{"id":"https://openalex.org/W4252200972","doi":"https://doi.org/10.1002/14651858.cd004448.pub3","title":"Phytomedicines (medicines derived from plants) for sickle cell disease","display_name":"Phytomedicines (medicines derived from plants) for sickle cell disease","publication_year":2010,"publication_date":"2010-09-28","ids":{"openalex":"https://openalex.org/W4252200972","doi":"https://doi.org/10.1002/14651858.cd004448.pub3","pmid":"https://pubmed.ncbi.nlm.nih.gov/20927735"},"language":"en","primary_location":{"id":"doi:10.1002/14651858.cd004448.pub3","doi":"https://doi.org/10.1002/14651858.cd004448.pub3","is_oa":false,"landing_page_url":"https://doi.org/10.1002/14651858.cd004448.pub3","pdf_url":null,"source":{"id":"https://openalex.org/S4210172715","display_name":"Cochrane Database of Systematic Reviews","issn_l":"1361-6137","issn":["1361-6137","1464-780X","1465-184X","1465-1858","1469-493X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-1","jufo-2","ki-jl-2","medline","norway-1","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cochrane Database of Systematic Reviews","raw_type":"reference-entry"},"volume":null,"type":"reference-entry","is_traditional":false,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110967714","display_name":"Oluseyi Oniyangi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210099503","display_name":"National Hospital Abuja","ror":"https://ror.org/014j33z40","country_code":"NG","type":"healthcare","lineage":["https://openalex.org/I4210099503"]}],"countries":["NG"],"is_corresponding":false,"raw_author_name":"Oluseyi Oniyangi","raw_affiliation_strings":["Paediatrics Department, National Hospital, Plot 132 Central District (Phase II), PMB 425 Garki, Abuja, Nigeria","National Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Paediatrics Department, National Hospital, Plot 132 Central District (Phase II), PMB 425 Garki, Abuja, Nigeria","institution_ids":["https://openalex.org/I4210099503"]},{"raw_affiliation_string":"National Hospital","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5015663919","display_name":"Damian Cohall","orcid":"https://orcid.org/0000-0002-2173-7322","observed_orcids":["https://orcid.org/0000-0002-2173-7322"]},"institutions":[{"id":"https://openalex.org/I4210088717","display_name":"University of the West Indies","ror":"https://ror.org/003kgv736","country_code":"TT","type":"education","lineage":["https://openalex.org/I137799390","https://openalex.org/I4210088717"]},{"id":"https://openalex.org/I4210129319","display_name":"University of the West Indies","ror":"https://ror.org/03fkc8c64","country_code":"JM","type":"education","lineage":["https://openalex.org/I137799390","https://openalex.org/I4210129319"]},{"id":"https://openalex.org/I4210158067","display_name":"University of the West Indies","ror":"https://ror.org/05p4f7w60","country_code":"BB","type":"education","lineage":["https://openalex.org/I137799390","https://openalex.org/I4210158067"]}],"countries":["BB","JM","TT"],"is_corresponding":false,"raw_author_name":"Damian H Cohall","raw_affiliation_strings":["University of the West Indies"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of the West Indies","institution_ids":["https://openalex.org/I4210088717","https://openalex.org/I4210129319","https://openalex.org/I4210158067"]}]}],"institutions":[],"countries_distinct_count":4,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5100,"currency":"USD","value_usd":5100},"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":9,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":"10","first_page":"CD004448","last_page":"CD004448"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10554","display_name":"Hemoglobinopathies and Related Disorders","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10554","display_name":"Hemoglobinopathies and Related Disorders","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10902","display_name":"Complementary and Alternative Medicine Studies","score":0.0015999999595806003,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14521","display_name":"Medicinal Plant Research","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sickle-cell-disease","display_name":"sickle cell disease","score":0.9909999966621399},{"id":"https://openalex.org/keywords/herbal-medicine","display_name":"herbal medicine","score":0.9629999995231628},{"id":"https://openalex.org/keywords/pigeonpea","display_name":"Cajanus cajan","score":0.8939999938011169},{"id":"https://openalex.org/keywords/hydroxyurea","display_name":"hydroxyurea","score":0.7749999761581421},{"id":"https://openalex.org/keywords/blood-transfusion","display_name":"blood