","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/clodronate","display_name":"clodronate","score":0.9959999918937683},{"id":"https://openalex.org/keywords/bisphosphonates","display_name":"bisphosphonates","score":0.9739999771118164},{"id":"https://openalex.org/keywords/bone-metastases","display_name":"bone metastasis","score":0.921999990940094},{"id":"https://openalex.org/keywords/dose-ranging-study","display_name":"dose-ranging","score":0.7760000228881836},{"id":"https://openalex.org/keywords/urinary-n-telopeptide","display_name":"urinary N-telopeptide","score":0.8489999771118164},{"id":"https://openalex.org/keywords/c-terminal-telopeptide","display_name":"C-terminal telopeptide","score":0.8970000147819519},{"id":"https://openalex.org/keywords/bone-resorption-markers","display_name":"bone resorption markers","score":0.9089999794960022},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.953000009059906},{"id":"https://openalex.org/keywords/prostate-cancer","display_name":"prostate cancer","score":0.9950000047683716}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9234853982925415},{"id":"https://openalex.org/C2781282405","wikidata":"https://www.wikidata.org/wiki/Q2035084","display_name":"Osteolysis","level":2,"score":0.7367395758628845},{"id":"https://openalex.org/C125870589","wikidata":"https://www.wikidata.org/wiki/Q16959485","display_name":"N-terminal telopeptide","level":5,"score":0.7353631258010864},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.6709961891174316},{"id":"https://openalex.org/C2776312127","wikidata":"https://www.wikidata.org/wiki/Q5299247","display_name":"Dose-ranging study","level":5,"score":0.6602680087089539},{"id":"https://openalex.org/C673006","wikidata":"https://www.wikidata.org/wiki/Q4941581","display_name":"Bone resorption","level":2,"score":0.6173161864280701},{"id":"https://openalex.org/C2777251235","wikidata":"https://www.wikidata.org/wiki/Q412205","display_name":"Bisphosphonate","level":3,"score":0.5755700469017029},{"id":"https://openalex.org/C126894567","wikidata":"https://www.wikidata.org/wiki/Q105650","display_name":"Urology","level":1,"score":0.5594757199287415},{"id":"https://openalex.org/C2777783956","wikidata":"https://www.wikidata.org/wiki/Q848085","display_name":"Bone metastasis","level":4,"score":0.5263779759407043},{"id":"https://openalex.org/C203092338","wikidata":"https://www.wikidata.org/wiki/Q1340863","display_name":"Clinical endpoint","level":3,"score":0.5156199336051941},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.5077808499336243},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4909546673297882},{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.43706053495407104},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.4355643391609192},{"id":"https://openalex.org/C2776169692","wikidata":"https://www.wikidata.org/wiki/Q4941552","display_name":"Bone disease","level":3,"score":0.41552498936653137},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.35558104515075684},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3479178249835968},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.32581794261932373},{"id":"https://openalex.org/C2776541429","wikidata":"https://www.wikidata.org/wiki/Q165328","display_name":"Osteoporosis","level":2,"score":0.30134880542755127},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.28999653458595276},{"id":"https://openalex.org/C131075544","wikidata":"https://www.wikidata.org/wiki/Q415863","display_name":"Osteocalcin","level":4,"score":0.15276485681533813},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.15172043442726135},{"id":"https://openalex.org/C2991744798","wikidata":"https://www.wikidata.org/wiki/Q608510","display_name":"Double blind","level":4,"score":0.09557005763053894},{"id":"https://openalex.org/C160160445","wikidata":"https://www.wikidata.org/wiki/Q24769688","display_name":"Alkaline