{"id":"https://openalex.org/W4251500706","doi":"https://doi.org/10.1158/1538-7445.sabcs18-5260","title":"Abstract 5260: Different cell metabolism by FAP-\u03b1 overexpression in triple negative breast cancer cells","display_name":"Abstract 5260: Different cell metabolism by FAP-\u03b1 overexpression in triple negative breast cancer cells","publication_year":2019,"publication_date":"2019-07-01","ids":{"openalex":"https://openalex.org/W4251500706","doi":"https://doi.org/10.1158/1538-7445.sabcs18-5260"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.sabcs18-5260","doi":"https://doi.org/10.1158/1538-7445.sabcs18-5260","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.sabcs18-5260","pdf_url":null,"source":{"id":"https://openalex.org/S4306520151","display_name":"Molecular and Cellular Biology / Genetics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular and Cellular Biology / Genetics","raw_type":"proceedings-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102508199","display_name":"Noriko Mori","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Noriko Mori","raw_affiliation_strings":["Division of Cancer Imaging Research, The Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cancer Imaging Research, The Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073317376","display_name":"Balaji Krishnamachary","orcid":"https://orcid.org/0000-0001-6137-5832","observed_orcids":["https://orcid.org/0000-0001-6137-5832"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Balaji Krishnamachary","raw_affiliation_strings":["Division of Cancer Imaging Research, The Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cancer Imaging Research, The Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022882865","display_name":"Jiefu Jin","orcid":"https://orcid.org/0000-0002-5318-1111","observed_orcids":["https://orcid.org/0000-0002-5318-1111"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jiefu Jin","raw_affiliation_strings":["Division of Cancer Imaging Research, The Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cancer Imaging Research, The Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]}]},{"author_position":"middle","author":{"id":null,"display_name":"James Barnett","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James Barnett","raw_affiliation_strings":["Division of Cancer Imaging Research, The Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cancer Imaging Research, The Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068651161","display_name":"Yelena Mironchik","orcid":"https://orcid.org/0000-0002-0330-5446","observed_orcids":["https://orcid.org/0000-0002-0330-5446"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yelena Mironchik","raw_affiliation_strings":["Division of Cancer Imaging Research, The Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cancer Imaging Research, The Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5009487218","display_name":"Zaver M. Bhujwalla","orcid":"https://orcid.org/0000-0002-6617-9360","observed_orcids":["https://orcid.org/0000-0002-6617-9360"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zaver M. Bhujwalla","raw_affiliation_strings":["Division of Cancer Imaging Research, The Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cancer Imaging Research, The Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"5260","last_page":"5260"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12505","display_name":"Peptidase Inhibition and Analysis","score":0.9258000254631042,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12505","display_name":"Peptidase Inhibition and Analysis","score":0.9258000254631042,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.03449999913573265,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12465","display_name":"Cancer, Lipids, and Metabolism","score":0.005499999970197678,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fibroblast-activation-protein","display_name":"fibroblast activation protein","score":0.9160000085830688},{"id":"https://openalex.org/keywords/triple-negative-breast-cancer","display_name":"triple-negative breast cancer","score":0.8880000114440918},{"id":"https://openalex.org/keywords/tumor-metabolism","display_name":"cancer metabolism","score":0.9259999990463257},{"id":"https://openalex.org/keywords/mda-mb-231-cells","display_name":"MDA-MB-231 