{"id":"https://openalex.org/W4248554608","doi":"https://doi.org/10.1080/00365517809104926","title":"Lipoprotein Morphology in Some LCAT-Deficient States","display_name":"Lipoprotein Morphology in Some LCAT-Deficient States","publication_year":1978,"publication_date":"1978-01-01","ids":{"openalex":"https://openalex.org/W4248554608","doi":"https://doi.org/10.1080/00365517809104926","pmid":"https://pubmed.ncbi.nlm.nih.gov/746349"},"language":"en","primary_location":{"id":"doi:10.1080/00365517809104926","doi":"https://doi.org/10.1080/00365517809104926","is_oa":false,"landing_page_url":"https://doi.org/10.1080/00365517809104926","pdf_url":null,"source":{"id":"https://openalex.org/S5501027","display_name":"Scandinavian Journal of Clinical and Laboratory Investigation","issn_l":"0036-5513","issn":["0036-5513","1502-7686"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scandinavian Journal of Clinical and Laboratory Investigation","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"G. Bode","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I196349391","display_name":"Universit\u00e4t Ulm","ror":"https://ror.org/032000t02","country_code":"DE","type":"education","lineage":["https://openalex.org/I196349391"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"G. Bode","raw_affiliation_strings":["Division of Metabolism and Nutrition, Dept. of Medicine, University of Ulm, Federal Republic of Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Metabolism and Nutrition, Dept. of Medicine, University of Ulm, Federal Republic of Germany","institution_ids":["https://openalex.org/I196349391"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110155507","display_name":"H. U. Kl\u00f6r","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I196349391","display_name":"Universit\u00e4t Ulm","ror":"https://ror.org/032000t02","country_code":"DE","type":"education","lineage":["https://openalex.org/I196349391"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"H. U. Kl\u00f6r","raw_affiliation_strings":["Division of Metabolism and Nutrition, Dept. of Medicine, University of Ulm, Federal Republic of Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Metabolism and Nutrition, Dept. of Medicine, University of Ulm, Federal Republic of Germany","institution_ids":["https://openalex.org/I196349391"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113433090","display_name":"H. Ditschuneit","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I196349391","display_name":"Universit\u00e4t Ulm","ror":"https://ror.org/032000t02","country_code":"DE","type":"education","lineage":["https://openalex.org/I196349391"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"H. Ditschuneit","raw_affiliation_strings":["Division of Metabolism and Nutrition, Dept. of Medicine, University of Ulm, Federal Republic of Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Metabolism and Nutrition, Dept. of Medicine, University of Ulm, Federal Republic of Germany","institution_ids":["https://openalex.org/I196349391"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I196349391"],"apc_list":null,"apc_paid":null,"fwci":1.2986,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.79304029,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"38","issue":"sup150","first_page":"199","last_page":"207"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13430","display_name":"Lipid metabolism and disorders","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T13430","display_name":"Lipid metabolism and disorders","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10394","display_name":"Lipoproteins and Cardiovascular Health","score":0.0027000000700354576,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11618","display_name":"Cholesterol and Lipid Metabolism","score":0.0019000000320374966,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lipoprotein-structure","display_name":"lipoprotein structure","score":0.5540000200271606},{"id":"https://openalex.org/keywords/lcat-deficiency","display_name":"LCAT deficiency","score":0.7549999952316284},{"id":"https://openalex.org/keywords/type-iii-hyperlipoproteinemia","display_name":"type III hyperlipoproteinemia","score":0.9539999961853027},{"id":"https://openalex.org/keywords/type-i-hyperlipoproteinemia","display_name":"type I hyperlipoproteinemia","score":0.9419999718666077},{"id":"https://openalex.org/keywords/zieve-s-syndrome","display_name":"Zieve's