{"id":"https://openalex.org/W42508214","doi":null,"title":"In favour of prophylactic treatment for post-operative recurrence in Crohn's disease.","display_name":"In favour of prophylactic treatment for post-operative recurrence in Crohn's disease.","publication_year":1998,"publication_date":"1998-04-01","ids":{"openalex":"https://openalex.org/W42508214","mag":"42508214","pmid":"https://pubmed.ncbi.nlm.nih.gov/9675663"},"language":"en","primary_location":{"id":"pmid:9675663","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9675663","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Italian journal of gastroenterology and hepatology","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5091201235","display_name":"R. Caprilli","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"R Caprilli","raw_affiliation_strings":["Gastroenterology Unit, University of Rome La Sapienza, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gastroenterology Unit, University of Rome La Sapienza, Rome, Italy","institution_ids":["https://openalex.org/I861853513"]}]},{"author_position":"middle","author":{"id":null,"display_name":"G Taddei","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G Taddei","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5049068984","display_name":"Angelo Viscido","orcid":"https://orcid.org/0000-0001-8513-3758","observed_orcids":["https://orcid.org/0000-0001-8513-3758"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A Viscido","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.629,"has_fulltext":false,"cited_by_count":12,"citation_normalized_percentile":{"value":0.69165247,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"30","issue":"2","first_page":"219","last_page":"25"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10335","display_name":"Colorectal Cancer Surgical Treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12518","display_name":"Diverticular Disease and Complications","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/postoperative-recurrence","display_name":"postoperative recurrence","score":0.7870000004768372},{"id":"https://openalex.org/keywords/prophylaxis","display_name":"prophylaxis","score":0.8700000047683716},{"id":"https://openalex.org/keywords/ileal-resection","display_name":"ileal resection","score":0.781000018119812},{"id":"https://openalex.org/keywords/aminosalicylates","display_name":"aminosalicylates","score":0.9100000262260437},{"id":"https://openalex.org/keywords/5-aminosalicylic-acid","display_name":"5-aminosalicylic acid","score":0.8190000057220459},{"id":"https://openalex.org/keywords/asacol","display_name":"Asacol","score":0.8180000185966492},{"id":"https://openalex.org/keywords/pentasa","display_name":"Pentasa","score":0.9950000047683716},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.7429999709129333},{"id":"https://openalex.org/keywords/interleukins","display_name":"interleukins","score":0.6000000238418579},{"id":"https://openalex.org/keywords/phospholipase-a2","display_name":"phospholipase A2","score":0.8840000033378601},{"id":"https://openalex.org/keywords/end-to-end-anastomosis","display_name":"end-to-end anastomosis","score":0.9150000214576721},{"id":"https://openalex.org/keywords/smoking","display_name":"smoking","score":0.7009999752044678},{"id":"https://openalex.org/keywords/metronidazole","display_name":"metronidazole","score":0.8349999785423279},{"id":"https://openalex.org/keywords/fish-oil","display_name":"fish oil","score":0.9860000014305115},{"id":"https://openalex.org/keywords/maintenance-therapy","display_name":"maintenance therapy","score":0.6129999756813049}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9514191150665283},{"id":"https://openalex.org/C2779280984","wikidata":"https://www.wikidata.org/wiki/Q1472","display_name":"Crohn's disease","level":3,"score":0.7571945190429688},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.6472063660621643},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.6328945755958557},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6053491234779358},{"id":"https://openalex.org/C2777226302","wikidata":"https://www.wikidata.org/wiki/Q233345","display_name":"Ileum","level":2,"score":0.49078568816185},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.4797405004501343},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.4229002594947815},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.4224843978881836}],"mesh":[{"descriptor_ui":"D000305","descriptor_name":"Adrenal Cortex Hormones","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000636","descriptor_name":"Aminosalicylic Acids","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D003424","descriptor_name":"Crohn Disease","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D003424","descriptor_name":"Crohn Disease","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005395","descriptor_name":"Fish Oils","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008795","descriptor_name":"Metronidazole","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D011182","descriptor_name":"Postoperative Care","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011687","descriptor_name":"Purines","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013505","descriptor_name":"Digestive