{"id":"https://openalex.org/W4249246656","doi":"https://doi.org/10.12688/f1000research.5827.1","title":"Nelfinavir and other protease inhibitors in cancer: mechanisms involved in anticancer activity","display_name":"Nelfinavir and other protease inhibitors in cancer: mechanisms involved in anticancer activity","publication_year":2015,"publication_date":"2015-01-12","ids":{"openalex":"https://openalex.org/W4249246656","doi":"https://doi.org/10.12688/f1000research.5827.1"},"language":"en","primary_location":{"id":"doi:10.12688/f1000research.5827.1","doi":"https://doi.org/10.12688/f1000research.5827.1","is_oa":true,"landing_page_url":"https://doi.org/10.12688/f1000research.5827.1","pdf_url":null,"source":{"id":"https://openalex.org/S4210239046","display_name":"F1000Research","issn_l":"2046-1402","issn":["2046-1402"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320357","host_organization_name":"Faculty of 1000","host_organization_lineage":["https://openalex.org/P4310320357","https://openalex.org/P4310320547"],"host_organization_lineage_names":["Faculty of 1000","Taylor & Francis"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"F1000Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.12688/f1000research.5827.1","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5024538800","display_name":"Tomas Koltai","orcid":"https://orcid.org/0000-0002-7398-5096","observed_orcids":["https://orcid.org/0000-0002-7398-5096"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Tomas Koltai","raw_affiliation_strings":["Centro de Diagnostico y Tratamiento de la Obra Social del Personal de la Alimentaci\u00f3n, Talar de Pacheco, Buenos Aires, 1618"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro de Diagnostico y Tratamiento de la Obra Social del Personal de la Alimentaci\u00f3n, Talar de Pacheco, Buenos Aires, 1618","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5024538800"],"corresponding_institution_ids":[],"apc_list":{"value":1350,"currency":"USD","value_usd":1350},"apc_paid":{"value":1350,"currency":"USD","value_usd":1350},"fwci":0.785,"has_fulltext":false,"cited_by_count":35,"citation_normalized_percentile":{"value":0.67952014,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.9028000235557556,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.9028000235557556,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":0.036400001496076584,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12465","display_name":"Cancer, Lipids, and Metabolism","score":0.012900000438094139,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nelfinavir","display_name":"nelfinavir","score":1.0},{"id":"https://openalex.org/keywords/protease-inhibitors","display_name":"protease inhibitors","score":0.8949999809265137},{"id":"https://openalex.org/keywords/anticancer-mechanism","display_name":"anticancer mechanism","score":0.8149999976158142},{"id":"https://openalex.org/keywords/endoplasmic-reticulum-stress","display_name":"endoplasmic reticulum stress","score":0.9850000143051147},{"id":"https://openalex.org/keywords/unfolded-protein-response","display_name":"unfolded protein response","score":0.9990000128746033},{"id":"https://openalex.org/keywords/akt-inhibition","display_name":"AKT inhibition","score":0.9819999933242798},{"id":"https://openalex.org/keywords/mmp-9-inhibition","display_name":"MMP-9 inhibition","score":0.8840000033378601},{"id":"https://openalex.org/keywords/angiogenesis-inhibition","display_name":"angiogenesis inhibition","score":0.7149999737739563},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.8999999761581421},{"id":"https://openalex.org/keywords/autophagy","display_name":"autophagy","score":0.7749999761581421},{"id":"https://openalex.org/keywords/radiosensitization","display_name":"radiosensitization","score":0.9120000004768372},{"id":"https://openalex.org/keywords/bax","display_name":"Bax","score":0.3630000054836273},{"id":"https://openalex.org/keywords/fatty-acid-synthase","display_name":"fatty acid synthase","score":0.6729999780654907},{"id":"https://openalex.org/keywords/vascular-endothelial-growth-factor","display_name":"vascular