{"id":"https://openalex.org/W4251365185","doi":"https://doi.org/10.1177/117762500700100009","title":"The Remarkable Mechanism of Prostaglandin E2 on Synaptic Plasticity","display_name":"The Remarkable Mechanism of Prostaglandin E2 on Synaptic Plasticity","publication_year":2007,"publication_date":"2007-01-01","ids":{"openalex":"https://openalex.org/W4251365185","doi":"https://doi.org/10.1177/117762500700100009","mag":"1580463033","pmid":"https://pubmed.ncbi.nlm.nih.gov/19936099","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2759147"},"language":"en","primary_location":{"id":"doi:10.1177/117762500700100009","doi":"https://doi.org/10.1177/117762500700100009","is_oa":true,"landing_page_url":"https://doi.org/10.1177/117762500700100009","pdf_url":null,"source":{"id":"https://openalex.org/S2764764968","display_name":"Gene Regulation and Systems Biology","issn_l":"1177-6250","issn":["1177-6250"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","poland-100"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gene Regulation and Systems Biology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1177/117762500700100009","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5000980697","display_name":"Yukio Akaneya","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Yukio Akaneya","raw_affiliation_strings":["Division of Neurophysiology, Department of Neuroscience, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita 565-0871 Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Neurophysiology, Department of Neuroscience, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita 565-0871 Japan","institution_ids":["https://openalex.org/I98285908"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5000980697"],"corresponding_institution_ids":["https://openalex.org/I98285908"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":15,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"1","issue":null,"first_page":"83","last_page":"9"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10678","display_name":"Inflammatory mediators and NSAID effects","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/prostaglandin-e2","display_name":"prostaglandin E2","score":1.0},{"id":"https://openalex.org/keywords/synaptic-plasticity","display_name":"synaptic plasticity","score":0.9390000104904175},{"id":"https://openalex.org/keywords/long-term-potentiation","display_name":"long-term potentiation","score":0.9959999918937683},{"id":"https://openalex.org/keywords/visual-cortex","display_name":"visual cortex","score":0.8730000257492065},{"id":"https://openalex.org/keywords/pge2-receptors","display_name":"PGE2 receptors","score":0.9179999828338623},{"id":"https://openalex.org/keywords/camp","display_name":"cyclic AMP","score":0.699999988079071},{"id":"https://openalex.org/keywords/ampa-receptor-trafficking","display_name":"AMPA receptor trafficking","score":0.9549999833106995},{"id":"https://openalex.org/keywords/intracellular-signaling","display_name":"intracellular signaling","score":0.796999990940094},{"id":"https://openalex.org/keywords/arachidonic-acid-metabolism","display_name":"arachidonic acid metabolism","score":0.8259999752044678}],"concepts":[{"id":"https://openalex.org/C25274449","wikidata":"https://www.wikidata.org/wiki/Q1805481","display_name":"Long-term potentiation","level":3,"score":0.7948083877563477},{"id":"https://openalex.org/C98229152","wikidata":"https://www.wikidata.org/wiki/Q1551556","display_name":"Synaptic plasticity","level":3,"score":0.7577773928642273},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.6951985955238342},{"id":"https://openalex.org/C127445978","wikidata":"https://www.wikidata.org/wiki/Q187181","display_name":"Synapse","level":2,"score":0.6140123009681702},{"id":"https://openalex.org/C194973443","wikidata":"https://www.wikidata.org/wiki/Q1420291","display_name":"Metaplasticity","level":4,"score":0.573989987373352},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.48264580965042114},{"id":"https://openalex.org/C5687787","wikidata":"https://www.wikidata.org/wiki/Q5889850","display_name":"Homeostatic plasticity","level":5,"score":0.4739266037940979},{"id":"https://openalex.org/C47611674","wikidata":"https://www.wikidata.org/wiki/Q849491","display_name":"Neuroplasticity","level":2,"score":0.46897515654563904},{"id":"https://openalex.org/C117718741","wikidata":"https://www.wikidata.org/wiki/Q7662041","display_name":"Synaptic scaling","level":5,"score":0.46515971422195435},{"id":"https://openalex.org/C197341189","wikidata":"https://www.wikidata.org/wiki/Q863533","display_name":"Postsynaptic potential","level":3,"score":0.4405844509601593},{"id":"https://openalex.org/C73009533","wikidata":"https://www.wikidata.org/wiki/Q1517140","display_name":"Long-term depression","level":5,"score":0.4391346871852875},{"id":"https://openalex.org/C194082555","wikidata":"https://www.wikidata.org/wiki/Q7317034","display_name":"Retrograde signaling","level":3,"score":0.4278862178325653},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.3923609256744385},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3465510308742523},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.34530383348464966},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.33420926332473755},{"id":"https://openalex.org/C160268369","wikidata":"https://www.wikidata.org/wiki/Q295251","display_name":"AMPA receptor","level":4,"score":0.30702394247055054},{"id":"https://openalex.org/C61174792","wikidata":"https://www.wikidata.org/wiki/Q420510","display_name":"Glutamate receptor","level":3,"score":0.14251157641410828},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.12849417328834534}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.1177/117762500700100009","doi":"https://doi.org/10.1177/117762500700100009","is_oa":true,"landing_page_url":"https://doi.org/10.1177/117762500700100009","pdf_url":null,"source":{"id":"https://openalex.org/S2764764968","display_name":"Gene