{"id":"https://openalex.org/W4251997802","doi":"https://doi.org/10.1134/s0026893320010033","title":"Hepatocellular Carcinoma Cells with Downregulated ZEB2 Become Resistant to Resveratrol by Concomitant Induction of ABCG2 Expression","display_name":"Hepatocellular Carcinoma Cells with Downregulated ZEB2 Become Resistant to Resveratrol by Concomitant Induction of ABCG2 Expression","publication_year":2020,"publication_date":"2020-01-01","ids":{"openalex":"https://openalex.org/W4251997802","doi":"https://doi.org/10.1134/s0026893320010033"},"language":"en","primary_location":{"id":"doi:10.1134/s0026893320010033","doi":"https://doi.org/10.1134/s0026893320010033","is_oa":false,"landing_page_url":"https://doi.org/10.1134/s0026893320010033","pdf_url":null,"source":{"id":"https://openalex.org/S191406736","display_name":"Molecular Biology","issn_l":"0026-8933","issn":["0026-8933","0026-8984","1608-3245","3034-5553"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-20","russia-white-list-1","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320267","host_organization_name":"Pleiades Publishing","host_organization_lineage":["https://openalex.org/P4310320267","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Pleiades Publishing","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Biology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5033979571","display_name":"Pelin Bal\u00e7\u0131k-Er\u00e7in","orcid":"https://orcid.org/0000-0002-3470-0393","observed_orcids":["https://orcid.org/0000-0002-3470-0393"]},"institutions":[{"id":"https://openalex.org/I109297418","display_name":"Gebze Technical University","ror":"https://ror.org/01sdnnq10","country_code":"TR","type":"education","lineage":["https://openalex.org/I109297418"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"P. Balcik-Ercin","raw_affiliation_strings":["Department of Molecular Biology and Genetics, Laboratory of Molecular Oncology,\nGebze Technical University, 41400, Gebze, Kocaeli, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biology and Genetics, Laboratory of Molecular Oncology,\nGebze Technical University, 41400, Gebze, Kocaeli, Turkey","institution_ids":["https://openalex.org/I109297418"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008265767","display_name":"Metin \u00c7et\u012fn","orcid":"https://orcid.org/0000-0001-9963-8407","observed_orcids":["https://orcid.org/0000-0001-9963-8407"]},"institutions":[{"id":"https://openalex.org/I109297418","display_name":"Gebze Technical University","ror":"https://ror.org/01sdnnq10","country_code":"TR","type":"education","lineage":["https://openalex.org/I109297418"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"M. Cetin","raw_affiliation_strings":["Department of Molecular Biology and Genetics, Laboratory of Molecular Oncology,\nGebze Technical University, 41400, Gebze, Kocaeli, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biology and Genetics, Laboratory of Molecular Oncology,\nGebze Technical University, 41400, Gebze, Kocaeli, Turkey","institution_ids":["https://openalex.org/I109297418"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027261587","display_name":"\u0130rem Yal\u0131m Camc\u0131","orcid":"https://orcid.org/0000-0002-2534-4155","observed_orcids":["https://orcid.org/0000-0002-2534-4155"]},"institutions":[{"id":"https://openalex.org/I109297418","display_name":"Gebze Technical University","ror":"https://ror.org/01sdnnq10","country_code":"TR","type":"education","lineage":["https://openalex.org/I109297418"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"I. Yalim-Camci","raw_affiliation_strings":["Department of Molecular Biology and Genetics, Laboratory of Molecular Oncology,\nGebze Technical University, 41400, Gebze, Kocaeli, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biology and Genetics, Laboratory of Molecular Oncology,\nGebze Technical University, 41400, Gebze, Kocaeli, Turkey","institution_ids":["https://openalex.org/I109297418"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080818087","display_name":"T. Uygur","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I109297418","display_name":"Gebze Technical University","ror":"https://ror.org/01sdnnq10","country_code":"TR","type":"education","lineage":["https://openalex.org/I109297418"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"T. Uygur","raw_affiliation_strings":["Department of Molecular Biology and Genetics, Laboratory of Molecular Oncology,\nGebze Technical University, 41400, Gebze, Kocaeli, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biology and Genetics, Laboratory of Molecular Oncology,\nGebze Technical University, 41400, Gebze, Kocaeli, Turkey","institution_ids":["https://openalex.org/I109297418"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5035238241","display_name":"Tamer