{"id":"https://openalex.org/W42498827","doi":null,"title":"[Adipokines and the metabolism of key nutrients in patients with obesity].","display_name":"[Adipokines and the metabolism of key nutrients in patients with obesity].","publication_year":2014,"publication_date":"2014-01-01","ids":{"openalex":"https://openalex.org/W42498827","mag":"42498827","pmid":"https://pubmed.ncbi.nlm.nih.gov/24754068"},"language":"ru","primary_location":{"id":"pmid:24754068","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24754068","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Terapevticheskii arkhiv","raw_type":"English Abstract"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doaj.org/article/ea62a19243a84232abc5c415851f8323","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108697745","display_name":"\u041e \u041e \u041a\u0438\u0440\u0438\u043b\u043b\u043e\u0432\u0430","orcid":"https://orcid.org/0000-0002-9298-6553","observed_orcids":["https://orcid.org/0000-0002-9298-6553"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"O O Kirillova","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060819639","display_name":"I.V. Vorozhko","orcid":"https://orcid.org/0000-0003-2529-9152","observed_orcids":["https://orcid.org/0000-0003-2529-9152"]},"institutions":[{"id":"https://openalex.org/I3129448551","display_name":"Federal Research Centre of Nutrition and Biotechnology","ror":"https://ror.org/05ssfag15","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I3129448551","https://openalex.org/I4210110862"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"I V Vorozhko","raw_affiliation_strings":["\u041d\u0418\u0418 \u043f\u0438\u0442\u0430\u043d\u0438\u044f \u0420\u0410\u041c\u041d, \u041c\u043e\u0441\u043a\u0432\u0430"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"\u041d\u0418\u0418 \u043f\u0438\u0442\u0430\u043d\u0438\u044f \u0420\u0410\u041c\u041d, \u041c\u043e\u0441\u043a\u0432\u0430","institution_ids":["https://openalex.org/I3129448551"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022030121","display_name":"\u041a.\u041c. \u0413\u0430\u043f\u043f\u0430\u0440\u043e\u0432\u0430","orcid":"https://orcid.org/0000-0003-1223-8545","observed_orcids":["https://orcid.org/0000-0003-1223-8545"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K M Gapparova","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066241009","display_name":"\u042e \u0413 \u0427\u0435\u0445\u043e\u043d\u0438\u043d\u0430","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3129448551","display_name":"Federal Research Centre of Nutrition and Biotechnology","ror":"https://ror.org/05ssfag15","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I3129448551","https://openalex.org/I4210110862"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Iu G Chekhonina","raw_affiliation_strings":["\u041d\u0418\u0418 \u043f\u0438\u0442\u0430\u043d\u0438\u044f \u0420\u0410\u041c\u041d, \u041c\u043e\u0441\u043a\u0432\u0430"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"\u041d\u0418\u0418 \u043f\u0438\u0442\u0430\u043d\u0438\u044f \u0420\u0410\u041c\u041d, \u041c\u043e\u0441\u043a\u0432\u0430","institution_ids":["https://openalex.org/I3129448551"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043246896","display_name":"\u0422 \u0411 \u0421\u0435\u043d\u0446\u043e\u0432\u0430","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T B Sentsova","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5108072635","display_name":"\u0412 \u0410 \u0422\u0443\u0442\u0435\u043b\u044c\u044f\u043d","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3129448551","display_name":"Federal Research Centre of Nutrition and Biotechnology","ror":"https://ror.org/05ssfag15","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I3129448551","https://openalex.org/I4210110862"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"V A Tutel'ian","raw_affiliation_strings":["\u041d\u0418\u0418 \u043f\u0438\u0442\u0430\u043d\u0438\u044f \u0420\u0410\u041c\u041d, \u041c\u043e\u0441\u043a\u0432\u0430"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"\u041d\u0418\u0418 \u043f\u0438\u0442\u0430\u043d\u0438\u044f \u0420\u0410\u041c\u041d, \u041c\u043e\u0441\u043a\u0432\u0430","institution_ids":["https://openalex.org/I3129448551"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.00317573,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"86","issue":"1","first_page":"45","last_page":"8"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10528","display_name":"Adipokines, Inflammation, and