cells","score":0.8690000176429749},{"id":"https://openalex.org/keywords/1h-magnetic-resonance-spectroscopy","display_name":"1H magnetic resonance spectroscopy","score":0.6389999985694885},{"id":"https://openalex.org/keywords/metabolomics","display_name":"metabolomics","score":0.46000000834465027},{"id":"https://openalex.org/keywords/aspartate","display_name":"aspartic acid","score":0.8410000205039978},{"id":"https://openalex.org/keywords/glycerophosphocholine","display_name":"glycerophosphocholine","score":0.9869999885559082},{"id":"https://openalex.org/keywords/lactate","display_name":"lactate","score":0.9789999723434448},{"id":"https://openalex.org/keywords/myo-inositol","display_name":"myo-inositol","score":0.9240000247955322},{"id":"https://openalex.org/keywords/phosphatidylcholine","display_name":"phosphatidylcholine","score":0.9700000286102295},{"id":"https://openalex.org/keywords/choline-metabolites","display_name":"choline metabolites","score":0.8429999947547913},{"id":"https://openalex.org/keywords/amino-acids","display_name":"amino acids","score":0.6269999742507935},{"id":"https://openalex.org/keywords/lipid-metabolism","display_name":"lipid metabolism","score":0.5059999823570251},{"id":"https://openalex.org/keywords/serine-protease","display_name":"serine protease","score":0.5820000171661377},{"id":"https://openalex.org/keywords/gene-overexpression","display_name":"gene overexpression","score":0.5070000290870667}],"concepts":[{"id":"https://openalex.org/C2780110267","wikidata":"https://www.wikidata.org/wiki/Q7843332","display_name":"Triple-negative breast cancer","level":4,"score":0.6069751977920532},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.5732265710830688},{"id":"https://openalex.org/C111798993","wikidata":"https://www.wikidata.org/wiki/Q21117471","display_name":"Fibroblast activation protein, alpha","level":3,"score":0.558413028717041},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.518038809299469},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.47787466645240784},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.4535350799560547},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.43537116050720215},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4327622950077057},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.398597776889801},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.39677804708480835},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.32370302081108093},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.210904061794281},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.11636623740196228}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.sabcs18-5260","doi":"https://doi.org/10.1158/1538-7445.sabcs18-5260","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.sabcs18-5260","pdf_url":null,"source":{"id":"https://openalex.org/S4306520151","display_name":"Molecular and Cellular Biology / Genetics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular and Cellular Biology / Genetics","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9476000070571899,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4322741334","https://openalex.org/W3081589870","https://openalex.org/W3121946489","https://openalex.org/W2971567338","https://openalex.org/W2587927363","https://openalex.org/W2337611268","https://openalex.org/W2037825783","https://openalex.org/W4245417903","https://openalex.org/W7205311294","https://openalex.org/W7062180164"],"abstract_inverted_index":{"Fibroblast":[0],"activation":[1],"protein-\u03b1":[2],"(FAP-\u03b1)":[3],"is":[4,11,294],"a":[5,61,77,161],"cell":[6,33,86,149,207,332,338,342,409],"surface":[7],"serine":[8],"protease":[9],"that":[10,88,121,263,296],"attracting":[12],"increasing":[13],"interest":[14,180],"because":[15],"of":[16,29,49,64,81,136,176,179,188,308,337,379,423],"its":[17,94],"role":[18,28,80,378],"in":[19,31,83,93,97,139,290,302,322,350,366,414],"immune":[20],"suppression":[21],"and":[22,45,51,69,169,183,190,234,237,270,276,281,368],"cancer":[23,32,85,98,418],"metastasis.":[24],"To":[25],"understand":[26],"the":[27,116,134,177,186,214,225,241,273,284,306,315,330,335,357,375,424],"FAP-\u03b1":[30,44,52,72,82,131,137,412],"metabolism":[34,87,410],"we":[35],"engineered":[36,114],"triple":[37,415],"negative":[38,416],"MDA-MB-231":[39],"cells":[40,54,112,144,189,304,324,419],"to":[41,185,319,326,348],"stably":[42],"overexpress":[43],"compared":[46,325],"metabolic":[47,376],"profiles":[48],"parental":[50,327],"overexpressing":[53],"using":[55,115,171,213,257],"1H":[56,155,258],"MR":[57,156,259],"spectroscopy.":[58],"We":[59,261,353],"observed":[60],"significant":[62,364],"increase":[63],"aspartate,":[65],"glycerophosphocholine,":[66],"lactate,":[67],"myoinositol":[68],"phosphatidylcholine":[70],"with":[71,130],"overexpression.":[73],"These":[74],"results":[75],"identify":[76],"previously":[78,152],"unknown":[79],"modifying":[84],"may":[89],"provide":[90,371],"new":[91,372],"insights":[92,373],"functional":[95],"roles":[96],"progression.MDA-231luc":[99],"(parent":[100],"cells),":[101],"derived":[102],"from":[103,107,201,205,224,240,272,283,312],"MDA-MB-231,":[104],"were":[105,113,145,158,181,195,287,340],"purchased":[106],"Sibtech":[108],"Inc.":[109],"MDA-231luc-FAP\u03b1":[110],"(231-FAP\u03b1)":[111],"gene":[117],"for":[118,147,427],"human":[119],"FAP":[120],"was":[122,211,299,389],"subcloned":[123],"into":[124,374],"lentiviral":[125],"vector":[126],"pMA3211.":[127],"Immunoblot":[128],"analysis":[129],"antibody":[132],"confirmed":[133],"overexpression":[135,413],"protein":[138],"231-FAP\u03b1":[140,291,303,323],"cells.":[141,292,328],"Approximately":[142],"3.5x107":[143],"used":[146],"dual-phase":[148],"extraction":[150],"as":[151,197],"described":[153],"[1].":[154],"spectra":[157],"recorded":[159],"on":[160],"Bruker":[162],"Biospin":[163],"Avance-III":[164],"750":[165],"MHz":[166],"NMR":[167],"spectrometer":[168],"analyzed":[170],"TOPSPIN":[172],"3.5":[173],"software.":[174],"Integrals":[175],"metabolites":[178,223,233,265],"determined":[182],"normalized":[184],"number":[187],"internal":[191],"standard.":[192],"Metabolite":[193],"levels":[194],"quantified":[196],"arbitrary":[198],"units":[199],"(A.U.)":[200],"three":[202],"experimental":[203],"samples":[204],"each":[206],"line.":[208],"Statistical":[209],"significance":[210],"evaluated":[212],"unpaired":[215],"one":[216],"tailed":[217],"Student":[218],"t":[219],"test.We":[220],"identified":[221],"18":[222],"aqueous":[226,274],"phase":[227,243,275,286],"(8":[228],"amino":[229],"acids,":[230],"3":[231],"choline":[232],"7":[235],"others)":[236],"10":[238],"signals":[239,278,310,317],"lipid":[242,285],"(7":[244],"Fatty":[245],"acids":[246],"(FA),":[247],"Cholesterol,":[248],"Phosphatidylethanolamine":[249],"(PtdE),":[250],"-N(CH3)3:":[251],"Phosphatidylcholine":[252],"(PtdCho)":[253],"&":[254],"Sphingomyelin":[255],"(SM))":[256],"spectra.":[260],"found":[262],"4":[264],"(aspartate,":[266],"glycerophosphocholine":[267],"(GPC),":[268],"lactate":[269],"myo-inositol)":[271],"2":[277],"(FA:":[279],"-CH2-CH2-CH=,":[280],"-N(CH3)3)":[282],"significantly":[288,300],"higher":[289,301,321],"It":[293],"likely":[295],"PtdCho":[297],"level":[298],"since":[305],"majority":[307],"-N(CH3)3":[309],"are":[311,354],"PtdCho.":[313],"All":[314],"FA":[316],"tended":[318],"be":[320],"Since":[329],"average":[331],"numbers":[333],"at":[334],"time":[336],"collection":[339],"similar,":[341],"density":[343],"differences":[344,349,365],"did":[345],"not":[346],"contribute":[347],"metabolite":[351],"levels.":[352],"currently":[355],"investigating":[356],"molecular":[358],"mechanisms":[359],"underlying":[360],"these":[361],"differences.":[362],"The":[363],"water-soluble":[367],"lipid-soluble":[369],"extracts":[370],"modulatory":[377],"FAP-\u03b1.[1]":[380],"Krishnamachary":[381],"B,":[382],"et":[383],"al.":[384],"Cancer":[385,428,442],"Res.":[386],"2009;15;69(8):3464-71This":[387],"work":[388],"supported":[390],"by":[391,411],"NIH":[392],"R35CA209960.Citation":[393],"Format:":[394],"Noriko":[395],"Mori,":[396],"Balaji":[397],"Krishnamachary,":[398],"Jiefu":[399],"Jin,":[400],"James":[401],"Barnett,":[402],"Yelena":[403],"Mironchik,":[404],"Zaver":[405],"M.":[406],"Bhujwalla.":[407],"Different":[408],"breast":[417],"[abstract].":[420],"In:":[421],"Proceedings":[422],"American":[425],"Association":[426],"Research":[429],"Annual":[430],"Meeting":[431],"2019;":[432],"2019":[433],"Mar":[434],"29-Apr":[435],"3;":[436],"Atlanta,":[437],"GA.":[438],"Philadelphia":[439],"(PA):":[440],"AACR;":[441],"Res":[443],"2019;79(13":[444],"Suppl):Abstract":[445],"nr":[446],"5260.":[447]},"counts_by_year":[{"year":2025,"cited_by_count":1}],"updated_date":"2026-10-08T09:06:37.294493","created_date":"2022-05-12T00:00:00"}
