{"id":"https://openalex.org/W4249587992","doi":"https://doi.org/10.21203/rs.3.rs-568729/v2","title":"Neutralization Characteristics of HIV-1 CRF01_AE Env Clones From Infections in China","display_name":"Neutralization Characteristics of HIV-1 CRF01_AE Env Clones From Infections in China","publication_year":2021,"publication_date":"2021-09-22","ids":{"openalex":"https://openalex.org/W4249587992","doi":"https://doi.org/10.21203/rs.3.rs-568729/v2"},"language":"en","primary_location":{"id":"doi:10.21203/rs.3.rs-568729/v2","doi":"https://doi.org/10.21203/rs.3.rs-568729/v2","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-568729/v2","pdf_url":"https://www.researchsquare.com/article/rs-568729/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},"volume":null,"type":"preprint","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.researchsquare.com/article/rs-568729/latest.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100769573","display_name":"Xinyu Zhang","orcid":"https://orcid.org/0000-0002-6492-6270","observed_orcids":["https://orcid.org/0000-0002-6492-6270"]},"institutions":[{"id":"https://openalex.org/I4210136676","display_name":"National Institutes for Food and Drug Control","ror":"https://ror.org/041rdq190","country_code":"CN","type":"other","lineage":["https://openalex.org/I4210136676"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xinyu Zhang","raw_affiliation_strings":["National Institutes for Food and Drug Control (NIFDC) and WHO Collaborating Center for Standardization and Evaluation of Biologicals"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Institutes for Food and Drug Control (NIFDC) and WHO Collaborating Center for Standardization and Evaluation of Biologicals","institution_ids":["https://openalex.org/I4210136676"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011261840","display_name":"Zehua Zhou","orcid":"https://orcid.org/0000-0001-6807-7424","observed_orcids":["https://orcid.org/0000-0001-6807-7424"]},"institutions":[{"id":"https://openalex.org/I4210136676","display_name":"National Institutes for Food and Drug Control","ror":"https://ror.org/041rdq190","country_code":"CN","type":"other","lineage":["https://openalex.org/I4210136676"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zehua Zhou","raw_affiliation_strings":["National Institutes for Food and Drug Control (NIFDC) and WHO Collaborating Center for Standardization and Evaluation of Biologicals"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Institutes for Food and Drug Control (NIFDC) and WHO Collaborating Center for Standardization and Evaluation of Biologicals","institution_ids":["https://openalex.org/I4210136676"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100763526","display_name":"Xueli Li","orcid":"https://orcid.org/0000-0001-7893-0978","observed_orcids":["https://orcid.org/0000-0001-7893-0978","https://orcid.org/0000-0002-3644-2594"]},"institutions":[{"id":"https://openalex.org/I4210136676","display_name":"National Institutes for Food and Drug Control","ror":"https://ror.org/041rdq190","country_code":"CN","type":"other","lineage":["https://openalex.org/I4210136676"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xueli Li","raw_affiliation_strings":["National Institutes for Food and Drug Control (NIFDC) and WHO Collaborating Center for Standardization and Evaluation of Biologicals"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Institutes for Food and Drug Control (NIFDC) and WHO Collaborating Center for Standardization and Evaluation of Biologicals","institution_ids":["https://openalex.org/I4210136676"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068095310","display_name":"Yimeng An","orcid":"https://orcid.org/0009-0003-7573-8210","observed_orcids":["https://orcid.org/0009-0003-7573-8210"]},"institutions":[{"id":"https://openalex.org/I4210136676","display_name":"National Institutes for Food and Drug Control","ror":"https://ror.org/041rdq190","country_code":"CN","type":"other","lineage":["https://openalex.org/I4210136676"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yimeng An","raw_affiliation_strings":["National Institutes for Food and Drug Control (NIFDC) and WHO Collaborating Center for Standardization and Evaluation of Biologicals"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Institutes for Food and Drug Control (NIFDC) and WHO Collaborating Center for Standardization and Evaluation of Biologicals","institution_ids":["https://openalex.org/I4210136676"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002610357","display_name":"Fei Jiang","orcid":"https://orcid.org/0000-0002-6529-6637","observed_orcids":["https://orcid.org/0000-0002-6529-6637"]},"institutions":[{"id":"https://openalex.org/I4210136676","display_name":"National Institutes for Food and Drug