{"id":"https://openalex.org/W4250323967","doi":"https://doi.org/10.20996/1819-6446-2013-9-1-90-98","title":"EFFECT OF LONG-TERM EXPOSURE TO LOWER LOW-DENSILIPOPROTEIN CHOLESTEROL BEGINNING EARLY IN LIFE ON THE RISK OF CORONARY HEART DISEASE. A MENDELIAN RANDOMIZATION ANALYSIS","display_name":"EFFECT OF LONG-TERM EXPOSURE TO LOWER LOW-DENSILIPOPROTEIN CHOLESTEROL BEGINNING EARLY IN LIFE ON THE RISK OF CORONARY HEART DISEASE. A MENDELIAN RANDOMIZATION ANALYSIS","publication_year":2013,"publication_date":"2013-01-01","ids":{"openalex":"https://openalex.org/W4250323967","doi":"https://doi.org/10.20996/1819-6446-2013-9-1-90-98","mag":"17691791"},"language":"en","primary_location":{"id":"doi:10.20996/1819-6446-2013-9-1-90-98","doi":"https://doi.org/10.20996/1819-6446-2013-9-1-90-98","is_oa":true,"landing_page_url":"https://doi.org/10.20996/1819-6446-2013-9-1-90-98","pdf_url":null,"source":{"id":"https://openalex.org/S2737589093","display_name":"Rational Pharmacotherapy in Cardiology","issn_l":"1819-6446","issn":["1819-6446","2225-3653"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","norway-1","poland-40","russia-white-list-1"],"host_organization":"https://openalex.org/P4310312825","host_organization_name":"Stolichnaya Izdatelskaya Kompaniya","host_organization_lineage":["https://openalex.org/P4310312825"],"host_organization_lineage_names":["Stolichnaya Izdatelskaya Kompaniya"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Rational Pharmacotherapy in Cardiology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://doi.org/10.20996/1819-6446-2013-9-1-90-98","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5105286197","display_name":"Brian A. Ference","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I185443292","display_name":"Wayne State University","ror":"https://ror.org/01070mq45","country_code":"US","type":"education","lineage":["https://openalex.org/I185443292"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"B. A. Ference","raw_affiliation_strings":["Wayne State University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wayne State University","institution_ids":["https://openalex.org/I185443292"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020774269","display_name":"Wonsuk Yoo","orcid":"https://orcid.org/0000-0003-2414-2399","observed_orcids":["https://orcid.org/0000-0003-2414-2399"]},"institutions":[{"id":"https://openalex.org/I75256744","display_name":"Tennessee State University","ror":"https://ror.org/01fpczx89","country_code":"US","type":"education","lineage":["https://openalex.org/I75256744"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"W. Yoo","raw_affiliation_strings":["Tennessee State University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tennessee State University","institution_ids":["https://openalex.org/I75256744"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077348889","display_name":"Issa G. Alesh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I185443292","display_name":"Wayne State University","ror":"https://ror.org/01070mq45","country_code":"US","type":"education","lineage":["https://openalex.org/I185443292"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"I. Alesh","raw_affiliation_strings":["Wayne State University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wayne State University","institution_ids":["https://openalex.org/I185443292"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081227888","display_name":"Nitin Mahajan","orcid":"https://orcid.org/0000-0002-0907-6410","observed_orcids":["https://orcid.org/0000-0002-0907-6410"]},"institutions":[{"id":"https://openalex.org/I185443292","display_name":"Wayne State University","ror":"https://ror.org/01070mq45","country_code":"US","type":"education","lineage":["https://openalex.org/I185443292"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"N. Mahajan","raw_affiliation_strings":["Wayne State University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wayne State University","institution_ids":["https://openalex.org/I185443292"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066011204","display_name":"Karolina K. Mirowska","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I185443292","display_name":"Wayne State University","ror":"https://ror.org/01070mq45","country_code":"US","type":"education","lineage":["https://openalex.org/I185443292"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"K. K. Mirowska","raw_affiliation_strings":["Wayne State University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wayne State University","institution_ids":["https://openalex.org/I185443292"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062361896","display_name":"Abhishek Mewada","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I185443292","display_name":"Wayne State University","ror":"https://ror.org/01070mq45","country_code":"US","type":"education","lineage":["https://openalex.org/I185443292"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A. Mewada","raw_affiliation_strings":["Wayne State University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wayne