Ya\u011fc\u0131","orcid":"https://orcid.org/0000-0003-2050-7477","observed_orcids":["https://orcid.org/0000-0003-2050-7477"]},"institutions":[{"id":"https://openalex.org/I109297418","display_name":"Gebze Technical University","ror":"https://ror.org/01sdnnq10","country_code":"TR","type":"education","lineage":["https://openalex.org/I109297418"]}],"countries":["TR"],"is_corresponding":true,"raw_author_name":"T. Yagci","raw_affiliation_strings":["Department of Molecular Biology and Genetics, Laboratory of Molecular Oncology,\nGebze Technical University, 41400, Gebze, Kocaeli, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biology and Genetics, Laboratory of Molecular Oncology,\nGebze Technical University, 41400, Gebze, Kocaeli, Turkey","institution_ids":["https://openalex.org/I109297418"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5035238241"],"corresponding_institution_ids":["https://openalex.org/I109297418"],"apc_list":null,"apc_paid":null,"fwci":0.7909,"has_fulltext":false,"cited_by_count":13,"citation_normalized_percentile":{"value":0.70758199,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"54","issue":"1","first_page":"75","last_page":"81"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.9868000149726868,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.9868000149726868,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.0035000001080334187,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hepatocellular-carcinoma","display_name":"hepatocellular carcinoma","score":1.0},{"id":"https://openalex.org/keywords/zeb2","display_name":"ZEB2","score":0.7960000038146973},{"id":"https://openalex.org/keywords/zeb1","display_name":"ZEB1","score":0.9980000257492065},{"id":"https://openalex.org/keywords/abcg2","display_name":"ABCG2","score":0.9990000128746033},{"id":"https://openalex.org/keywords/resveratrol","display_name":"resveratrol","score":0.8970000147819519},{"id":"https://openalex.org/keywords/drug-resistance","display_name":"drug resistance","score":0.8640000224113464},{"id":"https://openalex.org/keywords/cancer-stem-cells","display_name":"cancer stem cells","score":0.996999979019165},{"id":"https://openalex.org/keywords/epithelial-mesenchymal-transition","display_name":"epithelial-mesenchymal transition","score":1.0},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.4339999854564667},{"id":"https://openalex.org/keywords/cell-cycle-arrest","display_name":"cell cycle arrest","score":0.9929999709129333},{"id":"https://openalex.org/keywords/cd133","display_name":"CD133","score":0.7649999856948853},{"id":"https://openalex.org/keywords/cd44","display_name":"CD44","score":0.9789999723434448},{"id":"https://openalex.org/keywords/plc-prf-5-cells","display_name":"PLC/PRF/5 cells","score":0.9890000224113464}],"concepts":[{"id":"https://openalex.org/C2776816829","wikidata":"https://www.wikidata.org/wiki/Q407329","display_name":"Resveratrol","level":2,"score":0.8651086091995239},{"id":"https://openalex.org/C2780932548","wikidata":"https://www.wikidata.org/wiki/Q1056532","display_name":"CD44","level":3,"score":0.7067123651504517},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6121805906295776},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.5993754267692566},{"id":"https://openalex.org/C173396325","wikidata":"https://www.wikidata.org/wiki/Q1501275","display_name":"Gene knockdown","level":3,"score":0.5954394936561584},{"id":"https://openalex.org/C55427017","wikidata":"https://www.wikidata.org/wiki/Q1638475","display_name":"Cancer stem cell","level":3,"score":0.5875324606895447},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.5656774044036865},{"id":"https://openalex.org/C76419328","wikidata":"https://www.wikidata.org/wiki/Q74419","display_name":"Epithelial\u2013mesenchymal transition","level":4,"score":0.5245181322097778},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5045491456985474},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.4754828214645386},{"id":"https://openalex.org/C512196","wikidata":"https://www.wikidata.org/wiki/Q4650095","display_name":"Abcg2","level":5,"score":0.46838051080703735},{"id":"https://openalex.org/C2778695046","wikidata":"https://www.wikidata.org/wiki/Q421136","display_name":"Sorafenib","level":3,"score":0.4569156765937805},{"id":"https://openalex.org/C53227056","wikidata":"https://www.wikidata.org/wiki/Q189152","display_name":"Viability assay","level":3,"score":0.4273262619972229},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.4038099944591522},{"id":"https://openalex.org/C2778019345","wikidata":"https://www.wikidata.org/wiki/Q1148337","display_name":"Hepatocellular carcinoma","level":2,"score":0.37025564908981323},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.35519129037857056},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3183380365371704},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.2270275354385376},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.15755590796470642},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.13036593794822693},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.11304929852485657},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.07416808605194092},{"id":"https://openalex.org/C44312359","wikidata":"https://www.wikidata.org/wiki/Q286958","display_name":"ATP-binding