Control","ror":"https://ror.org/041rdq190","country_code":"CN","type":"other","lineage":["https://openalex.org/I4210136676"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Fei Jiang","raw_affiliation_strings":["National Institutes for Food and Drug Control (NIFDC) and WHO Collaborating Center for Standardization and Evaluation of Biologicals"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Institutes for Food and Drug Control (NIFDC) and WHO Collaborating Center for Standardization and Evaluation of Biologicals","institution_ids":["https://openalex.org/I4210136676"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027810140","display_name":"Youchun Wang","orcid":"https://orcid.org/0000-0001-9769-5141","observed_orcids":["https://orcid.org/0000-0001-9769-5141","https://orcid.org/0000-0002-1707-4386"]},"institutions":[{"id":"https://openalex.org/I4210136676","display_name":"National Institutes for Food and Drug Control","ror":"https://ror.org/041rdq190","country_code":"CN","type":"other","lineage":["https://openalex.org/I4210136676"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Youchun Wang","raw_affiliation_strings":["National Institutes for Food and Drug Control (NIFDC) and WHO Collaborating Center for Standardization and Evaluation of Biologicals"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Institutes for Food and Drug Control (NIFDC) and WHO Collaborating Center for Standardization and Evaluation of Biologicals","institution_ids":["https://openalex.org/I4210136676"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101529363","display_name":"Feng Gao","orcid":"https://orcid.org/0000-0001-6970-2746","observed_orcids":["https://orcid.org/0000-0001-6970-2746","https://orcid.org/0009-0000-1832-1361"]},"institutions":[{"id":"https://openalex.org/I194450716","display_name":"Jilin University","ror":"https://ror.org/00js3aw79","country_code":"CN","type":"education","lineage":["https://openalex.org/I194450716"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Feng Gao","raw_affiliation_strings":["Jilin University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Jilin University","institution_ids":["https://openalex.org/I194450716"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076011780","display_name":"Weijin Huang","orcid":"https://orcid.org/0000-0002-4246-8889","observed_orcids":["https://orcid.org/0000-0002-4246-8889"]},"institutions":[{"id":"https://openalex.org/I4210136676","display_name":"National Institutes for Food and Drug Control","ror":"https://ror.org/041rdq190","country_code":"CN","type":"other","lineage":["https://openalex.org/I4210136676"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Weijin Huang","raw_affiliation_strings":["National Institutes for Food and Drug Control (NIFDC) and WHO Collaborating Center for Standardization and Evaluation of Biologicals"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Institutes for Food and Drug Control (NIFDC) and WHO Collaborating Center for Standardization and Evaluation of Biologicals","institution_ids":["https://openalex.org/I4210136676"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101425516","display_name":"Lingjie Liao","orcid":"https://orcid.org/0000-0003-3880-4744","observed_orcids":["https://orcid.org/0000-0003-3880-4744"]},"institutions":[{"id":"https://openalex.org/I184490438","display_name":"Chinese Center For Disease Control and Prevention","ror":"https://ror.org/04wktzw65","country_code":"CN","type":"government","lineage":["https://openalex.org/I184490438","https://openalex.org/I4210127390","https://openalex.org/I4210151987"]},{"id":"https://openalex.org/I4210131009","display_name":"National Center for AIDS/STD Control and Prevention,China CDC","ror":"https://ror.org/02xnb4v27","country_code":"CN","type":"government","lineage":["https://openalex.org/I184490438","https://openalex.org/I4210127390","https://openalex.org/I4210131009","https://openalex.org/I4210151987"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lingjie Liao","raw_affiliation_strings":["National Center for AIDS/STD Control and Prevention, Chinese Center for Disease Control and Prevention"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Center for AIDS/STD Control and Prevention, Chinese Center for Disease Control and Prevention","institution_ids":["https://openalex.org/I184490438","https://openalex.org/I4210131009"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081590786","display_name":"Hui Qin Xing","orcid":"https://orcid.org/0000-0002-3067-0908","observed_orcids":["https://orcid.org/0000-0002-3067-0908"]},"institutions":[{"id":"https://openalex.org/I184490438","display_name":"Chinese Center For Disease Control and Prevention","ror":"https://ror.org/04wktzw65","country_code":"CN","type":"government","lineage":["https://openalex.org/I184490438","https://openalex.org/I4210127390","https://openalex.org/I4210151987"]},{"id":"https://openalex.org/I4210131009","display_name":"National