{"id":"https://openalex.org/W4252716636","doi":"https://doi.org/10.1194/jlr.m600163-jlr200","title":"Regulation of ABCA1 expression in human keratinocytes and murine epidermis","display_name":"Regulation of ABCA1 expression in human keratinocytes and murine epidermis","publication_year":2006,"publication_date":"2006-07-07","ids":{"openalex":"https://openalex.org/W4252716636","doi":"https://doi.org/10.1194/jlr.m600163-jlr200","pmid":"https://pubmed.ncbi.nlm.nih.gov/16825673"},"language":"en","primary_location":{"id":"doi:10.1194/jlr.m600163-jlr200","doi":"https://doi.org/10.1194/jlr.m600163-jlr200","is_oa":true,"landing_page_url":"https://doi.org/10.1194/jlr.m600163-jlr200","pdf_url":null,"source":{"id":"https://openalex.org/S11400418","display_name":"Journal of Lipid Research","issn_l":"0022-2275","issn":["0022-2275","1539-7262"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Lipid Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1194/jlr.m600163-jlr200","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111603319","display_name":"Yan J. Jiang","orcid":"https://orcid.org/0000-0002-5535-8347","observed_orcids":["https://orcid.org/0000-0002-5535-8347"]},"institutions":[{"id":"https://openalex.org/I1315708478","display_name":"San Francisco VA Medical Center","ror":"https://ror.org/049peqw80","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1315708478","https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210125474","https://openalex.org/I4210143381"]},{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]},{"id":"https://openalex.org/I4210166254","display_name":"Northern California Institute for Research and Education","ror":"https://ror.org/05p48p517","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210166254"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yan J. Jiang","raw_affiliation_strings":["Metabolism Section, Veterans Affairs Medical Center, Northern California Institute for Research and Education, University of California at San Francisco, San Francisco, CA 94121, USA","Metabolism Section, Veterans Affairs Medical Center, Northern California Institute for Research and Education, University of California at San Francisco, San Francisco, CA 94121"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Metabolism Section, Veterans Affairs Medical Center, Northern California Institute for Research and Education, University of California at San Francisco, San Francisco, CA 94121, USA","institution_ids":["https://openalex.org/I1315708478","https://openalex.org/I180670191","https://openalex.org/I4210166254"]},{"raw_affiliation_string":"Metabolism Section, Veterans Affairs Medical Center, Northern California Institute for Research and Education, University of California at San Francisco, San Francisco, CA 94121","institution_ids":["https://openalex.org/I1315708478","https://openalex.org/I180670191","https://openalex.org/I4210166254"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102901261","display_name":"Biao L\u00fc","orcid":"https://orcid.org/0000-0002-0307-9901","observed_orcids":["https://orcid.org/0000-0002-0307-9901"]},"institutions":[{"id":"https://openalex.org/I1315708478","display_name":"San Francisco VA Medical Center","ror":"https://ror.org/049peqw80","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1315708478","https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210125474","https://openalex.org/I4210143381"]},{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]},{"id":"https://openalex.org/I4210166254","display_name":"Northern California Institute for Research and Education","ror":"https://ror.org/05p48p517","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210166254"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Biao Lu","raw_affiliation_strings":["Metabolism Section, Veterans Affairs Medical Center, Northern California Institute for Research and Education, University of California at San Francisco, San Francisco, CA 94121"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Metabolism Section, Veterans Affairs Medical Center, Northern California Institute for Research and Education, University of California at San Francisco, San Francisco, CA 94121","institution_ids":["https://openalex.org/I1315708478","https://openalex.org/I180670191","https://openalex.org/I4210166254"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090934820","display_name":"Peggy Kim","orcid":"https://orcid.org/0000-0003-2256-2111","observed_orcids":["https://orcid.org/0000-0003-2256-2111"]},"institutions":[{"id":"https://openalex.org/I1315708478","display_name":"San Francisco VA Medical Center","ror":"https://ror.org/049peqw80","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1315708478","https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210125474","https://openalex.org/I4210143381"]},{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]},{"id":"https://openalex.org/I4210166254","display_name":"Northern California Institute for Research and Education","ror":"https://ror.org/05p48p517","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210166254"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peggy Kim","raw_affiliation_strings":["Metabolism Section, Veterans Affairs Medical Center, Northern California Institute for Research and Education, University of California at San Francisco, San Francisco, CA 94121"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Metabolism