phosphatase","level":3,"score":0.0},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1200/jco.2004.22.14_suppl.8056","doi":"https://doi.org/10.1200/jco.2004.22.14_suppl.8056","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2004.22.14_suppl.8056","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},{"id":"doi:10.1200/jco.2004.22.90140.8056","doi":"https://doi.org/10.1200/jco.2004.22.90140.8056","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2004.22.90140.8056","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2082107301","https://openalex.org/W1783763910","https://openalex.org/W2255970940","https://openalex.org/W2333181510","https://openalex.org/W1875067624","https://openalex.org/W2413258146","https://openalex.org/W130505114","https://openalex.org/W2135535385","https://openalex.org/W1906721103","https://openalex.org/W2037542472"],"abstract_inverted_index":{"8056":[0],"Background:":[1],"The":[2,165,177,232],"bisphosphonate":[3],"clodronate":[4,57,90,159],"is":[5,211],"effective":[6,131],"in":[7,64,99,132,137,182],"the":[8,45,48,53,183,191,196,212,226,237],"treatment":[9,184],"of":[10,18,47,55,62,115,124,149,158,179,204,241],"osteolytic":[11],"bone":[12,38,75,117,220],"metastases":[13],"at":[14],"an":[15],"oral":[16,56,89],"dose":[17,105,167],"1600":[19,125,242],"mg":[20,29,32,126,198,243,249],"per":[21],"day.":[22],"However":[23],"other":[24,83],"doses":[25,63],"such":[26,214],"as":[27,40,225],"2400":[28,93,248],"and":[30,81,94,147,172],"3200":[31,95,197],"have":[33,222],"also":[34,251],"been":[35,223],"used.":[36],"Using":[37],"markers":[39,118,221],"surrogate":[41],"biomarkers":[42],"for":[43,144,195],"osteolysis,":[44],"purpose":[46],"study":[49,108,216],"was":[50,186],"to":[51,88,229],"investigate":[52],"efficacy":[54],"(BONEFOS\u00ae)":[58],"across":[59],"a":[60,100,134,169,201],"range":[61],"patients":[65,72,205],"with":[66,73,109,217,236],"tumour":[67,84],"induced":[68],"osteolysis.":[69],"Methods:":[70],"125":[71],"metastatic":[74],"disease":[76],"(87":[77],"breast,":[78],"33":[79],"prostate":[80],"5":[82],"types)":[85],"were":[86,119,129,160],"randomized":[87],"(800,":[91],"1600,":[92],"mg)":[96],"or":[97,127,260,263],"placebo":[98,173,192],"phase":[101],"II":[102],"double":[103],"blind,":[104],"ranging,":[106],"multicentre":[107],"ethical":[110],"approval.":[111],"During":[112],"6":[113],"weeks":[114],"treatment,":[116],"assessed":[120],"weekly.":[121],"Results:":[122],"Doses":[123],"above":[128],"all":[130],"producing":[133],"mean":[135],"fall":[136],"both":[138],"urinary":[139],"N-telopeptide":[140],"(NTX,":[141],"see":[142],"table":[143],"breast":[145],"data)":[146],"C-telopeptide":[148],"over":[150],"40":[151],"%":[152],"from":[153,190],"baseline":[154],"values.":[155],"Moreover,":[156],"effects":[157],"seen":[161],"by":[162],"1":[163],"week.":[164],"800mg":[166],"gave":[168,174],"smaller":[170],"effect":[171],"no":[175],"effect.":[176],"number":[178,203],"adverse":[180],"events":[181],"arms":[185],"not":[187],"significantly":[188],"different":[189],"arm,":[193],"except":[194],"dose,":[199],"where":[200,219],"higher":[202],"had":[206],"significant":[207],"diarrhoea.":[208],"Conclusions:":[209],"This":[210],"first":[213],"dose-ranging":[215],"clodronate,":[218],"used":[224,253],"primary":[227],"end-point":[228],"assess":[230],"efficacy.":[231],"data":[233],"are":[234],"consistent":[235],"known":[238],"clinical":[239],"use":[240],"daily,":[244],"but":[245],"suggest":[246],"that":[247],"may":[250],"be":[252],"without":[254],"increased":[255],"toxicity.":[256],"Author":[257],"Disclosure":[258],"Employment":[259],"Leadership":[261],"Consultant":[262],"Advisory":[264],"Stock":[265],"Ownership":[266],"Honoraria":[267],"Research":[268],"Funding":[269],"Expert":[270],"Testimony":[271],"Other":[272],"Remuneration":[273],"Schering":[274,276,278,280],"OY":[275,277,279,281]},"counts_by_year":[],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2022-05-12T00:00:00"}