syndrome","score":0.984000027179718},{"id":"https://openalex.org/keywords/chylomicrons","display_name":"chylomicrons","score":0.7120000123977661},{"id":"https://openalex.org/keywords/very-low-density-lipoprotein","display_name":"VLDL","score":0.8289999961853027},{"id":"https://openalex.org/keywords/low-density-lipoprotein","display_name":"low-density lipoprotein","score":0.6470000147819519},{"id":"https://openalex.org/keywords/hdl-cholesterol","display_name":"HDL cholesterol","score":0.9810000061988831},{"id":"https://openalex.org/keywords/phospholipase","display_name":"phospholipase","score":0.6119999885559082},{"id":"https://openalex.org/keywords/cholesteryl-ester-hydrolase","display_name":"cholesterol ester hydrolase","score":0.9919999837875366},{"id":"https://openalex.org/keywords/lipolysis","display_name":"lipolysis","score":0.8939999938011169},{"id":"https://openalex.org/keywords/heparin","display_name":"heparin","score":0.6209999918937683}],"concepts":[{"id":"https://openalex.org/C964641","wikidata":"https://www.wikidata.org/wiki/Q424716","display_name":"Lecithin\u2014cholesterol acyltransferase","level":4,"score":0.7294290661811829},{"id":"https://openalex.org/C499950583","wikidata":"https://www.wikidata.org/wiki/Q183252","display_name":"Morphology (biology)","level":2,"score":0.5576524138450623},{"id":"https://openalex.org/C2780072125","wikidata":"https://www.wikidata.org/wiki/Q28350","display_name":"Lipoprotein","level":3,"score":0.45685747265815735},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.42053407430648804},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.3690163791179657},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3475353717803955},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.290284663438797},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.24707618355751038},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.22454127669334412},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.12002402544021606}],"mesh":[{"descriptor_ui":"D000437","descriptor_name":"Alcoholism","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D000437","descriptor_name":"Alcoholism","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D000743","descriptor_name":"Anemia, Hemolytic","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D000743","descriptor_name":"Anemia, Hemolytic","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D002784","descriptor_name":"Cholesterol","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D002788","descriptor_name":"Cholesterol Esters","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D006493","descriptor_name":"Heparin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006949","descriptor_name":"Hyperlipidemias","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D006949","descriptor_name":"Hyperlipidemias","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D007009","descriptor_name":"Hypolipoproteinemias","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D007863","descriptor_name":"Lecithin Cholesterol Acyltransferase Deficiency","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D008071","descriptor_name":"Lipoprotein Lipase","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D008074","descriptor_name":"Lipoproteins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D008074","descriptor_name":"Lipoproteins","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D008081","descriptor_name":"Liposomes","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D008563","descriptor_name":"Membrane Lipids","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D008854","descriptor_name":"Microscopy, Electron","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010740","descriptor_name":"Phospholipases","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D013577","descriptor_name":"Syndrome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014280","descriptor_name":"Triglycerides","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1080/00365517809104926","doi":"https://doi.org/10.1080/00365517809104926","is_oa":false,"landing_page_url":"https://doi.org/10.1080/00365517809104926","pdf_url":null,"source":{"id":"https://openalex.org/S5501027","display_name":"Scandinavian Journal of Clinical and Laboratory Investigation","issn_l":"0036-5513","issn":["0036-5513","1502-7686"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scandinavian Journal of Clinical and Laboratory Investigation","raw_type":"journal-article"},{"id":"doi:10.3109/00365517809104926","doi":"https://doi.org/10.3109/00365517809104926","is_oa":false,"landing_page_url":"https://doi.org/10.3109/00365517809104926","pdf_url":null,"source":{"id":"https://openalex.org/S5501027","display_name":"Scandinavian Journal of