transfusion","score":0.7089999914169312},{"id":"https://openalex.org/keywords/anemia","display_name":"anemia","score":0.7630000114440918},{"id":"https://openalex.org/keywords/traditional-medicine","display_name":"traditional medicine","score":0.7450000047683716},{"id":"https://openalex.org/keywords/hemoglobinopathies","display_name":"hemoglobinopathies","score":0.6520000100135803},{"id":"https://openalex.org/keywords/sub-saharan-africa","display_name":"sub-Saharan Africa","score":0.4480000138282776},{"id":"https://openalex.org/keywords/india","display_name":"India","score":0.4909999966621399},{"id":"https://openalex.org/keywords/caribbean","display_name":"Caribbean","score":0.527999997138977},{"id":"https://openalex.org/keywords/south-america","display_name":"South America","score":0.8080000281333923},{"id":"https://openalex.org/keywords/middle-east","display_name":"Middle East","score":0.8820000290870667}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.790369987487793},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.538976788520813},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.496185839176178},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.4840030372142792},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.4361860156059265},{"id":"https://openalex.org/C133925201","wikidata":"https://www.wikidata.org/wiki/Q188419","display_name":"Life expectancy","level":3,"score":0.4240206480026245},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.24660101532936096},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.21693968772888184},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.17550069093704224},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.15962573885917664},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.09280586242675781}],"mesh":[{"descriptor_ui":"D000755","descriptor_name":"Anemia, Sickle Cell","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D000986","descriptor_name":"Antisickling Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008517","descriptor_name":"Phytotherapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010936","descriptor_name":"Plant Extracts","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D016032","descriptor_name":"Randomized Controlled Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D036561","descriptor_name":"Cajanus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/14651858.cd004448.pub3","doi":"https://doi.org/10.1002/14651858.cd004448.pub3","is_oa":false,"landing_page_url":"https://doi.org/10.1002/14651858.cd004448.pub3","pdf_url":null,"source":{"id":"https://openalex.org/S4210172715","display_name":"Cochrane Database of Systematic Reviews","issn_l":"1361-6137","issn":["1361-6137","1464-780X","1465-184X","1465-1858","1469-493X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-1","jufo-2","ki-jl-2","medline","norway-1","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cochrane Database of Systematic Reviews","raw_type":"reference-entry"},{"id":"pmid:20927735","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20927735","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Cochrane database of systematic reviews","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":32,"referenced_works":["https://openalex.org/W96680208","https://openalex.org/W1540284949","https://openalex.org/W1554040650","https://openalex.org/W1566270415","https://openalex.org/W1596902544","https://openalex.org/W1964528195","https://openalex.org/W1981207144","https://openalex.org/W1986215651","https://openalex.org/W1993813575","https://openalex.org/W1998427422","https://openalex.org/W2004240616","https://openalex.org/W2005586323","https://openalex.org/W2023608111","https://openalex.org/W2027294558","https://openalex.org/W2036060686","https://openalex.org/W2037781228","https://openalex.org/W2045260987","https://openalex.org/W2045875999","https://openalex.org/W2069460368","https://openalex.org/W2071220778","https://openalex.org/W2080978993","https://openalex.org/W2093254050","https://openalex.org/W2097805484","https://openalex.org/W2099735999","https://openalex.org/W2103208617","https://openalex.org/W2125435699","https://openalex.org/W2130235475","https://openalex.org/W2134086699","https://openalex.org/W2169800461","https://openalex.org/W2334263927","https://openalex.org/W4210439924","https://openalex.org/W4243654077"],"related_works":["https://openalex.org/W4408448986","https://openalex.org/W4392662911","https://openalex.org/W2099735999","https://openalex.org/W7093376064","https://openalex.org/W2149456943","https://openalex.org/W6922492022","https://openalex.org/W7165471894","https://openalex.org/W3151870914