Section, Veterans Affairs Medical Center, Northern California Institute for Research and Education, University of California at San Francisco, San Francisco, CA 94121","institution_ids":["https://openalex.org/I1315708478","https://openalex.org/I180670191","https://openalex.org/I4210166254"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050608918","display_name":"Peter M. Elias","orcid":"https://orcid.org/0000-0001-7989-4032","observed_orcids":["https://orcid.org/0000-0001-7989-4032"]},"institutions":[{"id":"https://openalex.org/I1315708478","display_name":"San Francisco VA Medical Center","ror":"https://ror.org/049peqw80","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1315708478","https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210125474","https://openalex.org/I4210143381"]},{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]},{"id":"https://openalex.org/I4210166254","display_name":"Northern California Institute for Research and Education","ror":"https://ror.org/05p48p517","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210166254"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peter M. Elias","raw_affiliation_strings":["Dermatology Service, Veterans Affairs Medical Center, Northern California Institute for Research and Education, University of California at San Francisco, San Francisco, CA 94121"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dermatology Service, Veterans Affairs Medical Center, Northern California Institute for Research and Education, University of California at San Francisco, San Francisco, CA 94121","institution_ids":["https://openalex.org/I1315708478","https://openalex.org/I180670191","https://openalex.org/I4210166254"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108080994","display_name":"Kenneth R. Feingold","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1315708478","display_name":"San Francisco VA Medical Center","ror":"https://ror.org/049peqw80","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1315708478","https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210125474","https://openalex.org/I4210143381"]},{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]},{"id":"https://openalex.org/I4210166254","display_name":"Northern California Institute for Research and Education","ror":"https://ror.org/05p48p517","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210166254"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Kenneth R. Feingold","raw_affiliation_strings":["Metabolism Section, Veterans Affairs Medical Center, Northern California Institute for Research and Education, University of California at San Francisco, San Francisco, CA 94121"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Metabolism Section, Veterans Affairs Medical Center, Northern California Institute for Research and Education, University of California at San Francisco, San Francisco, CA 94121","institution_ids":["https://openalex.org/I1315708478","https://openalex.org/I180670191","https://openalex.org/I4210166254"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5108080994"],"corresponding_institution_ids":["https://openalex.org/I1315708478","https://openalex.org/I180670191","https://openalex.org/I4210166254"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":4.0667,"has_fulltext":false,"cited_by_count":53,"citation_normalized_percentile":{"value":0.9369861,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"47","issue":"10","first_page":"2248","last_page":"2258"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11618","display_name":"Cholesterol and Lipid Metabolism","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11618","display_name":"Cholesterol and Lipid Metabolism","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11072","display_name":"Peroxisome Proliferator-Activated Receptors","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/abca1","display_name":"ABCA1","score":1.0},{"id":"https://openalex.org/keywords/keratinocytes","display_name":"keratinocytes","score":0.9179999828338623},{"id":"https://openalex.org/keywords/epidermis","display_name":"epidermis","score":0.9660000205039978},{"id":"https://openalex.org/keywords/cholesterol-efflux","display_name":"cholesterol efflux","score":0.9300000071525574},{"id":"https://openalex.org/keywords/cholesterol-homeostasis","display_name":"cholesterol homeostasis","score":0.9779999852180481},{"id":"https://openalex.org/keywords/permeability-barrier","display_name":"permeability barrier","score":0.7580000162124634},{"id":"https://openalex.org/keywords/liver-x-receptor","display_name":"liver X receptor","score":0.9100000262260437},{"id":"https://openalex.org/keywords/pparalpha","display_name":"PPAR\u03b1","score":0.7850000262260437},{"id":"https://openalex.org/keywords/ppardelta","display_name":"PPAR\u03b4","score":0.9829999804496765},{"id":"https://openalex.org/keywords/retinoid-x-receptor","display_name":"retinoid X receptor","score":0.984000027179718},{"id":"https://openalex.org/keywords/low-density-lipoprotein","display_name":"low-density lipoprotein","score":0.5550000071525574},{"id":"https://openalex.org/keywords/mevalonate","display_name":"mevalonate","score":0.9729999899864197},{"id":"https://openalex.org/keywords/statins","display_name":"statins","score":0.9919999837875366},{"id":"https://openalex.org/keywords/cholesterol-sulfate","display_name":"cholesterol