{"id":"https://openalex.org/W4250411981","doi":"https://doi.org/10.1073/pnas.82.20.6874","title":"Prevention of a plant disease by specific inhibition of fungal polyamine biosynthesis.","display_name":"Prevention of a plant disease by specific inhibition of fungal polyamine biosynthesis.","publication_year":1985,"publication_date":"1985-10-01","ids":{"openalex":"https://openalex.org/W4250411981","doi":"https://doi.org/10.1073/pnas.82.20.6874","pmid":"https://pubmed.ncbi.nlm.nih.gov/3931079","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/390790"},"language":"en","primary_location":{"id":"doi:10.1073/pnas.82.20.6874","doi":"https://doi.org/10.1073/pnas.82.20.6874","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.82.20.6874","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://europepmc.org/pmc/articles/PMC390790","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5030853041","display_name":"Manchikatla Venkat Rajam","orcid":"https://orcid.org/0000-0003-2407-8323","observed_orcids":["https://orcid.org/0000-0003-2407-8323"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M V Rajam","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111718910","display_name":"L. H. Weinstein","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"L H Weinstein","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5086652016","display_name":"Arthur W. Galston","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A W Galston","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.4073,"has_fulltext":false,"cited_by_count":88,"citation_normalized_percentile":{"value":0.8024716,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"82","issue":"20","first_page":"6874","last_page":"6878"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11924","display_name":"Polyamine Metabolism and Applications","score":0.9878000020980835,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11924","display_name":"Polyamine Metabolism and Applications","score":0.9878000020980835,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11900","display_name":"Fungal Plant Pathogen Control","score":0.004900000058114529,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10076","display_name":"Plant-Microbe Interactions and Immunity","score":0.002099999925121665,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ornithine-decarboxylase-inhibition","display_name":"ornithine decarboxylase inhibition","score":0.9330000281333923},{"id":"https://openalex.org/keywords/polyamine-biosynthesis","display_name":"polyamine biosynthesis","score":0.9480000138282776},{"id":"https://openalex.org/keywords/uromyces-phaseoli","display_name":"Uromyces phaseoli","score":0.8389999866485596},{"id":"https://openalex.org/keywords/bean-rust","display_name":"bean rust","score":0.9480000138282776},{"id":"https://openalex.org/keywords/common-bean","display_name":"Phaseolus vulgaris","score":0.9399999976158142},{"id":"https://openalex.org/keywords/plant-disease-prevention","display_name":"plant disease prevention","score":0.6129999756813049},{"id":"https://openalex.org/keywords/fungicides","display_name":"fungicides","score":0.48100000619888306},{"id":"https://openalex.org/keywords/arginine-decarboxylase","display_name":"arginine decarboxylase","score":0.8560000061988831},{"id":"https://openalex.org/keywords/putrescine","display_name":"putrescine","score":0.8230000138282776},{"id":"https://openalex.org/keywords/spermidine","display_name":"spermidine","score":0.9860000014305115},{"id":"https://openalex.org/keywords/plant-pathogenic-fungi","display_name":"plant pathogenic fungi","score":0.7279999852180481}],"concepts":[{"id":"https://openalex.org/C2777167505","wikidata":"https://www.wikidata.org/wiki/Q410190","display_name":"Putrescine","level":3,"score":0.7853772044181824},{"id":"https://openalex.org/C2780115381","wikidata":"https://www.wikidata.org/wiki/Q421959","display_name":"Polyamine","level":2,"score":0.7469737529754639},{"id":"https://openalex.org/C2776286235","wikidata":"https://www.wikidata.org/wiki/Q310438","display_name":"Phaseolus","level":2,"score":0.7377796173095703},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7217496633529663},{"id":"https://openalex.org/C121289238","wikidata":"https://www.wikidata.org/wiki/Q931579","display_name":"Ornithine decarboxylase","level":3,"score":0.6848850846290588},{"id":"https://openalex.org/C2777497464","wikidata":"https://www.wikidata.org/wiki/Q418834","display_name":"Spermidine","level":3,"score":0.6088120937347412},{"id":"https://openalex.org/C2776109719","wikidata":"https://www.wikidata.org/wiki/Q424597","display_name":"Spermine","level":3,"score":0.6086901426315308},{"id":"https://openalex.org/C2777107663","wikidata":"https://www.wikidata.org/wiki/Q4789579","display_name":"Arginine decarboxylase","level":4,"score":0.5766155123710632},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4539225101470947},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.4038740396499634},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.3617209792137146},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.3453022837638855},{"id":"https://openalex.org/C144027150","wikidata":"https://www.wikidata.org/wiki/Q48803","display_name":"Horticulture","level":1,"score":0.3233029246330261}],"mesh":[{"descriptor_ui":"D000518","descriptor_name":"Eflornithine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001120","descriptor_name":"Arginine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D001120","descriptor_name":"Arginine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D001487","descriptor_name":"Basidiomycota","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D001487","descriptor_name":"Basidiomycota","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D007887","descriptor_name":"Fabaceae","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D007887","descriptor_name":"Fabaceae","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009952","descriptor_name":"Ornithine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D009952","descriptor_name":"Ornithine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D010935","descriptor_name":"Plant