Clinical and Laboratory Investigation","issn_l":"0036-5513","issn":["0036-5513","1502-7686"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scandinavian Journal of Clinical and Laboratory Investigation","raw_type":"journal-article"},{"id":"pmid:746349","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/746349","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scandinavian journal of clinical and laboratory investigation. Supplementum","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":6,"referenced_works":["https://openalex.org/W1978922020","https://openalex.org/W1985778027","https://openalex.org/W2005817393","https://openalex.org/W2076859900","https://openalex.org/W2090442024","https://openalex.org/W2109525279"],"related_works":["https://openalex.org/W2037519668","https://openalex.org/W2062784413","https://openalex.org/W2420520676","https://openalex.org/W2019568986","https://openalex.org/W2890737184","https://openalex.org/W2038657237","https://openalex.org/W1969931459","https://openalex.org/W2076576415","https://openalex.org/W132390190","https://openalex.org/W2482573853"],"abstract_inverted_index":{"A":[0],"situation":[1],"of":[2,87,107,112,138,173,198,211,216,227,233,236,248,261,278],"maximal":[3],"triglyceride":[4],"(TG)":[5],"hydrolysis":[6],"was":[7,75,103],"generated":[8],"in":[9,123,131,148,154,192,214,287],"normals":[10],"and":[11,23,50,67,80,93,111,150,156,161,204,240,271,280],"patients":[12],"with":[13,105,168],"type":[14,108],"III":[15],"hyperlipoproteinemia":[16,110],"by":[17,62,83],"a":[18,169],"large":[19,193,234],"oral":[20],"fat":[21,31],"load":[22],"subsequent":[24,68],"heparin":[25],"administration":[26],"one":[27],"hour":[28],"after":[29],"the":[30,85,132,246,285],"meal.":[32],"Lipoprotein":[33],"fractions":[34,82,215],"[chylomicrons,":[35],"very":[36],"low":[37,41],"density":[38,42,52,178],"lipoproteins":[39,43,53],"(VLDL),":[40],"(LDL1":[44],"d":[45,48,55,58,139,199,217],"1.006-1.019,":[46],"LDL2":[47,155],"1.019-1.063),":[49],"high":[51],"(HDL2":[54],"1.063-1.125,":[56],"HDL,":[57],"1.125-1.25)|":[59],"were":[60],"obtained":[61,102],"zonal":[63],"or":[64],"preparative":[65],"ultracentrifugation":[66],"chromatography":[69],"on":[70,77,245],"2%":[71],"agarose.":[72],"Electron":[73],"microscopy":[74,96],"performed":[76],"full":[78],"plasma":[79],"lipoprotein":[81,99,121],"using":[84],"techniques":[86],"negative":[88],"staining,":[89],"freeze":[90],"etching,":[91],"shadowing":[92],"scanning":[94],"electron":[95,174],"(SEM).":[97],"The":[98,231],"morphology":[100],"thus":[101],"compared":[104],"that":[106],"I":[109],"Zieve's":[113],"syndrome.":[114],"All":[115,220],"conditions":[116],"investigated":[117],"had":[118],"some":[119,167],"abnormal":[120],"structures":[122,142,164,182,221],"com":[124],"mon:":[125],"1)":[126],"Liposome-like":[127],"particles":[128,206,267],"(500-4000":[129],"\u00c5)":[130,144,186],"intermediate":[133],"molecular":[134,194],"weight":[135,195],"(IMW)":[136],"fraction":[137],"1.006-1.063.2)":[140],"Disc-shaped":[141],"(150-1000":[143],"tending":[145],"to":[146,243],"aggregate":[147],"stacks":[149],"rouleaux":[151],"upon":[152],"concentration":[153],"HDL2.":[157],"3)":[158,270],"Flattened,":[159],"translucent":[160],"mostly":[162],"round":[163],"(200-3500":[165],"\u00c5),":[166,208],"small":[170],"globular":[171],"area":[172],"dense":[175],"lipid":[176],"(all":[177],"classes).":[179],"4)":[180,239],"Sword-like":[181],"(1000-":[183],">":[184],"10000":[185],"representing":[187],"macrocrystalline":[188],"free":[189],"cholesterol":[190,213,251],"(FC)":[191],"(LMW)":[196],"subfractions":[197],"<":[200,218],"1.019.5).":[201],"Small,":[202],"edgy":[203],"rod-like":[205],"(150-500":[207],"probably":[209],"consisting":[210],"microcrystalline":[212],"1.063.":[219],"observed":[222],"represent":[223],"different":[224],"physical-chemical":[225],"arrangements":[226],"excess":[228,260],"surface":[229],"lipid.":[230],"appearance":[232],"amounts":[235,277],"crystalline":[237],"structures,":[238],"5),":[241],"seems":[242],"depend":[244],"presence":[247],"phospholipase":[249],"and/or":[250],"ester":[252],"hydrolase":[253],"activity":[254],"(Zieve's":[255],"syndrome)":[256],"which":[257],"generates":[258],"an":[259],"FC":[262,279],"over":[263],"phospholipid":[264],"(PL),":[265],"while":[266],"described":[268],"under":[269],"2)":[272],"predominate":[273],"when":[274],"roughly":[275],"equimolar":[276],"PL":[281],"accumulate,":[282],"as":[283],"is":[284],"case":[286],"'pure'":[288],"LCAT-deficiency.":[289]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2022-05-12T00:00:00"}