{"id":"https://openalex.org/W4249959490","doi":"https://doi.org/10.1177/070674378102600203","title":"Benzodiazepine Withdrawal","display_name":"Benzodiazepine Withdrawal","publication_year":1981,"publication_date":"1981-03-01","ids":{"openalex":"https://openalex.org/W4249959490","doi":"https://doi.org/10.1177/070674378102600203","pmid":"https://pubmed.ncbi.nlm.nih.gov/6114793"},"language":"en","primary_location":{"id":"doi:10.1177/070674378102600203","doi":"https://doi.org/10.1177/070674378102600203","is_oa":false,"landing_page_url":"https://doi.org/10.1177/070674378102600203","pdf_url":null,"source":{"id":"https://openalex.org/S8901149","display_name":"The Canadian Journal of Psychiatry","issn_l":"0706-7437","issn":["0706-7437","1497-0015"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Canadian Journal of Psychiatry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5008252939","display_name":"Y.D. Lapierre","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I153718931","display_name":"University of Ottawa","ror":"https://ror.org/03c4mmv16","country_code":"CA","type":"education","lineage":["https://openalex.org/I153718931"]},{"id":"https://openalex.org/I2800991225","display_name":"Royal Ottawa Mental Health Centre","ror":"https://ror.org/056vnsb08","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2800991225"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"Y.D. Lapierre","raw_affiliation_strings":["Department of Psychiatry & Pharmacology, University of Ottawa, Royal Ottawa Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry & Pharmacology, University of Ottawa, Royal Ottawa Hospital","institution_ids":["https://openalex.org/I153718931","https://openalex.org/I2800991225"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5008252939"],"corresponding_institution_ids":["https://openalex.org/I153718931","https://openalex.org/I2800991225"],"apc_list":{"value":4400,"currency":"USD","value_usd":4400},"apc_paid":null,"fwci":3.1765,"has_fulltext":false,"cited_by_count":27,"citation_normalized_percentile":{"value":0.92692828,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":87,"max":93},"biblio":{"volume":"26","issue":"2","first_page":"93","last_page":"95"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10043","display_name":"Substance Abuse Treatment and Outcomes","score":0.5375999808311462,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10043","display_name":"Substance Abuse Treatment and Outcomes","score":0.5375999808311462,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10496","display_name":"Pharmaceutical Practices and Patient Outcomes","score":0.11240000277757645,"subfield":{"id":"https://openalex.org/subfields/2717","display_name":"Geriatrics and Gerontology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13105","display_name":"Synthesis and pharmacology of benzodiazepine derivatives","score":0.02969999983906746,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/benzodiazepine-withdrawal","display_name":"benzodiazepine withdrawal","score":0.9819999933242798},{"id":"https://openalex.org/keywords/benzodiazepines","display_name":"benzodiazepines","score":0.9259999990463257},{"id":"https://openalex.org/keywords/drug-addiction","display_name":"drug addiction","score":0.6579999923706055},{"id":"https://openalex.org/keywords/tolerance-pharmacology-and-immunology","display_name":"tolerance (pharmacology and immunology)","score":0.8289999961853027},{"id":"https://openalex.org/keywords/withdrawal-reactions","display_name":"withdrawal reactions","score":0.5929999947547913},{"id":"https://openalex.org/keywords/long-acting-benzodiazepines","display_name":"long-acting benzodiazepines","score":0.9610000252723694},{"id":"https://openalex.org/keywords/bioactive-metabolites","display_name":"bioactive metabolites","score":0.7720000147819519},{"id":"https://openalex.org/keywords/sedative-hypnotics","display_name":"sedative-hypnotic drugs","score":0.7139999866485596}],"concepts":[{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.5243375897407532},{"id":"https://openalex.org/C2778173252","wikidata":"https://www.wikidata.org/wiki/Q83871","display_name":"Benzodiazepine","level":3,"score":0.42874112725257874},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.37106454372406006},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.3417789936065674},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.10378524661064148},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D001007","descriptor_name":"Anxiety","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D003975","descriptor_name":"Diazepam","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D004361","descriptor_name":"Drug Tolerance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007319","descriptor_name":"Sleep Initiation and Maintenance Disorders","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D008140","descriptor_name":"Lorazepam","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D010076","descriptor_name":"Oxazepam","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D013375","descriptor_name":"Substance Withdrawal Syndrome","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014151","descriptor_name":"Anti-Anxiety Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D014151","descriptor_name":"Anti-Anxiety Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1177/070674378102600203","doi":"https://doi.org/10.1177/070674378102600203","is_oa":false,"landing_page_url":"https://doi.org/10.1177/070674378102600203","pdf_url":null,"source":{"id":"https://openalex.org/S8901149","display_name":"The Canadian Journal of Psychiatry","issn_l":"0706-7437","issn":["0706-7437","1497-0015"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Canadian Journal of Psychiatry","raw_type":"journal-article"},{"id":"pmid:6114793","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6114793","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Canadian journal of psychiatry. Revue canadienne de psychiatrie","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9476000070571899,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":14,"referenced_works":["https://openalex.org/W69003780","https://openalex.org/W1973374000","https://openalex.org/W1982565234","https://openalex.org/W1984112365","https://openalex.org/W2007911341","https://openalex.org/W2028672020","https://openalex.org/W2040086787","https://openalex.org/W2055639263","https://openalex.org/W2069755811","https://openalex.org/W2082111758","https://openalex.org/W2093168683","https://openalex.org/W2405043891","https://openalex.org/W4231253110","https://openalex.org/W4238517656"],"related_works":["https://openalex.org/W2076117152","https://openalex.org/W2028672020","https://openalex.org/W578530718","https://openalex.org/W2063995940","https://openalex.org/W2010314003","https://openalex.org/W4248430134","https://openalex.org/W167748918","https://openalex.org/W1971478463","https://openalex.org/W2112166915","https://openalex.org/W2419634107"],"abstract_inverted_index":{"As":[0],"with":[1,13,55],"most":[2],"psychotropic":[3],"sedative":[4],"drugs,":[5],"the":[6,14,19,28,35,49,56,61,92],"potential":[7,20],"for":[8,21],"withdrawal":[9,22,52,73,95],"reactions":[10,23,53,74],"is":[11],"present":[12],"benzodiazepines":[15,67],"(19).":[16],"Signs":[17],"suggesting":[18],"can":[24],"be":[25,88],"gleaned":[26],"from":[27],"clinical":[29],"course":[30],"of":[31,37,51,58,63,81,94],"events":[32],"such":[33],"as":[34],"development":[36],"tolerance":[38],"anc":[39],"psychological":[40],"and":[41,60],"physiological":[42],"dependence.":[43],"If":[44],"high":[45],"doses":[46],"are":[47],"reached,":[48],"risk":[50,93],"increases":[54],"length":[57],"treatment":[59],"abruptness":[62],"cessation.":[64],"The":[65],"long-acting":[66],"have":[68],"a":[69],"built-in":[70],"mechanism":[71],"against":[72],"through":[75],"their":[76],"active":[77],"metabolites.":[78],"Abrupt":[79],"cessation":[80],"drug":[82],"therapy":[83],"in":[84],"high-dose":[85],"patients":[86],"should":[87],"avoided":[89],"to":[90],"reduce":[91],"reactions.":[96]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2022-05-12T00:00:00"}
