{"id":"https://openalex.org/W4248942017","doi":"https://doi.org/10.1242/dev.89.supplement.113","title":"Gene expression in Xenopus embryogenesis","display_name":"Gene expression in Xenopus embryogenesis","publication_year":1985,"publication_date":"1985-11-01","ids":{"openalex":"https://openalex.org/W4248942017","doi":"https://doi.org/10.1242/dev.89.supplement.113"},"language":"en","primary_location":{"id":"doi:10.1242/dev.89.supplement.113","doi":"https://doi.org/10.1242/dev.89.supplement.113","is_oa":false,"landing_page_url":"https://doi.org/10.1242/dev.89.supplement.113","pdf_url":null,"source":{"id":"https://openalex.org/S86558740","display_name":"Development","issn_l":"0950-1991","issn":["0950-1991","1477-9129"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311847","host_organization_name":"The Company of Biologists","host_organization_lineage":["https://openalex.org/P4310311847"],"host_organization_lineage_names":["The Company of Biologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Development","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5064390918","display_name":"Igor B. Dawid","orcid":"https://orcid.org/0000-0003-0579-5693","observed_orcids":["https://orcid.org/0000-0003-0579-5693"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210144228","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210144228"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Igor B. Dawid","raw_affiliation_strings":["Laboratory of Molecular Genetics, National Institute of Child Health and Human Development, Bethesda, MD 20205, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Molecular Genetics, National Institute of Child Health and Human Development, Bethesda, MD 20205, U.S.A","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210144228"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043689600","display_name":"Susan R. Haynes","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210144228","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210144228"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Susan R. Haynes","raw_affiliation_strings":["Laboratory of Molecular Genetics, National Institute of Child Health and Human Development, Bethesda, MD 20205, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Molecular Genetics, National Institute of Child Health and Human Development, Bethesda, MD 20205, U.S.A","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210144228"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012900167","display_name":"Milan Jamrich","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210144228","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210144228"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Milan Jamrich","raw_affiliation_strings":["Laboratory of Molecular Genetics, National Institute of Child Health and Human Development, Bethesda, MD 20205, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Molecular Genetics, National Institute of Child Health and Human Development, Bethesda, MD 20205, U.S.A","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210144228"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000180233","display_name":"Erzs\u00e9bet J\u00f3n\u00e1s","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210144228","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210144228"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Erzsebet Jonas","raw_affiliation_strings":["Laboratory of Molecular Genetics, National Institute of Child Health and Human Development, Bethesda, MD 20205, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Molecular Genetics, National Institute of Child Health and Human Development, Bethesda, MD 20205, U.S.A","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210144228"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025890679","display_name":"Seiji Miyatani","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210144228","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210144228"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Seiji Miyata\u00f1I","raw_affiliation_strings":["Laboratory of Molecular Genetics, National Institute of Child Health and Human Development, Bethesda, MD 20205, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Molecular Genetics, National Institute of Child Health and Human Development, Bethesda, MD 20205, U.S.A","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210144228"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018516469","display_name":"Thomas D. Sargent","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210144228","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210144228"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas D. Sargent","raw_affiliation_strings":["Laboratory of Molecular Genetics, National Institute