System Surgical Procedures","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D016032","descriptor_name":"Randomized Controlled Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055502","descriptor_name":"Secondary Prevention","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmid:9675663","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9675663","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Italian journal of gastroenterology and hepatology","raw_type":"Journal Article"},{"id":"pmh:oai:ricerca.univaq.it:11697/16307","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/11697/16307","pdf_url":null,"source":{"id":"https://openalex.org/S7407055225","display_name":"Archivio Istituzionale della Ricerca - Universit\u00e0 degli Studi dell Aquila","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"mag:42508214","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9675663","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2058268452","https://openalex.org/W1999329203","https://openalex.org/W7217902557","https://openalex.org/W2063527057","https://openalex.org/W2047524713","https://openalex.org/W1967968498","https://openalex.org/W149202834","https://openalex.org/W2123207274","https://openalex.org/W2009989994","https://openalex.org/W2111303051"],"abstract_inverted_index":{"Endoscopic":[0],"follow-up":[1,245],"of":[2,15,26,48,63,90,96,105,122,141,192,223,252,257,275,314,339,355],"patients":[3,43,97,123,202,298,364],"resected":[4,98,365],"for":[5,99,129,250,362,366],"ileal":[6],"Crohn's":[7,100,125,135,293,367],"disease":[8,126,136],"have":[9,80,172,304],"shown":[10,173],"that,":[11],"in":[12,39,44,87,118,134,138,201,231,254,266,273,292,295,297,311,317],"the":[13,17,27,42,61,119,139,189,232,255,312],"absence":[14,140],"treatment,":[16],"post-operative":[18,180,258,315],"recurrence":[19,35,55,194,259,316],"rate":[20],"is":[21,160,287],"70-90%":[22],"within":[23,31],"one":[24],"year":[25],"operation":[28,38],"and":[29,74,92,111,226,302,327,352],"83-100%":[30],"3":[32,243],"years.":[33],"Post-operative":[34],"requires":[36],"further":[37,322],"approximately":[40],"half":[41],"a":[45,130,280],"10-year":[46],"period":[47],"follow-up.":[49],"Therapeutic":[50],"strategies":[51],"aimed":[52],"to":[53,178,207,308,332,346],"prevent":[54,179],"are,":[56],"therefore,":[57,154],"needed.":[58],"Evidence":[59,71,162],"supporting":[60],"administration":[62,354],"drugs":[64],"early":[65,157,353],"after":[66,158,357],"surgery":[67,159,358],"are":[68,147,176,330],"listed":[69],"below.":[70],"from":[72,94,163,279],"morphological":[73],"immunological":[75],"studies:":[76],"minimal":[77],"mucosal":[78],"lesions":[79],"been":[81,116,306],"found":[82,117,307],"using":[83,246],"scanning":[84],"electron":[85],"microscopy":[86],"unaffected":[88,120],"specimens":[89],"ileum":[91],"colon":[93],"2/3":[95],"disease.":[101,368],"An":[102],"increased":[103,337],"production":[104],"TNF":[106],"alpha,":[107],"IL-1":[108],"beta,":[109],"IL-6":[110],"phospholipase":[112],"A2":[113],"has":[114],"also":[115,229,305],"mucosa":[121],"with":[124,204,299,335],"providing":[127],"evidence":[128,249,272],"sustained":[131],"immune":[132],"stimulation":[133],"even":[137],"patent":[142],"inflammation.":[143],"These":[144],"inflammatory":[145],"mediators":[146],"inhibited":[148],"\"in":[149],"vitro\"":[150],"by":[151,262],"aminosalicylates":[152,175,253],"and,":[153],"their":[155],"use":[156],"justified.":[161],"randomised":[164,168],"controlled":[165,169],"trials:":[166],"several":[167],"clinical":[170],"trials":[171],"that":[174,188,285,345],"able":[177],"recurrence.":[181,340],"In":[182],"particular,":[183],"an":[184,336],"Italian":[185],"study":[186,238],"demonstrated":[187],"cumulative":[190],"proportion":[191],"endoscopic":[193],"at":[195,242],"36":[196],"months":[197],"was":[198,228,260,269],"significantly":[199],"lower":[200],"treated":[203],"Asacol":[205,233],"compared":[206],"controls":[208],"(0.57":[209],"+/-":[210,214],"0.12":[211],"vs":[212],"0.83":[213],"0.07,":[215],"p":[216],"=":[217],"0.003).":[218],"A":[219,235],"less":[220],"frequent":[221],"occurrence":[222],"severe":[224],"complications":[225],"reoperations":[227],"observed":[230],"group.":[234],"North":[236],"American":[237],"confirmed":[239],"these":[240,342],"results":[241],"years'":[244],"Salofalk.":[247],"Additional":[248],"effectiveness":[251],"prevention":[256,313],"provided":[261],"two":[263],"more":[264],"studies":[265],"which":[267,283],"Pentasa":[268],"used.":[270],"Further":[271],"favour":[274],"5-ASA":[276,286],"treatment":[277,291],"comes":[278],"recent":[281],"metanalysis":[282],"showed":[284],"effective":[288],"as":[289],"maintenance":[290],"disease,":[294],"particular":[296],"resection.":[300],"Metronidazole":[301],"fish-oil":[303],"be":[309,333,360],"useful":[310],"isolated":[318],"reports":[319],"but":[320],"need":[321],"investigation.":[323],"Finally,":[324],"cigarette":[325],"smoking":[326],"end-to-end":[328,350],"anastomosis":[329,351],"considered":[331],"associated":[334],"risk":[338],"Overall,":[341],"data":[343],"suggest":[344],"stop":[347],"smoking,":[348],"avoiding":[349],"admino-salicylates":[356],"should":[359],"recommended":[361],"all":[363]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
