{"id":"https://openalex.org/W4249192304","doi":"https://doi.org/10.1002/(sici)1097-4547(19970115)47:2<216::aid-jnr10>3.3.co;2-1","title":"\u03b2\u2010Amyloid peptide induced cytoskeletal reorganization in cultured astrocytes","display_name":"\u03b2\u2010Amyloid peptide induced cytoskeletal reorganization in cultured astrocytes","publication_year":1997,"publication_date":"1997-01-15","ids":{"openalex":"https://openalex.org/W4249192304","doi":"https://doi.org/10.1002/(sici)1097-4547(19970115)47:2<216::aid-jnr10>3.3.co;2-1","mag":"2142558895","pmid":"https://pubmed.ncbi.nlm.nih.gov/9008152"},"language":"en","primary_location":{"id":"doi:10.1002/(sici)1097-4547(19970115)47:2<216::aid-jnr10>3.3.co;2-1","doi":"https://doi.org/10.1002/(sici)1097-4547(19970115)47:2<216::aid-jnr10>3.3.co;2-1","is_oa":false,"landing_page_url":"https://doi.org/10.1002/(sici)1097-4547(19970115)47:2<216::aid-jnr10>3.3.co;2-1","pdf_url":null,"source":{"id":"https://openalex.org/S76417895","display_name":"Journal of Neuroscience Research","issn_l":"0360-4012","issn":["0360-4012","1097-4547"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neuroscience Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5016803755","display_name":"Olga Salinero","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I134820265","display_name":"Consejo Superior de Investigaciones Cient\u00edficas","ror":"https://ror.org/02gfc7t72","country_code":"ES","type":"government","lineage":["https://openalex.org/I134820265"]},{"id":"https://openalex.org/I4210146061","display_name":"Centro de Biolog\u00eda Molecular Severo Ochoa","ror":"https://ror.org/03v9e8t09","country_code":"ES","type":"facility","lineage":["https://openalex.org/I134820265","https://openalex.org/I4210146061"]},{"id":"https://openalex.org/I63634437","display_name":"Universidad Aut\u00f3noma de Madrid","ror":"https://ror.org/01cby8j38","country_code":"ES","type":"education","lineage":["https://openalex.org/I63634437"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"O. Salinero","raw_affiliation_strings":["Centro de Biologi\u0301a Molecular \u201cSevero Ochoa,\u201d CSIC\u2014Universidad Autonoma de Madrid, Madrid, Spain","Centro de Biolog\u00eda Molecular \"Severo Ochoa,\" CSIC\u2014Universidad Autonoma de Madrid, Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro de Biologi\u0301a Molecular \u201cSevero Ochoa,\u201d CSIC\u2014Universidad Autonoma de Madrid, Madrid, Spain","institution_ids":["https://openalex.org/I134820265","https://openalex.org/I4210146061","https://openalex.org/I63634437"]},{"raw_affiliation_string":"Centro de Biolog\u00eda Molecular \"Severo Ochoa,\" CSIC\u2014Universidad Autonoma de Madrid, Madrid, Spain","institution_ids":["https://openalex.org/I134820265","https://openalex.org/I4210146061","https://openalex.org/I63634437"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027662401","display_name":"Mar\u00eda Teresa Moreno-Flores","orcid":"https://orcid.org/0000-0002-8494-8143","observed_orcids":["https://orcid.org/0000-0002-8494-8143"]},"institutions":[{"id":"https://openalex.org/I134820265","display_name":"Consejo Superior de Investigaciones Cient\u00edficas","ror":"https://ror.org/02gfc7t72","country_code":"ES","type":"government","lineage":["https://openalex.org/I134820265"]},{"id":"https://openalex.org/I4210146061","display_name":"Centro de Biolog\u00eda Molecular Severo Ochoa","ror":"https://ror.org/03v9e8t09","country_code":"ES","type":"facility","lineage":["https://openalex.org/I134820265","https://openalex.org/I4210146061"]},{"id":"https://openalex.org/I63634437","display_name":"Universidad Aut\u00f3noma de Madrid","ror":"https://ror.org/01cby8j38","country_code":"ES","type":"education","lineage":["https://openalex.org/I63634437"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"M.T. Moreno\u2010Flores","raw_affiliation_strings":["Centro de Biologi\u0301a Molecular \u201cSevero Ochoa,\u201d CSIC\u2014Universidad Autonoma de Madrid, Madrid, Spain","Centro de Biolog\u00eda Molecular \"Severo Ochoa,\" CSIC\u2014Universidad Autonoma de Madrid, Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro de Biologi\u0301a Molecular \u201cSevero Ochoa,\u201d CSIC\u2014Universidad Autonoma de Madrid, Madrid, Spain","institution_ids":["https://openalex.org/I134820265","https://openalex.org/I4210146061","https://openalex.org/I63634437"]},{"raw_affiliation_string":"Centro de Biolog\u00eda Molecular \"Severo Ochoa,\" CSIC\u2014Universidad Autonoma de Madrid, Madrid, Spain","institution_ids":["https://openalex.org/I134820265","https://openalex.org/I4210146061","https://openalex.org/I63634437"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044073690","display_name":"M.L. Ceballos","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2184545","display_name":"Instituto Cajal","ror":"https://ror.org/012gwbh42","country_code":"ES","type":"facility","lineage":["https://openalex.org/I134820265","https://openalex.org/I2184545"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"M.L. Ceballos","raw_affiliation_strings":["Instituto Cajal, Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto Cajal, Madrid, Spain","institution_ids":["https://openalex.org/I2184545"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5084027100","display_name":"Francisco G. Wandosell","orcid":"https://orcid.org/0000-0001-6537-2321","observed_orcids":["https://orcid.org/0000-0001-6537-2321"]},"institutions":[{"id":"https://openalex.org/I134820265","display_name":"Consejo Superior de Investigaciones Cient\u00edficas","ror":"https://ror.org/02gfc7t72","country_code":"ES","type":"government","lineage":["https://openalex.org/I134820265"]},{"id":"https://openalex.org/I4210146061","display_name":"Centro de Biolog\u00eda Molecular Severo Ochoa","ror":"https://ror.org/03v9e8t09","country_code":"ES","type":"facility","lineage":["https://openalex.org/I134820265","https://openalex.org/I4210146061"]},{"id":"https://openalex.org/I63634437","display_name":"Universidad Aut\u00f3noma de Madrid","ror":"https://ror.org/01cby8j38","country_code":"ES","type":"education","lineage":["https://openalex.org/I63634437"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"F. Wandosell","raw_affiliation_strings":["Centro de Biologi\u0301a Molecular \u201cSevero Ochoa,\u201d CSIC\u2014Universidad Autonoma de Madrid, Madrid, Spain","Centro de Biolog\u00eda Molecular \"Severo Ochoa,\" CSIC\u2014Universidad Autonoma de Madrid, Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro de Biologi\u0301a Molecular \u201cSevero Ochoa,\u201d CSIC\u2014Universidad Autonoma de Madrid, Madrid, Spain","institution_ids":["https://openalex.org/I134820265","https://openalex.org/I4210146061","https://openalex.org/I63634437"]},{"raw_affiliation_string":"Centro de Biolog\u00eda Molecular \"Severo Ochoa,\" CSIC\u2014Universidad Autonoma de Madrid, Madrid, Spain","institution_ids":["https://openalex.org/I134820265","https://openalex.org/I4210146061","https://openalex.org/I63634437"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5084027100"],"corresponding_institution_ids":["https://openalex.org/I134820265","https://openalex.org/I4210146061","https://openalex.org/I63634437"],"apc_list":{"value":4840,"currency":"USD","value_usd":4840},"apc_paid":null,"fwci":1.5141,"has_fulltext":false,"cited_by_count":45,"citation_normalized_percentile":{"value":0.8243981,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":95},"biblio":{"volume":"47","issue":"2","first_page":"216","last_page":"223"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/beta-amyloid-peptide","display_name":"beta-amyloid peptide","score":0.8309999704360962},{"id":"https://openalex.org/keywords/astrocytes","display_name":"astrocytes","score":0.8930000066757202},{"id":"https://openalex.org/keywords/cytoskeletal-remodeling","display_name":"cytoskeletal remodeling","score":0.9959999918937683},{"id":"https://openalex.org/keywords/astrocyte-morphology","display_name":"astrocyte morphology","score":0.8539999723434448},{"id":"https://openalex.org/keywords/cell-viability","display_name":"cell viability","score":0.7049999833106995},{"id":"https://openalex.org/keywords/glial-fibrillary-acidic-protein","display_name":"glial fibrillary acidic