sulfate","score":0.7599999904632568},{"id":"https://openalex.org/keywords/tape-stripping","display_name":"tape stripping","score":0.7490000128746033},{"id":"https://openalex.org/keywords/acetone","display_name":"acetone","score":0.871999979019165}],"concepts":[{"id":"https://openalex.org/C2777704780","wikidata":"https://www.wikidata.org/wiki/Q21115210","display_name":"ABCA1","level":4,"score":0.9594631195068359},{"id":"https://openalex.org/C167400880","wikidata":"https://www.wikidata.org/wiki/Q3454539","display_name":"Liver X receptor","level":5,"score":0.7834591865539551},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.6607010364532471},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5096688270568848},{"id":"https://openalex.org/C51911345","wikidata":"https://www.wikidata.org/wiki/Q4863604","display_name":"Barrier function","level":2,"score":0.49825191497802734},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4837948977947235},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.45510023832321167},{"id":"https://openalex.org/C2910322942","wikidata":"https://www.wikidata.org/wiki/Q21115210","display_name":"ATP Binding Cassette Transporter 1","level":5,"score":0.43855389952659607},{"id":"https://openalex.org/C110459506","wikidata":"https://www.wikidata.org/wiki/Q7318217","display_name":"Reverse cholesterol transport","level":4,"score":0.42676201462745667},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.40933215618133545},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.40560805797576904},{"id":"https://openalex.org/C63932345","wikidata":"https://www.wikidata.org/wiki/Q422500","display_name":"Nuclear receptor","level":4,"score":0.37636905908584595},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.23440870642662048},{"id":"https://openalex.org/C2780072125","wikidata":"https://www.wikidata.org/wiki/Q28350","display_name":"Lipoprotein","level":3,"score":0.17314550280570984},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.16196215152740479},{"id":"https://openalex.org/C149011108","wikidata":"https://www.wikidata.org/wiki/Q652985","display_name":"Transporter","level":3,"score":0.15130874514579773},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.08998891711235046},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000071518","descriptor_name":"Liver X Receptors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004789","descriptor_name":"Enzyme Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004817","descriptor_name":"Epidermis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015152","descriptor_name":"Blotting, Northern","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015603","descriptor_name":"Keratinocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018160","descriptor_name":"Receptors, Cytoplasmic and Nuclear","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018528","descriptor_name":"ATP-Binding Cassette Transporters","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D018528","descriptor_name":"ATP-Binding Cassette Transporters","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D047488","descriptor_name":"Retinoid X Receptors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D047495","descriptor_name":"PPAR gamma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D052816","descriptor_name":"Foreskin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057093","descriptor_name":"Orphan Nuclear Receptors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064286","descriptor_name":"ATP Binding Cassette Transporter 1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1194/jlr.m600163-jlr200","doi":"https://doi.org/10.1194/jlr.m600163-jlr200","is_oa":true,"landing_page_url":"https://doi.org/10.1194/jlr.m600163-jlr200","pdf_url":null,"source":{"id":"https://openalex.org/S11400418","display_name":"Journal of Lipid Research","issn_l":"0022-2275","issn":["0022-2275","1539-7262"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Lipid Research","raw_type":"journal-article"},{"id":"pmid:16825673","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16825673","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of lipid research","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.334.9619","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.334.9619","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.jlr.org/content/47/10/2248.full.pdf","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:33a47b2967da4a5c956ac0e22fcbbeda","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/33a47b2967da4a5c956ac0e22fcbbeda","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Lipid Research, Vol 47, Iss 10, Pp 2248-2258 (2006)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1194/jlr.m600163-jlr200","doi":"https://doi.org/10.1194/jlr.m600163-jlr200","is_oa":true,"landing_page_url":"https://doi.org/10.1194/jlr.m600163-jlr200","pdf_url":null,"source":{"id":"https://openalex.org/S11400418","display_name":"Journal of Lipid Research","issn_l":"0022-2275","issn":["0022-2275","1539-7262"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Lipid Research","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.8999999761581421,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G2177667179","display_name":null,"funder_award_id":"AR 050629","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"},{"id":"https://openalex.org/G4934480880","display_name":"PPARs and LXR Regulate Epidermal