{"id":"https://openalex.org/W4248962957","doi":"https://doi.org/10.1158/1538-7445.am2013-4586","title":"Abstract 4586: Targeting ROR1 inhibits epithelial-mesenchymal transition and metastasis.","display_name":"Abstract 4586: Targeting ROR1 inhibits epithelial-mesenchymal transition and metastasis.","publication_year":2013,"publication_date":"2013-04-01","ids":{"openalex":"https://openalex.org/W4248962957","doi":"https://doi.org/10.1158/1538-7445.am2013-4586"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am2013-4586","doi":"https://doi.org/10.1158/1538-7445.am2013-4586","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2013-4586","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5087255205","display_name":"Bing Cui","orcid":"https://orcid.org/0000-0001-8374-7801","observed_orcids":["https://orcid.org/0000-0001-8374-7801"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]},{"id":"https://openalex.org/I4390039236","display_name":"Moores Cancer Center","ror":"https://ror.org/01qkmtm61","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800935791","https://openalex.org/I36258959","https://openalex.org/I4390039236"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bing Cui","raw_affiliation_strings":["UCSD Moores Cancer Center, La Jolla, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UCSD Moores Cancer Center, La Jolla, CA","institution_ids":["https://openalex.org/I36258959","https://openalex.org/I4390039236"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019344762","display_name":"Suping Zhang","orcid":"https://orcid.org/0000-0003-0564-895X","observed_orcids":["https://orcid.org/0000-0003-0564-895X"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]},{"id":"https://openalex.org/I4390039236","display_name":"Moores Cancer Center","ror":"https://ror.org/01qkmtm61","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800935791","https://openalex.org/I36258959","https://openalex.org/I4390039236"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Suping Zhang","raw_affiliation_strings":["UCSD Moores Cancer Center, La Jolla, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UCSD Moores Cancer Center, La Jolla, CA","institution_ids":["https://openalex.org/I36258959","https://openalex.org/I4390039236"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036294739","display_name":"Liguang Chen","orcid":"https://orcid.org/0000-0001-5325-781X","observed_orcids":["https://orcid.org/0000-0001-5325-781X"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]},{"id":"https://openalex.org/I4390039236","display_name":"Moores Cancer Center","ror":"https://ror.org/01qkmtm61","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800935791","https://openalex.org/I36258959","https://openalex.org/I4390039236"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Liguang Chen","raw_affiliation_strings":["UCSD Moores Cancer Center, La Jolla, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UCSD Moores Cancer Center, La Jolla, CA","institution_ids":["https://openalex.org/I36258959","https://openalex.org/I4390039236"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051459499","display_name":"Jianqiang Yu","orcid":"https://orcid.org/0000-0003-3752-6527","observed_orcids":["https://orcid.org/0000-0003-3752-6527"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]},{"id":"https://openalex.org/I4390039236","display_name":"Moores Cancer Center","ror":"https://ror.org/01qkmtm61","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800935791","https://openalex.org/I36258959","https://openalex.org/I4390039236"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jianqiang Yu","raw_affiliation_strings":["UCSD Moores Cancer Center, La Jolla, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UCSD Moores Cancer Center, La Jolla, CA","institution_ids":["https://openalex.org/I36258959","https://openalex.org/I4390039236"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033222332","display_name":"George F. Widhopf","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]},{"id":"https://openalex.org/I4390039236","display_name":"Moores Cancer Center","ror":"https://ror.org/01qkmtm61","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800935791","https://openalex.org/I36258959","https://openalex.org/I4390039236"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"George F. Widhopf","raw_affiliation_strings":["UCSD Moores Cancer Center, La Jolla, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UCSD Moores Cancer Center, La Jolla, CA","institution_ids":["https://openalex.org/I36258959","https://openalex.org/I4390039236"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108616747","display_name":"Jessie-F. Fecteau","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]},{"id":"https://openalex.org/I4390039236","display_name":"Moores Cancer Center","ror":"https://ror.org/01qkmtm61","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800935791","https://openalex.org/I36258959","https://openalex.org/I4390039236"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jessie-F. Fecteau","raw_affiliation_strings":["UCSD Moores Cancer Center, La Jolla, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UCSD Moores Cancer Center, La