protein","score":0.972000002861023},{"id":"https://openalex.org/keywords/vimentin","display_name":"vimentin","score":1.0},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.824999988079071},{"id":"https://openalex.org/keywords/reactive-astrocytes","display_name":"reactive astrocytes","score":0.5929999947547913},{"id":"https://openalex.org/keywords/rat-cerebral-cortex","display_name":"rat cortex","score":0.3630000054836273}],"concepts":[{"id":"https://openalex.org/C142669718","wikidata":"https://www.wikidata.org/wiki/Q154626","display_name":"Cytoskeleton","level":3,"score":0.7985743880271912},{"id":"https://openalex.org/C2779281246","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide","level":2,"score":0.675268292427063},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5894110202789307},{"id":"https://openalex.org/C2777542381","wikidata":"https://www.wikidata.org/wiki/Q502961","display_name":"Astrocyte","level":3,"score":0.4951719343662262},{"id":"https://openalex.org/C2777633098","wikidata":"https://www.wikidata.org/wiki/Q2736051","display_name":"Amyloid (mycology)","level":2,"score":0.4542957842350006},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4457128345966339},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.44056257605552673},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2762174606323242},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1869640052318573},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.1059827208518982},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.10008427500724792},{"id":"https://openalex.org/C179104552","wikidata":"https://www.wikidata.org/wiki/Q11165","display_name":"Inorganic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001253","descriptor_name":"Astrocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D001253","descriptor_name":"Astrocytes","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002540","descriptor_name":"Cerebral Cortex","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D002540","descriptor_name":"Cerebral Cortex","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D003599","descriptor_name":"Cytoskeleton","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D003599","descriptor_name":"Cytoskeleton","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D007124","descriptor_name":"Immunoenzyme Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007381","descriptor_name":"Intermediate Filament Proteins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D007381","descriptor_name":"Intermediate Filament Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010446","descriptor_name":"Peptide Fragments","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D016229","descriptor_name":"Amyloid beta-Peptides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1002/(sici)1097-4547(19970115)47:2<216::aid-jnr10>3.3.co;2-1","doi":"https://doi.org/10.1002/(sici)1097-4547(19970115)47:2<216::aid-jnr10>3.3.co;2-1","is_oa":false,"landing_page_url":"https://doi.org/10.1002/(sici)1097-4547(19970115)47:2<216::aid-jnr10>3.3.co;2-1","pdf_url":null,"source":{"id":"https://openalex.org/S76417895","display_name":"Journal of Neuroscience Research","issn_l":"0360-4012","issn":["0360-4012","1097-4547"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neuroscience Research","raw_type":"journal-article"},{"id":"pmid:9008152","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9008152","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of neuroscience research","raw_type":"Journal Article"},{"id":"pmh:oai:digital.csic.es:10261/73424","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10261/73424","pdf_url":null,"source":{"id":"https://openalex.org/S4306400616","display_name":"DIGITAL.CSIC (Spanish National Research Council (CSIC))","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I134820265","host_organization_name":"Consejo Superior de Investigaciones Cient\u00edficas","host_organization_lineage":["https://openalex.org/I134820265"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"http://purl.org/coar/resource_type/c_6501"},{"id":"mag:2142558895","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9008152","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9476000070571899,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320332434","display_name":"ExxonMobil