Center for AIDS/STD Control and Prevention,China CDC","ror":"https://ror.org/02xnb4v27","country_code":"CN","type":"government","lineage":["https://openalex.org/I184490438","https://openalex.org/I4210127390","https://openalex.org/I4210131009","https://openalex.org/I4210151987"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hui Xing","raw_affiliation_strings":["National Center for AIDS/STD Control and Prevention, Chinese Center for Disease Control and Prevention"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Center for AIDS/STD Control and Prevention, Chinese Center for Disease Control and Prevention","institution_ids":["https://openalex.org/I184490438","https://openalex.org/I4210131009"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072570549","display_name":"Bin Yu","orcid":"https://orcid.org/0000-0002-8698-0155","observed_orcids":["https://orcid.org/0000-0002-8698-0155","https://orcid.org/0000-0002-8888-4060"]},"institutions":[{"id":"https://openalex.org/I194450716","display_name":"Jilin University","ror":"https://ror.org/00js3aw79","country_code":"CN","type":"education","lineage":["https://openalex.org/I194450716"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Bin Yu","raw_affiliation_strings":["Jilin University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Jilin University","institution_ids":["https://openalex.org/I194450716"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5016157564","display_name":"Chenyan Zhao","orcid":"https://orcid.org/0000-0002-1807-314X","observed_orcids":["https://orcid.org/0000-0002-1807-314X"]},"institutions":[{"id":"https://openalex.org/I4210136676","display_name":"National Institutes for Food and Drug Control","ror":"https://ror.org/041rdq190","country_code":"CN","type":"other","lineage":["https://openalex.org/I4210136676"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Chenyan Zhao","raw_affiliation_strings":["National Institutes for Food and Drug Control (NIFDC) and WHO Collaborating Center for Standardization and Evaluation of Biologicals"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Institutes for Food and Drug Control (NIFDC) and WHO Collaborating Center for Standardization and Evaluation of Biologicals","institution_ids":["https://openalex.org/I4210136676"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5016157564"],"corresponding_institution_ids":["https://openalex.org/I4210136676"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10118","display_name":"SARS-CoV-2 and COVID-19 Research","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hiv-1-crf01-ae","display_name":"CRF01_AE","score":1.0},{"id":"https://openalex.org/keywords/broadly-neutralizing-monoclonal-antibodies","display_name":"broadly neutralizing monoclonal antibodies","score":0.8980000019073486},{"id":"https://openalex.org/keywords/hiv-1-envelope-glycoprotein","display_name":"HIV-1 envelope glycoprotein","score":0.6579999923706055},{"id":"https://openalex.org/keywords/neutralization-resistance","display_name":"neutralization resistance","score":0.8220000267028809},{"id":"https://openalex.org/keywords/vrc01","display_name":"VRC01","score":0.6759999990463257},{"id":"https://openalex.org/keywords/3bnc117","display_name":"3BNC117","score":0.9319999814033508},{"id":"https://openalex.org/keywords/pg9","display_name":"PG9","score":0.7350000143051147},{"id":"https://openalex.org/keywords/4e10","display_name":"4E10","score":0.9179999828338623},{"id":"https://openalex.org/keywords/2f5","display_name":"2F5","score":0.6100000143051147},{"id":"https://openalex.org/keywords/2g12","display_name":"2G12","score":0.800000011920929},{"id":"https://openalex.org/keywords/membrane-proximal-external-region","display_name":"membrane-proximal external region","score":0.7929999828338623},{"id":"https://openalex.org/keywords/cd4-binding-site","display_name":"CD4 binding site","score":0.824999988079071},{"id":"https://openalex.org/keywords/v1v2-region","display_name":"V1V2 region","score":0.9319999814033508},{"id":"https://openalex.org/keywords/china","display_name":"China","score":0.7519999742507935}],"concepts":[{"id":"https://openalex.org/C14086860","wikidata":"https://www.wikidata.org/wiki/Q337120","display_name":"Neutralization","level":3,"score":0.9181289672851562},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.8006702661514282},{"id":"https://openalex.org/C3013748606","wikidata":"https://www.wikidata.org/wiki/Q15787","display_name":"Human immunodeficiency virus (HIV)","level":2,"score":0.5825054049491882},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.5289283394813538},{"id":"https://openalex.org/C542903549","wikidata":"https://www.wikidata.org/wiki/Q422248","display_name":"Monoclonal