endothelial growth factor","score":0.5490000247955322},{"id":"https://openalex.org/keywords/nf-kb","display_name":"NF-kB","score":0.7390000224113464},{"id":"https://openalex.org/keywords/stat3","display_name":"STAT3","score":0.8809999823570251},{"id":"https://openalex.org/keywords/hif-1alpha","display_name":"HIF-1\u03b1","score":0.7490000128746033},{"id":"https://openalex.org/keywords/egfr","display_name":"EGFR","score":0.6389999985694885},{"id":"https://openalex.org/keywords/abcg2","display_name":"ABCG2","score":0.7519999742507935},{"id":"https://openalex.org/keywords/androgen-receptor","display_name":"androgen receptor","score":0.6290000081062317},{"id":"https://openalex.org/keywords/proteasome","display_name":"proteasome","score":0.8119999766349792},{"id":"https://openalex.org/keywords/hepatocytes","display_name":"hepatocytes","score":0.5690000057220459},{"id":"https://openalex.org/keywords/adipocytes","display_name":"adipocytes","score":0.9980000257492065}],"concepts":[{"id":"https://openalex.org/C2781160516","wikidata":"https://www.wikidata.org/wiki/Q423366","display_name":"Nelfinavir","level":5,"score":0.938542366027832},{"id":"https://openalex.org/C2983643791","wikidata":"https://www.wikidata.org/wiki/Q1999993","display_name":"Open peer review","level":3,"score":0.7797785997390747},{"id":"https://openalex.org/C2776714187","wikidata":"https://www.wikidata.org/wiki/Q212410","display_name":"Protease","level":3,"score":0.7096014022827148},{"id":"https://openalex.org/C2992936677","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Plant biology","level":2,"score":0.6705684661865234},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5512824058532715},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5351501703262329},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.45852771401405334},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3889627456665039},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3262978494167328},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.27394700050354004},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.21404799818992615},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2018737494945526},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.19755932688713074},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.0750192403793335},{"id":"https://openalex.org/C3013748606","wikidata":"https://www.wikidata.org/wiki/Q15787","display_name":"Human immunodeficiency virus (HIV)","level":2,"score":0.053128451108932495},{"id":"https://openalex.org/C142462285","wikidata":"https://www.wikidata.org/wiki/Q2528140","display_name":"Viral load","level":3,"score":0.0},{"id":"https://openalex.org/C2993143319","wikidata":"https://www.wikidata.org/wiki/Q583050","display_name":"Antiretroviral therapy","level":4,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.12688/f1000research.5827.1","doi":"https://doi.org/10.12688/f1000research.5827.1","is_oa":true,"landing_page_url":"https://doi.org/10.12688/f1000research.5827.1","pdf_url":null,"source":{"id":"https://openalex.org/S4210239046","display_name":"F1000Research","issn_l":"2046-1402","issn":["2046-1402"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320357","host_organization_name":"Faculty of 1000","host_organization_lineage":["https://openalex.org/P4310320357","https://openalex.org/P4310320547"],"host_organization_lineage_names":["Faculty of 1000","Taylor & Francis"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"F1000Research","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.12688/f1000research.5827.1","doi":"https://doi.org/10.12688/f1000research.5827.1","is_oa":true,"landing_page_url":"https://doi.org/10.12688/f1000research.5827.1","pdf_url":null,"source":{"id":"https://openalex.org/S4210239046","display_name":"F1000Research","issn_l":"2046-1402","issn":["2046-1402"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320357","host_organization_name":"Faculty of 