Jolla, CA","institution_ids":["https://openalex.org/I36258959","https://openalex.org/I4390039236"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010336471","display_name":"Laura Z. Rassenti","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]},{"id":"https://openalex.org/I4390039236","display_name":"Moores Cancer Center","ror":"https://ror.org/01qkmtm61","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800935791","https://openalex.org/I36258959","https://openalex.org/I4390039236"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Laura Z. Rassenti","raw_affiliation_strings":["UCSD Moores Cancer Center, La Jolla, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UCSD Moores Cancer Center, La Jolla, CA","institution_ids":["https://openalex.org/I36258959","https://openalex.org/I4390039236"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5036828560","display_name":"Thomas J. Kipps","orcid":"https://orcid.org/0000-0002-0064-4549","observed_orcids":["https://orcid.org/0000-0002-0064-4549"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]},{"id":"https://openalex.org/I4390039236","display_name":"Moores Cancer Center","ror":"https://ror.org/01qkmtm61","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800935791","https://openalex.org/I36258959","https://openalex.org/I4390039236"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas J. Kipps","raw_affiliation_strings":["UCSD Moores Cancer Center, La Jolla, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UCSD Moores Cancer Center, La Jolla, CA","institution_ids":["https://openalex.org/I36258959","https://openalex.org/I4390039236"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"73","issue":"8_Supplement","first_page":"4586","last_page":"4586"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.7782999873161316,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.7782999873161316,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.15389999747276306,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13437","display_name":"Mechanisms of cancer metastasis","score":0.029400000348687172,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ror1","display_name":"ROR1","score":0.9549999833106995},{"id":"https://openalex.org/keywords/epithelial-mesenchymal-transition","display_name":"epithelial-mesenchymal transition","score":0.968999981880188},{"id":"https://openalex.org/keywords/breast-cancer-metastasis","display_name":"breast cancer metastasis","score":0.9359999895095825},{"id":"https://openalex.org/keywords/basal-like-breast-cancer","display_name":"basal-like breast cancer","score":0.746999979019165},{"id":"https://openalex.org/keywords/luminal-breast-cancer","display_name":"luminal breast cancer","score":0.8230000138282776},{"id":"https://openalex.org/keywords/cell-migration-and-invasion","display_name":"cell migration and invasion","score":0.6700000166893005},{"id":"https://openalex.org/keywords/vimentin","display_name":"vimentin","score":0.5839999914169312},{"id":"https://openalex.org/keywords/zeb1","display_name":"ZEB1","score":0.9959999918937683},{"id":"https://openalex.org/keywords/tight-junction-proteins","display_name":"tight junction proteins","score":0.7369999885559082},{"id":"https://openalex.org/keywords/cytokeratin","display_name":"cytokeratin","score":0.7059999704360962},{"id":"https://openalex.org/keywords/early-recurrence","display_name":"early recurrence","score":0.527999997138977},{"id":"https://openalex.org/keywords/survival","display_name":"survival","score":0.4350000023841858}],"concepts":[{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5693163275718689},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.5638751983642578},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5537258982658386},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.5514284372329712},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5161624550819397},{"id":"https://openalex.org/C101544691","wikidata":"https://www.wikidata.org/wiki/Q420511","display_name":"Receptor tyrosine kinase","level":3,"score":0.5020825862884521},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.45881137251853943},{"id":"https://openalex.org/C76419328","wikidata":"https://www.wikidata.org/wiki/Q74419","display_name":"Epithelial\u2013mesenchymal transition","level":4,"score":0.45058223605155945},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4099140465259552},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.38037991523742676},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.33850497007369995}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am2013-4586","doi":"https://doi.org/10.1158/1538-7445.am2013-4586","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2013-4586","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2012179344","https://openalex.org/W1983054966","https://openalex.org/W1964370097","https://openalex.org/W3006510753","https://openalex.org/W1975711182","https://openalex.org/W2802547338","https://openalex.org/W1995394695","https://openalex.org/W2913445208","https://openalex.org/W2280704516","https://openalex.org/W2496440151"],"abstract_inverted_index":{"Abstract":[0],"The":[1],"receptor":[2,6],"tyrosine":[3],"kinase-like":[4],