{"id":"https://openalex.org/W4249170759","doi":"https://doi.org/10.1158/1538-7445.sabcs18-2827","title":"Abstract 2827: Identification of chemotherapeutic resistant microbiota profile in colorectal cancer","display_name":"Abstract 2827: Identification of chemotherapeutic resistant microbiota profile in colorectal cancer","publication_year":2019,"publication_date":"2019-07-01","ids":{"openalex":"https://openalex.org/W4249170759","doi":"https://doi.org/10.1158/1538-7445.sabcs18-2827"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.sabcs18-2827","doi":"https://doi.org/10.1158/1538-7445.sabcs18-2827","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1538-7445.sabcs18-2827","pdf_url":null,"source":{"id":"https://openalex.org/S12644804","display_name":"Tumor Biology","issn_l":"1010-4283","issn":["1010-4283","1423-0380"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","jufo-1","medline","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Tumor Biology","raw_type":"proceedings-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1158/1538-7445.sabcs18-2827","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5054498115","display_name":"Shuyun Rao","orcid":"https://orcid.org/0000-0002-1073-6682","observed_orcids":["https://orcid.org/0000-0002-1073-6682"]},"institutions":[{"id":"https://openalex.org/I193531525","display_name":"George Washington University","ror":"https://ror.org/00y4zzh67","country_code":"US","type":"education","lineage":["https://openalex.org/I193531525"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shuyun Rao","raw_affiliation_strings":["George Washington Univ., Washington, DC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"George Washington Univ., Washington, DC","institution_ids":["https://openalex.org/I193531525"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102843534","display_name":"Charles Hadley S. King","orcid":"https://orcid.org/0000-0003-1409-4549","observed_orcids":["https://orcid.org/0000-0003-1409-4549"]},"institutions":[{"id":"https://openalex.org/I193531525","display_name":"George Washington University","ror":"https://ror.org/00y4zzh67","country_code":"US","type":"education","lineage":["https://openalex.org/I193531525"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Charles Hadley King","raw_affiliation_strings":["George Washington Univ., Washington, DC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"George Washington Univ., Washington, DC","institution_ids":["https://openalex.org/I193531525"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020517234","display_name":"Raja Mazumder","orcid":"https://orcid.org/0000-0001-8823-9945","observed_orcids":["https://orcid.org/0000-0001-8823-9945"]},"institutions":[{"id":"https://openalex.org/I193531525","display_name":"George Washington University","ror":"https://ror.org/00y4zzh67","country_code":"US","type":"education","lineage":["https://openalex.org/I193531525"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Raja Mazumder","raw_affiliation_strings":["George Washington Univ., Washington, DC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"George Washington Univ., Washington, DC","institution_ids":["https://openalex.org/I193531525"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037332686","display_name":"Shoujun Gu","orcid":"https://orcid.org/0000-0003-1041-3813","observed_orcids":["https://orcid.org/0000-0003-1041-3813","https://orcid.org/0009-0006-1166-3573"]},"institutions":[{"id":"https://openalex.org/I193531525","display_name":"George Washington University","ror":"https://ror.org/00y4zzh67","country_code":"US","type":"education","lineage":["https://openalex.org/I193531525"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shoujun Gu","raw_affiliation_strings":["George Washington Univ., Washington, DC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"George Washington Univ., Washington, DC","institution_ids":["https://openalex.org/I193531525"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049261258","display_name":"RICHARD L. AMDUR","orcid":"https://orcid.org/0000-0002-4900-653X","observed_orcids":["https://orcid.org/0000-0002-4900-653X"]},"institutions":[{"id":"https://openalex.org/I193531525","display_name":"George Washington University","ror":"https://ror.org/00y4zzh67","country_code":"US","type":"education","lineage":["https://openalex.org/I193531525"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Richard Amdur","raw_affiliation_strings":["George Washington Univ., Washington, DC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"George Washington Univ., Washington, DC","institution_ids":["https://openalex.org/I193531525"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102841128","display_name":"Bibhuti Mishra","orcid":"https://orcid.org/0000-0001-5302-2447","observed_orcids":["https://orcid.org/0000-0001-5302-2447"]},"institutions":[{"id":"https://openalex.org/I193531525","display_name":"George Washington University","ror":"https://ror.org/00y4zzh67","country_code":"US","type":"education","lineage":["https://openalex.org/I193531525"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bibhuti