State University","institution_ids":["https://openalex.org/I185443292"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114203297","display_name":"Joel Kahn","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800326109","display_name":"Detroit Medical Center","ror":"https://ror.org/05gehxw18","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800326109"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. Kahn","raw_affiliation_strings":["Detroit Medical Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Detroit Medical Center","institution_ids":["https://openalex.org/I2800326109"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018006972","display_name":"Lu\u00eds Adriano Preto Mendes Afonso","orcid":"https://orcid.org/0000-0003-4032-7019","observed_orcids":["https://orcid.org/0000-0003-4032-7019"]},"institutions":[{"id":"https://openalex.org/I185443292","display_name":"Wayne State University","ror":"https://ror.org/01070mq45","country_code":"US","type":"education","lineage":["https://openalex.org/I185443292"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"L. Afonso","raw_affiliation_strings":["Wayne State University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wayne State University","institution_ids":["https://openalex.org/I185443292"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065752371","display_name":"Kirk Williams","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I185443292","display_name":"Wayne State University","ror":"https://ror.org/01070mq45","country_code":"US","type":"education","lineage":["https://openalex.org/I185443292"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"K. A. Williams","raw_affiliation_strings":["Wayne State University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wayne State University","institution_ids":["https://openalex.org/I185443292"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113470208","display_name":"JM Flack","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I185443292","display_name":"Wayne State University","ror":"https://ror.org/01070mq45","country_code":"US","type":"education","lineage":["https://openalex.org/I185443292"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. M. Flack","raw_affiliation_strings":["Wayne State University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wayne State University","institution_ids":["https://openalex.org/I185443292"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":12,"citation_normalized_percentile":{"value":0.51467117,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":98},"biblio":{"volume":"9","issue":"1","first_page":"90","last_page":"98"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10394","display_name":"Lipoproteins and Cardiovascular Health","score":0.9765999913215637,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10394","display_name":"Lipoproteins and Cardiovascular Health","score":0.9765999913215637,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.01679999940097332,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12975","display_name":"Paraoxonase enzyme and polymorphisms","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/1308","display_name":"Clinical Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ldl-cholesterol","display_name":"LDL cholesterol","score":0.9700000286102295},{"id":"https://openalex.org/keywords/coronary-heart-disease-risk","display_name":"coronary heart disease risk","score":0.8849999904632568},{"id":"https://openalex.org/keywords/cardiovascular-risk","display_name":"cardiovascular risk","score":0.33899998664855957}],"concepts":[{"id":"https://openalex.org/C2779901538","wikidata":"https://www.wikidata.org/wiki/Q6816584","display_name":"Mendelian randomization","level":5,"score":0.9112389087677002},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.861881673336029},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5352016091346741},{"id":"https://openalex.org/C3018906752","wikidata":"https://www.wikidata.org/wiki/Q844935","display_name":"Coronary heart disease","level":2,"score":0.5209911465644836},{"id":"https://openalex.org/C204243189","wikidata":"https://www.wikidata.org/wiki/Q1363085","display_name":"Randomization","level":3,"score":0.4991443157196045},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.4693516194820404},{"id":"https://openalex.org/C61797465","wikidata":"https://www.wikidata.org/wiki/Q1188986","display_name":"Term (time)","level":2,"score":0.4644676744937897},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4563468396663666},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.42306017875671387},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.26406633853912354},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.11166158318519592},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.08364561200141907},{"id":"https://openalex.org/C2993967602","wikidata":"https://www.wikidata.org/wiki/Q5532932","display_name":"Genetic