Differentiation","funder_award_id":"R01AR050629","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"},{"id":"https://openalex.org/G5258078802","display_name":null,"funder_award_id":"AR39448","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"},{"id":"https://openalex.org/G6460069243","display_name":"Relationship of Keratinocyte Function to Differentiation","funder_award_id":"P01AR039448","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"}],"funders":[{"id":"https://openalex.org/F4320337362","display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","ror":"https://ror.org/006zn3t30"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":51,"referenced_works":["https://openalex.org/W128536076","https://openalex.org/W180788089","https://openalex.org/W1524478189","https://openalex.org/W1796779887","https://openalex.org/W1858990538","https://openalex.org/W1860908381","https://openalex.org/W1886532757","https://openalex.org/W1923430025","https://openalex.org/W1964795669","https://openalex.org/W1973649841","https://openalex.org/W1975045025","https://openalex.org/W1985196273","https://openalex.org/W1986256219","https://openalex.org/W1988967018","https://openalex.org/W1997073923","https://openalex.org/W2004168108","https://openalex.org/W2007956036","https://openalex.org/W2013278446","https://openalex.org/W2022670053","https://openalex.org/W2046797281","https://openalex.org/W2048216962","https://openalex.org/W2052130357","https://openalex.org/W2059129424","https://openalex.org/W2077749125","https://openalex.org/W2078643477","https://openalex.org/W2080254988","https://openalex.org/W2085329188","https://openalex.org/W2088364769","https://openalex.org/W2088464509","https://openalex.org/W2092806318","https://openalex.org/W2093296161","https://openalex.org/W2094753712","https://openalex.org/W2097228145","https://openalex.org/W2099823654","https://openalex.org/W2100693237","https://openalex.org/W2107272707","https://openalex.org/W2119201362","https://openalex.org/W2119448646","https://openalex.org/W2121243509","https://openalex.org/W2126394796","https://openalex.org/W2128986402","https://openalex.org/W2129745115","https://openalex.org/W2141390960","https://openalex.org/W2142239045","https://openalex.org/W2154213419","https://openalex.org/W2154535219","https://openalex.org/W2157682988","https://openalex.org/W2168359294","https://openalex.org/W2168569267","https://openalex.org/W2168849174","https://openalex.org/W2408298703"],"related_works":["https://openalex.org/W2127923213","https://openalex.org/W1984474696","https://openalex.org/W1980532494","https://openalex.org/W2094753712","https://openalex.org/W2031767983","https://openalex.org/W2046013039","https://openalex.org/W2015270219","https://openalex.org/W1975045025","https://openalex.org/W2013278446","https://openalex.org/W2043737194"],"abstract_inverted_index":{"Keratinocytes":[0],"require":[1],"abundant":[2],"cholesterol":[3,13,26,36,100,112,117,142,146,173,202,223],"for":[4,25,148],"cutaneous":[5],"permeability":[6,126,206],"barrier":[7,127,180,207],"function;":[8],"hence,":[9],"the":[10,151,176],"regulation":[11],"of":[12,16,74,150,165,179,214],"homeostasis":[14],"is":[15,20,42,188,194],"great":[17],"importance.":[18],"ABCA1":[19,41,59,94,108,120,135,159,187],"a":[21,30,198],"membrane":[22],"transporter":[23],"responsible":[24],"efflux":[27],"and":[28,49,61,66,80,138,209,217],"plays":[29],"pivotal":[31],"role":[32],"in":[33,44,64,96,99,122,190,200,221],"regulating":[34],"cellular":[35,141,201,222],"levels.":[37,224],"We":[38],"demonstrate":[39],"that":[40,186],"expressed":[43,189],"cultured":[45],"human":[46],"keratinocytes":[47],"(CHKs)":[48],"murine":[50],"epidermis.":[51,68],"Liver":[52],"X":[53,82],"receptor":[54,77,83],"(LXR)":[55],"activation":[56],"markedly":[57],"stimulates":[58],"mRNA":[60],"protein":[62],"levels":[63,203],"CHKs":[65],"mouse":[67],"In":[69,153],"addition":[70],"to":[71],"LXR,":[72,215],"activators":[73,213],"peroxisome":[75],"proliferator-activated":[76],"(PPAR)alpha,":[78],"PPARbeta/delta,":[79],"retinoid":[81],"(RXR),":[84],"but":[85],"neither":[86],"PPARgamma":[87],"nor":[88],"retinoic":[89],"acid":[90],"receptor,":[91],"also":[92],"increase":[93],"expression":[95,121,136,160],"CHKs.":[97,123],"Increases":[98],"supply":[101],"induced":[102],"by":[103,129,197,212],"LDL":[104],"or":[105,116,132,204,219],"mevalonate":[106],"stimulate":[107],"expression,":[109],"whereas":[110],"inhibiting":[111],"synthesis":[113],"with":[114],"statins":[115],"sulfate":[118],"decreases":[119,161],"After":[124],"acute":[125],"disruption":[128],"either":[130],"tape-stripping":[131],"acetone":[133],"treatment,":[134],"declines,":[137],"this":[139],"attenuates":[140],"efflux,":[143],"making":[144],"more":[145,172],"available":[147,174],"regeneration":[149],"barrier.":[152],"addition,":[154],"during":[155,175],"fetal":[156],"epidermal":[157],"development,":[158],"at":[162],"days":[163],"18-22":[164],"gestation":[166],"(term":[167],"=":[168],"22":[169],"days),":[170],"leaving":[171],"critical":[177],"period":[178],"formation.":[181],"Together,":[182],"our":[183],"results":[184],"show":[185],"keratinocytes,":[191],"where":[192],"it":[193],"negatively":[195],"regulated":[196,211],"decrease":[199],"altered":[205],"requirements":[208],"positively":[210],"PPARs,":[216],"RXR":[218],"increases":[220]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":5}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2022-05-12T00:00:00"}
