{"id":"https://openalex.org/W4251966328","doi":"https://doi.org/10.1158/1538-7445.am2019-4308","title":"Abstract 4308: Phosphatidic acid binds to ERK3 and stimulates phosphorylation of the ERK3 activation loop","display_name":"Abstract 4308: Phosphatidic acid binds to ERK3 and stimulates phosphorylation of the ERK3 activation loop","publication_year":2019,"publication_date":"2019-07-01","ids":{"openalex":"https://openalex.org/W4251966328","doi":"https://doi.org/10.1158/1538-7445.am2019-4308"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am2019-4308","doi":"https://doi.org/10.1158/1538-7445.am2019-4308","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2019-4308","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Amanda Myers","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I19648265","display_name":"Wright State University","ror":"https://ror.org/04qk6pt94","country_code":"US","type":"education","lineage":["https://openalex.org/I19648265"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Amanda Myers","raw_affiliation_strings":["Wright State University, Datyon, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wright State University, Datyon, OH","institution_ids":["https://openalex.org/I19648265"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088676280","display_name":"Hitham Aldharee","orcid":"https://orcid.org/0000-0002-4230-4462","observed_orcids":["https://orcid.org/0000-0002-4230-4462"]},"institutions":[{"id":"https://openalex.org/I19648265","display_name":"Wright State University","ror":"https://ror.org/04qk6pt94","country_code":"US","type":"education","lineage":["https://openalex.org/I19648265"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hitham Aldharee","raw_affiliation_strings":["Wright State University, Datyon, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wright State University, Datyon, OH","institution_ids":["https://openalex.org/I19648265"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043507269","display_name":"Shimpi Bedi","orcid":"https://orcid.org/0000-0003-3277-7845","observed_orcids":["https://orcid.org/0000-0003-3277-7845"]},"institutions":[{"id":"https://openalex.org/I19648265","display_name":"Wright State University","ror":"https://ror.org/04qk6pt94","country_code":"US","type":"education","lineage":["https://openalex.org/I19648265"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shimpi Bedi","raw_affiliation_strings":["Wright State University, Datyon, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wright State University, Datyon, OH","institution_ids":["https://openalex.org/I19648265"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5059026866","display_name":"Weiwen Long","orcid":"https://orcid.org/0000-0002-4792-242X","observed_orcids":["https://orcid.org/0000-0002-4792-242X"]},"institutions":[{"id":"https://openalex.org/I19648265","display_name":"Wright State University","ror":"https://ror.org/04qk6pt94","country_code":"US","type":"education","lineage":["https://openalex.org/I19648265"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Weiwen Long","raw_affiliation_strings":["Wright State University, Datyon, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wright State University, Datyon, OH","institution_ids":["https://openalex.org/I19648265"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I19648265"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"79","issue":"13_Supplement","first_page":"4308","last_page":"4308"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.9735999703407288,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.9735999703407288,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11533","display_name":"Melanoma and MAPK Pathways","score":0.011699999682605267,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11308","display_name":"Sphingolipid Metabolism and Signaling","score":0.009399999864399433,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/erk3","display_name":"ERK3","score":0.9990000128746033},{"id":"https://openalex.org/keywords/phosphatidic-acid","display_name":"phosphatidic acid","score":0.9580000042915344},{"id":"https://openalex.org/keywords/activation-loop-phosphorylation","display_name":"activation loop phosphorylation","score":0.8669999837875366},{"id":"https://openalex.org/keywords/mapk-family","display_name":"MAPK family","score":0.39500001072883606},{"id":"https://openalex.org/keywords/phospholipid-binding","display_name":"phospholipid binding","score":0.6959999799728394},{"id":"https://openalex.org/keywords/c-terminal-domain","display_name":"C-terminal domain","score":0.7649999856948853},{"id":"https://openalex.org/keywords/membrane-localization","display_name":"membrane