{"id":"https://openalex.org/W4252591138","doi":"https://doi.org/10.1002/9781118286067.ch2","title":"Transport Model","display_name":"Transport Model","publication_year":2012,"publication_date":"2012-05-07","ids":{"openalex":"https://openalex.org/W4252591138","doi":"https://doi.org/10.1002/9781118286067.ch2"},"language":"en","primary_location":{"id":"doi:10.1002/9781118286067.ch2","doi":"https://doi.org/10.1002/9781118286067.ch2","is_oa":false,"landing_page_url":"https://doi.org/10.1002/9781118286067.ch2","pdf_url":null,"source":{"id":"https://openalex.org/S4306464293","display_name":"Wiley eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Absorption and Drug Development","raw_type":"other"},"volume":{"id":"https://openalex.org/W2485283686","display_name":"Absorption and Drug Development"},"type":"other","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5078166589","display_name":"Alex Avdeef","orcid":"https://orcid.org/0000-0002-3139-5442","observed_orcids":["https://orcid.org/0000-0002-3139-5442"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Alex Avdeef","raw_affiliation_strings":["Boston, Massachusetts, USA","Cambridge, Massachusetts, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Boston, Massachusetts, USA","institution_ids":[]},{"raw_affiliation_string":"Cambridge, Massachusetts, USA","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5078166589"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"12","last_page":"30"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10256","display_name":"Drug Solubulity and Delivery Systems","score":0.9258000254631042,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10256","display_name":"Drug Solubulity and Delivery Systems","score":0.9258000254631042,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.03200000151991844,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.01979999989271164,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/drug-transport","display_name":"drug transport","score":0.6100000143051147},{"id":"https://openalex.org/keywords/permeability","display_name":"permeability","score":0.6629999876022339},{"id":"https://openalex.org/keywords/solubility","display_name":"solubility","score":0.984000027179718},{"id":"https://openalex.org/keywords/charge-state","display_name":"charge states","score":0.8159999847412109},{"id":"https://openalex.org/keywords/ph-partition-hypothesis","display_name":"pH-partition hypothesis","score":0.8399999737739563},{"id":"https://openalex.org/keywords/gastrointestinal-tract-ph","display_name":"gastrointestinal tract pH","score":0.8029999732971191},{"id":"https://openalex.org/keywords/intracellular-ph","display_name":"intracellular pH","score":0.949999988079071},{"id":"https://openalex.org/keywords/tight-junctions","display_name":"tight junctions","score":0.9800000190734863},{"id":"https://openalex.org/keywords/1-octanol","display_name":"1-octanol","score":0.7480000257492065},{"id":"https://openalex.org/keywords/biopharmaceutics-classification-system","display_name":"Biopharmaceutics Classification System","score":0.968999981880188}],"concepts":[{"id":"https://openalex.org/C2781430271","wikidata":"https://www.wikidata.org/wiki/Q278760","display_name":"Biopharmaceutics Classification System","level":3,"score":0.837164580821991},{"id":"https://openalex.org/C2910701995","wikidata":"https://www.wikidata.org/wiki/Q679692","display_name":"Biopharmaceutics","level":5,"score":0.563309907913208},{"id":"https://openalex.org/C155574463","wikidata":"https://www.wikidata.org/wiki/Q170731","display_name":"Solubility","level":2,"score":0.5419519543647766},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.48704007267951965},{"id":"https://openalex.org/C42812","wikidata":"https://www.wikidata.org/wiki/Q1082910","display_name":"Partition (number theory)","level":2,"score":0.4303474724292755},{"id":"https://openalex.org/C120882062","wikidata":"https://www.wikidata.org/wiki/Q28352","display_name":"Permeability (electromagnetism)","level":3,"score":0.41398167610168457},{"id":"https://openalex.org/C199289684","wikidata":"https://www.wikidata.org/wiki/Q83353","display_name":"Mineralogy","level":1,"score":0.3784976899623871},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.18280932307243347},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.16607871651649475},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.15850213170051575},{"id":"https://openalex.org/C114614502","wikidata":"https://www.wikidata.org/wiki/Q76592","display_name":"Combinatorics","level":1,"score":0.11467063426971436},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.07796376943588257},{"id":"https://openalex.org/C116073593","wikidata":"https://www.wikidata.org/wiki/Q864491","display_name":"Biological activity","level":3,"score":0.0},{"id":"https://openalex.org/C160492267","wikidata":"https://www.wikidata.org/wiki/Q319616","display_name":"Pharmacognosy","level":4,"score":0.0},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1002/9781118286067.ch2","doi":"https://doi.org/10.1002/9781118286067.ch2","is_oa":false,"landing_page_url":"https://doi.org/10.1002/9781118286067.ch2","pdf_url":null,"source":{"id":"https://openalex.org/S4306464293","display_name":"Wiley eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Absorption and Drug Development","raw_type":"other"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":49,"referenced_works":["https://openalex.org/W43727906","https://openalex.org/W56971897","https://openalex.org/W134089957","https://openalex.org/W171838349","https://openalex.org/W340965742","https://openalex.org/W573226132","https://openalex.org/W601386163","https://openalex.org/W624149752","https://openalex.org/W1488219765","https://openalex.org/W1498305210","https://openalex.org/W1499935265","https://openalex.org/W1508582984","https://openalex.org/W1522767714","https://openalex.org/W1545266804","https://openalex.org/W1971771344","https://openalex.org/W1972553581","https://openalex.org/W1980792687","https://openalex.org/W1986246787","https://openalex.org/W1986486038","https://openalex.org/W1991979573","https://openalex.org/W1993195479","https://openalex.org/W1997764055","https://openalex.org/W1998584026","https://openalex.org/W2006311035","https://openalex.org/W2008836424","https://openalex.org/W2014259987","https://openalex.org/W2024362305","https://openalex.org/W2025223874","https://openalex.org/W2028358602","https://openalex.org/W2034508336","https://openalex.org/W2039218089","https://openalex.org/W2047924254","https://openalex.org/W2049200458","https://openalex.org/W2058738094","https://openalex.org/W2060917067","https://openalex.org/W2076708105","https://openalex.org/W2077987770","https://openalex.org/W2080068747","https://openalex.org/W2092815169","https://openalex.org/W2094422849","https://openalex.org/W2140661985","https://openalex.org/W2176544002","https://openalex.org/W2182358381","https://openalex.org/W2224010948","https://openalex.org/W2285524653","https://openalex.org/W2426277199","https://openalex.org/W2604060680","https://openalex.org/W4234156166","https://openalex.org/W4240384253"],"related_works":["https://openalex.org/W2951386727","https://openalex.org/W142074258","https://openalex.org/W2008039044","https://openalex.org/W1945024134","https://openalex.org/W2917577366","https://openalex.org/W2916020856","https://openalex.org/W2769438080","https://openalex.org/W1979724519","https://openalex.org/W2059279620","https://openalex.org/W7202081403"],"abstract_inverted_index":{"This":[0],"chapter":[1],"contains":[2],"sections":[3],"titled:":[4],"Permeability\u2013Solubility\u2013Charge":[5],"State":[6],"and":[7],"pH-Partition":[8],"Hypothesis":[9],"Properties":[10],"of":[11,25],"the":[12],"Gastrointestinal":[13],"Tract":[14],"(GIT)":[15],"pH":[16,19],"Microclimate":[17],"Intracellular":[18],"Environment":[20],"Tight":[21],"Junction":[22],"Complex":[23],"Structure":[24],"Octanol":[26],"Biopharmaceutics":[27],"Classification":[28],"System":[29],"References":[30]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2018,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2022-05-12T00:00:00"}