Diseases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010944","descriptor_name":"Plants","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010946","descriptor_name":"Plants, Medicinal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011073","descriptor_name":"Polyamines","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D065108","descriptor_name":"Ornithine Decarboxylase Inhibitors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1073/pnas.82.20.6874","doi":"https://doi.org/10.1073/pnas.82.20.6874","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.82.20.6874","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:64075","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC390790","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmid:3931079","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3931079","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences of the United States of America","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:390790","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC390790/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:64075","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC390790","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/2","display_name":"Zero hunger","score":0.8409000039100647}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":13,"referenced_works":["https://openalex.org/W989099206","https://openalex.org/W1494632330","https://openalex.org/W1518416688","https://openalex.org/W1632490275","https://openalex.org/W1663235327","https://openalex.org/W1826725990","https://openalex.org/W1866493067","https://openalex.org/W2037695453","https://openalex.org/W2057784457","https://openalex.org/W2079547899","https://openalex.org/W2081129124","https://openalex.org/W2132664565","https://openalex.org/W2411624166"],"related_works":["https://openalex.org/W4256458664","https://openalex.org/W2053999798","https://openalex.org/W2079952745","https://openalex.org/W1818786745","https://openalex.org/W1973721821","https://openalex.org/W7134248257","https://openalex.org/W1970688137","https://openalex.org/W2490126395","https://openalex.org/W1997626844","https://openalex.org/W1505261418"],"abstract_inverted_index":{"DL-alpha-Difluoromethylornithine":[0],"(DFMO),":[1],"an":[2,198,212],"inhibitor":[3,200],"of":[4,17,20,38,42,63,75,86,104,136,163,171,184,190,201,236,241],"the":[5,15,36,64,122,146,188,208,233,239],"polyamine":[6,216,246],"biosynthetic":[7],"enzyme":[8,210],"ornithine":[9,230],"decarboxylase":[10,203,231],"(EC":[11,204],"4.1.1.17),":[12],"strongly":[13],"retards":[14],"growth":[16,41],"several":[18],"species":[19],"phytopathogenic":[21],"fungi":[22],"in":[23,91,109,111,211,218],"vitro.":[24],"Such":[25],"inhibition":[26],"can":[27,50],"be":[28],"completely":[29],"reversed":[30],"by":[31,61,244],"putrescine":[32],"or":[33,99,140],"spermidine,":[34],"confirming":[35],"essentiality":[37],"polyamines":[39],"for":[40,128,215,238],"fungal":[43],"hyphae.":[44],"We":[45],"now":[46],"show":[47],"that":[48],"DFMO":[49,87,137,154,172,177],"protect":[51],"bean":[52,65],"plants":[53,118,166],"(Phaseolus":[54],"vulgaris":[55],"Linnaeus":[56],"cv.":[57],"Pinto)":[58],"against":[59,145],"infection":[60],"uredospores":[62,103],"rust":[66],"fungus,":[67],"Uromyces":[68],"phaseoli":[69],"Linnaeus,":[70],"race":[71],"O.":[72],"Unifoliolate":[73],"leaves":[74],"10-day-old":[76],"greenhouse-grown":[77],"seedlings":[78],"were":[79,119,155],"sprayed":[80,195],"with":[81,102,153,168],"400":[82],"microliter":[83],"per":[84],"leaf":[85],"at":[88,95,148,225],"various":[89],"concentrations":[90,135,170],"0.01%":[92],"Tween":[93],"20":[94],"pH":[96],"7.0":[97],"before":[98],"after":[100],"inoculation":[101],"Uromyces.":[105],"After":[106],"16":[107],"hr":[108],"darkness":[110],"dew":[112],"chambers":[113],"to":[114,121],"facilitate":[115],"spore":[116],"germination,":[117],"transferred":[120],"greenhouse,":[123],"arranged":[124],"randomly,":[125],"and":[126],"examined":[127],"local":[129],"lesions":[130,164],"7":[131],"days":[132],"later.":[133],"All":[134],"0.50":[138],"mM":[139],"higher":[141,219],"gave":[142],"complete":[143],"protection":[144,180,223],"pathogen;":[147],"lower":[149,169],"concentrations,":[150],"postinoculation":[151],"treatments":[152],"generally":[156],"more":[157],"effective":[158],"than":[159],"preinoculation.":[160],"The":[161],"appearance":[162],"on":[165,181],"treated":[167,185],"was":[173],"retarded":[174],"2-6":[175],"days.":[176],"also":[178],"confers":[179,221],"unsprayed":[182],"parts":[183],"plants,":[186,220],"indicating":[187],"translocation":[189],"some":[191],"protective":[192],"effect":[193],"from":[194],"areas.":[196],"DL-alpha-Difluoromethylarginine,":[197],"analogous":[199],"arginine":[202],"4.1.1.19),":[205],"which":[206],"is":[207],"rate-limiting":[209],"alternative":[213],"pathway":[214],"biosynthesis":[217],"no":[222],"even":[224],"5":[226],"mM.":[227],"This":[228],"emphasizes":[229],"as":[232],"biochemical":[234],"locus":[235],"choice":[237],"prevention":[240],"plant":[242],"diseases":[243],"inhibiting":[245],"metabolism.":[247]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2022-05-12T00:00:00"}