of Child Health and Human Development, Bethesda, MD 20205, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Molecular Genetics, National Institute of Child Health and Human Development, Bethesda, MD 20205, U.S.A","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210144228"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5032029297","display_name":"Jeffrey A. Winkles","orcid":"https://orcid.org/0000-0002-3305-1424","observed_orcids":["https://orcid.org/0000-0002-3305-1424"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210144228","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210144228"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeffrey A. Winkles","raw_affiliation_strings":["Laboratory of Molecular Genetics, National Institute of Child Health and Human Development, Bethesda, MD 20205, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Molecular Genetics, National Institute of Child Health and Human Development, Bethesda, MD 20205, U.S.A","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210144228"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.31092173,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"89","issue":"Supplement","first_page":"113","last_page":"124"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.0027000000700354576,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/xenopus-laevis","display_name":"Xenopus laevis","score":0.9259999990463257},{"id":"https://openalex.org/keywords/embryonic-development","display_name":"embryonic development","score":0.6819999814033508},{"id":"https://openalex.org/keywords/midblastula-transition","display_name":"midblastula transition","score":0.9490000009536743},{"id":"https://openalex.org/keywords/gastrulation","display_name":"gastrulation","score":0.7310000061988831},{"id":"https://openalex.org/keywords/gene-activation","display_name":"gene activation","score":0.6830000281333923},{"id":"https://openalex.org/keywords/poly-a-rna","display_name":"polyadenylated RNA","score":0.8600000143051147},{"id":"https://openalex.org/keywords/mrna-accumulation","display_name":"mRNA accumulation","score":0.37599998712539673},{"id":"https://openalex.org/keywords/trna","display_name":"tRNA","score":0.4230000078678131},{"id":"https://openalex.org/keywords/ribosomal-rna","display_name":"ribosomal RNA","score":0.9290000200271606},{"id":"https://openalex.org/keywords/mitochondrial-rna","display_name":"mitochondrial RNA","score":0.9639999866485596}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.9468584656715393},{"id":"https://openalex.org/C2779535977","wikidata":"https://www.wikidata.org/wiki/Q1342298","display_name":"Xenopus","level":3,"score":0.8678910136222839},{"id":"https://openalex.org/C129536746","wikidata":"https://www.wikidata.org/wiki/Q1141026","display_name":"Gastrulation","level":4,"score":0.6665008068084717},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5746938586235046},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.5716633796691895},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5341782569885254},{"id":"https://openalex.org/C187882448","wikidata":"https://www.wikidata.org/wiki/Q283478","display_name":"Complementary DNA","level":3,"score":0.5283751487731934},{"id":"https://openalex.org/C87073359","wikidata":"https://www.wikidata.org/wiki/Q33196","display_name":"Embryogenesis","level":3,"score":0.5261373519897461},{"id":"https://openalex.org/C196843134","wikidata":"https://www.wikidata.org/wiki/Q33196","display_name":"Embryo","level":2,"score":0.5113381743431091},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.49856066703796387},{"id":"https://openalex.org/C189482833","wikidata":"https://www.wikidata.org/wiki/Q869146","display_name":"cDNA library","level":4,"score":0.47730931639671326},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4633975327014923},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.4402925372123718},{"id":"https://openalex.org/C121050878","wikidata":"https://www.wikidata.org/wiki/Q5135020","display_name":"Cloning (programming)","level":2,"score":0.4379584789276123},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.43640410900115967},{"id":"https://openalex.org/C194058213","wikidata":"https://www.wikidata.org/wiki/Q7209147","display_name":"Polarity in embryogenesis","level":5,"score":0.4148775339126587},{"id":"https://openalex.org/C196436469","wikidata":"https://www.wikidata.org/wiki/Q6587700","display_name":"Suppression subtractive