localization","score":0.7400000095367432},{"id":"https://openalex.org/keywords/kinase-activation","display_name":"kinase activation","score":0.652999997138977}],"concepts":[{"id":"https://openalex.org/C2776909261","wikidata":"https://www.wikidata.org/wiki/Q66000256","display_name":"Phosphatidic acid","level":4,"score":0.8852648735046387},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.7426534295082092},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.7328712344169617},{"id":"https://openalex.org/C57074206","wikidata":"https://www.wikidata.org/wiki/Q14197552","display_name":"MAPK/ERK pathway","level":3,"score":0.6051739454269409},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5869832634925842},{"id":"https://openalex.org/C75217442","wikidata":"https://www.wikidata.org/wiki/Q423650","display_name":"Protein kinase B","level":3,"score":0.49981021881103516},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.49283671379089355},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.4605395793914795},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3791671395301819},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3556212782859802},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.0},{"id":"https://openalex.org/C2778918659","wikidata":"https://www.wikidata.org/wiki/Q186915","display_name":"Phospholipid","level":3,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am2019-4308","doi":"https://doi.org/10.1158/1538-7445.am2019-4308","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2019-4308","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2085362455","https://openalex.org/W2012074445","https://openalex.org/W2170723584","https://openalex.org/W2062502416","https://openalex.org/W1992802441","https://openalex.org/W1999628035","https://openalex.org/W2083076387","https://openalex.org/W3016582550","https://openalex.org/W2108246579","https://openalex.org/W2032711371"],"abstract_inverted_index":{"Abstract":[0],"Protein":[1,37],"kinases":[2],"modulate":[3],"the":[4,32,51,67,123,138,147,189,197],"activity":[5,159],"of":[6,18,31,35,56,61,146,188,196],"other":[7],"proteins":[8],"through":[9],"phosphorylation":[10,17,60,145,187],"and":[11,91,96,122,185],"themselves":[12],"are":[13,84,99],"often":[14],"regulated":[15,65],"by":[16,66,101,163],"their":[19],"activation":[20,47,148,191],"loop.":[21],"Extracellular":[22],"signal-Regulated":[23],"Kinase":[24],"3":[25],"(ERK3)":[26],"is":[27,63],"an":[28],"atypical":[29],"member":[30],"ERK":[33],"family":[34],"Mitogen-Activated":[36],"Kinases":[38],"(MAPK),":[39],"with":[40],"a":[41],"SerGlu-Gly":[42],"(SEG)":[43],"motif":[44,55],"in":[45,120,150,168],"its":[46],"loop":[48,59,149,192],"rather":[49],"than":[50],"canonical":[52],"Thr-Xaa-Tyr":[53],"(TXY)":[54],"ERK1/2.":[57],"Activation":[58],"ERK3":[62,82,115,134,157,184,190],"not":[64],"signals":[68],"known":[69],"to":[70,103,117,137,183],"activate":[71],"ERK1/2,":[72],"such":[73,108],"as":[74,109],"mitogenic":[75],"growth":[76],"factors.":[77],"The":[78],"cellular":[79],"stimuli":[80],"activating":[81],"kinase":[83,94,158],"virtually":[85],"unknown.":[86],"Some":[87],"kinases,":[88],"including":[89],"mTOR":[90],"p21":[92],"activated":[93],"1":[95],"2":[97],"(PAK1/2),":[98],"stimulated":[100,144],"binding":[102],"certain":[104],"phospho-lipid":[105],"signaling":[106],"molecules,":[107],"phosphatidic":[110,142,165],"acids.":[111],"Here,":[112],"we":[113],"show":[114],"binds":[116,182],"specific":[118,164],"phospholipids":[119],"vitro,":[121],"C-terminal":[124],"domain":[125],"may":[126],"be":[127,161],"important":[128],"for":[129,200],"this":[130],"interaction.":[131],"In":[132],"addition,":[133],"can":[135],"localize":[136],"cell":[139],"membrane.":[140],"Further,":[141],"acid":[143,166,181],"ERK3.":[151],"Together,":[152],"these":[153],"results":[154],"suggest":[155],"that":[156],"might":[160],"upregulated":[162],"species":[167],"cells.":[169],"Citation":[170],"Format:":[171],"Amanda":[172],"Myers,":[173],"Hitham":[174],"Aldharee,":[175],"Shimpi":[176],"Bedi,":[177],"Weiwen":[178],"Long.":[179],"Phosphatidic":[180],"stimulates":[186],"[abstract].":[193],"In:":[194],"Proceedings":[195],"American":[198],"Association":[199],"Cancer":[201,215],"Research":[202],"Annual":[203],"Meeting":[204],"2019;":[205],"2019":[206],"Mar":[207],"29-Apr":[208],"3;":[209],"Atlanta,":[210],"GA.":[211],"Philadelphia":[212],"(PA):":[213],"AACR;":[214],"Res":[216],"2019;79(13":[217],"Suppl):Abstract":[218],"nr":[219],"4308.":[220]},"counts_by_year":[],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2022-05-12T00:00:00"}