antibody","level":3,"score":0.4303811192512512},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.367032527923584},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.2708008289337158},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.1493510901927948}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.21203/rs.3.rs-568729/v2","doi":"https://doi.org/10.21203/rs.3.rs-568729/v2","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-568729/v2","pdf_url":"https://www.researchsquare.com/article/rs-568729/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.21203/rs.3.rs-568729/v2","doi":"https://doi.org/10.21203/rs.3.rs-568729/v2","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-568729/v2","pdf_url":"https://www.researchsquare.com/article/rs-568729/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8371999859809875}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2431031858","display_name":null,"funder_award_id":"2017ZX10201101","funder_id":"https://openalex.org/F4320322392","funder_display_name":"Tsinghua University"}],"funders":[{"id":"https://openalex.org/F4320317237","display_name":"National Institutes for Food and Drug Control","ror":"https://ror.org/041rdq190"},{"id":"https://openalex.org/F4320322392","display_name":"Tsinghua University","ror":"https://ror.org/03cve4549"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4249587992.pdf","grobid_xml":"https://content.openalex.org/works/W4249587992.grobid-xml"},"referenced_works_count":22,"referenced_works":["https://openalex.org/W1975610170","https://openalex.org/W1989174077","https://openalex.org/W1990967787","https://openalex.org/W1997677784","https://openalex.org/W2039098603","https://openalex.org/W2083726777","https://openalex.org/W2098324528","https://openalex.org/W2111628537","https://openalex.org/W2381153372","https://openalex.org/W2493518412","https://openalex.org/W2557711954","https://openalex.org/W2572760626","https://openalex.org/W2791925365","https://openalex.org/W2810793103","https://openalex.org/W2891811769","https://openalex.org/W2900729970","https://openalex.org/W2905349504","https://openalex.org/W2968415893","https://openalex.org/W2995307281","https://openalex.org/W4245781185","https://openalex.org/W6608096288","https://openalex.org/W6649784784"],"related_works":["https://openalex.org/W3168708800","https://openalex.org/W1974974163","https://openalex.org/W2891811769","https://openalex.org/W2407262451","https://openalex.org/W1990967787","https://openalex.org/W2060118323","https://openalex.org/W2039098603","https://openalex.org/W1974290153","https://openalex.org/W4225426292","https://openalex.org/W6920846398"],"abstract_inverted_index":{"Abstract":[0],"Owing":[1],"to":[2,12,20,48,174],"the":[3,14,54,72,78,83,91,99,127,143,146,149],"increasing":[4],"prevalence":[5],"of":[6,17,53,63,126,140,142,148,158,163,189],"HIV-1":[7,39,178],"CRF01_AE,":[8],"it":[9],"is":[10],"necessary":[11],"understand":[13],"neutralization":[15,139,185],"properties":[16],"CRF01_AE":[18,164,179],"and":[19,46,69,88,96,116,132,187],"develop":[21],"broadly":[22],"neutralizing":[23,61,120,122,136,154],"monoclonal":[24],"antibodies":[25],"(bnmAbs)":[26],"that":[27],"can":[28],"neutralize":[29],"this":[30],"virus.":[31],"The":[32,60],"full-length":[33],"Env":[34,161],"gene":[35],"was":[36],"cloned":[37],"from":[38,165],"CRF01_AE-infected":[40],"plasma":[41],"specimens":[42],"collected":[43],"in":[44,172,194],"China":[45],"used":[47,183],"establish":[49],"pseudoviruses.":[50],"Neutralization":[51],"phenotypes":[52],"pseudoviruses":[55,106,159,180],"were":[56,107,152],"characterized":[57,177],"with":[58,138],"bnmAbs.":[59],"activities":[62],"11":[64],"bnmAbs":[65,151],"VRC01,":[66,114],"VRC03,":[67],"IgG1b12":[68],"3BNC117":[70,117],"(targeting":[71,77,82,90,98],"CD4":[73],"binding":[74],"site);":[75],"PG9":[76,131],"V1V2":[79],"region);":[80],"2G12":[81],"high":[84],"mannose":[85],"patch),":[86],"PGT135":[87],"10-1074":[89],"V3":[92],"glycans);":[93],"2F5,":[94],"4E10":[95],"10E8":[97,115],"membrane":[100],"proximal":[101],"external":[102],"region),":[103],"against":[104],"36":[105],"analyzed,":[108],"demonstrating":[109],"varying":[110],"efficacies.":[111],"In":[112],"general,":[113],"showed":[118,169],"strong":[119],"activity,":[121],"more":[123],"than":[124,156],"75%":[125],"pseudoviruses;":[128,144],"followed":[129],"by":[130],"4E10,":[133],"showing":[134],"moderate":[135],"activity":[137],"50%\u201360%":[141],"whereas":[145],"efficacies":[147],"remaining":[150],"poor,":[153],"less":[155],"15%":[157],"tested.":[160],"variants":[162],"one":[166],"infection":[167],"also":[168],"significant":[170],"differences":[171],"resistance":[173],"neutralization.":[175],"These":[176],"could":[181],"be":[182],"for":[184],"studies":[186],"evaluation":[188],"vaccines":[190],"or":[191],"anti-HIV-1":[192],"products":[193],"China.":[195]},"counts_by_year":[],"updated_date":"2026-10-13T10:08:12.033832","created_date":"2022-05-12T00:00:00"}