variants","level":4,"score":0.07209211587905884},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.20996/1819-6446-2013-9-1-90-98","doi":"https://doi.org/10.20996/1819-6446-2013-9-1-90-98","is_oa":true,"landing_page_url":"https://doi.org/10.20996/1819-6446-2013-9-1-90-98","pdf_url":null,"source":{"id":"https://openalex.org/S2737589093","display_name":"Rational Pharmacotherapy in Cardiology","issn_l":"1819-6446","issn":["1819-6446","2225-3653"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","norway-1","poland-40","russia-white-list-1"],"host_organization":"https://openalex.org/P4310312825","host_organization_name":"Stolichnaya Izdatelskaya Kompaniya","host_organization_lineage":["https://openalex.org/P4310312825"],"host_organization_lineage_names":["Stolichnaya Izdatelskaya Kompaniya"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Rational Pharmacotherapy in Cardiology","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:8cd6cac39ecd4a3880782b2426b524d8","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/8cd6cac39ecd4a3880782b2426b524d8","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"\u0420\u0430\u0446\u0438\u043e\u043d\u0430\u043b\u044c\u043d\u0430\u044f \u0444\u0430\u0440\u043c\u0430\u043a\u043e\u0442\u0435\u0440\u0430\u043f\u0438\u044f \u0432 \u043a\u0430\u0440\u0434\u0438\u043e\u043b\u043e\u0433\u0438\u0438, Vol 9, Iss 1, Pp 90-98 (2015)","raw_type":"article"},{"id":"pmh:oai:doaj.org/article:8fe7c234b5384223bc0d00865c34d4bf","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/8fe7c234b5384223bc0d00865c34d4bf","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"\u0420\u0430\u0446\u0438\u043e\u043d\u0430\u043b\u044c\u043d\u0430\u044f \u0444\u0430\u0440\u043c\u0430\u043a\u043e\u0442\u0435\u0440\u0430\u043f\u0438\u044f \u0432 \u043a\u0430\u0440\u0434\u0438\u043e\u043b\u043e\u0433\u0438\u0438, Vol 9, Iss 1, Pp 90-98 (2015)","raw_type":"article"},{"id":"mag:17691791","doi":null,"is_oa":false,"landing_page_url":"https://cyberleninka.ru/article/n/vliyanie-dlitelnogo-snizheniya-holesterina-lipoproteinov-nizkoy-plotnosti-nachatogo-v-molodom-vozraste-na-risk-razvitiya-ishemicheskoy","pdf_url":null,"source":{"id":"https://openalex.org/S4306540098","display_name":"\u0420\u0430\u0446\u0438\u043e\u043d\u0430\u043b\u044c\u043d\u0430\u044f \u0444\u0430\u0440\u043c\u0430\u043a\u043e\u0442\u0435\u0440\u0430\u043f\u0438\u044f \u0432 \u043a\u0430\u0440\u0434\u0438\u043e\u043b\u043e\u0433\u0438\u0438","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"\u0420\u0430\u0446\u0438\u043e\u043d\u0430\u043b\u044c\u043d\u0430\u044f \u0444\u0430\u0440\u043c\u0430\u043a\u043e\u0442\u0435\u0440\u0430\u043f\u0438\u044f \u0432 \u043a\u0430\u0440\u0434\u0438\u043e\u043b\u043e\u0433\u0438\u0438","raw_type":null}],"best_oa_location":{"id":"doi:10.20996/1819-6446-2013-9-1-90-98","doi":"https://doi.org/10.20996/1819-6446-2013-9-1-90-98","is_oa":true,"landing_page_url":"https://doi.org/10.20996/1819-6446-2013-9-1-90-98","pdf_url":null,"source":{"id":"https://openalex.org/S2737589093","display_name":"Rational Pharmacotherapy in Cardiology","issn_l":"1819-6446","issn":["1819-6446","2225-3653"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","norway-1","poland-40","russia-white-list-1"],"host_organization":"https://openalex.org/P4310312825","host_organization_name":"Stolichnaya Izdatelskaya Kompaniya","host_organization_lineage":["https://openalex.org/P4310312825"],"host_organization_lineage_names":["Stolichnaya Izdatelskaya Kompaniya"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Rational Pharmacotherapy in Cardiology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2338825905","https://openalex.org/W2094941186","https://openalex.org/W17691791","https://openalex.org/W72392028","https://openalex.org/W2081728367","https://openalex.org/W2010986951","https://openalex.org/W2331320282","https://openalex.org/W2304056429","https://openalex.org/W3083239500","https://openalex.org/W2333012521"],"abstract_inverted_index":{"Translation":[0],"articles:":[1],"B.A.":[2],"Ference,":[3],"W.":[4],"Yoo,":[5],"I.":[6],"Alesh,":[7],"N.":[8],"Mahajan,":[9],"K.K.":[10],"Mirowska,":[11],"A.":[12],"Mewada,":[13],"J.":[14],"Kahn,":[15],"L.":[16],"Afonso,":[17],"K.A.":[18],"Williams,":[19],"J.M.":[20],"Flack":[21],"\u00abEffect":[22],"of":[23,38],"Long-Term":[24],"Exposure":[25],"to":[26],"Lower":[27],"Low-Density":[28],"Lipoprotein":[29],"Cholesterol":[30],"Beginning":[31],"Early":[32],"in":[33],"Life":[34],"on":[35],"the":[36,61],"Risk":[37],"Coronary":[39],"Heart":[40],"Disease.":[41],"A":[42],"Mendelian":[43],"Randomization":[44],"Analysis\u00bb":[45],"\u0432\u043f\u0435\u0440\u0432\u044b\u0435":[46],"\u043e\u043f\u0443\u0431\u043b\u0438\u043a\u043e\u0432\u0430\u043d\u0430":[47],"\u0432":[48],"\u0436\u0443\u0440\u043d\u0430\u043b\u0435":[49],"J":[50],"Am":[51],"Coll":[52],"Cardiol":[53],"2012;":[54],"60(25):":[55],"2631-9;":[56],"doi:10.1016/j.jacc.2012.09.017":[57],"\u00a9":[58],"2012":[59],"by":[60],"AmericanCollegeofCardiology":[62],"Foundation":[63]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":6},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2022-05-12T00:00:00"}