Research and Engineering Company","ror":"https://ror.org/01xcepn55"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":41,"referenced_works":["https://openalex.org/W1250647964","https://openalex.org/W1524211161","https://openalex.org/W1534349023","https://openalex.org/W1588478093","https://openalex.org/W1594700207","https://openalex.org/W1964723113","https://openalex.org/W1971213127","https://openalex.org/W1972133688","https://openalex.org/W1977707793","https://openalex.org/W1984996311","https://openalex.org/W1994857072","https://openalex.org/W1996917933","https://openalex.org/W2011424449","https://openalex.org/W2017132797","https://openalex.org/W2019383843","https://openalex.org/W2023960956","https://openalex.org/W2029552699","https://openalex.org/W2032920422","https://openalex.org/W2033382511","https://openalex.org/W2036288989","https://openalex.org/W2038012168","https://openalex.org/W2050232551","https://openalex.org/W2058110454","https://openalex.org/W2059214757","https://openalex.org/W2059457068","https://openalex.org/W2059994807","https://openalex.org/W2060955976","https://openalex.org/W2072682191","https://openalex.org/W2075050842","https://openalex.org/W2075304472","https://openalex.org/W2078525459","https://openalex.org/W2081678091","https://openalex.org/W2100837269","https://openalex.org/W2112599260","https://openalex.org/W2127061690","https://openalex.org/W2134812217","https://openalex.org/W2144809647","https://openalex.org/W2148568069","https://openalex.org/W2148999943","https://openalex.org/W2158748165","https://openalex.org/W2159916470"],"related_works":["https://openalex.org/W4300520946","https://openalex.org/W2142558895","https://openalex.org/W2089797604","https://openalex.org/W2023960956","https://openalex.org/W2061622977","https://openalex.org/W2082356521","https://openalex.org/W2052718388","https://openalex.org/W2066286044","https://openalex.org/W2002498474","https://openalex.org/W2021717517"],"abstract_inverted_index":{"The":[0,52,61,119],"effects":[1,159],"of":[2,18,33,63,88,138,157,160,171],"beta-amyloid":[3],"(25-35)":[4],"(betaA)":[5],"on":[6],"cultured":[7],"astrocytes":[8,90,124,152],"from":[9],"rat":[10],"cortex":[11],"were":[12,57,143],"studied":[13],"and":[14,22,59,100,113,140,162],"compared":[15],"with":[16,23,74],"those":[17],"a":[19,37,131],"scrambled":[20,65],"peptide":[21,35,66],"untreated":[24,75],"cultures.":[25,77],"Single":[26],"addition":[27,62],"(from":[28],"5":[29],"to":[30,126,130,167],"200":[31],"microg/ml)":[32],"betaA":[34,56,161],"induced":[36,54],"marked":[38],"morphological":[39,120],"change":[40],"in":[41,72,94,122],"astrocytes,":[42],"changing":[43],"their":[44],"flat":[45],"polygonal":[46],"shape":[47],"into":[48],"stellate":[49],"process-bearing":[50],"morphology.":[51],"changes":[53,121],"by":[55,84],"concentration":[58],"time-dependent.":[60],"the":[64,135,158,169],"did":[67],"not":[68,144],"alter":[69],"cell":[70,79],"viability":[71,80],"comparison":[73],"astrocyte":[76,107],"However,":[78],"was":[81],"dose-dependently":[82],"decreased":[83],"betaA.":[85],"A":[86],"subpopulation":[87],"betaA-treated":[89,123],"showed":[91],"an":[92],"increase":[93],"glial":[95],"fibrillary":[96],"acidic":[97],"protein":[98],"(GFAP)":[99],"Vimentin":[101],"(Vim)":[102],"immunostaining":[103],"while":[104],"other":[105],"reactive":[106],"markers":[108],"such":[109],"as":[110],"S100beta,":[111],"MAP2,":[112],"ApoE":[114],"remained":[115],"unaltered":[116],"or":[117],"undetectable.":[118],"appeared":[125],"be":[127,165],"mainly":[128],"due":[129],"cytoskeletal":[132],"reorganization,":[133],"since":[134],"total":[136],"amounts":[137],"GFAP":[139],"Vim":[141],"proteins":[142],"essentially":[145],"modified.":[146],"These":[147],"results":[148],"strongly":[149],"suggest":[150],"that":[151],"are":[153],"another":[154],"cellular":[155],"target":[156],"this":[163],"may":[164],"relevant":[166],"understanding":[168],"neuropathology":[170],"Alzheimer's":[172],"disease.":[173]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2022-05-12T00:00:00"}