1000","host_organization_lineage":["https://openalex.org/P4310320357","https://openalex.org/P4310320547"],"host_organization_lineage_names":["Faculty of 1000","Taylor & Francis"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"F1000Research","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","score":0.8399999737739563,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":116,"referenced_works":["https://openalex.org/W77064049","https://openalex.org/W85711568","https://openalex.org/W1546392779","https://openalex.org/W1815884866","https://openalex.org/W1941580799","https://openalex.org/W1963524125","https://openalex.org/W1965372015","https://openalex.org/W1965541995","https://openalex.org/W1966191320","https://openalex.org/W1967651592","https://openalex.org/W1970833175","https://openalex.org/W1971249781","https://openalex.org/W1971493748","https://openalex.org/W1974447310","https://openalex.org/W1979192842","https://openalex.org/W1980942517","https://openalex.org/W1998455345","https://openalex.org/W2002786537","https://openalex.org/W2004860944","https://openalex.org/W2006594180","https://openalex.org/W2008383151","https://openalex.org/W2009598346","https://openalex.org/W2010645035","https://openalex.org/W2011360946","https://openalex.org/W2013985252","https://openalex.org/W2014003702","https://openalex.org/W2015856700","https://openalex.org/W2019702920","https://openalex.org/W2021206455","https://openalex.org/W2021632088","https://openalex.org/W2021670707","https://openalex.org/W2024180703","https://openalex.org/W2024789710","https://openalex.org/W2028339433","https://openalex.org/W2028704745","https://openalex.org/W2029531496","https://openalex.org/W2033013430","https://openalex.org/W2039177121","https://openalex.org/W2041679053","https://openalex.org/W2043834364","https://openalex.org/W2046640957","https://openalex.org/W2047498253","https://openalex.org/W2049159646","https://openalex.org/W2051783184","https://openalex.org/W2052920914","https://openalex.org/W2056537433","https://openalex.org/W2059136727","https://openalex.org/W2060045688","https://openalex.org/W2061676934","https://openalex.org/W2063291472","https://openalex.org/W2066699439","https://openalex.org/W2068288481","https://openalex.org/W2068665741","https://openalex.org/W2069377117","https://openalex.org/W2070756073","https://openalex.org/W2071345969","https://openalex.org/W2071998110","https://openalex.org/W2073144681","https://openalex.org/W2078197243","https://openalex.org/W2079046174","https://openalex.org/W2080071021","https://openalex.org/W2082563994","https://openalex.org/W2084380831","https://openalex.org/W2085504755","https://openalex.org/W2086973335","https://openalex.org/W2088303467","https://openalex.org/W2089186306","https://openalex.org/W2089867969","https://openalex.org/W2091689893","https://openalex.org/W2092159694","https://openalex.org/W2092297057","https://openalex.org/W2092591128","https://openalex.org/W2092631756","https://openalex.org/W2093576485","https://openalex.org/W2095957345","https://openalex.org/W2098608476","https://openalex.org/W2106531295","https://openalex.org/W2110506701","https://openalex.org/W2112740677","https://openalex.org/W2117991078","https://openalex.org/W2121595165","https://openalex.org/W2125175095","https://openalex.org/W2135364779","https://openalex.org/W2135501389","https://openalex.org/W2136409533","https://openalex.org/W2137926918","https://openalex.org/W2140960742","https://openalex.org/W2141083721","https://openalex.org/W2142747296","https://openalex.org/W2144769066","https://openalex.org/W2145315801","https://openalex.org/W2146652769","https://openalex.org/W2146780639","https://openalex.org/W2149065175","https://openalex.org/W2149076352","https://openalex.org/W2150555063","https://openalex.org/W2151092952","https://openalex.org/W2152604441","https://openalex.org/W2155608888","https://openalex.org/W2155846381","https://openalex.org/W2158240289","https://openalex.org/W2159834768","https://openalex.org/W2160939527","https://openalex.org/W2161908322","https://openalex.org/W2164610579","https://openalex.org/W2166377845","https://openalex