","https://openalex.org/W2521824634","https://openalex.org/W4400257265"],"abstract_inverted_index":{"BACKGROUND:":[0],"Sickle":[1],"cell":[2],"disease":[3],"(SCD),":[4],"a":[5,33,235,266,275,301,364],"common":[6],"recessively":[7],"inherited":[8],"haemoglobin":[9],"disorder,":[10],"affects":[11],"people":[12,81,317],"from":[13,40,52],"sub-Saharan":[14],"Africa,":[15],"the":[16,49,56,74,97,109,120,131,168,242,248,281,314,321,336,342,351,388],"Middle":[17],"East,":[18],"Mediterranean":[19],"basin,":[20],"Indian":[21],"subcontinent,":[22],"Caribbeans":[23],"and":[24,32,76,101,108,183,195,204,212,274,293,320,347,356,390],"South":[25],"America.":[26],"It":[27,238],"is":[28],"associated":[29],"with":[30,82,157,162,271,318],"complications":[31,246],"reduced":[34],"life":[35],"expectancy.":[36],"Phytomedicines":[37],"(medicine":[38],"derived":[39],"plants":[41],"in":[42,80,90,164,226,295,313,348,353,368,372,380,394],"their":[43,69],"original":[44],"state)":[45],"encompass":[46],"many":[47],"of":[48,68,78,84,87,127,137,159,170,229,244,250,261,283,316,323,338,350,358,392],"plant":[50],"remedies":[51],"traditional":[53],"healers":[54],"which":[55],"populations":[57],"most":[58,138],"affected":[59],"would":[60],"encounter.":[61],"There":[62],"has":[63],"been":[64],"little":[65],"systematic":[66],"appraisal":[67],"benefits.":[70],"OBJECTIVES:":[71],"To":[72],"assess":[73,310],"benefits":[75],"risks":[77],"phytomedicines":[79,206,361,393],"SCD":[83,232,319],"all":[85,113,160,165],"types,":[86],"any":[88,91,173],"age,":[89],"setting.":[92],"SEARCH":[93],"STRATEGY:":[94],"We":[95],"searched":[96,118],"Cochrane":[98],"Cystic":[99],"Fibrosis":[100],"Genetic":[102],"Disorders":[103],"Group":[104],"Haemoglobinopathies":[105],"Trials":[106,141],"Register":[107,111],"ISRCTN":[110],"for":[112,123,130,345],"publication":[114],"years;":[115],"AMED":[116],"was":[117,224],"by":[119,172],"previous":[121],"authors":[122,190],"an":[124],"earlier":[125],"version":[126],"this":[128],"review":[129],"period":[132],"1985":[133],"to":[134,175,269,290,309,376],"August":[135,149],"2003.Dates":[136],"recent":[139],"searches:Haemoglobinopathies":[140],"Register:":[142],"07":[143],"July":[144],"2010;ISRCTN:":[145],"28":[146],"December":[147],"2009;AMED:":[148],"2003.":[150],"SELECTION":[151],"CRITERIA:":[152],"Randomised":[153],"or":[154,177,247],"quasi-randomised":[155],"trials":[156,201,306,326,384],"participants":[158],"ages":[161],"SCD,":[163],"settings,":[166],"comparing":[167],"administration":[169],"phytomedicines,":[171],"mode":[174],"placebo":[176],"conventional":[178],"treatment,":[179],"including":[180],"blood":[181],"transfusion":[182],"hydroxyurea.":[184],"DATA":[185],"COLLECTION":[186],"AND":[187],"ANALYSIS:":[188],"Both":[189],"independently":[191],"assessed":[192],"trial":[193,220,260],"quality":[194],"extracted":[196],"data.":[197],"MAIN":[198],"RESULTS:":[199],"Two":[200],"(182":[202],"participants)":[203],"two":[205],"Niprisan(\u00ae)":[207,223,288,346],"(also":[208],"known":[209],"as":[210],"Nicosan(\u00ae))":[211],"Ciklavit(\u00ae))":[213],"were":[214,256],"included.":[215],"The":[216,258],"Phase":[217],"IIB":[218],"(pivotal)":[219],"suggests":[221],"that":[222],"effective":[225,294],"reducing":[227,296,369],"episodes":[228],"severe":[230,245,297],"painful":[231,272,298,370],"crisis":[233],"over":[234,300],"six-month":[236,302],"period.":[237],"did":[239],"not":[240],"affect":[241],"risk":[243],"level":[249,282],"anaemia.":[251,284],"No":[252],"serious":[253],"adverse":[254,277],"effects":[255],"reported.":[257],"single":[259],"Cajanus":[262],"cajan":[263],"(Ciklavit(\u00ae))":[264],"reported":[265],"possible":[267,276],"benefit":[268],"individuals":[270],"crises,":[273],"effect":[278,367],"(non-significant)":[279],"on":[280,341,387],"AUTHORS'":[285],"CONCLUSIONS:":[286],"While":[287],"appeared":[289],"be":[291,333,377],"safe":[292],"crises":[299,371],"follow-up":[303],"period,":[304],"further":[305,378],"are":[307,327,385],"required":[308,386],"its":[311,324],"role":[312],"management":[315],"results":[322,344],"multicentre":[325],"awaited.":[328],"Currently":[329],"no":[330],"conclusions":[331],"can":[332],"made":[334],"regarding":[335],"efficacy":[337,391],"Ciklavit(\u00ae).":[339],"Based":[340],"published":[343],"view":[349],"limitations":[352],"data":[354],"collection":[355],"analysis":[357],"both":[359],"trials,":[360],"may":[362],"have":[363],"potential":[365],"beneficial":[366],"SCD.":[373,396],"This":[374],"needs":[375],"validated":[379],"future":[381],"trials.":[382],"More":[383],"safety":[389],"managing":[395]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2022-05-12T00:00:00"}
