{"id":"https://openalex.org/W4249856478","doi":"https://doi.org/10.21236/ada487929","title":"Role of cdc25 Phosphatases in Human Breast Cancer","display_name":"Role of cdc25 Phosphatases in Human Breast Cancer","publication_year":2008,"publication_date":"2008-05-01","ids":{"openalex":"https://openalex.org/W4249856478","doi":"https://doi.org/10.21236/ada487929"},"language":"en","primary_location":{"id":"doi:10.21236/ada487929","doi":"https://doi.org/10.21236/ada487929","is_oa":false,"landing_page_url":"http://doi.org/10.21236/ada487929","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"US Dept of the Army","raw_type":"report"},"volume":null,"type":"report","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5029300120","display_name":"James J. Manfredi","orcid":"https://orcid.org/0000-0003-2234-9097","observed_orcids":["https://orcid.org/0000-0003-2234-9097"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"James J. Manfredi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5029300120"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.9897000193595886,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.9897000193595886,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12104","display_name":"Protein Tyrosine Phosphatases","score":0.00279999990016222,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10492","display_name":"Microtubule and mitosis dynamics","score":0.0015999999595806003,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cdc25-phosphatase","display_name":"Cdc25 phosphatase","score":0.9959999918937683},{"id":"https://openalex.org/keywords/cdc25b","display_name":"CDC25B","score":0.9789999723434448},{"id":"https://openalex.org/keywords/cdc25c","display_name":"Cdc25C","score":0.9990000128746033},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.9380000233650208},{"id":"https://openalex.org/keywords/tumor-cell-proliferation","display_name":"tumor cell proliferation","score":0.7960000038146973},{"id":"https://openalex.org/keywords/alternative-splicing","display_name":"alternative splicing","score":0.9860000014305115},{"id":"https://openalex.org/keywords/carcinogenesis","display_name":"carcinogenesis","score":0.871999979019165},{"id":"https://openalex.org/keywords/breast-cancer-treatment","display_name":"breast cancer treatment","score":0.7490000128746033},{"id":"https://openalex.org/keywords/protein-phosphatase","display_name":"protein phosphatase","score":0.6259999871253967}],"concepts":[{"id":"https://openalex.org/C2778583388","wikidata":"https://www.wikidata.org/wiki/Q3775177","display_name":"Cdc25","level":5,"score":0.6612071394920349},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.6030863523483276},{"id":"https://openalex.org/C2994423619","wikidata":"https://www.wikidata.org/wiki/Q9103","display_name":"Human breast","level":4,"score":0.551790714263916},{"id":"https://openalex.org/C178666793","wikidata":"https://www.wikidata.org/wiki/Q422476","display_name":"Phosphatase","level":3,"score":0.520675778388977},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5175253748893738},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.38840845227241516},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.35475435853004456},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3267151713371277},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.30078449845314026},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.12748408317565918},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.11807093024253845},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.048638105392456055},{"id":"https://openalex.org/C120504264","wikidata":"https://www.wikidata.org/wiki/Q1147372","display_name":"Cyclin-dependent kinase 1","level":4,"score":0.043639540672302246}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.21236/ada487929","doi":"https://doi.org/10.21236/ada487929","is_oa":false,"landing_page_url":"http://doi.org/10.21236/ada487929","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"US Dept of the Army","raw_type":"report"},{"id":"pmh:ADA484675","doi":null,"is_oa":false,"landing_page_url":"http://oai.dtic.mil/oai/oai?&verb=getRecord&metadataPrefix=html&identifier=ADA484675","pdf_url":null,"source":{"id":"https://openalex.org/S4406923043","display_name":"Defense Technical Information Center (DTIC)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"DTIC","raw_type":"Text"},{"id":"pmh:ADA489010","doi":null,"is_oa":false,"landing_page_url":"http://oai.dtic.mil/oai/oai?&verb=getRecord&metadataPrefix=html&identifier=ADA489010","pdf_url":null,"source":{"id":"https://openalex.org/S4406923043","display_name":"Defense Technical Information Center (DTIC)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"DTIC","raw_type":"Text"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9074000120162964,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1555072662","https://openalex.org/W2154930300","https://openalex.org/W249932562","https://openalex.org/W2075744273","https://openalex.org/W1990830210","https://openalex.org/W4245508822","https://openalex.org/W2062219923","https://openalex.org/W2007571515","https://openalex.org/W1972082186","https://openalex.org/W1971664667"],"abstract_inverted_index":{"A":[0],"summary":[1],"is":[2,57],"presented":[3],"of":[4,11,18,37,50,60,74,83],"research":[5,26,85],"performed":[6],"during":[7],"the":[8,16,32,35,58,61],"second":[9,62],"year":[10],"a":[12,65,89],"project":[13],"to":[14,53,87,100,107],"determine":[15,102],"role":[17,36,91],"Cdc25":[19],"phosphatases":[20],"in":[21,39,94,111],"human":[22,54,108],"breast":[23,40,55,68,95,109],"cancer.":[24],"The":[25,79],"involves":[27],"three":[28],"specific":[29],"aims.":[30],"In":[31],"first":[33],"aim,":[34],"Cdc25B":[38,93],"cancer":[41,56,69],"proliferation":[42,98],"will":[43,76],"be":[44,77],"determined.":[45],"Examining":[46],"whether":[47,103],"alternative":[48],"splicing":[49],"Cdc25C":[51,75,104],"contributes":[52],"focus":[59],"aim.":[63],"Finally,":[64],"potential":[66],"novel":[67],"therapy":[70],"involving":[71],"altered":[72],"expression":[73],"explored.":[78],"long":[80],"term":[81],"goals":[82],"this":[84],"are":[86],"validate":[88],"clear":[90],"for":[92],"tumor":[96],"cell":[97],"and":[99],"rigorously":[101],"may":[105],"contribute":[106],"tumorigenesis":[110],"other":[112],"ways":[113],"besides":[114],"its":[115],"overexpression.":[116]},"counts_by_year":[],"updated_date":"2026-08-26T07:47:46.906454","created_date":"2022-05-12T00:00:00"}