Mishra","raw_affiliation_strings":["George Washington Univ., Washington, DC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"George Washington Univ., Washington, DC","institution_ids":["https://openalex.org/I193531525"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5091703176","display_name":"Lopa Mishra","orcid":"https://orcid.org/0000-0002-6850-0808","observed_orcids":["https://orcid.org/0000-0002-6850-0808"]},"institutions":[{"id":"https://openalex.org/I193531525","display_name":"George Washington University","ror":"https://ror.org/00y4zzh67","country_code":"US","type":"education","lineage":["https://openalex.org/I193531525"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lopa Mishra","raw_affiliation_strings":["George Washington Univ., Washington, DC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"George Washington Univ., Washington, DC","institution_ids":["https://openalex.org/I193531525"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I193531525"],"apc_list":{"value":1500,"currency":"USD","value_usd":1500},"apc_paid":{"value":1500,"currency":"USD","value_usd":1500},"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"2827","last_page":"2827"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.788100004196167,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.788100004196167,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11501","display_name":"TGF-\u03b2 signaling in diseases","score":0.09759999811649323,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":0.0421999990940094,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/colorectal-cancer","display_name":"colorectal cancer","score":0.9900000095367432},{"id":"https://openalex.org/keywords/gut-microbiota","display_name":"gut microbiota","score":0.8849999904632568},{"id":"https://openalex.org/keywords/chemoresistance","display_name":"chemoresistance","score":0.9089999794960022},{"id":"https://openalex.org/keywords/tgf-beta-signaling","display_name":"TGF-beta signaling","score":0.949999988079071},{"id":"https://openalex.org/keywords/carcinoembryonic-antigen-related-cell-adhesion-molecules","display_name":"CEACAM","score":0.8989999890327454},{"id":"https://openalex.org/keywords/transforming-growth-factor-beta-receptor-1","display_name":"TGFBR1","score":0.9739999771118164},{"id":"https://openalex.org/keywords/cisplatin-sensitivity","display_name":"cisplatin sensitivity","score":0.746999979019165},{"id":"https://openalex.org/keywords/5-fluorouracil","display_name":"5-fluorouracil","score":0.9319999814033508},{"id":"https://openalex.org/keywords/dna-repair","display_name":"DNA repair","score":0.8349999785423279},{"id":"https://openalex.org/keywords/tumor-invasion","display_name":"tumor invasion","score":0.5550000071525574},{"id":"https://openalex.org/keywords/metastasis","display_name":"metastasis","score":0.796999990940094},{"id":"https://openalex.org/keywords/microbiome-signatures","display_name":"microbiome signatures","score":0.4959999918937683},{"id":"https://openalex.org/keywords/dna-cross-linking-agents","display_name":"DNA cross-linking agents","score":0.6759999990463257}],"concepts":[{"id":"https://openalex.org/C116834253","wikidata":"https://www.wikidata.org/wiki/Q2039217","display_name":"Identification (biology)","level":2,"score":0.6651208400726318},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.6356905698776245},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5354530811309814},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.40394821763038635},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.391030490398407},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.35325127840042114},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3333016633987427},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3225993514060974},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2843483090400696},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.27282077074050903},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.07662323117256165}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.sabcs18-2827","doi":"https://doi.org/10.1158/1538-7445.sabcs18-2827","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1538-7445.sabcs18-2827","pdf_url":null,"source":{"id":"https://openalex.org/S12644804","display_name":"Tumor Biology","issn_l":"1010-4283","issn":["1010-4283","1423-0380"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","jufo-1","medline","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Tumor Biology","raw_type":"proceedings-article"}],"best_oa_location":{"id":"doi:10.1158/1538-7445.sabcs18-2827","doi":"https://doi.org/10.1158/1538-7445.sabcs18-2827","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1538-7445.sabcs18-2827","pdf_url":null,"source":{"id":"https://openalex.org/S12644804","display_name":"Tumor Biology","issn_l":"1010-4283","issn":["1010-4283","1423-0380"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","jufo-1","medline","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Tumor