Regulation and Systems Biology","issn_l":"1177-6250","issn":["1177-6250"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","poland-100"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gene Regulation and Systems Biology","raw_type":"journal-article"},{"id":"pmid:19936099","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19936099","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gene regulation and systems biology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2759147","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2759147/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gene Regul Syst Bio","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:3038523caa5a4796b469e41a1f1ba49c","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/3038523caa5a4796b469e41a1f1ba49c","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Gene Regulation and Systems Biology, Vol 1 (2007)","raw_type":"article"},{"id":"mag:1580463033","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19936099","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"doi:10.1177/117762500700100009","doi":"https://doi.org/10.1177/117762500700100009","is_oa":true,"landing_page_url":"https://doi.org/10.1177/117762500700100009","pdf_url":null,"source":{"id":"https://openalex.org/S2764764968","display_name":"Gene Regulation and Systems Biology","issn_l":"1177-6250","issn":["1177-6250"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","poland-100"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gene Regulation and Systems Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.4043000042438507,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":43,"referenced_works":["https://openalex.org/W198838389","https://openalex.org/W1523969239","https://openalex.org/W1546944401","https://openalex.org/W1562714701","https://openalex.org/W1647075334","https://openalex.org/W1647648618","https://openalex.org/W1666619344","https://openalex.org/W1863572237","https://openalex.org/W1965507972","https://openalex.org/W1975013131","https://openalex.org/W1976576124","https://openalex.org/W1977816613","https://openalex.org/W1979861588","https://openalex.org/W1987151245","https://openalex.org/W2002927748","https://openalex.org/W2008424322","https://openalex.org/W2010929645","https://openalex.org/W2019378068","https://openalex.org/W2019673607","https://openalex.org/W2028984555","https://openalex.org/W2033810486","https://openalex.org/W2035600628","https://openalex.org/W2051473177","https://openalex.org/W2065445418","https://openalex.org/W2067634545","https://openalex.org/W2072601766","https://openalex.org/W2074126807","https://openalex.org/W2077831608","https://openalex.org/W2079302576","https://openalex.org/W2081901335","https://openalex.org/W2084363696","https://openalex.org/W2091646105","https://openalex.org/W2115622309","https://openalex.org/W2117401390","https://openalex.org/W2121612337","https://openalex.org/W2141549406","https://openalex.org/W2156999424","https://openalex.org/W2157630878","https://openalex.org/W2315930495","https://openalex.org/W2412479045","https://openalex.org/W2429686456","https://openalex.org/W4248634331","https://openalex.org/W4293052548"],"related_works":["https://openalex.org/W1977816613","https://openalex.org/W2091646105","https://openalex.org/W2137004069","https://openalex.org/W2141186235","https://openalex.org/W2043906255","https://openalex.org/W2018403116","https://openalex.org/W2081901335","https://openalex.org/W2535255747","https://openalex.org/W401182283","https://openalex.org/W2011686494"],"abstract_inverted_index":{"Prostanoids":[0],"have":[1,26,86,115],"a":[2,9,44,62,88,187,202],"broad":[3],"spectrum":[4],"of":[5,11,65,75,93,97,108,111,128,139,148,151,159,164,169,193,205,207],"biological":[6],"activities":[7],"in":[8,22,32,36,50,67,100,118,131,141,195,210,213],"variety":[10],"organs":[12],"including":[13],"the":[14,23,37,51,68,91,101,106,126,132,137,142,160,167,170,174,181,191,196,214],"brain.":[15,215],"However,":[16],"their":[17],"effects":[18],"on":[19,73,166],"synaptic":[20,76,98,211],"plasticity":[21,77,99,212],"brain,":[24],"which":[25],"been":[27],"recently":[28],"revealed,":[29],"are":[30],"ambiguous":[31],"comparison":[33],"to":[34],"those":[35],"other":[38],"organs.":[39],"Prostaglandin":[40],"E(2)":[41],"(PGE(2))":[42],"is":[43,59,157],"prostanoid":[45],"produced":[46],"from":[47],"arachidonic":[48],"acid":[49],"cellular":[52],"membrane,":[53],"and":[54,176],"knowledge":[55],"about":[56],"its":[57],"functions":[58,117],"increasing.":[60],"Recently,":[61],"novel":[63],"function":[64],"PGE(2)":[66,112,152,184,208],"brain":[69],"has":[70],"shed":[71],"light":[72],"aspects":[74],"such":[78],"as":[79,186],"long-term":[80],"potentiation":[81],"(LTP).":[82],"More":[83],"recently,":[84],"we":[85,179],"proposed":[87],"hypothesis":[89,156,182],"for":[90,136,190],"mechanisms":[92,123,138],"this":[94,155],"PGE(2)-related":[95],"form":[96],"visual":[102,143,197],"cortex.":[103,144,198],"This":[104,199],"involves":[105],"dynamics":[107],"two":[109],"subtypes":[110],"receptors":[113,153,172,209],"that":[114,124,183],"opposing":[116],"intracellular":[119],"signal":[120],"transduction.":[121],"Consequently,":[122],"increase":[125],"level":[127],"cyclic":[129],"AMP":[130],"cytosol":[133],"may":[134],"explain":[135],"LTP":[140,165,194],"The":[145],"current":[146],"notion":[147],"bidirectional":[149],"trafficking":[150,168],"under":[154],"reminiscent":[158],"\"silent":[161],"synapse\"":[162],"mechanism":[163],"AMPA":[171],"between":[173],"membrane":[175],"cytosol.":[177],"Moreover,":[178],"propose":[180],"acts":[185],"\"post-to-postsynaptic":[188],"messenger\"":[189],"induction":[192],"review":[200],"describes":[201],"complex":[203],"mode":[204],"action":[206]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2022-05-12T00:00:00"}