cassette transporter","level":4,"score":0.06579920649528503},{"id":"https://openalex.org/C149011108","wikidata":"https://www.wikidata.org/wiki/Q652985","display_name":"Transporter","level":3,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1134/s0026893320010033","doi":"https://doi.org/10.1134/s0026893320010033","is_oa":false,"landing_page_url":"https://doi.org/10.1134/s0026893320010033","pdf_url":null,"source":{"id":"https://openalex.org/S191406736","display_name":"Molecular Biology","issn_l":"0026-8933","issn":["0026-8933","0026-8984","1608-3245","3034-5553"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-20","russia-white-list-1","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320267","host_organization_name":"Pleiades Publishing","host_organization_lineage":["https://openalex.org/P4310320267","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Pleiades Publishing","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Biology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":39,"referenced_works":["https://openalex.org/W42625690","https://openalex.org/W157402533","https://openalex.org/W1483167997","https://openalex.org/W1816870561","https://openalex.org/W1935604522","https://openalex.org/W1968293690","https://openalex.org/W1970400827","https://openalex.org/W1973051534","https://openalex.org/W1990946553","https://openalex.org/W1991098379","https://openalex.org/W2006174435","https://openalex.org/W2014691022","https://openalex.org/W2028593825","https://openalex.org/W2031079863","https://openalex.org/W2041776945","https://openalex.org/W2049633890","https://openalex.org/W2062190575","https://openalex.org/W2079125904","https://openalex.org/W2093063287","https://openalex.org/W2098891057","https://openalex.org/W2109909380","https://openalex.org/W2129883523","https://openalex.org/W2132737274","https://openalex.org/W2137005750","https://openalex.org/W2163403599","https://openalex.org/W2176805330","https://openalex.org/W2273522842","https://openalex.org/W2344838182","https://openalex.org/W2394942272","https://openalex.org/W2414596392","https://openalex.org/W2565585273","https://openalex.org/W2582775233","https://openalex.org/W2588473297","https://openalex.org/W2606001457","https://openalex.org/W2651510138","https://openalex.org/W2759896015","https://openalex.org/W2791912900","https://openalex.org/W2889646458","https://openalex.org/W2988730021"],"related_works":["https://openalex.org/W3008782569","https://openalex.org/W2472838456","https://openalex.org/W195656991","https://openalex.org/W2974035103","https://openalex.org/W2093063287","https://openalex.org/W1765254582","https://openalex.org/W4390167566","https://openalex.org/W2999466484","https://openalex.org/W4296836661","https://openalex.org/W2609193769"],"abstract_inverted_index":{"Abstract":[0],"In":[1],"hepatocellular":[2],"carcinoma":[3],"(HCC),":[4],"the":[5,27,37,63,72],"presence":[6],"of":[7,30,39,50,74,126,134,137],"cancer":[8,22],"stem":[9],"cells":[10,44,60,122,155],"(CSCs)":[11],"have":[12],"been":[13],"linked":[14],"to":[15,130,157],"drug":[16],"resistance,":[17],"epithelial-mesenchymal":[18],"transition":[19],"(EMT),":[20],"and":[21,36,53,71,80,93,101,139],"relapse.":[23],"This":[24],"study":[25],"investigates":[26],"expression":[28,49,70,135],"profile":[29],"ZEB1,":[31,51],"ZEB2,":[32],"ABCG2":[33,54,68,94,138],"in":[34,43,58,84,99,102,117,149,153],"HCC-CSCs,":[35],"role":[38,148],"EMT":[40,142],"promoter":[41],"ZEB2":[42,52,127],"treated":[45],"with":[46,123],"resveratrol.":[47,158],"The":[48,105,132],"transcripts":[55],"were":[56,82,96,128],"analyzed":[57],"CD133+/CD44+":[59],"isolated":[61],"from":[62],"PLC/PRF/5":[64],"cell":[65,78,86,110,114],"line.":[66],"ZEB2-dependent":[67],"gene":[69],"effects":[73],"resveratrol":[75,106],"on":[76],"proliferation,":[77],"cycle":[79,115],"apoptosis":[81],"explored":[83],"SNU398":[85],"clones.":[87],"An":[88],"inverse":[89],"correlation":[90],"between":[91],"ZEB1/ZEB2":[92],"levels":[95,125,136],"observed":[97],"both":[98],"CSCs":[100],"ZEB2-knockdown":[103],"cells.":[104],"treatment":[107],"significantly":[108],"decreased":[109],"viability,":[111],"while":[112],"promoting":[113],"arrest":[116],"ZEB2-independent":[118],"manner.":[119],"Interestingly,":[120],"resveratrol-treated":[121],"low":[124],"resistant":[129,156],"apoptosis.":[131],"interplay":[133],"ZEB":[140],"family":[141],"transcription":[143],"factors":[144],"may":[145],"play":[146],"a":[147],"establishing":[150],"CSC-like":[151],"phenotype":[152],"HCC":[154]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2022-05-12T00:00:00"}