Biology","raw_type":"proceedings-article"},"sustainable_development_goals":[{"score":0.9940000176429749,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3164984851","https://openalex.org/W7212739134","https://openalex.org/W7154625625","https://openalex.org/W4393085862","https://openalex.org/W3182008211","https://openalex.org/W4282932818","https://openalex.org/W4205826887","https://openalex.org/W4379984669","https://openalex.org/W2757517219","https://openalex.org/W4389428046"],"abstract_inverted_index":{"Background:":[0],"Emerging":[1],"data":[2],"shows":[3],"a":[4,19,149,208,232],"rise":[5],"in":[6,9,26,75,81,152,190,201,213,224,269,277,303,368],"CRC":[7,35,50,76,82,204,228],"incidence":[8],"men":[10],"and":[11,37,42,69,88,114,134,139,169,180,187,194,203,206,229,250,285,314,329,344],"women":[12],"under":[13],"55":[14],"years":[15],"of":[16,65,71,126,219,227,294,363,374],"age,":[17],"with":[18,116,221,231,312],"potential":[20],"new":[21,43],"risk":[22],"factors":[23],"including":[24,99],"alterations":[25,218],"the":[27,47,66,72,92,145,154,166,272,278,318,375],"microbiome.":[28,273],"While":[29],"recent":[30],"advances":[31],"have":[32],"significantly":[33],"reduced":[34],"morbidity":[36],"mortality,":[38],"such":[39,119,289,341],"as":[40,110,120,263,265,290,342],"screening":[41],"therapeutic":[44],"strategies,":[45],"how":[46],"microbiome":[48,74,147,199],"modulates":[49],"chemotherapy":[51,171,192,340],"response":[52,95],"remains":[53],"understudied.":[54],"This":[55],"alarming":[56],"trend":[57],"presents":[58],"an":[59],"urgent":[60],"need":[61],"for":[62,378],"further":[63],"understanding":[64],"molecular":[67],"mechanisms":[68],"\u201csignatures\u201d":[70],"gut":[73,93,146,184,315],"patients.":[77],"Key":[78],"driving":[79],"pathways":[80,118],"include":[83],"WNT,":[84],"RAS,":[85],"RAF,":[86],"APC":[87],"TGF-\u03b2":[89,121,127,155,167,188,220,243,256,279,299],"signaling.":[90],"Modulating":[91],"immune":[94],"includes":[96],"multiple":[97],"mechanisms,":[98],"sensors":[100],"through":[101,292,310],"carcinoembryonic":[102],"antigen-related":[103],"cell":[104,235,307],"adhesion":[105],"molecules":[106],"(CEACAMs)":[107],"that":[108,144,240,335],"serve":[109],"receptors":[111],"to":[112,129,132,160,176,283,327,339],"microbes,":[113],"crosstalk":[115],"signaling":[117,122,189,246],"pathway.":[123],"Interestingly,":[124],"disruption":[125,293],"leads":[128],"increased":[130],"sensitivity":[131,282],"cisplatin":[133,343],"other":[135],"DNA":[136,286,295],"cross-linking":[137,287],"agents.Hypothesis":[138],"Aims:":[140],"Our":[141,173],"hypothesis":[142],"is":[143,301,320],"plays":[148],"key":[150,275],"role":[151],"modulating":[153],"pathway":[156,168,280,300,319],"by":[157,247,271],"CEACAMs":[158,241,313],"binding":[159],"specific":[161,333],"microbial":[162],"species,":[163],"thereby":[164],"impeding":[165],"altering":[170],"response.":[172],"aims":[174],"are":[175,324,336],"explore":[177],"TCGA":[178,211],"genomics,":[179],"functional":[181],"interactions":[182,311],"between":[183],"microbiota,":[185],"CEACAMs,":[186],"processing":[191],"response.Methods":[193],"Results:":[195],"We":[196],"first":[197],"analyzed":[198],"signatures":[200],"normal":[202],"patients,":[205],"identified":[207],"signature":[209],"pattern.":[210],"analyses":[212],"9,125":[214],"human":[215],"cancers":[216],"reveal":[217,239],"CEACAM":[222],"members":[223],"over":[225],"40%":[226],"correlate":[230],"cancer":[233,370],"stem":[234],"signature.":[236],"Mechanistic":[237],"studies":[238],"inhibit":[242],"tumor":[244],"suppressor":[245],"blocking":[248],"TGFBR1,":[249],"promoting":[251],"invasive":[252],"CRC.":[253],"Likewise,":[254],"our":[255],"signaling-deficient":[257],"mouse":[258],"models":[259],"spontaneously":[260],"develop":[261],"CRC,":[262],"well":[264],"metastases,":[266],"likely":[267],"modulated":[268],"part":[270],"Furthermore,":[274],"defects":[276],"alter":[281],"5-FU":[284],"agents,":[288],"cisplatin,":[291],"repair":[296],"pathways.Conclusion:":[297],"The":[298],"important":[302],"maintaining":[304],"colon":[305],"epithelial":[306,322],"homeostasis":[308],"potentially":[309,331],"microbiota.":[316],"When":[317],"disrupted,":[321],"cells":[323],"more":[325,337],"susceptible":[326],"transformation":[328],"invasion,":[330],"identifying":[332],"populations":[334],"sensitive":[338],"5FU.Citation":[345],"Format:":[346],"Shuyun":[347],"Rao,":[348],"Charles":[349],"Hadley":[350],"King,":[351],"Raja":[352],"Mazumder,":[353],"Shoujun":[354],"Gu,":[355],"Richard":[356],"Amdur,":[357],"Bibhuti":[358],"Mishra,":[359],"Lopa":[360],"Mishra.":[361],"Identification":[362],"chemotherapeutic":[364],"resistant":[365],"microbiota":[366],"profile":[367],"colorectal":[369],"[abstract].":[371],"In:":[372],"Proceedings":[373],"American":[376],"Association":[377],"Cancer":[379,393],"Research":[380],"Annual":[381],"Meeting":[382],"2019;":[383],"2019":[384],"Mar":[385],"29-Apr":[386],"3;":[387],"Atlanta,":[388],"GA.":[389],"Philadelphia":[390],"(PA):":[391],"AACR;":[392],"Res":[394],"2019;79(13":[395],"Suppl):Abstract":[396],"nr":[397],"2827.":[398]},"counts_by_year":[],"updated_date":"2026-10-29T09:56:32.521200","created_date":"2022-05-12T00:00:00"}