"orphan":[5],"1":[7],"(ROR1)":[8],"is":[9,16],"an":[10],"evolutionarily-conserved,":[11],"type-I":[12],"membrane":[13],"glycoprotein":[14],"that":[15,45,93,378,386],"expressed":[17,36,237],"in":[18,101,136,214,250,286,291,297,331,356],"embryonic":[19],"development,":[20],"but":[21],"not":[22,241],"by":[23,37],"virtually":[24],"all":[25],"normal":[26],"post-partum":[27],"tissues.":[28],"Recent":[29],"studies":[30],"have":[31,50],"found":[32],"the":[33,74,120,137,142,161,242,251,311,428,433],"ROR1":[34,111,146,169,212,249,296,347,379,389,418],"protein":[35,70,112],"a":[38,64,95,102,149,185,341],"variety":[39],"of":[40,82,89,97,110,122,133,145,153,168,188,201,256,270,334,427,432],"different":[41,103],"cancers,":[42],"particularly":[43],"those":[44],"appear":[46],"less":[47],"differentiated":[48],"and/or":[49],"high-grade":[51],"histology":[52],"(Am":[53],"J":[54],"Pathol.":[55],"2012,":[56,115],"PMID":[57,116],"23041612).":[58],"Because":[59,88],"there":[60],"appeared":[61],"to":[62,310,320,367],"be":[63],"tight":[65],"association":[66],"between":[67],"gene":[68],"and":[69,191,226,266,273,278,280,288,305,328,350,383,385,394,422],"expression,":[71],"we":[72,118],"interrogated":[73],"gene-expression":[75],"data":[76],"on":[77],"breast":[78,98,223,229],"adenocarcinomas":[79],"from":[80],"each":[81,282,317,352],"582":[83,123],"patients":[84],"(pt)":[85],"for":[86,211,244,346,436],"ROR1.":[87,134],"our":[90],"earlier":[91],"observation":[92],"approximately":[94],"third":[96],"cancer":[99,224,230,392],"pt":[100,124,157,180,196],"cohort":[104,121],"had":[105,148,184],"tumors\u2019":[106,130],"with":[107,139,158,181,197,259,340,371],"high-level":[108],"expression":[109,132,144,167,213,255,269],"(PLoS":[113],"One,":[114],"22403610),":[117],"divided":[119],"into":[125],"tertiles":[126],"based":[127],"upon":[128],"their":[129],"relative":[131],"Pt":[135],"tertile":[138],"cancers":[140],"having":[141,160],"highest":[143],"(ROR1H)":[147],"significantly":[150,361],"higher":[151,186],"rate":[152,187],"metastases":[154,324,330],"than":[155,194],"did":[156,195],"tumors":[159,183],"mid":[162],"(ROR1M)":[163],"or":[164,174,203,313,325,336],"lowest":[165],"(ROR1L)":[166],"(e.g.":[170,263,276],"61%":[171],"vs.":[172],"35%":[173],"41%,":[175],"respectively,":[176],"p<":[177],"0.0001).":[178],"Moreover,":[179,294],"ROR1H":[182],"early":[189],"relapse":[190],"poorer":[192],"survival":[193],"ROR1L/M":[198],"tumors,":[199],"irrespective":[200],"ER":[202],"HER2":[204],"status":[205],"(HR=2.3,":[206],"p<0.0001).":[207],"We":[208],"also":[209,360],"examined":[210],"14":[215],"distinct":[216],"breast-cancer":[217],"epithelial":[218,271],"cell-lines,":[219],"including":[220],"6":[221,233],"basal-type":[222,338],"cell-lines":[225,236,253,339],"8":[227],"luminal-type":[228,246],"cell-lines.":[231,247],"All":[232],"basal-type,":[234],"metastases-prone,":[235],"ROR1,":[238],"which":[239,307],"was":[240],"case":[243],"low-invasive,":[245],"Silencing":[248],"basal":[252],"attenuated":[254],"proteins":[257,275],"associated":[258],"epithelial-mesenchymal":[260,420],"transition":[261,421],"(EMT)":[262],"vimentin,":[264],"SNAIL-1/2,":[265],"ZEB1),":[267],"enhanced":[268],"cytokeratins":[272],"tight-junction":[274],"CK-19":[277],"ZO-1),":[279],"impaired":[281],"cell-line's":[283,318],"migration/invasion":[284,354],"capacity":[285,319,355],"vitro":[287],"metastatic":[289],"potential":[290],"immune-deficient":[292,368],"mice.":[293],"silencing":[295],"parental":[298],"MDA-MB-231":[299,335,372],"cells":[300],"(or":[301],"its":[302],"derivatives":[303],"LM2-4175":[304],"BoM-1833,":[306],"preferentially":[308],"metastasize":[309],"lung":[312,323,327],"bone,":[314],"respectively)":[315],"inhibited":[316,351,362],"generate":[321],"orthotopic":[322],"experimental":[326],"bone":[329],"vivo.":[332],"Treatment":[333],"other":[337],"monoclonal":[342],"antibody":[343],"(mAb)":[344],"specific":[345],"down-modulated":[348],"vimentin":[349],"cancer-cell-line's":[353],"vitro.":[357],"This":[358],"mAb":[359],"tumor":[363],"metastasis":[364],"when":[365],"given":[366],"mice":[369],"engrafted":[370],"cells.":[373],"Collectively,":[374],"this":[375],"study":[376],"indicates":[377],"may":[380],"regulate":[381],"EMT":[382],"metastasis,":[384],"antibodies":[387],"targeting":[388],"can":[390],"inhibit":[391],"progression":[393],"metastasis.":[395,423],"Citation":[396],"Format:":[397],"Bing":[398],"Cui,":[399],"Suping":[400],"Zhang,":[401],"Liguang":[402],"Chen,":[403],"Jianqiang":[404],"Yu,":[405],"George":[406],"F.":[407],"Widhopf,":[408],"Jessie-F.":[409],"Fecteau,":[410],"Laura":[411],"Z.":[412],"Rassenti,":[413],"Thomas":[414],"J.":[415],"Kipps.":[416],"Targeting":[417],"inhibits":[419],"[abstract].":[424],"In:":[425],"Proceedings":[426],"104th":[429],"Annual":[430],"Meeting":[431],"American":[434],"Association":[435],"Cancer":[437,447],"Research;":[438],"2013":[439],"Apr":[440],"6-10;":[441],"Washington,":[442],"DC.":[443],"Philadelphia":[444],"(PA):":[445],"AACR;":[446],"Res":[448],"2013;73(8":[449],"Suppl):Abstract":[450],"nr":[451],"4586.":[452],"doi:10.1158/1538-7445.AM2013-4586":[453]},"counts_by_year":[],"updated_date":"2026-10-27T15:51:10.671819","created_date":"2022-05-12T00:00:00"}