Metabolic Diseases","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10528","display_name":"Adipokines, Inflammation, and Metabolic Diseases","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10489","display_name":"Regulation of Appetite and Obesity","score":0.0027000000700354576,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11457","display_name":"Adipose Tissue and Metabolism","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/adipokines","display_name":"adipokines","score":0.9800000190734863},{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.9980000257492065},{"id":"https://openalex.org/keywords/adiponectin","display_name":"adiponectin","score":0.9700000286102295},{"id":"https://openalex.org/keywords/ghrelin","display_name":"ghrelin","score":1.0},{"id":"https://openalex.org/keywords/resistin","display_name":"resistin","score":0.9980000257492065},{"id":"https://openalex.org/keywords/insulin-resistance","display_name":"insulin resistance","score":0.9570000171661377},{"id":"https://openalex.org/keywords/homa-ir","display_name":"HOMA-IR","score":0.824999988079071},{"id":"https://openalex.org/keywords/oxidized-ldl","display_name":"oxidized LDL","score":0.8149999976158142},{"id":"https://openalex.org/keywords/triglycerides","display_name":"triglycerides","score":0.8970000147819519},{"id":"https://openalex.org/keywords/carbohydrate-metabolism","display_name":"carbohydrate metabolism","score":0.8830000162124634},{"id":"https://openalex.org/keywords/lipid-metabolism","display_name":"lipid metabolism","score":0.9990000128746033},{"id":"https://openalex.org/keywords/body-mass-index","display_name":"body mass index","score":0.9120000004768372},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.9549999833106995},{"id":"https://openalex.org/keywords/cardiovascular-disease","display_name":"cardiovascular disease","score":0.7730000019073486}],"concepts":[{"id":"https://openalex.org/C194832188","wikidata":"https://www.wikidata.org/wiki/Q2638593","display_name":"Adipokine","level":4,"score":0.9616672992706299},{"id":"https://openalex.org/C2776782570","wikidata":"https://www.wikidata.org/wiki/Q357439","display_name":"Adiponectin","level":4,"score":0.9027096629142761},{"id":"https://openalex.org/C2779760629","wikidata":"https://www.wikidata.org/wiki/Q419499","display_name":"Resistin","level":5,"score":0.8489055633544922},{"id":"https://openalex.org/C2779357093","wikidata":"https://www.wikidata.org/wiki/Q422269","display_name":"Ghrelin","level":3,"score":0.7925674319267273},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7860615253448486},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7792916297912598},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.7442958354949951},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.7204981446266174},{"id":"https://openalex.org/C511355011","wikidata":"https://www.wikidata.org/wiki/Q12174","display_name":"Obesity","level":2,"score":0.5295218825340271},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.49968719482421875},{"id":"https://openalex.org/C2780221984","wikidata":"https://www.wikidata.org/wiki/Q131191","display_name":"Body mass index","level":2,"score":0.46483632922172546},{"id":"https://openalex.org/C4733338","wikidata":"https://www.wikidata.org/wiki/Q2792936","display_name":"Lipid metabolism","level":2,"score":0.43014079332351685},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.1326485574245453}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004734","descriptor_name":"Energy Metabolism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004797","descriptor_name":"Enzyme-Linked Immunosorbent Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005500","descriptor_name":"Follow-Up Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005502","descriptor_name":"Food","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007333","descriptor_name":"Insulin Resistance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000178","qualifier_name":"diet therapy","is_major_topic":false},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013053","descriptor_name":"Spectrophotometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D054392","descriptor_name":"Adipokines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:24754068","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24754068","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Terapevticheskii