.org/W2166630192","https://openalex.org/W2167077512","https://openalex.org/W2167612672","https://openalex.org/W2168554267","https://openalex.org/W2170405149","https://openalex.org/W2254386269","https://openalex.org/W2333058262","https://openalex.org/W3026032990","https://openalex.org/W4238567307","https://openalex.org/W7073937469"],"related_works":["https://openalex.org/W2248904208","https://openalex.org/W2240080159","https://openalex.org/W2624797522","https://openalex.org/W2247484637","https://openalex.org/W2078218631","https://openalex.org/W2061128535","https://openalex.org/W2734166346","https://openalex.org/W2100707893","https://openalex.org/W2619815702","https://openalex.org/W2236937313"],"abstract_inverted_index":{"Objective:":[0],"To":[1],"review":[2],"the":[3,20,27,191,209,248,255],"mechanisms":[4,66,250],"of":[5,8,43,49,57,91,107,133,145,245,251],"anti-cancer":[6,36,47,69,226],"activity":[7,70,176],"nelfinavir":[9,30,55],"and":[10,38,78,89,103,131,140,156,163,186,202,214,267,270],"other":[11,39,85,224],"protease":[12],"inhibitors":[13],"(PIs)":[14],"based":[15,45],"on":[16,46,247],"evidences":[17],"reported":[18],"in":[19,68,98,127,181,208,221,231,240,260,264,268],"published":[21],"literature.":[22],"Methods:":[23],"We":[24],"extensively":[25],"reviewed":[26],"literature":[28],"concerning":[29],"(NFV)":[31],"as":[32],"an":[33,235],"off":[34],"target":[35],"drug":[37],"PIs.":[40],"A":[41],"classification":[42],"PIs":[44,168],"mode":[48,56],"action":[50,58],"was":[51],"proposed.":[52],"Controversies":[53],"regarding":[54],"were":[59],"also":[60],"addressed.":[61],"Conclusions:":[62],"The":[63,142,243],"two":[64],"main":[65],"involved":[67],"are":[71,83,206],"endoplasmic":[72],"reticulum":[73],"stress-unfolded":[74],"protein":[75],"response":[76],"pathway":[77],"Akt":[79,187],"inhibition.":[80],"However":[81],"there":[82],"many":[84],"effects,":[86],"partially":[87],"dependent":[88],"independent":[90],"those":[92],"mentioned,":[93],"that":[94,195,257],"may":[95,169],"be":[96,170,229],"useful":[97],"cancer":[99,165,211,241],"treatment,":[100],"including":[101],"MMP-9":[102],"MMP-2":[104],"inhibition,":[105],"down-regulation":[106],"CDK-2,":[108],"VEGF,":[109],"bFGF,":[110],"NF-kB,":[111],"STAT-3,":[112],"HIF-1":[113],"alfa,":[114],"IGF,":[115],"EGFR,":[116],"survivin,":[117],"BCRP,":[118],"androgen":[119],"receptor,":[120],"proteasome,":[121],"fatty":[122],"acid":[123],"synthase":[124],"(FAS),":[125],"decrease":[126],"cellular":[128],"ATP":[129],"concentration":[130],"upregulation":[132],"TRAIL":[134],"receptor":[135],"DR5,":[136],"Bax,":[137],"increased":[138,157,164],"radiosensitivity,":[139],"autophagy.":[141],"end":[143],"result":[144],"all":[146],"these":[147],"effects":[148],"is":[149,219],"slower":[150],"growth,":[151],"decreased":[152,154],"angiogenesis,":[153],"invasion":[155],"apoptosis,":[158],"which":[159],"means":[160],"reduced":[161],"proliferation":[162],"cells":[166,266],"death.":[167],"classified":[171],"according":[172],"to":[173,233,254],"their":[174],"anticancer":[175],"at":[177],"clinically":[178],"achievable":[179],"doses,":[180],"AKT":[182],"inhibitors,":[183],"ER":[184],"stressors":[185],"inhibitors/ER":[188],"stressors.":[189],"Beyond":[190],"phase":[192],"I":[193],"trials":[194,205,216],"have":[196],"been":[197],"recently":[198],"completed,":[199],"adequately":[200],"powered":[201],"well-designed":[203],"clinical":[204],"needed":[207],"various":[210],"type":[212],"settings,":[213],"specific":[215],"where":[217],"NFV":[218,239,252,258],"tested":[220],"association":[222],"with":[223],"known":[225],"pharmaceuticals":[227],"should":[228],"sought,":[230],"order":[232],"find":[234],"appropriate":[236],"place":[237],"for":[238],"treatment.":[242],"analysis":[244],"controversies":[246],"molecular":[249],"hints":[253],"possibility":[256],"works":[259],"a":[261],"different":[262],"way":[263],"tumor":[265],"hepatocytes":[269],"adipocytes.":[271]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":8},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2025-10-10T00:00:00"}