hybridization","level":5,"score":0.41317445039749146},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.38243556022644043},{"id":"https://openalex.org/C144024400","wikidata":"https://www.wikidata.org/wiki/Q21201","display_name":"Sociology","level":0,"score":0.0},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0},{"id":"https://openalex.org/C149923435","wikidata":"https://www.wikidata.org/wiki/Q37732","display_name":"Demography","level":1,"score":0.0},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1242/dev.89.supplement.113","doi":"https://doi.org/10.1242/dev.89.supplement.113","is_oa":false,"landing_page_url":"https://doi.org/10.1242/dev.89.supplement.113","pdf_url":null,"source":{"id":"https://openalex.org/S86558740","display_name":"Development","issn_l":"0950-1991","issn":["0950-1991","1477-9129"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311847","host_organization_name":"The Company of Biologists","host_organization_lineage":["https://openalex.org/P4310311847"],"host_organization_lineage_names":["The Company of Biologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Development","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":46,"referenced_works":["https://openalex.org/W19279815","https://openalex.org/W258394342","https://openalex.org/W1513717105","https://openalex.org/W1542023975","https://openalex.org/W1786629375","https://openalex.org/W1965389651","https://openalex.org/W1966056582","https://openalex.org/W1967178432","https://openalex.org/W1970119743","https://openalex.org/W1980921651","https://openalex.org/W1983122156","https://openalex.org/W1986425464","https://openalex.org/W1989841259","https://openalex.org/W1990077572","https://openalex.org/W1990537861","https://openalex.org/W1993635522","https://openalex.org/W1994758233","https://openalex.org/W2008099807","https://openalex.org/W2009823036","https://openalex.org/W2011770798","https://openalex.org/W2021069133","https://openalex.org/W2021839313","https://openalex.org/W2027636173","https://openalex.org/W2036786006","https://openalex.org/W2038529404","https://openalex.org/W2039610005","https://openalex.org/W2065904366","https://openalex.org/W2066384411","https://openalex.org/W2067259243","https://openalex.org/W2071076550","https://openalex.org/W2071789894","https://openalex.org/W2075042809","https://openalex.org/W2077551493","https://openalex.org/W2082304865","https://openalex.org/W2082573646","https://openalex.org/W2086659612","https://openalex.org/W2089482316","https://openalex.org/W2094957189","https://openalex.org/W2096611980","https://openalex.org/W2103431676","https://openalex.org/W2107332774","https://openalex.org/W2109291482","https://openalex.org/W2133074709","https://openalex.org/W2146304997","https://openalex.org/W2329464713","https://openalex.org/W2513972281"],"related_works":["https://openalex.org/W7100058822","https://openalex.org/W1994692641","https://openalex.org/W2406361562","https://openalex.org/W1537421463","https://openalex.org/W2021484263","https://openalex.org/W2077500199","https://openalex.org/W2077551493","https://openalex.org/W2419124918","https://openalex.org/W2012771708","https://openalex.org/W2047309503"],"abstract_inverted_index":{"ABSTRACT":[0],"This":[1],"article":[2],"considers":[3],"some":[4,103],"aspects":[5],"of":[6,9,14,20,33,47,57,60,74,76,99,118,129,145,147],"the":[7,12,18,38,41,64,70,89,100,116,136],"storage":[8],"macromolecules":[10],"in":[11,37,107,154,159],"oocyte":[13],"Xenopus":[15],"laevis":[16],"and":[17,30,72,84,141,164],"activation":[19],"previously":[21],"unexpressed":[22],"genes":[23,133,153],"during":[24],"early":[25],"embryogenesis.":[26],"The":[27],"large":[28],"quantity":[29],"complex":[31],"nature":[32],"poly(A)+":[34,90],"RNA":[35,78,91,109],"accumulated":[36,111],"egg":[39,101,108],"provides":[40],"cleavage":[42],"embryo":[43],"with":[44],"a":[45,119,127],"supply":[46],"mRNA":[48],"sufficient":[49],"to":[50,69,97,162],"sustain":[51],"protein":[52],"synthesis":[53,71],"for":[54,135],"several":[55,146],"hours":[56],"development.":[58],"Onset":[59],"gene":[61],"activity":[62,161],"at":[63],"midblastula":[65],"transition":[66],"(MBT)":[67],"leads":[68],"accumulation":[73],"molecules":[75],"various":[77],"classes,":[79],"including":[80],"tRNAs,":[81],"rRNAs,":[82],"mRNAs":[83],"mitochondrial":[85],"RNAs.":[86],"At":[87],"gastrulation":[88],"population":[92],"is":[93],"still":[94],"qualitatively":[95],"similar":[96],"that":[98,131,152],"but":[102],"sequences":[104,130],"not":[105],"present":[106],"have":[110,125],"by":[112],"this":[113,155],"time.":[114],"Through":[115],"use":[117],"subtractive":[120],"cDNA":[121,149],"cloning":[122],"procedure":[123],"we":[124],"prepared":[126],"library":[128],"represent":[132],"activated":[134],"first":[137],"time":[138],"between":[139],"MBT":[140],"gastrula.":[142],"A":[143],"study":[144],"these":[148],"clones":[150],"suggests":[151],"class":[156],"are":[157],"restricted":[158],"their":[160],"embryonic":[163],"tadpole":[165],"stages.":[166]},"counts_by_year":[{"year":2018,"cited_by_count":1}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2022-05-12T00:00:00"}