arkhiv","raw_type":"English Abstract"},{"id":"pmh:oai:doaj.org/article:ea62a19243a84232abc5c415851f8323","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/ea62a19243a84232abc5c415851f8323","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"\u0422\u0435\u0440\u0430\u043f\u0435\u0432\u0442\u0438\u0447\u0435\u0441\u043a\u0438\u0439 \u0430\u0440\u0445\u0438\u0432, Vol 86, Iss 1, Pp 45-48 (2014)","raw_type":"article"}],"best_oa_location":{"id":"pmh:oai:doaj.org/article:ea62a19243a84232abc5c415851f8323","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/ea62a19243a84232abc5c415851f8323","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"\u0422\u0435\u0440\u0430\u043f\u0435\u0432\u0442\u0438\u0447\u0435\u0441\u043a\u0438\u0439 \u0430\u0440\u0445\u0438\u0432, Vol 86, Iss 1, Pp 45-48 (2014)","raw_type":"article"},"sustainable_development_goals":[{"score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2379059458","https://openalex.org/W2783105429","https://openalex.org/W1857085379","https://openalex.org/W2126478077","https://openalex.org/W7096007785","https://openalex.org/W3011838425","https://openalex.org/W4385297773","https://openalex.org/W4285405924","https://openalex.org/W2035812981","https://openalex.org/W2938370622"],"abstract_inverted_index":{"AIM:":[0],"To":[1],"study":[2],"the":[3,8,32,82,94,107,116,149,170,203,222,234,256],"effect":[4],"of":[5,10,34,41,45,62,96,119,172,205,224,258],"adipokines":[6],"on":[7],"metabolism":[9],"key":[11],"nutrients":[12],"in":[13,80,93,115,180,221,233,248],"patients":[14,21,99,182,250],"with":[15,78,100],"obesity.":[16],"SUBJECTS":[17],"AND":[18],"METHODS:":[19],"Ninety":[20],"aged":[22],"18":[23],"to":[24,106,231,241,254,267],"66":[25],"years":[26],"old":[27],"who":[28],"were":[29,48,54,70,90],"treated":[30],"at":[31],"Department":[33],"Preventive":[35],"and":[36,51,58,65,124,132,137,145,155,174,176,227,245,263,266],"Rehabilitative":[37],"Nutrition,":[38,42],"Research":[39],"Institute":[40],"Russian":[43],"Academy":[44],"Medical":[46],"Sciences,":[47],"examined.":[49],"Carbohydrate":[50],"lipid":[52],"metabolisms":[53],"assessed":[55,77],"by":[56,72],"turbidimetry":[57],"spectrophotometry.":[59],"The":[60,98],"levels":[61,147,204],"adipokines,":[63],"insulin,":[64,226],"oxidized":[66,210],"low-density":[67],"lipoproteins":[68],"(LDL)":[69],"measured":[71],"ELISA.":[73],"Insulin":[74],"resistance":[75,217],"was":[76,86,165,193,197],"HOMA-IR":[79],"all":[81],"patients.":[83],"RESULTS:":[84],"It":[85],"found":[87],"that":[88,195],"there":[89,196],"discoordinated":[91],"changes":[92],"content":[95,171],"adipokines.":[97],"Grade":[101],"1":[102],"obesity,":[103],"as":[104,219,229],"compared":[105,230],"control":[108,235],"group,":[109],"had":[110],"a":[111],"statistically":[112],"significant":[113],"decrease":[114],"serum":[117],"concentrations":[118,223],"adiponectin":[120,173],"(5.94":[121],"+/-":[122,126,135,139,153,157],"0.90":[123],"15.34":[125],"0.45":[127],"microg/ml;":[128],"p":[129,160,189],"<":[130,143,161,190,213],"0.05)":[131,144],"ghrelin":[133],"(215.50":[134],"104.50":[136],"540.67":[138],"0.76":[140],"pg/ml;":[141],"(p":[142,212],"resistin":[146],"above":[148],"normal":[150],"values":[151],"(7.34":[152],"1.24":[154],"5.12":[156],"0.22":[158],"ng/ml;":[159],"0.05;":[162],"respectively).":[163],"There":[164,192],"an":[166,199],"inverse":[167,200],"correlation":[168,201],"between":[169,202],"ghrelin,":[175],"body":[177],"mass":[178],"index":[179],"obese":[181,249],"(r1":[183],"=":[184,187],"-0.25,":[185],"r2":[186],"-0.15;":[188],"0.05).":[191,214],"evidence":[194],"also":[198],"adiponectin,":[206],"triglycerides,":[207],"LDL,":[208],"particularly":[209],"LDL":[211],"Adipokine-induced":[215],"insulin":[216],"appeared":[218],"increases":[220],"glucose,":[225],"HOMA-IR,":[228],"those":[232],"group.":[236],"CONCLUSION:":[237],"A":[238],"comprehensive":[239],"approach":[240],"evaluating":[242],"metabolic":[243],"disorders":[244],"adipokine":[246],"synthesis":[247],"makes":[251],"it":[252],"possible":[253],"optimize":[255],"diagnosis":[257],"type":[259],"2":[260],"diabetes":[261],"mellitus":[262],"cardiovascular":[264],"diseases":[265],"personalize":[268],"diet":[269],"therapy.":[270]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2018,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}